Reproductive Toxicology

(The TQCC of Reproductive Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice80
Review of the environmental prenatal exposome and its relationship to maternal and fetal health69
Intrauterine growth restriction: Clinical consequences on health and disease at adulthood61
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine51
An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches41
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies40
Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat39
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models38
Exposure to phthalates and female reproductive health: A literature review38
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies36
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation36
Maternal exposure to Δ9-tetrahydrocannabinol impairs female offspring glucose homeostasis and endocrine pancreatic development in the rat35
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system35
Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency31
Exposure to Di-2-ethylhexyl phthalate (DEHP) and infertility in women, NHANES 2013-201629
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city29
SARS-COV-2 (Covid-19) and male fertility: Where are we?29
Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model29
Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway28
Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress28
Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression27
Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates27
Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats25
Actin binding proteins, actin cytoskeleton and spermatogenesis – Lesson from toxicant models25
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models25
Mechanisms of doxorubicin-mediated reproductive toxicity – A review25
The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays24
Predicting risk of low birth weight offspring from maternal features and blood polycyclic aromatic hydrocarbon concentration24
Effects of the 2018 Camp Fire on birth outcomes in non-human primates: Case-control study23
Primary and Secondary Markers of Doxorubicin-Induced Female Infertility and the Alleviative Properties of Quercetin and Vitamin E in a Rat Model23
MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP123
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model23
Placental outcomes of phthalate exposure23
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content22
Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals22
Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats22
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study22
Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities20
Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis20
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures20
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps20
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice20
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)19
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-1019
Associations of exposure to phthalates and environmental phenols with gynecological disorders19
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice19
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells19
Investigating the effects of fipronil on male fertility: Insight into the mechanism of capacitation19
Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development19
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress18
Machine learning on drug-specific data to predict small molecule teratogenicity18
Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast18
A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes18
Endocrine disruptors and endometriosis18
Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity18
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta17
Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling17
Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor17
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges17
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity17
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring16
Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP116
Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study16
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evi16
An ontology for developmental processes and toxicities of neural tube closure16
Radiofrequency radiation: A possible threat to male fertility16
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model15
Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice15
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain developmen15
Iron overload compromises preimplantation mouse embryo development14
Effects of flame retardants on ovarian function14
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube14
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole14
Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats14
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and gli14
Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice14
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice14
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor14
Selenium Ameliorates Ibuprofen Induced Testicular Toxicity by Redox Regulation14
Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic14
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period14
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary13
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing13
Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac13
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats13
Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus13
Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects13
Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring13
Changes in serum heavy metals in polycystic ovary syndrome and their association with endocrine, lipid-metabolism, inflammatory characteristics and pregnancy outcomes13
GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway13
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats12
SRT1720 plays a role in oxidative stress and the senescence of human trophoblast HTR8/SVneo cells induced by D-galactose through the SIRT1/FOXO3a/ROS signalling pathway12
Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats12
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review12
Prenatal perfluoroalkyl substances and newborn anogenital distance in a Canadian cohort12
Gestational vitamin D deficiency impairs fetal lung development through suppressing type II pneumocyte differentiation12
High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation12
Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier12
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice12
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data12
Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures12
Detrimental effects of temephos on male fertility: An in vitro study on a mouse model12
Ovarian toxicity of nanoparticles12
Retinoid signaling in skeletal development: Scoping the system for predictive toxicology11
Scalable expansion of iPSC and their derivatives across multiple lineages11
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish11
A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells11
Bisphenol analogs AF, S and F: Effects on functional characteristics of porcine granulosa cells11
Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas11
Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway11
“Real life” polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines11
Vitamin D3 protects against lead-induced testicular toxicity by modulating Nrf2 and NF-κB genes expression in rat11
Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein11
Novel methods to detect ROS in viable spermatozoa of native semen samples10
Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission10
Associations of phthalates with prostate cancer among the US population10
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption10
Effects of marijuana on human reproduction10
Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers10
A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population10
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature10
The deleterious toxic effects of bifenthrin on male fertility10
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice10
Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis10
Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) causes multigenerational adverse effects on the uterus of F1 and F2 offspring rats.10
Metal(loid)s and human semen quality: The LIFE Study10
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries10
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis10
Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension10
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition9
Vanadium adversely affects sperm motility and capacitation status via protein kinase A activity and tyrosine phosphorylation9
Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis9
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells9
Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review9
The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological orga9
Fine particulate matter reduces the pluripotency and proliferation of human embryonic stem cells through ROS induced AKT and ERK signaling pathway9
Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging9
Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles9
Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone9
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes9
Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity9
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study9
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone developm9
Comparing the effects of bisphenol A, C, and F on bovine theca cells in vitro8
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine8
Dissimilar effects of curcumin on human granulosa cells: Beyond its anti-oxidative role8
Effects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems8
Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland8
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study8
Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells8
Effects of Bisphenol A on expression of genes related to amino acid transporters, insulin- like growth factor, aquaporin and amino acid release by porcine trophectoderm cells8
The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature8
The reversible reproductive toxicity of 5-fluorouracil in mice8
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary8
Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies8
Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): Focus on benzo[a]pyrene neurotoxicity8
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats8
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule ne8
Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder8
Reproductive toxicity of ritonavir in male: Insight into mouse sperm capacitation8
Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure8
Long-term transplantation human menstrual blood mesenchymal stem cell loaded collagen scaffolds repair endometrium histological injury8
Placental model as an important tool to study maternal-fetal interface8
Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence8
Vitamin C protects early mouse embryos against juglone toxicity8
Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary7
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway7
Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism7
An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity7
Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation7
Paraben exposure alters cell cycle progression and survival of spontaneously immortalized secretory murine oviductal epithelial (MOE) cells7
Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide7
Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing7
Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study7
EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway7
Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies7
Effects of prepubertal exposure to forchlorfenuron through prenatal and postnatal gavage administration in developing Sprague-Dawley rats7
Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study7
Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis7
No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-197
MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome7
Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs7
Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs7
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 20197
Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance7
Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats7