Biotechnology and Applied Biochemistry

Article	Citations
Caspase‐3: Structure, function, and biotechnological aspects	197
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation	176
SELEX: Critical factors and optimization strategies for successful aptamer selection	114
An overview on the conversion of glycerol to value‐added industrial products via chemical and biochemical routes	79
Laccase: Various types and applications	74
Glucose oxidase: Applications, sources, and recombinant production	64
Enzyme engineering and its industrial applications	61
Biosensors based on aptamer‐conjugated gold nanoparticles: A review	48
β‐Galactosidase: From its source and applications to its recombinant form	43
The antibacterial mechanism of perilla rosmarinic acid	41
CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines	35
The antidiabetic potential of endophytic fungi: Future prospects as therapeutic agents	28
Application of natural products for inducing ferroptosis in tumor cells	27
An electrochemical aptasensor for detection of prostate‐specific antigen‐based on carbon quantum dots‐gold nanoparticles	26
Ellagic acid as a potent anticancer drug: A comprehensive review on in vitro, in vivo, in silico, and drug delivery studies	26
Bacterial pigments: A colorful palette reservoir for biotechnological applications	25
CRISPR/Cas9‐based genome engineering: A new breakthrough in the genetic manipulation of filamentous fungi	25
Versatility of subtilisin: A review on structure, characteristics, and applications	24
Futuristic avenues of metabolic engineering techniques in bioremediation	24
Hyaluronic acid–graphene quantum dot nanocomposite: Potential target drug delivery and cancer cell imaging	23
Vitamin E at a high dose as an anti‐ferroptosis drug and not just a supplement for COVID‐19 treatment	23
An electrochemical aptasensor for detection of prostate‐specific antigen using reduced graphene gold nanocomposite and Cu/carbon quantum dots	22
Urea biosensors: A comprehensive review	22
A brief overview on the application and sources of α‐amylase and expression hosts properties in order to production of recombinant α‐amylase	21
Ophthalmic drugs: in vitro paraoxonase 1 inhibition and molecular docking studies	21

Combining technology with liquid‐formulated lipases for in‐spec biodiesel production	21
Trends in lipase engineering for enhanced biocatalysis	21
Role of neddylation in neurological development and diseases	21
Production of myo‐inositol: Recent advance and prospective	20
Highly sensitive and selective acute myocardial infarction detection using aptamer‐tethered MoS 2 nanoflower and screen‐printed electrodes	19
The effect of brimonidine and proparacaine on metabolic enzymes: Glucose‐6‐phosphate dehydrogenase, 6‐phosphogluconate dehydrogenase, and glutathione reductase	18
Upregulation of TRPM8 can promote the colon cancer liver metastasis through mediating Akt/GSK‐3 signal pathway	18
Advances in biochemistry and the biotechnological production of taxifolin and its derivatives	18
In situ product recovery techniques aiming to obtain biotechnological products: A glance to current knowledge	17
Technofunctional quality assessment of soymilk fermented with Lactobacillus acidophilus and Lactobacillus casei	17
Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclature	17
Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors	17
β‐Carotene—production methods, biosynthesis from Phaffia rhodozyma, factors affecting its production during fermentation, pharmacological properties: A review	16
Esterases as emerging biocatalysts: Mechanistic insights, genomic and metagenomic, immobilization, and biotechnological applications	16
Production of a fermented solid containing lipases from Penicillium roqueforti ATCC 10110 and its direct employment in organic medium in ethyl oleate synthesis	15
A stable biosensor for organophosphorus pesticide detection based on chitosan modified graphene	15
Enzymatic hydrolysis of lignocellulosic biomass using native cellulase produced by Aspergillus niger ITV02 under liquid state fermentation	15
Microbial nitroreductases: A versatile tool for biomedical and environmental applications	14
In vitro evaluation of copper sulfide nanoparticles decorated with folic acid/chitosan as a novel pH‐sensitive nanocarrier for the efficient controlled targeted delivery of cytarabine as an anticancer	14
Different experimental approaches for Fourier‐transform infrared spectroscopy applications in biology and biotechnology: A selected choice of representative results	14
Pain pathways and potential new targets for pain relief	14
Green synthesis and characterization of silver nanoparticles using Pteris vittata extract and their therapeutic activities	14
Monascin and ankaflavin—Biosynthesis from Monascus purpureus, production methods, pharmacological properties: A review	14
CircSEC24A promotes IL‐1β‐induced apoptosis and inflammation in chondrocytes by regulating miR‐142‐5p/SOX5 axis	14
Novel enzyme‐based electrochemical and colorimetric biosensors for tetracycline monitoring in milk	13
Enhancement and mechanisms of MC3T3‐E1 osteoblast‐like cell adhesion to albumin through calcium exposure	13
Fermentation optimization of surfactin production of Bacillus amyloliquefaciens HM618	13
Biochanin‐A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF‐β1 and PAR‐2 genes expression in kidney tissues of STZ‐induced diab	13
Platelet‐rich plasma‐hyaluronic acid/chondrotin sulfate/carboxymethyl chitosan hydrogel for cartilage regeneration	13
Thermostable trypsin‐like protease by Penicillium roqueforti secreted in cocoa shell fermentation: Production optimization, characterization, and application in milk clotting	13
A comprehensive review on anticancer mechanism of bazedoxifene	13
Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol‐induced myocardial infarction in Wistar rats	13
Novel green synthesis and characterization of a chemotherapeutic supplement by silver nanoparticles containing Berberis thunbergii leaf for the treatment of human pancreatic cancer	12
Influence of calcium and magnesium elimination on plant biomass and secondary metabolites of Stevia rebaudiana Bertoni	12
Vitamin K: A novel cancer chemosensitizer	12
Preparation of PEI‐modified nanoparticles by dopamine self‐polymerization for efficient DNA delivery	12
An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease	12
Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation	12
Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of f	11
Liposomes: Ideal drug delivery systems in breast cancer	11
3D‐printed scaffold composites for the stimuli‐induced local delivery of bioactive adjuncts	11
microRNAs: Small molecules with a large impact on colorectal cancer	11
Evaluation of antityrosinase activity and mechanism, antioxidation, and UV filter properties of theaflavin	11
Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma	10
Icaritin and icariin reduce p‐Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β	10
Purification, characterization, and antifungal activity of Bacillus cereus strain NK91 chitinase from rhizospheric soil samples of Himachal Pradesh, India	10
CircRNA circ_0006892 regulates miR‐24/PHLPP2 axis to mitigate cigarette smoke extract‐induced bronchial epithelial cell injury	10
Multifaceted antiviral therapeutic potential of dietary flavonoids: Emerging trends and future perspectives	10
EGF‐functionalized lipid–polymer hybrid nanoparticles of 5‐fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma	10
Progress in gene therapy treatments for prostate cancer	10

The multipotent thidiazuron: A mechanistic overview of its roles in callogenesis and other plant cultures in vitro	10
Some indazoles as alternative inhibitors for potato polyphenol oxidase	10
Prodigiosin production from Serratia marcescens strain CSK and their antioxidant, antibacterial, cytotoxic effect and in silico study of caspase‐3 apoptotic protein	10
Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin	10
Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review	9
Preparation and antibacterial effect of chitooligosaccharides monomers with different polymerization degrees from crab shell chitosan by enzymatic hydrolysis	9
Biosensor as an alternative diagnostic method for rabies virus detection: A literature review	9
Investigation of inhibition effect of butanol and water extracts of Matricaria chamomilla L. on angiotensin‐converting enzyme purified from human plasma	9
Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications	9
Chromosomal editing of Corynebacterium glutamicum ATCC 13032 to produce gamma‐aminobutyric acid	9
Isolation of cyanide‐degrading bacteria and molecular characterization of its cyanide‐degrading nitrilase	9
Colorimetric identification of miRNA‐195 sequence for diagnosing osteosarcoma	9
Effective‐by‐method for the preparation of folic acid‐coated TiO2 nanoparticles with high targeting potential for apoptosis induction against bladder cancer cells (T24)	9
The genus Simplicillium and Emericellopsis: A review of phytochemistry and pharmacology	9
Successful use of Nicotiana tabacum hairy roots for the recombinant production of Cecropin A peptide	9
Phytocompounds curcumin, quercetin, indole‐3‐carbinol, and resveratrol modulate lactate–pyruvate level along with cytotoxic activity in HeLa cervical cancer cells	8
β‐Glucosidase produced by Moniliophthora perniciosa: Characterization and application in the hydrolysis of sugarcane bagasse	8
Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold	8
Usage of peptidases by SARS‐CoV‐2 and several human coronaviruses as receptors: A mysterious story	8
A liquid crystal‐based sensor exploiting the aptamer‐mediated recognition at the aqueous/liquid crystal interface for sensitive detection of serotonin	8
Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats	8
Dilute acid pretreatment for enhancing the enzymatic saccharification of agroresidues using a Botrytis ricini endoglucanase	8
Unveiling the dermatological potential of marine fungal species components: Antioxidant and inhibitory capacities over tyrosinase	8
Preparation and in vitro characterization of histidine trimethyl chitosan conjugated nanocomplex incorporated into injectable thermosensitive hydrogels for localized gene delivery	8
In silico prediction of T‐cell and B‐cell epitopes of human papillomavirus type 16 L1 protein	8
Evaluation of anti‐EGFR potential of quinazoline derivatives using molecular docking: An in silico approach	8
Enzymatic synthesis of structured lipids from grape seed (Vitis vinifera L.) oil in associated packed bed reactors	8
Exploration of potential inhibitors for SARS‐CoV‐2 Mpro considering its mutants via structure‐based drug design, molecular docking, MD simulations, MM/PBSA, and DFT calculations	8
Rheum ribes extract‐loaded nanoliposome as a novel phytogenic antibiotic alternative in mice challenged by Escherichia coli (O157:H7)	8
Characterization of a phospholipase D from Streptomyces cinnamoneum SK43.003 suitable for phosphatidylserine synthesis	7
Construction and characterization of novel bifunctional fusion proteins composed of alcohol dehydrogenase and NADH oxidase with efficient oxidized cofactor regeneration	7
The flavonoid 3′‐hydroxylase gene from the Antarctic moss Pohlia nutans is involved in regulating oxidative and salt stress tolerance	7
Zerumbone‐induced reactive oxygen species‐mediated oxidative stress re‐sensitizes breast cancer cells to paclitaxel	7
Bacterial cellulose: Nature's greener tool for industries	7
Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF‐κB signaling	7
Recent advances in techniques for fabrication and characterization of nanogap biosensors: A review	7
Surface engineered iron oxide nanoparticles as efficient materials for antibiofilm application	7
Penicillium fellutanum lipase as a green and ecofriendly biocatalyst for depolymerization of poly (ɛ‐caprolactone): Biochemical, kinetic, and thermodynamic investigations	7
Genetic engineering of the branched‐chain fatty acid biosynthesis pathway to enhance surfactin production from Bacillus subtilis	7
Chronic stress and Alzheimer's disease	7
Determination of cardiac disease biomarker by plasmonic sandwich ELISA	7
Highly sensitive colorimetric aptasensor for 17β‐estradiol detection in milk based on the repetitive‐loop aptamer	7
Glutamine alleviates the renal dysfunction associated with gentamicin‐induced acute kidney injury in Sprague–Dawley rats	7
Improving squalene production by blocking the competitive branched pathways and expressing rate‐limiting enzymes in Rhodopseudomonas palustris	7
α‐Amylase and cellulase production by novel halotolerant Bacillus sp.PM06 isolated from sugarcane pressmud	6
Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPKα and miR‐33a levels to increase apoptosis in Panc‐1 and MiaPaCa‐2 cells	6
Resveratrol‐loaded decellularized ovine pericardium: ECM introduced for tissue engineering	6
Protective effect of bromelain on some metabolic enzyme activities in tyloxapol‐induced hyperlipidemic rats	6
Impedance spectroscopy for identifying tau protein to monitor anesthesia‐based issues	6
Green synthesis of silver nanoparticles using seagrass Cymodocea serrulata (R.Br.) Asch. & Magnus, characterization, and evaluation of anticancer, antioxidant, and antiglycemic index	6
Recombinant human carbonic anhydrase VII: Purification, characterization, inhibition, and molecular docking studies	6
Genus Streptomyces: Recent advances for biotechnological purposes	6
Arsenic trioxide and Erlotinib loaded in RGD‐modified nanoliposomes for targeted combination delivery to PC3 and PANC‐1 cell lines	6
Nutritional qualities and antioxidant activity of Pleurotus floridanus grown on composted peach sawdust substrate with different composting time	6
Genome engineering and synthetic biology for biofuels: A bibliometric analysis	6
Spectroscopic studies and molecular docking on the interaction of delphinidin‐3‐O‐galactoside with tyrosinase	6
Accelerated wound closure: Systematic evaluation of cellulose acetate effects on biologically active molecules release from amniotic fluid stem cells	6
Delivery of superoxide dismutase by TAT and abalone peptides for the protection of skin cells against oxidative stress	6
Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity	6
A comparative molecular dynamic simulation study on potent ligands targeting mTOR/FRB domain for breast cancer therapy	6
Constitutive secretory expression and characterization of nitrilase from Alcaligenes faecalis in Pichia pastoris for production of R‐mandelic acid	6
Inducible expression of human papillomavirus‐16 L1 capsomeres in the plastomes of Nicotiana tabacum: Transplastomic plants develop normal flowers and pollen	6
Neural networks and genetic algorithm as robust optimization tools for modeling the microbial production of poly‐β‐hydroxybutyrate (PHB) from Brewers’ spent grain	6
Heat‐induced overexpression of the thermophilic lipase from Bacillus thermocatenulatus in Escherichia coli by fermentation and its application in preparation biodiesel using rapeseed oil	6
A comprehensive review of COVID‐19 in India: A frequent catch of the information	6
Identifying mineral decrement with bone injury by quantifying osteocalcin on current‐volt sensor	6
Proteomic analysis of human follicular fluid from polycystic ovary syndrome patients	6
Simple colorimetric screening of paraquat residue in vegetables evaluated by localized surface plasmon resonance of gold nanoparticles	6
Optimization of culture conditions for enhanced production of extracellular α‐amylase using solid‐state and submerged fermentation from Aspergillus tamarii MTCC5152	6
Metal‐free Sulfur‐doped graphitic carbon nitride‐modified GCE‐based electrocatalyst for the enhanced electrochemical determination of Omeprazole in Drug formulations and Biological Samples	6
Lipase immobilization on biodegradable film with sericin	5
Antibacterial metabolites from an unexplored strain of marine fungiEmericellopsis minimaand determination of the probable mode of action againstStaphylococcus aureusand methicillin‐resis	5
Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR‐455‐5p/PARVA axis	5
Introducing sorghum DREB2 gene in maize (Zea mays L.) to improve drought and salinity tolerance	5
Optimization of the hongqu starter preparation process for the manufacturing of red mold rice with high gamma‐aminobutyric acid production by solid‐state fermentation	5
Asiaticoside inhibits renal fibrosis development by regulating the miR‐142‐5p/ACTN4 axis	5
Fluorescent xylitol carbon dots: A potent antimicrobial agent and drug carrier	5
Purification and anticancer activity of glutaminase and urease‐free l‐asparaginase from novel endophyte Chaetomium sp	5
Mutation screening of multiple Pakistani MCPH families revealed novel and recurrent protein‐truncating mutations of ASPM	5
Pterostilbene regulates cell proliferation and apoptosis in non‐small‐cell lung cancer via targeting COX‐2	5

Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases	5
An insight into microbial sources, classification, and industrial applications of xylanases: A rapid review	5
Cell membrane biomimetic nanoparticles in drug delivery	5
Tauroursodeoxycholic acid protects Schwann cells from high glucose–induced cytotoxicity by targeting NLRP3 to regulate cell migration and pyroptosis	5
Identification ofMycoplasma pneumoniaeby DNA‐modified gold nanomaterials in a colorimetric assay	5
Industrial light at the end of the iron‐containing (group III) alcohol dehydrogenase tunnel	5
Modeling and optimization of antibacterial effect of lichen‐associated bacteria, Bacillus subtilis KSRLAB3 strain against marine fouling bacteria, Vibrio alginolyticus	5
Targeted therapies in non‐small cell lung cancer and the potential role of AI interventions in cancer treatment	5
Ornamental cabbage (Brassica oleracea var. acephala) responses to phytase enzyme purified from Lactobacillus coryniformis application	5
Development of a recombinant nucleocapsid protein‐based ELISA for the detection of IgM and IgG antibodies to SARS‐CoV‐2	5
Green tea polyphenols inhibit malignant melanoma progression via regulating circ_MITF/miR‐30e‐3p/HDAC2 axis	5
Measurement of red blood cell size based on a lensless imaging system	5
Isolation and neuronal apoptosis inhibitory property of bacoside‐A3 via downregulation of β‐amyloid induced inflammatory response	5
High production of d‐psicose from d‐fructose by immobilized whole recombinant Bacillus subtilis cells expressing d‐psicose 3‐epimerase from Agrobacterium tum	5
Effective immobilization of lactate dehydrogenase onto mesoporous silica	5
Cardiotoxicity of immune checkpoint inhibitors: An updated review	5
Structure‐based engineering of an antiangiogenic scFv antibody for soluble production in E. coli without loss of activity	5
A dual responsive robust human serum albumin‐based nanocarrier for doxorubicin	5
Transesterification of castor oil catalyzed by a fermented solid produced by Burkholderia contaminans using a bioreactor coupled with ultrasound irradiation	5
Bile acid profiles in bile and feces of obese mice by a high‐performance liquid chromatography–tandem mass spectrometry	5
Methyl benzoate derivatives as inhibitors of pentose phosphate pathway, which promotes cancer progression and drug resistance: An in silico study supported by in vitro results	5
Characterization of decellularized chicken skin as a tissue engineering scaffold	5
Long noncoding RNA CASC2 protect ROS‐induced oxidative stress in myocardial infarction by miR‐18a/SIRT2	5