OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Investigations is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Investigation of IL-35 and IL-39, New Members of the IL-12 Family, in Different Clinical Presentations of Brucellosis	44
Differential GPR56 Expression in T Cell Subpopulations for Early-Stage Lung Adenocarcinoma Patient Identification	31
Automated Analysis of PD1 and PDL1 Expression in Lymph Nodes and the Microenvironment of Transmissible Tumors in Tasmanian Devils	27
The Protection of Astragalus Polysaccharide in BALB/C Mice during Brucella melitensis M5 Infection	26
Leptin’s Immune Action: A Review Beyond Satiety	22
The Relationship Between Serum and Tissue Levels of IL-13 and TYK2 in Colorectal Cancer Patients	16
Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer’s Disease	16
The Power of Antibodies: Advancing Biomarker-Based Disease Detection and Surveillance	15
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis	15
Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes	14
Immune Dysregulation in Chronic Obstructive Pulmonary Disease	14
Knockdown of circRNA Paralemmin 2 Ameliorates Lipopolysaccharide-induced Murine Lung Epithelial Cell Injury by Sponging miR-330-5p to Reduce ROCK2 Expression	13
Synovial Fluid-Derived Exosomes from Osteoarthritis Patients Modulate Cell Surface Phenotypes of Monocytes and Cytokine Secretions	13
Nanomedicine at the Pulmonary Frontier: Immune-Centric Approaches for Respiratory Disease Treatment	11
Quantitative Analysis of Innate Lymphoid Cells in Patients with ST-Segment Elevation Myocardial Infarction	10
IL-37 Alleviates Sepsis-Induced Lung Injury by Inhibiting Inflammatory Response Through the TGF-β/Smad3 Pathway	10
Interleukin-18 Inhibition Protects Against Intervertebral Disc Degeneration via the Inactivation of Caspase-3/9 Dependent Apoptotic Pathways	10
USP7 Enables Immune Escape of Glioma Cells by Regulating PD-L1 Expression	9
Low Expression Levels of CXCL12, CXCR4, and CXCR 7 in Peripheral Blood and Decidual Tissues are Associated with Miscarriage in Women	9
Role of TAK-242-Induced Histone Lactylation in Modulating Repair Macrophage Transformation in Ulcerative Colitis	8
Role of Extracellular Vesicles in Immunity and Host Defense	8
EGR-1 Contributes to Pulmonary Edema by Regulating the Epithelial Sodium Channel in Lipopolysaccharide-Induced Acute Lung Injury	8
Circ_0008365 Suppresses Apoptosis, Inflammation and Extracellular Matrix Degradation of IL-1β-treated Chondrocytes in Osteoarthritis by Regulating miR-324-5p/BMPR2/NF-κB Signaling Axis	8
Vitamin D decreases cell death and inflammation in human umbilical vein endothelial cells and placental explants from pregnant women with preeclampsia cultured with TNF-α	8
IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus	8

IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4 ⁺ T Lymphocyte Differentiation	8
NOD1 Agonist Induces Proliferation and Plasma Cell Differentiation of Mouse B Cells Especially CD23 ^high B Cells	8
BMSCs Downregulate CXCL12 by Secreting Exosomal miR-20a-5p to Promote Macrophage M2 Polarization and Alleviate the Development of Sepsis	8
Insights into the Roles of Natural Killer Cells in Osteoarthritis	8
The Association of Angiopoietin-2 1064 C/T Rs3020221 Gene Polymorphism with Knee Osteoarthritis	8
Combination Effect of Radiotherapy and Targeted Therapy with NK Cell-Based Immunotherapy in head and Neck Squamous Cell Carcinoma	8
The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity	7
Letter from the Editor: 2021	7
Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development	7
Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome	7
Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets	7
Immunological Investigations Thematic: Editors’ Introduction	7
Variable Lymphocyte Receptor B Technologies – Are They Ready for Prime Time?	7
MicroRNA-762 Modulates Lipopolysaccharide-induced Acute Lung Injury via SIRT7	7
Describing Elephants: An Update on the Immunopathology of Multisystem Inflammatory Syndrome in Children	7
MiR-494-mediated Effects on the NF-κB Signaling Pathway Regulate Lipopolysaccharide-Induced Acute Kidney Injury in Mice	7
Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes	7
Letter from the Editor and Introduction to the 2023 Thematic Issue	6
Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling	6
Leukemia Inhibitory Factor Impairs the Function of Peripheral γδT Cells in Patients with Colorectal Cancer	6
All-Trans Retinoic Acid Promotes M2 Macrophage Polarization in Vitro by Activating the p38MAPK/STAT6 Signaling Pathway	6
A Novel Class of On-Treatment Cancer Immunotherapy Biomarker: Trough Levels of Antibody Therapeutics in Peripheral Blood	6
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status	5
Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc	5
miR-34a-5p Predicts the Risk of Diabetic Neuropathic Pain and Mediates Neuroinflammation in Microglia via Targeting ENPP3	5
The Cooperation of IL-29 and PLGA Nanoparticles Improves the Protective Immunity of the gD-1 DNA Vaccine Against Herpes Simplex Virus Type 1 in Mice	5
Establishment of Cell-Based Assay System for Evaluating Cytotoxic Activity Modulated by the Blockade of PD-1 and PD-L1 Interactions with a Therapeutic Antibody	5
Camel Whey Protein and Baicalein Suppressed Mast Cell Degranulation in Mice Models of IgE- and Non-IgE-Mediated Anaphylaxes: Potential Mechanisms on Downstream Cell Signaling of Mast Cells	5
HLA-A, -C, -B, -DRB1, -DQA1, and -DQB1 Allele and Haplotype Repertoires in the Albanian Population from Kosovo	5
Immunomodulatory Role and Therapeutic Potential of HLA-DR ⁺ Regulatory T Cells in Systemic Lupus Erythematosus	4
Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses	4
The Role of Exosomes in Central Immune Tolerance and Myasthenia Gravis	4
Extracellular Vesicles and the Immune System: From Immunological Function to Therapeutic Application	4
The Impact of Tumor-Associated Macrophages Found at Mammary Carcinoma Sites is Dependent Upon the Tumor Type	4
The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer	4
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma	4
Differential Expression of Granulysin, MHC Class I-Related Chain A, and Perforin in Serum and Peritoneal Fluid: Immune Dysregulation in Endometriosis-Related Infertility	4
2-DG Re-Normalized IFN-γ Production in T Cells Excluding T_EMRA Cells from Patients with Aplastic Anemia	4
Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study	4
MicroRNA-30a Targets Notch1 to Alleviate Podocyte Injury in Lupus Nephritis	4
The Lasting Impact of IL-2: Approaching 50 Years of Advancing Immune Tolerance, Cancer Immunotherapies, and Autoimmune Diseases	4
Tissue-Resident Memory T Cells in Tumor Immunity and Immunotherapy of Digestive System Tumors	4
Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of ‘A’ Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Lin	4
The Impact of STAT3 rs1053005 Variation on Type 1 Diabetes Mellitus Susceptibility: Association Study and in Silico Analysis	4
Association between Psoriasis Disease and IFN-λ Gene Polymorphisms	4
Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains	4