OOIR: Observatory of International Research

Papers

(The median citation count of Metabolic Brain Disease is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson’s disease-like motor and non-motor symptoms induced by rotenone in rats	78
Conditioned medium of human menstrual blood-derived endometrial stem cells protects against cell inflammation and apoptosis of Npc1KO N2a cells	69
Inhibition of hyperpolarization-activated cyclic nucleotide-gated cation channel attenuates cerebral ischemia reperfusion-induced impairment of learning and memory by regulating apoptotic pathway	57
The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease	49
Retraction Note to: Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats	39
Stellate ganglion block suppresses hippocampal ferroptosis to attenuate cerebral ischemia-reperfusion injury via the Hippo pathway	33
Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus	33
Complete Loss of Myelin protein zero (MPZ) in a patient with a late onset Charcot-Marie-Tooth (CMT)	31
Deterioration of visual quality and acuity as the first sign of ceroid lipofuscinosis type 3 (CLN3), a rare neurometabolic disease	30
Flavonoid-enrich extract of Autranella congolensis (Sapotaceae) protects against aluminium chloride-mediated Alzheimer’s disease-like oxidative stress in rat through the antioxidant properties	29
Retraction Note: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Al	28
3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress	27
Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities	26
Necroptosis in the developing brain: role in neurodevelopmental disorders	26
Neuroprotective effects of methyl jasmonate in male Wistar rats exposed to delayed acetic acid-induced ulcerative colitis: involvement of antioxidant status, GFAP, and IBA-1 immunoreactivities	25
Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a 1H NMR-based metabolomics analysis	24
A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum	24
Stem cell therapy combined with luteolin alleviates experimental neuropathy	23
Multimodal MRI in Leigh syndrome due to m.13513G > A	23
Anti-apoptotic capacity of MALAT1 on hippocampal neurons correlates with CASP3 DNA methylation in a mouse model of autism	23
Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs	22
Exposure to leucine alters glutamate levels and leads to memory and social impairment in zebrafish	22
Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer’s disease in aging women	22
Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease	22
Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy	22

Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy	21
Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression	20
Correction to: Necrostatin-1 S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis	20
Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma	20
Correction to: Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway	20
The role of brain inflammation and abnormal brain oxygen homeostasis in the development of hepatic encephalopathy	20
miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation	19
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy	19
Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats	19
Acute effects of intracerebroventricular administration of α-ketoisocaproic acid in young rats on inflammatory parameters	19
Correction to: Methylphenidate disrupts cytoskeletal homeostasis and reduces membrane-associated lipid content in juvenile rat hippocampus	19
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease	18
Cerebrolysin reduces excitotoxicity by modulation of cell-death proteins in delayed hours of ischemic reperfusion injury	18
A novel homozygous PIGO mutation associated with severe infantile epileptic encephalopathy, profound developmental delay and psychomotor retardation: structural and 3D modelling investigations and gen	18
p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain	18
Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation	18
Proteomic advance of ischemic stroke: preclinical, clinical, and intervention	18
Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats	17
Predicting which patients with cirrhosis will develop overt hepatic encephalopathy: Beyond psychometric testing	17
Kif15 deficiency contributes to depression-like behavior in mice	16
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy	16
Dysregulation of genes coding for proteins involved in metabolic processes in mucopolysaccharidoses, evidenced by a transcriptomic approach	15
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a	15
Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro	15
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	15
Regulation of oxygen–glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin	15
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines	15
Retraction Note to: Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons	15
Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients	15
Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways	15
Pathology and prevention of brain microvascular and neuronal dysfunction induced by a high-fructose diet in rats	15
Deregulation of NF-κB associated long non-coding RNAs in bipolar disorder	14
Brown adipose tissue and alzheimer’s disease	14
Circ_0003611 regulates apoptosis and oxidative stress injury of Alzheimer’s disease via miR-383-5p/KIF1B axis	14
miRNA dysregulation in traumatic brain injury and epilepsy: a systematic review to identify putative biomarkers for post-traumatic epilepsy	14
LncRNA CRNDE binds hnRNPA1 to facilitate carbon monoxide poisoning-induced delayed encephalopathy via inhibiting UCHL5-mediated SMO deubiquitination	14
Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous	14
Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α	14
PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2ɑ/ATF4/CHOP signaling	14
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features	14
The effects of Ibuprofen and 1, 8- cineol on anxiety and spatial memory in hyperammonemic rats	14
Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour	14
Confusion assessment method accurately screens for hepatic encephalopathy and predicts short-term mortality in hospitalized patients with cirrhosis	13
Prophylactic effects of cucurbitacin B in the EAE Model of multiple sclerosis by adjustment of STAT3/IL-23/IL-17 axis and improvement of neuropsychological symptoms	13
Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron	13
Correction to: Indian ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke	13
Mangiferin exerts neuroprotective effects against focal cerebral ischemia in mice by regulating NF-κB signaling pathway	12
Genistein attenuates neuroinflammation and oxidative stress and improves cognitive impairment in a rat model of sepsis-associated encephalopathy: potential role of the Nrf2 signaling pathway	12
Administration of α-lipoic acid and silymarin attenuates aggression by modulating endocrine, oxidative stress and inflammatory pathways in mice	12
8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice	12

Branched-chain amino acids (BCAA) administration increases autophagy and the autophagic pathway in brain tissue of rats submitted to a Maple Syrup Urine Disease (MSUD) protocol	12
Targeting inflammation: a potential approach for the treatment of depression	12
Correction to: Involvement of regulation of the excitation:inhibition functional balance in the mPFC in the antidepressant-anxiolytic effect of YL-IPA08, a novel TSPO ligand	12
Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats	12
Blood-based biomarkers in Alzheimer’s disease: a mini-review	12
Special Issue: Pathophysiology, diagnosis, and management of hepatic encephalopathy	12
Correction to: D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	12
Sequencing and Bioinformatics analysis of lncRNA/circRNA-miRNA-mRNA in Glioblastoma multiforme	12
Vitamin D3 improves spatial memory and modulates cytokine levels in aged rats	11
Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways	11
Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice	11
An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways	11
Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats	11
G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats	11
Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model	11
Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome	11
The critical role of gut-brain axis microbiome in mental disorders	11
Remote monitoring of cognition in cirrhosis and encephalopathy: future opportunity and challenge	11
Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer’s Disease	11
Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats	11
Unlocking therapeutic potential of trigonelline through molecular docking as a promising approach for treating diverse neurological disorders	11
Vitamin D3 supplementation ameliorates cognitive impairment and alters neurodegenerative and inflammatory markers in scopolamine induced rat model	11
Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation	10
Reversal of oxidative stress, cytokine toxicity and DNA fragmentation by quercetin in dizocilpine-induced animal model of Schizophrenia	10
Cannabidiol ameliorates the anxiogenic and compulsive-like behaviors induced by chronic consumption of a high-carbohydrate diet in male mice	10
Ameliorative effect of Brassica oleracea var. Italica extract on oxidative damage of arsenic in the rat’s brain: biochemical, pathological, and behavioral aspects	10
Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation	10
An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention	10
Correction to: Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression	10
Novel sights on therapeutic, prognostic, and diagnostics aspects of non-coding RNAs in glioblastoma multiforme	10
Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke	10
Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats	10
The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus	10
Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway	9
Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats	9
Electroacupuncture alleviates traumatic brain injury by inhibiting autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway in rats	9
Partial blood replacement ameliorates middle cerebral artery occlusion generated neurological aberrations by intervening TLR4 and NLRP3 cascades in rats	9
Diabetes mellitus – risk factor and potential future target for hepatic encephalopathy in patients with liver cirrhosis?	9
The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders	9
Emerging role of extracellular vesicles in the pathogenesis of glioblastoma	9
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets	9
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway	9
Exploring the potential anti-Alzheimer disease mechanisms of Alpiniae Oxyphyliae Fructus by network pharmacology study and molecular docking	9
Effects of a novel probiotic mixture on the modulation of brain and intestine Aquaporin-4 gene expression in rats exposed to Cadmium	9
Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats	9
Celastrol assuages oxygen-glucose deprivation and reoxygenation-induced damage in human brain microvascular endothelial cells through the circDLGAP4/miR-6085/GDF11 pathway	9
Correction to: Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model	9
Oxidative stress: a common imbalance in diabetes and epilepsy	9
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure	9
Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment	9
Exploring the therapeutic mechanism of Banxia Xiexin Decoction in mild cognitive impairment and diabetes mellitus: a network pharmacology approach	8
Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop	8
Prevention of post-tips hepatic encephalopathy: The search of the ideal candidate	8
An overview of hyperbaric oxygen preconditioning against ischemic stroke	8
Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury	8
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series	8
Role of SIRT3 in neurological diseases and rehabilitation training	8
Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain	8
Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice	8
Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis	8
Selenium and cognitive function	8
Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver	8
Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis	8
The effects of polyvinyl alcohol-coated selenium nanoparticles on memory impairment in rats	8
Traversing through the cell signaling pathways of neuroprotection by betanin: therapeutic relevance to Alzheimer’s Disease and Parkinson’s Disease	8
Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis	8
Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice	8
Melatonin improves behavioral parameters and oxidative stress in zebrafish submitted to a leucine-induced MSUD protocol	8