Reproductive Toxicology

(The TQCC of Reproductive Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-11-01 to 2023-11-01.)
Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health72
Review of the environmental prenatal exposome and its relationship to maternal and fetal health56
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice48
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine47
Intrauterine growth restriction: Clinical consequences on health and disease at adulthood45
The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis41
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies35
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models35
Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders33
An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches32
Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat31
Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells31
Maternal exposure to Δ9-tetrahydrocannabinol impairs female offspring glucose homeostasis and endocrine pancreatic development in the rat30
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies29
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation29
Prenatal exposure to a phthalate mixture leads to multigenerational and transgenerational effects on uterine morphology and function in mice28
SARS-COV-2 (Covid-19) and male fertility: Where are we?28
Elevated blood mercury level has a non-linear association with infertility in U.S. women: Data from the NHANES 2013–201628
Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model27
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city27
Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency26
Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort26
Regulatory needs and activities to address the retinoid system in the context of endocrine disruption: The European viewpoint26
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system24
Iodoacetic acid inhibits follicle growth and alters expression of genes that regulate apoptosis, the cell cycle, estrogen receptors, and ovarian steroidogenesis in mouse ovarian follicles24
Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice23
In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer23
Exposure to low doses of oxybenzone during perinatal development alters mammary gland morphology in male and female mice23
Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum22
Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960’s22
Mechanisms of doxorubicin-mediated reproductive toxicity – A review21
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models21
Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates21
Predicting risk of low birth weight offspring from maternal features and blood polycyclic aromatic hydrocarbon concentration20
Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats20
Actin binding proteins, actin cytoskeleton and spermatogenesis – Lesson from toxicant models20
Exposure to phthalates and female reproductive health: A literature review20
Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling20
Effects of the 2018 Camp Fire on birth outcomes in non-human primates: Case-control study19
Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression19
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content19
Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway19
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model19
MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP119
Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress19
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice18
Exposure to Di-2-ethylhexyl phthalate (DEHP) and infertility in women, NHANES 2013-201618
Primary and Secondary Markers of Doxorubicin-Induced Female Infertility and the Alleviative Properties of Quercetin and Vitamin E in a Rat Model18
Placental outcomes of phthalate exposure18
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity17
The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays17
Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities17
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study17
Molecular characterization of a toxicological tipping point during human stem cell differentiation17
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures17
Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development17
Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast17
Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling16
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells16
Acute low-dose bisphenol S exposure affects mouse oocyte quality16
Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA16
Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor15
In utero DDT exposure and breast density before age 5015
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice15
Investigating the effects of fipronil on male fertility: Insight into the mechanism of capacitation15
A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes15
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta15
Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice15
Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity15
Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study14
Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice14
Machine learning on drug-specific data to predict small molecule teratogenicity14
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps14
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evi14
Maternal benzo[a]pyrene exposure is correlated with the meiotic arrest and quality deterioration of offspring oocytes in mice14
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-1014
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)13
Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis13
Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice13
A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins13
An ontology for developmental processes and toxicities of neural tube closure13
Copper and lead exposures disturb reproductive features of primary endometrial stromal and epithelial cells13
Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats13
Associations of exposure to phthalates and environmental phenols with gynecological disorders13
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and gli13
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period13
Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac13
Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals13
Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures12
Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs12
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole12
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing12
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice12
Critical review of the association between perineal use of talc powder and risk of ovarian cancer12
N-acetyl-l-cysteine protects porcine oocytes undergoing meiotic resumption from heat stress12
DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study12
BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions11
Prenatal perfluoroalkyl substances and newborn anogenital distance in a Canadian cohort11
In utero DDT exposure and breast density in early menopause by maternal history of breast cancer11
Biological interactions between nanomaterials and placental development and function following oral exposure11
Radiofrequency radiation: A possible threat to male fertility11
Ovarian toxicity of nanoparticles11
Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats11
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring11
Dioxin male rat reproductive toxicity mode of action and relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran characterized by fetal pituitary and testis transcr11
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice11
SRT1720 plays a role in oxidative stress and the senescence of human trophoblast HTR8/SVneo cells induced by D-galactose through the SIRT1/FOXO3a/ROS signalling pathway11
Selenium Ameliorates Ibuprofen Induced Testicular Toxicity by Redox Regulation11
Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects10
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model10
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats10
Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus10
Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic10
Trichostatin A alleviated ovarian tissue damage caused by cigarette smoke exposure10
Gestational vitamin D deficiency impairs fetal lung development through suppressing type II pneumocyte differentiation10
Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway10
Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier10
Detrimental effects of temephos on male fertility: An in vitro study on a mouse model10
Bisphenol analogs AF, S and F: Effects on functional characteristics of porcine granulosa cells10
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data10
Retinoid signaling in skeletal development: Scoping the system for predictive toxicology10
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature10
Neural crest related gene transcript regulation by valproic acid analogues in the cardiac embryonic stem cell test10
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube10
Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP110
A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells9
Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children9
Effects of marijuana on human reproduction9
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges9
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain developmen9
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals9
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress9
Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles9
The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological orga9
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish9
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice9
“Real life” polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines9
Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein9
Iron overload compromises preimplantation mouse embryo development9
Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas8
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine8
Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring8
Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application8
Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension8
Vitamin K antagonist rodenticides display different teratogenic activity8
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats8
Anti-Müllerian hormone participates in ovarian granulosa cell damage due to cadmium exposure by negatively regulating stem cell factor8
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor8
Dissimilar effects of curcumin on human granulosa cells: Beyond its anti-oxidative role8
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption8
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats8
Vitamin D3 protects against lead-induced testicular toxicity by modulating Nrf2 and NF-κB genes expression in rat8
Novel methods to detect ROS in viable spermatozoa of native semen samples8
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary8
Brominated diphenyl ether-47 differentially regulates cellular migration and invasion in a human first trimester trophoblast cell line8
Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats8
Prenatal toxicity of the environmental pollutants on neuronal and cardiac development derived from embryonic stem cells8
Scalable expansion of iPSC and their derivatives across multiple lineages8
Kallikrein-kinin system and oxidative stress in cisplatin-induced ovarian toxicity7
Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers7
Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells7
Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs7
The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation7
Effects of flame retardants on ovarian function7
The reversible reproductive toxicity of 5-fluorouracil in mice7
Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis7
Male infertility: A proximate look at the advanced glycation end products7
MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome7
Vitamin C protects early mouse embryos against juglone toxicity7
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition7
High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation7
Predicting the safety of medicines in pregnancy: A workshop report7
Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure7
A vision for exposome epidemiology: The pregnancy exposome in relation to breast cancer in the Child Health and Development Studies7
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis7
Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies7
Fetal safety of methylphenidate—A scoping review and meta analysis7
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone developm7
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes7
Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study7
Can maternal exposure to paracetamol impair reproductive parameters of male rat offspring?7
Metal(loid)s and human semen quality: The LIFE Study7
Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis7
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study7