Metabolic Brain Disease

Article	Citations
Emerging role of non‐coding RNA in health and disease	104
Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside	80
Role of metals in Alzheimer’s disease	76
Towards a new model and classification of mood disorders based on risk resilience, neuro-affective toxicity, staging, and phenome features using the nomothetic network psychiatry approach	71
Crossing the blood-brain barrier with AAV vectors	52
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease	50
Cellular and molecular pathophysiology in the progression of Parkinson’s disease	47
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability	46
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS	41
Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain	36
Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers	36
Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms	35
A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol	33
Cannabidiol induces antidepressant and anxiolytic‐like effects in experimental type-1 diabetic animals by multiple sites of action	32
Methods used for the measurement of blood-brain barrier integrity	31
The role of syringic acid as a neuroprotective agent for neurodegenerative disorders and future expectations	30
Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppress	30
Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by inhibiting microRNA-15a-5p	29
Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment	29
Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway	29
Profiles of urine and blood metabolomics in autism spectrum disorders	29
Protective mechanism of Syringic acid in an experimental model of Parkinson’s disease	28
A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis	26
Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells	26
Targeting inflammation: a potential approach for the treatment of depression	26

Treatment trials in Niemann-Pick type C disease	25
MiRNA-34c-5p protects against cerebral ischemia/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities	25
Reactive gliosis in Alzheimer’s disease: a crucial role for cognitive impairment and memory loss	25
Metabolic disorder in Alzheimer’s disease	25
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway	25
Circ_0006768 upregulation attenuates oxygen–glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell injuries by upregulating VEZF1 via miR-222-3p inhibition	24
Physical exercise prevents amyloid β1−40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice	23
MALDI imaging mass spectrometry: an emerging tool in neurology	23
Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress	22
Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer’s disease	22
RhoA/ROCK signaling pathway and astrocytes in ischemic stroke	22
Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non‐motor outcomes	22
Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration	21
Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy	21
Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke	21
Mercury and Alzheimer’s disease: a look at the links and evidence	21
Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity	20
Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury	20
Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men	20
Animal models of gestational diabetes: characteristics and consequences to the brain and behavior of the offspring	20
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats	20
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway	19
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson’s disease	19
Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress	19
Lipid metabolic dysregulation is involved in Parkinson’s disease dementia	19
Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats	18
Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid	18
Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation	18
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway	18
Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism	18
Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer’s disease model	17
Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotran	17
Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use	17
Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin	17
Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes	17
Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells	17
Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats	17
Downregulation of lncRNA MEG3 is involved in Parkinson’s disease	16
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme	16
Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer’s disease	16
Exercise training ameliorates cognitive dysfunction in amyloid beta-injected rat model: possible mechanisms of Angiostatin/VEGF signaling	16
Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions	15
Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities	15
Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis	15
Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats	15
Metabolism in Huntington’s disease: a major contributor to pathology	15
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer’s disease	15
Metabolomics of ischemic stroke: insights into risk prediction and mechanisms	14
Association between thyroid function and Alzheimer's disease: A systematic review	14
Administration of Selenium Nanoparticles Reverses Streptozotocin-Induced Neurotoxicity in the male rats	14

Benefits of betanin in rotenone-induced Parkinson mice	14
Circular RNA circLIFR regulates the proliferation, migration, invasion and apoptosis of human vascular smooth muscle cells via the miR-1299/KDR axis	14
Serum fractalkine and 3-nitrotyrosine levels correlate with disease severity in Parkinson’s disease: a pilot study	14
Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+	14
Drug delivery for neuronopathic lysosomal storage diseases: evolving roles of the blood brain barrier and cerebrospinal fluid	14
Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade	14
Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease	14
Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury	14
Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose	13
Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population	13
Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice	13
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats	13
Thioacetamide-induced acute hepatic encephalopathy: central vs peripheral effect of Allicin	13
Remote ischemic preconditioning protects against cerebral ischemia injury in rats by upregulating miR-204-5p and activating the PINK1/Parkin signaling pathway	13
Alzheimer’s disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels	13
LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3	13
Gut brain axis: an insight into microbiota role in Parkinson’s disease	13
Carotid intima media thickness measurements coupled with stroke severity strongly predict short-term outcome in patients with acute ischemic stroke: a machine learning study	13
Adult human neurogenesis: early studies clarify recent controversies and go further	13
Association of lncRNA with regulatory molecular factors in brain and their role in the pathophysiology of schizophrenia	13
Ruxolitinib in Aicardi-Goutières syndrome	13
Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase	13
Network pharmacology and bioinformatics approach reveals the therapeutic mechanism of action of curcumin in Alzheimer disease	12
Effects of physical exercise on memory in type 2 diabetes: a brief review	12
Hepatoprotective and neuroprotective effect of taxifolin on hepatic encephalopathy in rats	12
Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking	12
Blood–brain barrier leakage and perivascular collagen accumulation precede microvessel rarefaction and memory impairment in a chronic hypertension animal model	12
Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice	12
Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease	12
A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder	12
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway	12
Molecular mechanisms of cognitive impairment associated with stroke	12
The critical role of gut-brain axis microbiome in mental disorders	12
Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex	12
Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice	12
Manifestation of renin angiotensin system modulation in traumatic brain injury	12
Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α	11
Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma	11
Bio-synthesized selenium nanoparticles ameliorate Brain oxidative stress in Parkinson disease rat models	11
Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress	11
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat	11
EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR	11
Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease	11
Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1	11
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	11
An overview of the orexinergic system in different animal species	11
RETRACTED ARTICLE: The effects of thymoquinone on memory impairment and inflammation in rats with hepatic encephalopathy induced by thioacetamide	11
The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease	11
Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier	11
Possible role of rice bran extract in microglial modulation through PPAR-gamma receptors in alzheimer’s disease mice model	11
Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration	11
Patients with cerebrotendinous xanthomatosis diagnosed with diverse multisystem involvement	11
Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling	11
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease	11
Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy	10
miR-25-3p ameliorates SAE by targeting the TLR4/NLRP3 axis	10
Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders	10
Adiponectin: a potential target for obesity-associated Alzheimer’s disease	10
miR-219 overexpressing oligodendrocyte progenitor cells for treating compression spinal cord injury	10
Modulating neuroinflammation in neurodegeneration-related dementia: can microglial toll-like receptors pull the plug?	10
Therapeutic potential of probiotics – Lactobacillus plantarum UBLP40 and Bacillus clausii UBBC07 on thioacetamide-induced acute hepatic encephalopathy in rats	10
Neuroprotective effect of herniarin following transient focal cerebral ischemia in rats	10
Review of neuropsychological outcomes in isolated methylmalonic acidemia: recommendations for assessing impact of treatments	10
Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action	10
Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model	10
Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation	10
Circular RNA: A novel and potential regulator in pathophysiology of schizophrenia	10
Expression of BDNF-Associated lncRNAs in Parkinson’s disease	10
Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-β-induced neuronal injury in Alzheimer’s disease	10
Oxytocin levels in individuals with schizophrenia are high in cerebrospinal fluid but low in serum: A systematic review and meta-analysis	10
Do selenium-enriched foods provide cognitive benefit?	10
Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine	10
Nanostructure lipid carriers enhance alpha-mangostin neuroprotective efficacy in mice with rotenone-induced neurodegeneration	9
White matter abnormalities and iron deposition in prenatal mucolipidosis IV- fetal imaging and pathology	9
Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation	9
Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells	9
Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats	9
Thrombin generation and activity in multiple sclerosis	9
Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling	9
Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition	9

Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway	9
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice	9
Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin	9
Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs	9
Wuzi Yanzong pill attenuates MPTP-induced Parkinson’s Disease via PI3K/Akt signaling pathway	9
The role of Rho/ROCK in epileptic seizure-related neuronal damage	9
Identification of methylation markers for diagnosis of autism spectrum disorder	9
Improvement of cognitive function in mice by Citrus reticulata var. kinnow via modulation of central cholinergic system and oxidative stress	9
Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice	9
Oxidative stress: a common imbalance in diabetes and epilepsy	9
Withania coagulans extract attenuates oxidative stress-mediated apoptosis of cerebellar purkinje neurons after ischemia/reperfusion injury	9
The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis	9
Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells	9
New insights on the potential effect of vinpocetine in Parkinson’s disease: one of the neglected warden and baffling topics	9
Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia	9
Prevention of post-tips hepatic encephalopathy: The search of the ideal candidate	9
Ginger and turmeric lipid-solubles attenuate heated oil-induced oxidative stress in the brain via the upregulation of NRF2 and improve cognitive function in rats	9
Neuroprotective effects of coenzyme Q10 in Parkinson's model via a novel Q10/miR-149-5p/MMPs pathway	9
Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR	9
Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron	9
MEG3 lncRNA is over-expressed in autism spectrum disorder	9
Gli2-induced lncRNA Peg13 alleviates cerebral ischemia-reperfusion injury by suppressing Yy1 transcription in a PRC2 complex-dependent manner	9