Renal Failure

Papers
(The TQCC of Renal Failure is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review56
Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy36
Estrogen and estrogen receptors in kidney diseases33
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis32
Development and internal validation of machine learning algorithms for end-stage renal disease risk prediction model of people with type 2 diabetes mellitus and diabetic kidney disease29
Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus28
Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation27
Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease27
Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania26
Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports26
Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis25
Incidence and risk factors of acute kidney injury in COVID-19 patients with and without acute respiratory distress syndrome (ARDS) during the first wave of COVID-19: a systematic review and Meta-Analy23
Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review22
The furosemide stress test: current use and future potential22
The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies21
Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention20
miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury19
Outcomes of critically ill patients with acute kidney injury in COVID-19 infection: an observational study19
Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysis18
Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis18
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway17
Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention17
Pro- and anti-fibrotic effects of vascular endothelial growth factor in chronic kidney diseases16
Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy16
Prognosis and risk factors of chronic kidney disease progression in patients with diabetic kidney disease and non-diabetic kidney disease: a prospective cohort CKD-ROUTE study16
Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications15
Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease15
Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition involving the inactivation of the NLRP3 inflammasome14
Machine learning for the prediction of acute kidney injury in critical care patients with acute cerebrovascular disease14
Divergence between serum creatine and cystatin C in estimating glomerular filtration rate of critically ill COVID-19 patients14
ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte13
Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease – a fifteen year single center experience13
Hydroxychloroquine in IgA nephropathy: a systematic review13
Risk factors for calciphylaxis in Chinese hemodialysis patients: a matched case-control study12
Intestinal microbiota dysbiosis in acute kidney injury: novel insights into mechanisms and promising therapeutic strategies12
Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy12
Value of contrast-enhanced ultrasonography in radiofrequency ablation of secondary hyperparathyroidism12
Platelet-to-albumin ratio: a risk factor associated with technique failure and mortality in peritoneal dialysis patients11
Contrast associated nephropathy after intravenous administration: what is the magnitude of the problem?11
Use of the systemic inflammation response index (SIRI) as a novel prognostic marker for patients on peritoneal dialysis11
The miR-26a-5p/IL-6 axis alleviates sepsis-induced acute kidney injury by inhibiting renal inflammation11
Chronic kidney disease correlates with MRI findings of cerebral small vessel disease11
Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery11
Alteration of normal level of serum urate may contribute to decrease in estimated glomerular filtration rate decline in healthy Japanese men11
Inhaled nitric oxide and acute kidney injury risk: a meta-analysis of randomized controlled trials11
A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury11
A case of peritoneal dialysis in which SARS-CoV-2 was diagnosed by sudden hearing loss11
Peritoneal dialysis-related peritonitis caused by gram-negative organisms: ten-years experience in a single center11
LncRNA MALAT1-deficiency restrains lipopolysaccharide (LPS)-induced pyroptotic cell death and inflammation in HK-2 cells by releasing microRNA-135b-5p11
MicroRNA-122-5p ameliorates tubular injury in diabetic nephropathy via FIH-1/HIF-1α pathway11
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway10
Downregulation of miR-574-5p inhibits HK-2 cell viability and predicts the onset of acute kidney injury in sepsis patients10
Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection10
Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis10
Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients10
Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway10
The relationship between calcification inhibitor levels in chronic kidney disease and the development of atherosclerosis10
Intraoperative vasopressor use and early postoperative acute kidney injury in elderly patients undergoing elective noncardiac surgery10
Prevalence of depression and anxiety and their predictors among patients undergoing maintenance hemodialysis in Northern China: a cross-sectional study10
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1)10
The blood urea nitrogen/creatinine (BUN/cre) ratio was U-shaped associated with all-cause mortality in general population10
Predicting renal function recovery and short-term reversibility among acute kidney injury patients in the ICU: comparison of machine learning methods and conventional regression10
Vitamin D/vitamin D receptor/Atg16L1 axis maintains podocyte autophagy and survival in diabetic kidney disease10
The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review10
Retrospective analysis on incidence and risk factors of early onset acute kidney injury after lung transplantation and its association with mortality10
Retrospective analysis of Tripterygium wilfordii polyglycoside combined with angiotensin receptor blockers for the treatment of primary membranous nephropathy with sub-nephrotic proteinuria10
Pro-inflammatory cytokines as potential predictors for intradialytic hypotension9
p53 inhibition attenuates cisplatin-induced acute kidney injury through microRNA-142-5p regulating SIRT7/NF-κB9
Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus9
Post COVID 19 multisystem inflammatory syndrome in an older adult9
Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis9
Elevated atherogenic index and higher triglyceride increase risk of kidney function decline: a 7-year cohort study in Chinese adults9
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress9
Hematuria was a high risk for renal progression and ESRD in immunoglobulin a nephropathy: a systematic review and meta-analysis9
Pan-immune-inflammation value is associated with poor prognosis in patients undergoing peritoneal dialysis9
Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study9
Kidney tissue elastography and interstitial fibrosis observed in kidney biopsy9
Therapeutic apheresis in kidney diseases: an updated review9
Derivation and validation of a model to predict acute kidney injury following cardiac surgery in patients with normal renal function8
Diagnostic value of procalcitonin for bacterial infections in patients undergoing hemodialysis: a systematic review and meta-analysis8
The roles of hydrogen sulfide in renal physiology and disease states8
Red blood cell lifespan in long-term hemodialysis patients treated with roxadustat or recombinant human erythropoietin8
Feasibility of a break-in period of less than 24 hours for urgent start peritoneal dialysis: a multicenter study8
Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression8
Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis8
Negative anti-phospholipase A2 receptor antibody status at three months predicts remission in primary membranous nephropathy8
Monocyte-to-lymphocyte ratio: a potential novel predictor for acute kidney injury in the intensive care unit8
The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis7
The predictive value of the Oxford Acute Severity of Illness Score for clinical outcomes in patients with acute kidney injury7
Serum metabolomics of end-stage renal disease patients with depression: potential biomarkers for diagnosis7
Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis7
Use of the optimized sodium thiosulfate regimen for the treatment of calciphylaxis in Chinese patients7
Acute kidney injury after COVID-19 vaccines: a real-world study7
The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1–3 cm renal stones and risk factors of renal function changes7
Effects of hemodialysis treatment on saliva flow rate and saliva composition during in-center maintenance dialysis: a cross-sectional study7
Urinary calprotectin, NGAL, and KIM-1 in the differentiation of primarily inflammatory vs. non-inflammatory stable chronic kidney diseases7
MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone7
Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis7
MicroRNAs in IgA nephropathy7
The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model7
Ibrutinib-induced acute kidney injury via interstitial nephritis7
Comparison of bone microstructures via high-resolution peripheral quantitative computed tomography in patients with different stages of chronic kidney disease before and after starting hemodialysis7
Early prediction of acute kidney injury after liver transplantation by scoring system and decision tree7
Association of the modified creatinine index with muscle strength and mortality in patients undergoing hemodialysis7
Immunosuppression in kidney transplant recipients with COVID-19 infection – where do we stand and where are we heading?7
Reevaluation of lock solutions for Central venous catheters in hemodialysis: a narrative review7
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) overexpression alleviates endoplasmic reticulum stress after acute kidney injury7
Platelet-leukocyte aggregates – a predictor for acute kidney injury after cardiac surgery7
Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients7
Role of tRNA derived fragments in renal ischemia–reperfusion injury7
Addition of terlipressin to norepinephrine in septic shock and effect of renal perfusion: a pilot study6
Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease6
Expression of urinary exosomal miRNA-615-3p and miRNA-3147 in diabetic kidney disease and their association with inflammation and fibrosis6
Prognosis and risk factors for cardiac valve calcification in Chinese end-stage kidney disease patients on combination therapy with hemodialysis and hemodiafiltration6
Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey6
Urine N-terminal pro-B-type natriuretic peptide and plasma proenkephalin are promising biomarkers for early diagnosis of cardiorenal syndrome type 1 in acute decompensated heart failure: a prospective6
Effects of allopurinol on renal function in patients with diabetes: a systematic review and meta-analysis6
In-hospital acute kidney injury and atrial fibrillation: incidence, risk factors, and outcome6
Association between fluid infusions and the recovery from acute kidney injury in patients administered liposomal amphotericin B: a nationwide observational study6
All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats6
Efficacy of Roxadustat on anemia and residual renal function in patients new to peritoneal dialysis6
LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis6
The clinical and immunological features of the post-extracorporeal shock wave lithotripsy anti-glomerular basement membrane disease6
Paclitaxel coated balloon versus conventional balloon angioplasty in dysfunctional dialysis arteriovenous fistula: a systematic review and meta-analysis of randomized controlled trials6
Macroscopic hematuria in wasp sting patients: a retrospective study6
Effects of parathyroidectomy on plasma PTH fragments and heart rate variability in stage 5 chronic kidney disease patients6
Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway6
A single-center experience of parathyroidectomy in 1500 cases for secondary hyperparathyroidism: a retrospective study6
Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis6
Association of D-dimer and acute kidney injury associated with rhabdomyolysis in patients with exertional heatstroke: an over 10-year intensive care survey6
Association of metabolic dysfunction-associated fatty liver disease with chronic kidney disease: a Chinese population-based study6
The comprehensive analysis of clinical trials registration for IgA nephropathy therapy on ClinicalTrials.gov6
The effect of body mass index on the development of acute kidney injury and mortality in intensive care unit: is obesity paradox valid?6
Performance of the renal resistive index and usual clinical indicators in predicting persistent AKI6
The optimal range of serum intact parathyroid hormone for a lower risk of mortality in the incident hemodialysis patients6
MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt/β-catenin pathway6
Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysi6
Elevated circulating growth differentiation factor 15 is related to decreased heart rate variability in chronic kidney disease patients6
Adverse events following the first, second and third doses of a COVID-19 vaccine in hemodialysis patients5
Exploring agreement and feasibility between virtual home visits and in-person home visits for peritoneal dialysis patients—a paired study5
A new model to predict acute kidney injury after cardiac surgery in patients with renal insufficiency5
Is it safe to receive kidneys from deceased kidney donors tested positive for covid-19 infection?5
Relationship between gut microbiota and vascular calcification in hemodialysis patients5
A risk prediction model for acute kidney injury in patients with pulmonary tuberculosis during anti-tuberculosis treatment5
Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction5
B-type natriuretic peptide levels and volume status in twice-weekly hemodialysis patients5
Comparison of outcomes of peritoneal dialysis between patients after failed kidney transplant and transplant-naïve patients: a meta-analysis of observational studies5
Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells5
Outcomes and risk management in type B aortic dissection patients with acute kidney injury: a concise review5
Development and validation of a nomogram for predicting acute kidney injury after orthotopic liver transplantation5
Depletion of macrophages with clodronate liposomes partially attenuates renal fibrosis on AKI–CKD transition5
Correlates of objective sleep quality in older peritoneal dialysis patients5
Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial5
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro5
COQ2 mutation associated isolated nephropathy in two siblings from a Chinese pedigree5
A validation study of UCSD-Mayo risk score in predicting hospital-acquired acute kidney injury in COVID-19 patients5
Validation of the EKFC equation for glomerular filtration rate estimation and comparison with the Asian-modified CKD-EPI equation in Chinese chronic kidney disease patients in an external study5
Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis5
Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells5
The landscape of renal replacement therapy in Veterans Affairs Medical Center intensive care units5
Efficacy of extracorporeal plasma therapy for adult native kidney patients with Primary FSGS: a Systematic review5
Efficacy of pre-emptive kidney transplantation for adults with end-stage kidney disease: a systematic review and meta-analysis5
Assessment of complications and short-term outcomes of percutaneous peritoneal dialysis catheter insertion by conventional or modified Seldinger technique5
Higher serum trimethylamine-N-oxide levels are associated with increased abdominal aortic calcification in hemodialysis patients5
The impact of location and patency of the arteriovenous fistula on quality of life of kidney transplant recipients5
Risk factors for acute kidney injury after Stanford type A aortic dissection repair surgery: a systematic review and meta-analysis5
Different kidney function trajectory patterns before dialysis in elderly patients: clinical implications and outcomes5
Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes5
Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression5
Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid5
Identification of circular RNA expression profiles in renal fibrosis induced by obstructive injury5
The association of echocardiographic parameters on renal outcomes in chronic kidney disease5
Identification of differentially expressed genes and pathways in kidney of ANCA-associated vasculitis by integrated bioinformatics analysis5
Artificial intelligence in peritoneal dialysis: general overview5
MicroRNA-21-containing microvesicles from tubular epithelial cells promote cardiomyocyte hypertrophy5
Comparison of clinical outcome between incremental peritoneal dialysis and conventional peritoneal dialysis: a propensity score matching study5
Risk factors for hypocalcemia in dialysis patients with refractory secondary hyperparathyroidism after parathyroidectomy: a meta-analysis5
Association of serum mannose-binding lectin, anti-phospholipase A2 receptor antibody and renal outcomes in idiopathic membranous nephropathy and atypical membranous nephropathy: a single center retros4
The antioxidative effects of empagliflozin on high glucose‑induced epithelial-mesenchymal transition in peritoneal mesothelial cells via the Nrf2/HO-1 signaling4
High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study4
Development and validation of a prediction model for the early occurrence of acute kidney injury in patients with acute pancreatitis4
Acid–base balance in hemodialysis patients in everyday practice4
Gallic acid improves the metformin effects on diabetic kidney disease in mice4
15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury4
A risk prediction model for contrast-induced nephropathy associated with gadolinium-based contrast agents4
Rituximab for the treatment of refractory anti-glomerular basement membrane disease4
Effectiveness of thiazide and thiazide-like diuretics in advanced chronic kidney disease: a systematic review and meta-analysis4
Efficacy and safety of expanded hemodialysis in hemodialysis patients: a meta-analysis and systematic review4
The triglyceride-glucose index as a novel marker associated with sarcopenia in non-diabetic patients on maintenance hemodialysis4
Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease4
Utilization of HCV viremic donors in kidney transplantation: a chance or a threat?4
Diagnostic value of TWEAK for predicting active lupus nephritis in patients with systemic lupus erythematosus: a systematic review and meta-analysis4
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy4
Correlation between serum trimethylamine-N-oxide concentration and protein energy wasting in patients on maintenance hemodialysis4
Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study4
The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study4
Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database4
Hydroxychloroquine/chloroquine and the risk of acute kidney injury in COVID-19 patients: a systematic review and meta-analysis4
Nomogram for predicting 1-, 5-, and 10-year survival in hemodialysis (HD) patients: a single center retrospective study4
Iguratimod alleviates tubulo-interstitial injury in mice with lupus4
Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients4
Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells4
The value of urinary interleukin-18 in predicting acute kidney injury: a systematic review and meta-analysis4
Histopathological assessment of radial artery calcification in patients with end-stage kidney disease4
The history of peritoneal dialysis in China: past, present and future trends4
Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo4
Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells4
Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL14
Mechanism of action ofTripterygium wilfordiifor treatment of idiopathic membranous nephropathy based on network pharmacology4
Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome4
Machine learning algorithm to predict the in-hospital mortality in critically ill patients with chronic kidney disease4
Peritoneal transport status and first episode of peritonitis: a large cohort study4
Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study4
Effect of galectin-3 in the pathogenesis of arteriovenous fistula stenosis formation4
Retrospective analysis of nontraumatic subdural hematoma incidence and outcomes in Egyptian patients with end-stage renal disease on hemodialysis4
Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival4
Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho4
The intellectual base and global trends in contrast-induced acute kidney injury: a bibliometric analysis4
Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway4
Comparative safety of sodium-glucose co-transporter 2 inhibitors in elderly patients with type 2 diabetes mellitus and diabetic kidney disease: a systematic review and meta-analysis4
A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment4
Cinnamaldehyde attenuates kidney senescence and injury through PI3K/Akt pathway-mediated autophagy via downregulating miR-1554
Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis4
Evaluation of cerebral dysfunction in patients with chronic kidney disease using neuropsychometric and neurophysiological tests4
0.091590881347656