Toxicology in Vitro

Article	Citations
Dinaciclib inhibits the growth of acute myeloid leukemia cells through either cell cycle-related or ERK1/STAT3/MYC pathways	55
Evaluation of in vitro cornea models for quantifying destructive effects of chemicals	49
Editorial Board	49
Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals	39
Minimum information for studies of extracellular vesicles (MISEV) as toolbox for rigorous, reproducible and homogeneous studies on extracellular vesicles	36
Emerging trends in immunotoxin targeting cancer stem cells	34
Prediction of acute oral toxicity using the Hansen solubility parameter	33
Essential oil from Ocimum carnosum induces ROS mediated mitochondrial dysfunction and intrinsic apoptosis in HL-60 cells	33
Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array	30
The selected epigenetic effects of phthalates: DBP, BBP and their metabolites: MBP, MBzP on human peripheral blood mononuclear cells (In Vitro)	29
Transcriptomic analysis suggests ferroptosis as a potential mechanism of fipronil-induced cytotoxicity in human glioblastoma cells	29
Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death	28
Using cimetidine to mitigate cisplatin-induced ototoxicity	27
Mechanism for inhibition of cytotoxicity of Shiga toxin by luteolin	27
Organochlorine pesticides disrupt T helper cell regulation and reduce IL-2 and IFN-γ favoring infection and production of autoantibodies among pemphigus patients	26
In vitro safety evaluation of sunscreen formulation from nanostructured lipid carriers using human cells and skin model	26
Metformin and buparlisib synergistically induce apoptosis of non-small lung cancer (NSCLC) cells via Akt/FoxO3a/Puma axis	26
The evaluation of anticancer activity by synthesizing 5FU loaded albumin nanoparticles by exposure to UV light	24
Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides	24
Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells	24
An in vitro nerve agent brain poisoning transwell model for convenient and accurate antidote evaluation	23
In-house performance assessment of 3D QobuR-Reconstructed Human Cornea-Like Epithelium (RhCE) for the evaluation of eye hazard	23
Development of a human FaFg prediction system for polyphenols using human induced pluripotent stem cell-derived small intestinal epithelial cells	23
Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells	22
Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol	21

A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells	20
Machine learning predictive classification models for the carcinogenic activity of activated metabolites derived from aromatic amines and nitroaromatics	20
Cisplatin adducts at DNA or RNA do not affect their cellular isolation efficiencies using column-based kits or manual Trizol-based purification methods	20
Hazard associated with the synthesis of epoxy-vitrimer: In vitro risk assessment and scoring strategy	19
In vitro genotoxic and antigenotoxic effects of an exopolysaccharide isolated from Lactobacillus salivarius KC27L	19
Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?	19
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations.	19
Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor	18
Streptomycin generates oxidative stress in melanin-producing cells: In vitro study with EPR spectroscopy evidence	18
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products	18
Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells	17
Editorial Board	17
Anti-migratory and cytotoxic effect of indole derivative in C6 glioma cells	17
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system	17
Corrigendum to “Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species” [Tox	17
Editorial Board	17
Particulate matter exposure-induced cholesterol metabolism dysregulation in lung epithelial cells	16
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes	16
Genotoxicity of putrescine and its effects on gene expression in HepG2 cell line	16
CYP-mediated metabolic divergence underpins oxoglaucine selectivity: Detoxification in healthy hepatocytes versus mitochondrial apoptosis in hepatocellular carcinoma	16
Lupeol-loaded PLGA particles conserve anti-topoisomerase activity and decrease the cytotoxicity of lupeol	16
Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system	16
Editorial Board	15
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs	15
Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis	15
Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation	15
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells	15
The importance of metrological tools to implementation of alternative method OECD TG 428	15
Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells	15
Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro	15
Species differences in microsomal metabolism of hydroxychloroquine	14
Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells	14
Editorial Board	14
Studying the intracellular bile acid concentration and toxicity in drug-induced cholestasis: Comprehensive LC-MS/MS analysis with human liver slices	14
In vitro inhibitory effects of selumetinib on activity of human UDP-glucuronosyltransferases and prediction of in vivo drug-drug interactions	14
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed	13
Editorial Board	13
Stronger prooxidative effects of chromium(VI) comparing to chromium(III) in endocrine and non-endocrine tissues with the thyroid being completely resistant to antioxidant protection	13
Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities	13
Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells	13
In vitro immune and redox response induced by cationic cellulose-based nanomaterials	13
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic	13
Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates	13
Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells	13
Editorial Board	13
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model	13
Organ-specific in vitro models for prediction of hazard assessment of nanomaterials	13
Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment	13
Isolation and characterization of bovine Limbal mesenchymal stromal cells for application in ocular toxicity studies	13
Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)	13

ESTIV 2022: Key enabling non-animal technologies for research, education and testing	13
In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals	12
Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based a	12
Differential comparison of genotoxic effects of aristolochic acid I and II in human cells by the mass spectroscopic quantification of γ-H2AX	12
Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines	12
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway	12
The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood – A combinatory approach using three in vitro models	12
Synergistic and divergent effects of dietary sugars on hepatocyte viability and steatosis	12
Optimization of in vitro culture of honeybee nervous tissue for pesticide risk assessment	12
Cigarette smoke extract decreases human bone marrow mesenchymal stromal cell adipogenic differentiation	12
Fragrances as a trigger of immune responses in different environments	12
First toxicity profile of aminoindane-based new psychoactive substances: 2-aminoindane (2-AI, CAS: 2975-41-9) and N-Methyl-2-aminoindane (NM-2-AI, CAS: 24445–44–1) – comprehensive prediction of toxico	12
The Nrf2 activator tBHQ inhibits dendritic cell maturation and activation in response to bacterial and viral stimuli	11
TNF-α and MMPs mediated mucus hypersecretion induced by cigarette smoke: An in vitro study	11
Editorial Board	11
Mesoporous nanosilica: A thromboprotective nanomaterial for biomedical applications	11
Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine	11
DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level	11
Effects of culture media on gene expression in reconstructed human epidermis and THP-1 monocytes for skin sensitization evaluation in co-culture systems	11
Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy	11
Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 431	11
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells	11
Assessing the skin sensitization potential of fragrance ingredients in consumer products using the peroxidase peptide reactivity assay (PPRA) as an additional weight of evidence	11
Nonylphenol reduced the number of haploids in in vitro spermatogenesis of the endangered cyprinid Gnathopogon caerulescens	11
Intragenic antimicrobial peptide Hs02 toxicity against leukemia cell lines is associated with increased expression of select pyroptotic components	11
Frankenstein's followers. Maintenance of human cells outside the body. Issue 1	11
Risk assessment of chlorophenols (CPs) exposure in vitro:Inhibition of sulfotransferases (SULTs) activity	10
Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells	10
Editorial Board	10
Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells	10
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT	10
Mictlan-D3: A novel medium sized RGD-Disintegrin obtained from Crotalus mictlantecuhtli venom, in vitro tested against human breast Cancer and endothelial cells	10
Pracaxi oil affects xenobiotic metabolisms, cellular proliferation, and oxidative stress without cytotogenotoxic effects in HepG2/C3A cells	10
N-acetyl-L-cysteine attenuated the toxicity of ZIF-8 on EA.hy926 endothelial cells by wnt/β-catenin pathway	10
In vitro toxicity of two functionalized reduced graphene oxide materials with potential application in food packaging	10
How to use an in vitro approach to characterize the toxicity of airborne compounds	10
Benzo[a]pyrene inhibits myoblast differentiation through downregulating the Hsp70-MK2-p38MAPK complex	10
Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes	10
Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line	10
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells	10
Use of centromeric probe to identify micronuclei origin and its advantages in genetic toxicology studies	10
4-O-methylascochlorin-stimulated HIF-1α expression induces the epithelial mesenchymal transition and cell survival in breast cancer cells	10
4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1	10
Potential risk of drug-drug interactions of ponatinib via inhibition against human UDP-glucuronosyltransferases	10
Acrylamide-induced damage to postsynaptic plasticity is CYP2E1 dependent in an SH-SY5Y co-culture system	10
Transdermal permeation of inorganic cerium salts in intact human skin	10
Study on percutaneous penetration of representative cosmetic ingredients in a baby wipe product in an in vitro diaper rash skin model	9
Perfluorooctanoic acid inhibits cell proliferation through mitochondrial damage	9
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line	9
The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines	9
Metabolic stability and effects of microsomal enzymes on the activity of the sonic hedgehog pathway inhibitor piperonyl butoxide	9
Bufadienolides from the Bufo viridis toad venom exert cytotoxic effects on cancer cells by inducing cell apoptosis and cell cycle arrest	9
Editorial Board	9
Testing chemicals for CYP19 inhibition: Comparison of a modified H295R steroidogenesis assay to a commercial fluorometric enzyme inhibition kit	9
In vitro eye irritation testing models may play pivotal role in effort to pursue mild baby cleansers	9
(-)-Epigallocatechin gallate as an inhibitor of hemoglobin-catalyzed lipid oxidation: molecular mechanism of action and nutritional application	9
High-throughput assay for predicting diarrhea risk using a 2D human intestinal stem cell-derived model	9
Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis	9
Polystyrene nanoparticles incorporate into the endoplasmic reticulum and disturb translation during meiotic maturation in mouse oocytes	9
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway	9
In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution	9
Washing with buffered vitamin C after corrosive chemical (sodium hypochlorite) exposure reduces ocular depth of injury	9
Thymoquinone attenuates poly(I:C)-induced cellular stress via PKR/ATF4/CHOP signaling and autophagy modulation in human alveolar epithelial cells	9
Effects of methylation of arginine residue 83 on the enzymatic activity of human arsenic (+3 oxidation state) methyltransferase	9
Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells	9
Cytotoxicity of ZnO nanoparticles in human melanocyte cells in the presence or absence of UV radiation: A preliminary comparative study with TiO2 nanoparticles	9
6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model)	9
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury	9
Strategies for the evaluation of the eye irritation potential of different types of surfactants and silicones used in cosmetic products	9
Advances in thyroid hormone system disruption testing – In vitro method for monitoring disrupted thyrotropin signaling through the human TSH receptor (hTSHR)	9
Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells	8
Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo	8
Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay	8
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models	8
Antifungal climbazole alters androgenic pathways in mammalian cells	8
Liposomal nanoparticles containing adenosine triphosphate targeted by heart-specific peptide ligands as antidotes for aluminum phosphide poisoning in isolated rat cardiomyocyte cell line	8
The impact of bisphenol AF on skeletal muscle function and differentiation in vitro	8
Interactions of oleanane pentacyclic triterpenoids with human organic anion transporting polypeptide 1B1 and 1B3	8
Mettl3-mediated transcriptome-wide m6A methylation induced by cigarette smoking in human bronchial epithelial cells	8
STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential	8

Editorial Board	8
A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies	8
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis	8
Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro	8
Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1	8
The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States	8
Delta-9 tetrahydrocannabinol (THC) effects on the cortisol stress response in bovine granulosa cells	8
Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds	8
Chronic exposure to palmitic acid-induced adipocyte hypertrophy and altered batokine gene expression in T37i brown adipocytes	8
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes	8
Toxicity of New Psychoactive Substance (NPS): Threo-4-methylmethylphenidate (4-Mmph) – Prediction of toxicity using in silico methods	8
A novel O2- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway	8
Tributyltin propionate and tributyltin salicylate represent novel RXR ligands: Effects on transcriptional activity of thyroid hormone receptor and vitamin D3 receptor	8
Effect of curcumin on the embryotoxic effect of ethanol in a zebrafish model	8
Chemometric modeling of acute toxicity of diverse aromatic compounds against Rana japonica	8
Mitochondria oxidative stress mediated nicotine-promoted activation of pancreatic stellate cells by regulating mitochondrial dynamics	8