Reproductive Toxicology

Article	Citations
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice	83
Review of the environmental prenatal exposome and its relationship to maternal and fetal health	69
Intrauterine growth restriction: Clinical consequences on health and disease at adulthood	63
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine	52
An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches	42
Exposure to phthalates and female reproductive health: A literature review	40
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies	40
Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat	39
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models	38
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies	38
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system	37
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation	36
Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency	31
Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress	31
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city	30
Mechanisms of doxorubicin-mediated reproductive toxicity – A review	30
Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model	30
Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway	29
Exposure to Di-2-ethylhexyl phthalate (DEHP) and infertility in women, NHANES 2013-2016	29
SARS-COV-2 (Covid-19) and male fertility: Where are we?	29
Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates	27
Actin binding proteins, actin cytoskeleton and spermatogenesis – Lesson from toxicant models	26
Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats	25
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models	25
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model	24

The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays	24
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps	24
Placental outcomes of phthalate exposure	24
MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP1	23
Primary and Secondary Markers of Doxorubicin-Induced Female Infertility and the Alleviative Properties of Quercetin and Vitamin E in a Rat Model	23
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content	23
Effects of the 2018 Camp Fire on birth outcomes in non-human primates: Case-control study	23
Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development	23
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress	22
Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals	22
Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats	22
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study	22
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)	21
Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities	21
Associations of exposure to phthalates and environmental phenols with gynecological disorders	20
Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor	20
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures	20
Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis	20
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice	20
Endocrine disruptors and endometriosis	19
A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes	19
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice	19
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells	19
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10	19
Machine learning on drug-specific data to predict small molecule teratogenicity	19
Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast	18
Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity	18
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta	17
Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling	17
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges	17
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity	17
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring	17
An ontology for developmental processes and toxicities of neural tube closure	17
Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP1	16
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evi	16
Radiofrequency radiation: A possible threat to male fertility	16
Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study	16
Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice	15
Selenium Ameliorates Ibuprofen Induced Testicular Toxicity by Redox Regulation	15
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary	15
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube	15
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain developmen	15
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model	15
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor	14
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and gli	14
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period	14
Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac	14
GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway	14
High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation	14
Effects of flame retardants on ovarian function	14

Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice	14
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole	14
Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats	14
Iron overload compromises preimplantation mouse embryo development	14
Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic	14
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice	14
Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats	13
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats	13
Detrimental effects of temephos on male fertility: An in vitro study on a mouse model	13
Scalable expansion of iPSC and their derivatives across multiple lineages	13
Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects	13
Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring	13
Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus	13
Retinoid signaling in skeletal development: Scoping the system for predictive toxicology	13
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing	13
Changes in serum heavy metals in polycystic ovary syndrome and their association with endocrine, lipid-metabolism, inflammatory characteristics and pregnancy outcomes	13
SRT1720 plays a role in oxidative stress and the senescence of human trophoblast HTR8/SVneo cells induced by D-galactose through the SIRT1/FOXO3a/ROS signalling pathway	12
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature	12
Ovarian toxicity of nanoparticles	12
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats	12
Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway	12
Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier	12
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice	12
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data	12
Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures	12
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review	12
Vitamin D3 protects against lead-induced testicular toxicity by modulating Nrf2 and NF-κB genes expression in rat	12
Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas	11
A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells	11
Bisphenol analogs AF, S and F: Effects on functional characteristics of porcine granulosa cells	11
Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein	11
Metal(loid)s and human semen quality: The LIFE Study	11
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish	11
“Real life” polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines	11
Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) causes multigenerational adverse effects on the uterus of F1 and F2 offspring rats.	10
Associations of phthalates with prostate cancer among the US population	10
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice	10
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis	10
Novel methods to detect ROS in viable spermatozoa of native semen samples	10
Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission	10
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries	10
Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis	10
Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension	10
A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population	10
The deleterious toxic effects of bifenthrin on male fertility	10
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption	10
Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging	10
Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers	10
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition	10
The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological orga	9
Fine particulate matter reduces the pluripotency and proliferation of human embryonic stem cells through ROS induced AKT and ERK signaling pathway	9
Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance	9
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study	9
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary	9
Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence	9
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes	9
Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review	9
Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity	9
Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis	9
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells	9
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study	9
Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): Focus on benzo[a]pyrene neurotoxicity	9
Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone	9
Vanadium adversely affects sperm motility and capacitation status via protein kinase A activity and tyrosine phosphorylation	9
Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder	9
Effects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems	9
Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles	9
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone developm	9
Dissimilar effects of curcumin on human granulosa cells: Beyond its anti-oxidative role	8
Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland	8
Placental model as an important tool to study maternal-fetal interface	8
Vitamin C protects early mouse embryos against juglone toxicity	8
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule ne	8
Effects of Bisphenol A on expression of genes related to amino acid transporters, insulin- like growth factor, aquaporin and amino acid release by porcine trophectoderm cells	8
Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies	8
Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure	8
Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies	8
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats	8
Comparing the effects of bisphenol A, C, and F on bovine theca cells in vitro	8
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine	8

The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature	8
The reversible reproductive toxicity of 5-fluorouracil in mice	8
Long-term transplantation human menstrual blood mesenchymal stem cell loaded collagen scaffolds repair endometrium histological injury	8
Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells	8
Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study	8
Reproductive toxicity of ritonavir in male: Insight into mouse sperm capacitation	8
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway	7
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 2019	7
Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis	7
Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary	7
Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism	7
Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse	7
No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19	7
Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study	7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation	7
Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats	7
MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome	7
EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway	7
Effects of prepubertal exposure to forchlorfenuron through prenatal and postnatal gavage administration in developing Sprague-Dawley rats	7
Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide	7
Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs	7
An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity	7
Paraben exposure alters cell cycle progression and survival of spontaneously immortalized secretory murine oviductal epithelial (MOE) cells	7
Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation	7
Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing	7
Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs	7
Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6	7
Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats	7