Reproductive Toxicology

Article	Citations
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice	93
Intrauterine growth restriction: Clinical consequences on health and disease at adulthood	70
Review of the environmental prenatal exposome and its relationship to maternal and fetal health	70
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine	56
Exposure to phthalates and female reproductive health: A literature review	51
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies	42
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies	41
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system	39
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation	39
Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress	38
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models	38
Mechanisms of doxorubicin-mediated reproductive toxicity – A review	35
Exposure to Di-2-ethylhexyl phthalate (DEHP) and infertility in women, NHANES 2013-2016	35
Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency	32
Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model	31
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps	31
Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals	29
SARS-COV-2 (Covid-19) and male fertility: Where are we?	29
Placental outcomes of phthalate exposure	27
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models	26
Effects of the 2018 Camp Fire on birth outcomes in non-human primates: Case-control study	25
Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development	24
MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP1	24
The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays	24
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content	24

Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress	24
Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis	23
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice	23
Endocrine disruptors and endometriosis	22
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells	22
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures	21
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10	21
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice	20
Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast	20
Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP1	19
A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes	19
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges	18
Radiofrequency radiation: A possible threat to male fertility	18
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring	18
Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice	18
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary	18
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model	17
Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects	17
An ontology for developmental processes and toxicities of neural tube closure	17
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta	17
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats	17
Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study	16
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evi	16
Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats	16
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain developmen	16
Iron overload compromises preimplantation mouse embryo development	15
Effects of flame retardants on ovarian function	15
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole	15
High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation	15
Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus	15
Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac	15
GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway	15
A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells	15
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube	15
Ovarian toxicity of nanoparticles	15
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice	14
Bisphenol analogs AF, S and F: Effects on functional characteristics of porcine granulosa cells	14
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats	14
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and gli	14
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review	14
Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): Focus on benzo[a]pyrene neurotoxicity	14
Vitamin D3 protects against lead-induced testicular toxicity by modulating Nrf2 and NF-κB genes expression in rat	14
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data	14
Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats	14
Changes in serum heavy metals in polycystic ovary syndrome and their association with endocrine, lipid-metabolism, inflammatory characteristics and pregnancy outcomes	14
Scalable expansion of iPSC and their derivatives across multiple lineages	14
SRT1720 plays a role in oxidative stress and the senescence of human trophoblast HTR8/SVneo cells induced by D-galactose through the SIRT1/FOXO3a/ROS signalling pathway	14
Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring	14
Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) causes multigenerational adverse effects on the uterus of F1 and F2 offspring rats.	13
A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population	13

Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway	13
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing	13
Retinoid signaling in skeletal development: Scoping the system for predictive toxicology	13
The deleterious toxic effects of bifenthrin on male fertility	13
Associations of phthalates with prostate cancer among the US population	12
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature	12
Metal(loid)s and human semen quality: The LIFE Study	12
Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission	12
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study	12
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice	11
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes	11
Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence	11
Novel methods to detect ROS in viable spermatozoa of native semen samples	11
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish	11
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis	11
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition	11
Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas	11
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 2019	11
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary	11
Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein	11
Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity	11
Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder	10
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries	10
Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis	10
The reversible reproductive toxicity of 5-fluorouracil in mice	10
Placental model as an important tool to study maternal-fetal interface	10
Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers	10
Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study	10
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption	10
Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging	10
Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells	10
Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review	9
Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study	9
Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis	9
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells	9
Juvenile exposure and adult risk assessment with single versus repeated exposure of melphalan in the germ cells of male SD rat: Deciphering the molecular mechanisms	9
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone developm	9
Protective effect of gallic acid on doxorubicin-induced ovarian toxicity in mouse	9
Reproductive toxicity of ritonavir in male: Insight into mouse sperm capacitation	9
Effects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems	9
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study	9
Vitamin C protects early mouse embryos against juglone toxicity	9
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule ne	9
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway	9
The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature	9
Sphingosine 1-phosphate alleviates radiation-induced ferroptosis in ovarian granulosa cells by upregulating glutathione peroxidase 4	9
Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland	9
Association between exposures to phthalate metabolites and preterm birth and spontaneous preterm birth: A systematic review and meta-analysis	9
Transcriptional profiling of Chinese hamster ovary (CHO) cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)	8
Long-term transplantation human menstrual blood mesenchymal stem cell loaded collagen scaffolds repair endometrium histological injury	8
Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary	8
Association between early oxidative DNA damage and iron status in women with gestational diabetes mellitus	8
Effects of prepubertal exposure to forchlorfenuron through prenatal and postnatal gavage administration in developing Sprague-Dawley rats	8
AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles	8
Comparing the effects of bisphenol A, C, and F on bovine theca cells in vitro	8
An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity	8
Paraben exposure alters cell cycle progression and survival of spontaneously immortalized secretory murine oviductal epithelial (MOE) cells	8
Sertoli cells-derived exosomal miR-30a-5p regulates ubiquitin E3 ligase Zeb2 to affect the spermatogonial stem cells proliferation and differentiation	8
Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility	8
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats	8
Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6	8
No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19	8
Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs	8
Mogroside V ameliorates the oxidative stress-induced meiotic defects in porcine oocytes in vitro	8
Iron deficiency and overload in men and woman of reproductive age, and pregnant women	8
Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation	8
Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse	8
BPA disrupts meiosis I in oogonia by acting on pathways including cell cycle regulation, meiosis initiation and spindle assembly	8
Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats	8
Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies	8
Host microRNAs regulate expression of hepatitis B virus genes during transmission from patients’ sperm to embryo	7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation	7
Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats	7
Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing	7
Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats	7
Association of environmental phenols with endometriosis and uterine leiomyoma: An analysis of NHANES, 2003–2006	7
Reproductive and developmental toxicity of perfluorooctane sulfonate (PFOS) in the white-footed mouse (Peromyscus leucopus)	7
Identification and verification of hub microRNAs in varicocele rats through high-throughput sequencing and bioinformatics analysis	7
Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction	7
The influence of lead exposure on male semen parameters: A systematic review and meta-analysis	7

The optimal compound reference genes for qRT-PCR analysis in the developing rat long bones under physiological conditions and prenatal dexamethasone exposure model	7
Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing	7
MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome	7
EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway	7
Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs	7