Toxicology in Vitro

Article	Citations
Uptake and cellular effects of PE, PP, PET and PVC microplastic particles	131
Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models	70
Cytotoxic and cytocompatible comparison among seven photoinitiators-triggered polymers in different tissue cells	48
In vitro toxicity assessment of crosslinking agents used in hyaluronic acid dermal filler	46
Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells	41
Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids	39
Microplastics and nanoplastics: Size, surface and dispersant – What causes the effect?	36
Cellular uptake and toxicity of gold nanoparticles on two distinct hepatic cell models	34
Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions	34
Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products	33
Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations	32
Potential application of two cobalt (III) Schiff base complexes in cancer chemotherapy: Leads from a study using breast and lung cancer cells	28
In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase	26
In vitro cytotoxicity of zinc oxide nanoparticles in mouse ovarian germ cells	25
Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells	24
Calycosin induces mitochondrial-dependent apoptosis and cell cycle arrest, and inhibits cell migration through a ROS-mediated signaling pathway in HepG2 hepatocellular carcinoma cells	24
E-cigarettes induce toxicity comparable to tobacco cigarettes in airway epithelium from patients with COPD	24
Extrapolating from acute to chronic toxicity in vitro	22
Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: The role of oxidative stress	22
Radiation-induced H3K9 methylation on E-cadherin promoter mediated by ROS/Snail axis : Role of G9a signaling during lung epithelial-mesenchymal transition	22
Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model	22
Curcumin induces autophagic cell death in human thyroid cancer cells	21
Environmental dose of 16 priority-controlled PAHs mixture induce damages of vascular endothelial cells involved in oxidative stress and inflammation	21
Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin	21
Perfluorooctane sulfonate induced toxicity in embryonic stem cell-derived cardiomyocytes via inhibiting autophagy-lysosome pathway	21

Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines	21
Ophiopogonin D suppresses TGF-β1-mediated metastatic behavior of MDA-MB-231 breast carcinoma cells via regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis	21
Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study	20
Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation	20
Design, synthesis and biological evaluation of novel 1,2,3-triazole analogues of Imidazo-[1,2-a]-pyridine-3-carboxamide against Mycobacterium tuberculosis	19
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action	19
Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples	19
Monolayer (2D) or spheroids (3D) cell cultures for nanotoxicological studies? Comparison of cytotoxicity and cell internalization of nanoparticles	19
Investigation of nanoplastic cytotoxicity using SH-SY5Y human neuroblastoma cells and polystyrene nanoparticles	18
In silico prediction of chemical acute contact toxicity on honey bees via machine learning methods	18
Comparative analysis of the impact of e-cigarette vapor and cigarette smoke on human gingival fibroblasts	17
Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs	17
Comparison of the different protocols of the Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) by evaluating the eye irritation potential of surfactants	17
Anticancer effects of non-steroidal anti-inflammatory drugs against cancer cells and cancer stem cells	17
Toxicological analysis of aerosols derived from three electronic nicotine delivery systems using normal human bronchial epithelial cells	16
Skin permeation of nickel, cobalt and chromium salts in ex vivo human skin, visualized using mass spectrometry imaging	16
p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells	16
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets	15
TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1	15
In vitro toxicological evaluation of a tobacco heating product THP COO and 3R4F research reference cigarette on human lung cancer cells	15
USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling	14
Mechanisms of peripheral neurotoxicity associated with four chemotherapy drugs using human induced pluripotent stem cell-derived peripheral neurons	14
Toxicity of pesticides widely applied on soybean cultivation: Synergistic effects of fipronil, glyphosate and imidacloprid in HepG2 cells	14
Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells	14
Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells	14
Acrylamide and its metabolite induce neurotoxicity via modulation of protein kinase C and AMP-activated protein kinase pathways	14
Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p	14
An evaluation of a new high-sensitivity PrestoBlue assay for measuring cell viability and drug cytotoxicity using EA.hy926 endothelial cells	13
Cigarette smoke extracts induce apoptosis in Raw264.7 cells via endoplasmic reticulum stress and the intracellular Ca2+/P38/STAT1 pathway	13
Transcriptomic and proteomic responses of silver nanoparticles in hepatocyte-like cells derived from human induced pluripotent stem cells	13
Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette	13
Dissolution of titanium dioxide nanoparticles in synthetic biological and environmental media to predict their biodurability and persistence	13
Paraquat-activated BV-2 microglia induces neuroinflammatory responses in the neuron model through NF-κB signaling pathway	13
An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat	13
Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound	13
E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models	13
Mogroside V exerts anti-inflammatory effects on fine particulate matter-induced inflammation in porcine alveolar macrophages	13
Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes	13
Molecular fingerprints of conazoles via functional genomic profiling of	13
Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells' membrane	13
Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells	13
Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline	13
Underlying mechanisms of cytotoxicity in HepG2 hepatocarcinoma cells exposed to arsenic, cadmium and mercury individually and in combination	13
Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells	12
Developmental toxicity testing of unsubstituted and methylated 4- and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test	12
Synthesis and characterization of modified magnetic nanoparticles as theranostic agents: in vitro safety assessment in healthy cells	12
Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells	12
Arsenic-induced autophagy regulates apoptosis in AML-12 cells	12
Uranium induces genomic instability and slows cell cycle progression in human lymphocytes in acute toxicity study	12
A novel synergistic anticancer effect of fungal cholestanol glucoside and paclitaxel: Apoptosis induced by an intrinsic pathway through ROS generation in cervical cancer cell line (HeLa)	12

Plumbagin downregulates UHRF1, p-Akt, MMP-2 and suppresses survival, growth and migration of cervical cancer CaSki cells	12
Maximizing the relevance and reproducibility of A549 cell culture using FBS-free media	12
Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis	12
Validation study of a new reconstructed human epidermis model EPiTRI for in vitro skin irritation test according to OECD guidelines	12
Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening	12
Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells	12
Novel diphenyl urea derivative serves as an inhibitor on human lung cancer cell migration by disrupting EMT via Wnt/β-catenin and PI3K/Akt signaling	12
Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals	12
An in vitro model for microbial fructoselysine degradation shows substantial interindividual differences in metabolic capacities of human fecal slurries	11
Limonene-carvacrol: A combination of monoterpenes with enhanced antileishmanial activity	11
Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models	11
Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities	11
In vitro differentiation modifies the neurotoxic response of SH-SY5Y cells	11
Polyphenol effects on CuO-nanoparticle-mediated DNA damage, reactive oxygen species generation, and fibroblast cell death	11
Recent advancements and application of in vitro models for predicting inhalation toxicity in humans	11
Toxicological impact of organic ultrafine particles (UFPs) in human bronchial epithelial BEAS-2B cells at air-liquid interface	11
Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines	11
Effects of vanadium (sodium metavanadate) and aflatoxin-B1 on cytochrome p450 activities, DNA damage and DNA methylation in human liver cell lines	11
Silica nanoparticle induces pulmonary fibroblast transdifferentiation via macrophage route: Potential mechanism revealed by proteomic analysis	11
Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures	11
Meta-analysis of in-vitro cytotoxicity evaluation studies of zinc oxide nanoparticles: Paving way for safer innovations	11
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects	11
Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose met	11
N-acetylcysteine protect inner hair cells from cisplatin by alleviated celluar oxidative stress and apoptosis	10
Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways	10
A quantitative AOP of mitochondrial toxicity based on data from three cell lines	10
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs	10
Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential	10
Novel podophyllotoxin and benzothiazole derivative induces transitional morphological and functional changes in HaCaT cells	10
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway	10
Standardized pyrogen testing of medical products with the bacterial endotoxin test (BET) as a substitute for rabbit Pyrogen testing (RPT): A scoping review	10
Hazard assessment using an in-silico toxicity assessment of the transformation products of boscalid, pyraclostrobin, fenbuconazole and glyphosate generated by exposure to an advanced oxidative process	10
Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in	10
Exploring in vitro to in vivo extrapolation for exposure and health impacts of e-cigarette flavor mixtures	10
The dissolution of stone wool fibers with sugar-based binder and oil in different synthetic lung fluids	10
Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test	10
Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells	10
Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology	10
Mutagenicity evaluation of pesticide analogs using standard and 6-well miniaturized bacterial reverse mutation tests	10
Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells	10
Genotoxic impact of aluminum-containing nanomaterials in human intestinal and hepatic cells	10
Emerging trends in immunotoxin targeting cancer stem cells	10
The role of UVA radiation in ketoprofen-mediated BRAF-mutant amelanotic melanoma cells death – A study at the cellular and molecular level	9
The numerical probability of carcinogenicity to humans of some antimicrobials: Nitro-monoaromatics (including 5-nitrofurans and 5-nitroimidazoles), quinoxaline-1,4-dioxides (including carbadox), and c	9
Triclosan affects the expression of nitric oxide synthases (NOSs), peroxisome proliferator-activated receptor gamma (PPARγ), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)	9
Development of the SkinEthic HCE Time-to-Toxicity test method for identifying liquid chemicals not requiring classification and labelling and liquids inducing serious eye damage and eye irritation	9
In vitro toxicity of naringin and berberine alone, and encapsulated within PMMA nanoparticles	9
Multifunctional PLGA nanoparticles combining transferrin-targetability and pH-stimuli sensitivity enhanced doxorubicin intracellular delivery and in vitro antineoplastic activity in MDR tumor cells	9
Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells	9
Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes	9
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes	9
Donor-to-donor variability of a human three-dimensional bronchial epithelial model: A case study of cigarette smoke exposure	9
MicroRNA-184 attenuates hypoxia and oxidative stress-related injury via suppressing apoptosis, DNA damage and angiogenesis in an in vitro age-related macular degeneration model	9
L-cysteine embedded core-shell ZnO microspheres composed of nanoclusters enhances anticancer activity against liver and breast cancer cells	9
SkinEthic HCE Time-to-Toxicity on solids: A test method for distinguishing chemicals inducing serious eye damage, eye irritation and not requiring classification and labelling	9
Microcystin-LR-induced autophagy regulates oxidative stress, inflammation, and apoptosis in grass carp ovary cells in vitro	9
Responses of increasingly complex intestinal epithelium in vitro models to bacterial toll-like receptor agonists	9
Antiangiogenic effects of phospholipase A2 Lys49 BnSP-7 from Bothrops pauloensis snake venom on endothelial cells: An in vitro and ex vivo approach	9
PDE-5 inhibitors in selected herbal supplements from the Ghanaian market for better erectile function as tested by a bioassay	9
In vitro evaluation of cytotoxic effects of di (2-ethylhexyl) phthalate (DEHP) produced by Bacillus velezensis strain RP137 isolated from Persian Gulf	8
Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro	8
Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells	8
The evaluation of anticancer activity by synthesizing 5FU loaded albumin nanoparticles by exposure to UV light	8
Validation of the SkinEthic HCE Time-to-Toxicity test method for eye hazard classification of chemicals according to UN GHS	8
Albumin binds to uncoupler CCCP to diminish depolarization of mitochondria	8
Co-culture hydrogel micro-chamber array-based plate for anti-tumor drug development at single-element resolution	8
Lapatinib enhances paclitaxel toxicity in MCF-7, T47D, and MDA-MB-321 breast cancer cells	8
Scoparone induces both apoptosis and ferroptosis via multiple mechanisms in non-small-cell lung cancer cells	8
TGF-β1 decreases CHOP expression and prevents cardiac fibroblast apoptosis induced by endoplasmic reticulum stress	8
Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion	8
In vitro biocompatibility and wound healing properties of latex proteins dressing	8
Transcriptome sequencing of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes.	8
Tomentosin induces apoptosis in pancreatic cancer cells through increasing reactive oxygen species and decreasing mitochondrial membrane potential	8
In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays	8
Pentachlorophenol mediated regulation of DAMPs and inflammation: In vitro study	8
Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells	8
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models	8
Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen	8
Characterization of a rapid condensate collection apparatus for in vitro assays of electronic nicotine delivery systems	8
Long-term in vitro exposure of human granulosa cells to the mixture of endocrine disrupting chemicals found in human follicular fluid disrupts steroidogenesis	8

Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure	8
Machine learning predictive classification models for the carcinogenic activity of activated metabolites derived from aromatic amines and nitroaromatics	8
Imbalance in the antioxidant defence system and pro-genotoxic status induced by high glucose concentrations: In vitro testing in human liver cells	8
In vitro cytotoxicity study of superparamagnetic iron oxide and silica nanoparticles on pneumocyte organelles	8
Assessment of perfluorooctanoic acid toxicity in pancreatic cells	8
YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells	8
Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells	8
2′-Hydroxyflavanone prevents LPS-induced inflammatory response and cytotoxicity in murine macrophages	8
Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells	7
Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway	7
High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated	7
Dose and route dependent effects of the mycotoxin deoxynivalenol in a 3D gut-on-a-chip model with flow	7
Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide	7
The effects of Acyclovir administration to NCI-H1975 non-small cell lung cancer cells	7
Vincristine promotes differential levels of apoptosis, mitotic catastrophe, and senescence depending on the genetic background of glioblastoma cells	7
Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways	7
Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells	7
Trovafloxacin drives inflammation-associated drug-induced adverse hepatic reaction by changing macrophage polarization	7
Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment	7
The suitability of reconstructed human epidermis models for medical device irritation assessment: A comparison of In Vitro and In Vivo testing results	7
Cellular evaluation of the metal-organic framework PCN-224 associated with inflammation and autophagy	7
Planarian toxicity fluorescent assay: A rapid and cheap pre-screening tool for potential skin irritants	7
Simultaneous screening of the stability and dosimetry of nanoparticles dispersions for in vitro toxicological studies with static multiple light scattering technique	7
Effect of perfluorohexane sulfonate on pig oocyte maturation, gap-junctional intercellular communication, mitochondrial membrane potential and DNA damage in cumulus cells in vitro	7
Multi-label classification and label dependence in in silico toxicity prediction	7
Evaluation of inhibitors of intestinal UDP-glucuronosyltransferases 1A8 and 1A10 using raloxifene as a substrate in Caco-2 cells: Studies with four flavonoids of Scutellaria baicalensis	7
The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells	7
Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury	7
Epigenetic priming by EHMT1/EHMT2 in acute lymphoblastic leukemia induces TP53 and TP73 overexpression and promotes cell death	7
Propofol inhibits proliferation and migration of glioma cells by up-regulating lncRNA GAS5	7
Pre-validation of SENS-IS assay for in vitro skin sensitization of medical devices	7
Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage	7
Differential comparison of genotoxic effects of aristolochic acid I and II in human cells by the mass spectroscopic quantification of γ-H2AX	7
Hepatic stellate cell activation by TGFβ induces hedgehog signaling and endoplasmic reticulum stress simultaneously	7
Puerarin alleviates hyperosmotic stress-induced oxidative stress, inflammation, apoptosis and barrier damage of human corneal epithelial cells by targeting SIRT1/NLRP3 signaling	7
Differential toxicity of abrin in human cell lines of different organ origin	7
Aqua-(2-formylbenzoato)triphenyltin(IV) induces cell cycle arrest and apoptosis in hypoxic triple negative breast cancer cells	7
Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis	7