Toxicology in Vitro

Article	Citations
Dinaciclib inhibits the growth of acute myeloid leukemia cells through either cell cycle-related or ERK1/STAT3/MYC pathways	57
Evaluation of in vitro cornea models for quantifying destructive effects of chemicals	57
Editorial Board	53
Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death	43
Using cimetidine to mitigate cisplatin-induced ototoxicity	39
Metformin and buparlisib synergistically induce apoptosis of non-small lung cancer (NSCLC) cells via Akt/FoxO3a/Puma axis	38
Prediction of acute oral toxicity using the Hansen solubility parameter	37
Emerging trends in immunotoxin targeting cancer stem cells	35
Essential oil from Ocimum carnosum induces ROS mediated mitochondrial dysfunction and intrinsic apoptosis in HL-60 cells	34
Organochlorine pesticides disrupt T helper cell regulation and reduce IL-2 and IFN-γ favoring infection and production of autoantibodies among pemphigus patients	34
Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array	33
Mechanism for inhibition of cytotoxicity of Shiga toxin by luteolin	31
The selected epigenetic effects of phthalates: DBP, BBP and their metabolites: MBP, MBzP on human peripheral blood mononuclear cells (In Vitro)	31
Transcriptomic analysis suggests ferroptosis as a potential mechanism of fipronil-induced cytotoxicity in human glioblastoma cells	31
Minimum information for studies of extracellular vesicles (MISEV) as toolbox for rigorous, reproducible and homogeneous studies on extracellular vesicles	30
In vitro safety evaluation of sunscreen formulation from nanostructured lipid carriers using human cells and skin model	29
Cisplatin adducts at DNA or RNA do not affect their cellular isolation efficiencies using column-based kits or manual Trizol-based purification methods	28
Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol	27
Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells	26
Development of a human FaFg prediction system for polyphenols using human induced pluripotent stem cell-derived small intestinal epithelial cells	25
An in vitro nerve agent brain poisoning transwell model for convenient and accurate antidote evaluation	25
The evaluation of anticancer activity by synthesizing 5FU loaded albumin nanoparticles by exposure to UV light	25
In vitro genotoxic and antigenotoxic effects of an exopolysaccharide isolated from Lactobacillus salivarius KC27L	25
Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells	21
In-house performance assessment of 3D QobuR-Reconstructed Human Cornea-Like Epithelium (RhCE) for the evaluation of eye hazard	21

A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells	21
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells	20
Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides	20
Hazard associated with the synthesis of epoxy-vitrimer: In vitro risk assessment and scoring strategy	20
Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells	20
Orthogonal viability assays and high-content phenotyping identify enhanced cytotoxicity of SLN–pDNA complexes and heightened sensitivity in PC-3 cells	20
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products	19
Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor	19
Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro	19
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs	19
CYP-mediated metabolic divergence underpins oxoglaucine selectivity: Detoxification in healthy hepatocytes versus mitochondrial apoptosis in hepatocellular carcinoma	18
Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?	18
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations.	18
Anti-migratory and cytotoxic effect of indole derivative in C6 glioma cells	17
Streptomycin generates oxidative stress in melanin-producing cells: In vitro study with EPR spectroscopy evidence	17
Editorial Board	17
Particulate matter exposure-induced cholesterol metabolism dysregulation in lung epithelial cells	17
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system	17
Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system	16
Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis	16
The importance of metrological tools to implementation of alternative method OECD TG 428	16
Lupeol-loaded PLGA particles conserve anti-topoisomerase activity and decrease the cytotoxicity of lupeol	16
Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation	16
Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells	16
Corrigendum to “Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species” [Tox	16
Genotoxicity of putrescine and its effects on gene expression in HepG2 cell line	16
Editorial Board	16
Species differences in microsomal metabolism of hydroxychloroquine	15
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed	15
Isolation and characterization of bovine Limbal mesenchymal stromal cells for application in ocular toxicity studies	15
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model	15
Editorial Board	15
Editorial Board	15
Organ-specific in vitro models for prediction of hazard assessment of nanomaterials	15
In vitro inhibitory effects of selumetinib on activity of human UDP-glucuronosyltransferases and prediction of in vivo drug-drug interactions	15
Studying the intracellular bile acid concentration and toxicity in drug-induced cholestasis: Comprehensive LC-MS/MS analysis with human liver slices	15
Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells	15
Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells	15
Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)	14
Stronger prooxidative effects of chromium(VI) comparing to chromium(III) in endocrine and non-endocrine tissues with the thyroid being completely resistant to antioxidant protection	14
Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities	14
In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals	14
In vitro immune and redox response induced by cationic cellulose-based nanomaterials	14
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic	14
Editorial Board	14
Cigarette smoke extract decreases human bone marrow mesenchymal stromal cell adipogenic differentiation	14
Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates	14
Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment	14
Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells	14
ESTIV 2022: Key enabling non-animal technologies for research, education and testing	14

TNF-α and MMPs mediated mucus hypersecretion induced by cigarette smoke: An in vitro study	13
Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines	13
DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level	13
Synergistic and divergent effects of dietary sugars on hepatocyte viability and steatosis	13
Assessing the skin sensitization potential of fragrance ingredients in consumer products using the peroxidase peptide reactivity assay (PPRA) as an additional weight of evidence	13
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells	13
First toxicity profile of aminoindane-based new psychoactive substances: 2-aminoindane (2-AI, CAS: 2975-41-9) and N-Methyl-2-aminoindane (NM-2-AI, CAS: 24445–44–1) – comprehensive prediction of toxico	13
Nonylphenol reduced the number of haploids in in vitro spermatogenesis of the endangered cyprinid Gnathopogon caerulescens	13
The Nrf2 activator tBHQ inhibits dendritic cell maturation and activation in response to bacterial and viral stimuli	12
Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine	12
Editorial Board	12
Optimization of in vitro culture of honeybee nervous tissue for pesticide risk assessment	12
Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells	12
Ultrafine particles induce ferroptosis-like stress features in human dopaminergic LUHMES cells via the p53/xCT/GSH/cGPx4 axis	12
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway	12
Effects of culture media on gene expression in reconstructed human epidermis and THP-1 monocytes for skin sensitization evaluation in co-culture systems	12
The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood – A combinatory approach using three in vitro models	12
Fragrances as a trigger of immune responses in different environments	12
Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based a	12
Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules	12
Benzo[a]pyrene inhibits myoblast differentiation through downregulating the Hsp70-MK2-p38MAPK complex	12
Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy	11
Editorial Board	11
Intragenic antimicrobial peptide Hs02 toxicity against leukemia cell lines is associated with increased expression of select pyroptotic components	11
Potential risk of drug-drug interactions of ponatinib via inhibition against human UDP-glucuronosyltransferases	11
Use of centromeric probe to identify micronuclei origin and its advantages in genetic toxicology studies	11
Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 431	11
Mesoporous nanosilica: A thromboprotective nanomaterial for biomedical applications	11
In vitro toxicity of two functionalized reduced graphene oxide materials with potential application in food packaging	11
In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution	11
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells	11
Frankenstein's followers. Maintenance of human cells outside the body. Issue 1	11
How to use an in vitro approach to characterize the toxicity of airborne compounds	11
Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells	11
N-acetyl-L-cysteine attenuated the toxicity of ZIF-8 on EA.hy926 endothelial cells by wnt/β-catenin pathway	11
4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1	11
Editorial Board	10
Washing with buffered vitamin C after corrosive chemical (sodium hypochlorite) exposure reduces ocular depth of injury	10
Study on percutaneous penetration of representative cosmetic ingredients in a baby wipe product in an in vitro diaper rash skin model	10
Thymoquinone attenuates poly(I:C)-induced cellular stress via PKR/ATF4/CHOP signaling and autophagy modulation in human alveolar epithelial cells	10
Transdermal permeation of inorganic cerium salts in intact human skin	10
Bufadienolides from the Bufo viridis toad venom exert cytotoxic effects on cancer cells by inducing cell apoptosis and cell cycle arrest	10
Mictlan-D3: A novel medium sized RGD-Disintegrin obtained from Crotalus mictlantecuhtli venom, in vitro tested against human breast Cancer and endothelial cells	10
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT	10
Advances in thyroid hormone system disruption testing – In vitro method for monitoring disrupted thyrotropin signaling through the human TSH receptor (hTSHR)	10
Polystyrene nanoparticles incorporate into the endoplasmic reticulum and disturb translation during meiotic maturation in mouse oocytes	10
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway	10
Testing chemicals for CYP19 inhibition: Comparison of a modified H295R steroidogenesis assay to a commercial fluorometric enzyme inhibition kit	10
Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line	10
Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells	10
Risk assessment of chlorophenols (CPs) exposure in vitro:Inhibition of sulfotransferases (SULTs) activity	10
Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes	10
Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis	10
Perfluorooctanoic acid inhibits cell proliferation through mitochondrial damage	10
In vitro eye irritation testing models may play pivotal role in effort to pursue mild baby cleansers	10
Cytotoxicity of ZnO nanoparticles in human melanocyte cells in the presence or absence of UV radiation: A preliminary comparative study with TiO2 nanoparticles	10
Acrylamide-induced damage to postsynaptic plasticity is CYP2E1 dependent in an SH-SY5Y co-culture system	10
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury	10
Pracaxi oil affects xenobiotic metabolisms, cellular proliferation, and oxidative stress without cytotogenotoxic effects in HepG2/C3A cells	10
Chronic exposure to palmitic acid-induced adipocyte hypertrophy and altered batokine gene expression in T37i brown adipocytes	9
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line	9
Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells	9
Metabolic stability and effects of microsomal enzymes on the activity of the sonic hedgehog pathway inhibitor piperonyl butoxide	9
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models	9
A novel O2- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway	9
Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds	9
Current perspectives on the in vitro cytotoxic effects of tebuconazole, imidacloprid, and microplastics: A comprehensive review	9
Effects of methylation of arginine residue 83 on the enzymatic activity of human arsenic (+3 oxidation state) methyltransferase	9
Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells	9
High-throughput assay for predicting diarrhea risk using a 2D human intestinal stem cell-derived model	9
Delta-9 tetrahydrocannabinol (THC) effects on the cortisol stress response in bovine granulosa cells	9
Chemometric modeling of acute toxicity of diverse aromatic compounds against Rana japonica	9
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis	9
Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay	9
STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential	9
Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo	9
(-)-Epigallocatechin gallate as an inhibitor of hemoglobin-catalyzed lipid oxidation: molecular mechanism of action and nutritional application	9
The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines	9
Editorial Board	9
Toxicity of New Psychoactive Substance (NPS): Threo-4-methylmethylphenidate (4-Mmph) – Prediction of toxicity using in silico methods	9

Mettl3-mediated transcriptome-wide m6A methylation induced by cigarette smoking in human bronchial epithelial cells	9
A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies	9
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes	9
6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model)	9
Liposomal nanoparticles containing adenosine triphosphate targeted by heart-specific peptide ligands as antidotes for aluminum phosphide poisoning in isolated rat cardiomyocyte cell line	8
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy	8
Antifungal climbazole alters androgenic pathways in mammalian cells	8
Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs	8
The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides	8
Discovery of potent antitubercular agents: Design, synthesis and biological evaluation of 4-(3-(4-substitutedpiperazin-1-yl)-quinoxalin-2-yl)-naphthalen-1-ol analogues	8
miRNA-6515-5p regulates particulate matter-induced inflammatory responses by targeting CSF3 in human bronchial epithelial cells	8
Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1	8
Tributyltin propionate and tributyltin salicylate represent novel RXR ligands: Effects on transcriptional activity of thyroid hormone receptor and vitamin D3 receptor	8
Impact of gadolinium oxide based nanoparticles on genotoxic, cytotoxic and oxidative stress in human lymphocytes	8
In vitro effects of polystyrene microplastics exposure on adipose tissue dysfunction	8
Mitochondria oxidative stress mediated nicotine-promoted activation of pancreatic stellate cells by regulating mitochondrial dynamics	8
Effect of curcumin on the embryotoxic effect of ethanol in a zebrafish model	8
18-β-Glycyrrhetinic-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles downregulate the expression LPS-induced proteins mediating tissue remodelling in vitro	8
The impact of bisphenol AF on skeletal muscle function and differentiation in vitro	8
ESTIV early career network: A growing initiative to support the next generation of NAMs-oriented toxicologists	8
The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States	8
Effect of long-term inorganic arsenic exposure on erythropoietin production in vitro	8
Interactions of oleanane pentacyclic triterpenoids with human organic anion transporting polypeptide 1B1 and 1B3	8
Lead inhibits the odontogenic differentiation potential of dental pulp stem cells by affecting WNT1/β-catenin signaling and related miRNAs expression	8
Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro	8
Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes	8
Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells	8
The role of growth differentiation factor 15 in the polarization and foaming of THP-1 macrophages induced by trans fatty acids from different sources	8
METTL3 regulates FAM83D m6A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway	8
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression	8
Binding of plutonium and americium to small molecular weight ligands favors their paracellular transfer across lung epithelium in vitro	8
Suitability of human HepaRG cells and liver spheroids as in vitro model to investigate the bioactivation of the organothiophosphate pesticide parathion	8
Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations	8