OOIR: Observatory of International Research

Papers

(The TQCC of Physiological Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Pharmacological Inhibition of eIF2α Phosphorylation by Integrated Stress Response Inhibitor (ISRIB) Ameliorates Vascular Calcification in Rats	39
Gait Changes Following Robot-Assisted Gait Training in Children With Cerebral Palsy	37
Contralateral and Ipsilateral Arterial Vasculature of the Human Uterus: The Pilot Results of an Anatomical Study	34
Analysis of sex difference in the tubular reabsorption of lithium in rats	32
MiR-18a Inhibits PI3K/AKT Signaling Pathway to Regulate PDGF BB-Induced Airway Smooth Muscle Cell Proliferation and Phenotypic Transformation	31
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism	31
Prediction of Akute Kidney Injury Development in Critically Ill Septic Patients Based on NGAL Determination	28
Acute and Chronic Effects of High-Intensity Interval Training (HIIT) on Postexercise Intramuscular Lipid Metabolism in Rats	25
The Role of AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin	25
Our First Experience Implementing “Clinical Embryology and Reproductive Medicine” as a Curriculum Course of the Study Program General Medicine at the Faculty of Medicine in Bratislava, Slovakia	22
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?	21
Synthetic Pyridoindole and Rutin Affect Upregulation of Endothelial Nitric Oxide Synthase and Heart Function in Rats Fed a High-Fat-Fructose Diet	21
Electroacupuncture Stimulation Alleviates Inflammatory Pain in Male Rats by Suppressing Oxidative Stress	20
Interactions of Renin-Angiotensin System and COVID-19: The Importance of Daily Rhythms in ACE2, ADAM17 and TMPRSS2 Expression	19
Comparative Analysis of Matrix Metalloproteinases by Zymography in Patients With Colorectal Carcinoma	17
Jaroslava Folbergrová, Dr.Sc. (1932 – 2024)	17
Assessment of the Cardiovascular Risk of High-Fat-High-Fructose Diet in Hereditary Hypertriacylglycerolemic Rats and Venlafaxine Effect	16
GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner	16
Can Prenatal Methamphetamine Exposure be Considered a Good Animal Model for ADHD?	16
Vitamin D Levels During Fracture Healing in Children	15
The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems	15
Herbal Compounds in the Treatment of Pulmonary Silicosis	15
Steroid Conjugates and Their Physiological Role	15
Side Effects of Amino Acid Supplements	15
Roles of Isometric Contraction Training in Promoting Neuroprotection and Angiogenesis After Stroke in Adult Rats	15

Pancreatic stellate cells - rising stars in pancreatic pathologies	14
Methamphetamine, Neurotransmitters and Neurodevelopment	14
Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes	14
Ellagic Acid Attenuates Muscle Atrophy in STZ-Induced Diabetic Mice	13
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The Relationship Between Hormonal Contraceptives, Level of Anxiety and Emotional Awareness: Pilot Project	12
Ovarian Steroid Hormone Secretion by Human Granulosa Cells After Supplementation of Sambucus nigra L. Extract	12
Effects of Hindlimb Suspension on the Development of Hip Bone Morphologies in Growing Rats	12
Cholecystokinin system is involved in the anorexigenic effect of peripherally applied palmitoylated prolactin-releasing peptide in fasted mice	12
Distinct Cardiac Connexin-43 Expression in Hypertrophied and Atrophied Myocardium May Impact the Vulnerability of the Heart to Malignant Arrhythmias. A Pilot Study	11
Effects of Treadmill Exercise on Sexual Behavior and Reproductive Parameters in Chronically Stressed-Male Rats	11
Pancreatic stellate cells - rising stars in pancreatic pathologies	11
The impact of atrial fibrillation and atrial tachycardias on the hemodynamic status of patients with pulmonary hypertension	11
Inflammation and Fibrosis Induced by Joint Remobilization, and Relevance to Progression of Arthrogenic Joint Contracture: A Narrative Review	10
Can Buckwheat Affect Health and Female Reproductive Functions?	10
The Temporal and Spatial Effects of Reconstructive Surgery on the Atrophy of Hindlimb Muscles in Anterior Cruciate Ligament Transected Rats	10
Association Between Cardiac High-Energy Phosphate Metabolism and Whole Body Metabolism in Healthy Female Adults	10
Effect of Methylprednisolone on Experimental Brain Edema in Rats – Own Experience Reviewed	10
Altered Expression of ORAI and STIM Isoforms in Activated Human Cardiac Fibroblasts	9
Influence of Blood Pressure and Heart Rate on PWV Measurement: Assessment Under Real-Time Blood Pressure Monitoring	9
The Effects of Titanium Topography and Chemical Composition on Human Osteoblast Cell	9
Puncture vine (Tribulus Terrestris L.) in control of health and reproduction	9
Role of 5-HT2 Receptors Family in the Allergy-Induced Increased Aorta Contractile Responses to 5-HT	9
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition	9
Endocrine Risk Factors for COVID-19 in Context of Aging	9
Mitochondrial Dysfunction in Kidney Cortex and Medulla of Subtotally Nephrectomized Rat	9
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy	8
Antioxidative Effect of Dietary Flavonoid Isoquercitrin on Human Ovarian Granulosa Cells HGL5 In Vitro	8
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity – A Pilot Study: Part 1 – Laparoscopic Greater Curvature Plication	8
The Long-Term Effects of Growth Hormone Replacement on Bone Mineral Density and Trabecular Bone Score: Results of the 10-Year Prospective Follow-up	8
Sex differences in blood pressure, free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages	8
Noninvasive arterial compliance estimation	8
Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain	8
Effects of H3 and H4 Histones Acetylation and Bindings of CREB Binding Protein and p300 at the Promoter on Hepatic Expression of γ-glutamyltransferase Gene in a Streptozotocin-Induced Moderate Hypoins	8
Dissociation Between the Epileptogenic Lesion and Primary Seizure Onset Zone in the Tetanus Toxin Model of Temporal Lobe Epilepsy	8
Mitochondrial Respiration of Human Platelets in Young Adult and Advanced Age – Seahorse or O2k?	8
Serum Vitamin D Level in Overweight Individuals and Its Correlation With the Incidence of Non-alcoholic Fatty Liver Disease	8
Direct Effects of Waterpipe Smoke Extract on Aortic Endothelial Cells: An In Vitro Study	7
First Application of Whole Genome Sequencing in Myelinated Retinal Nerve Fibers (MRNF)	7
The Effect of Sulforaphane on Perinatal Hypoxic-Ischemic Brain Injury in Rats	7
Sex Difference in Plasma Deoxyribonuclease Activity in Rats	7
Cytokine Cascade in Kawasaki Disease Versus Kawasaki-Like Syndrome	7
Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity	7
History of Blood Pressure Measurement in Newborns and Infants	7
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague	7
Circadian Disruption as a Risk Factor for Development of Cardiovascular and Metabolic Disorders – From Animal Models to Human Population	7
Prediction of Vertebral Fractures by Trabecular Bone Score in Patients With Ankylosing Spondylitis	7
ASIC1a Involves the Acid-Mediated Activation of Pancreatic Stellate Cells Associated With Autophagy Induction	7
Neurophysiological Assessment of H-Reflex Alterations in Compressive Radiculopathy	7
Application of Modified Mesenchymal Stem Cells Transplantation in the Treatment of Liver Injury	7

Rho-Kinase Inhibition Ameliorates Non-Alcoholic Fatty Liver Disease in Type 2 Diabetic Rats	6
The potential applications of artificial intelligence in drug discovery and development	6
PAR2: The Cornerstone of Pancreatic Diseases	6
Unusual Functions of Insect Vitellogenins: Minireview	6
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4	6
The Effect of Bariatric-Metabolic Surgery on Selected Components of Metabolic Syndrome and Visceral Adipose Tissue – The Pilot Study	6
Anti-Müllerian Hormone Can Help With Predicting Ovarian Failure for Premenopausal Women Who Have Undergone Ablative Radioiodine Treatment for Thyroid Cancer	6
Waterpipe Smoke Inhalation Induces Lung Injury and Aortic Endothelial Dysfunction in Mice	6
Cholesterol efflux and macrophage polarization in human adipose tissue	6
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension	6
Experimental Lung Transplantation Related With HIF-1, VEGF, ROS. Assessment of HIF-1α, VEGF, and Reactive Oxygen Species After Competitive Blockade of Chetomin for Lung Transplantation in Rats	6
Cardiorenal Syndromes and Their Role in Water and Sodium Homeostasis	6
Brain Fluid Channels for Metabolite Removal	6
Ten Years of Our Translational Research in the Field of Veno-Arterial Extracorporeal Membrane Oxygenation	6
The Effect of Dietary Oat Consumption and Its Constituents on Fat Storage and Obesity	6
Correlation Between Nongenomic Action of C19-Steroids and COVID-19 Severity	5
Inhibition of Extracellular Signal-Regulated Kinase Downregulates Endoplasmic Reticulum Stress-Induced Apoptosis and Decreases Brain Injury in a Cardiac Arrest Rat Model	5
From a Passive Conduit to Highly Dynamic Organ. What are the Roles of Uterine Tube Epithelium in Reproduction?	5
Immune Disorders and Sex Differences in Spontaneously Diabetic Torii Rats, Type 2 Diabetic Model	5
NADPH oxidase 4 contributes to oxidative stress in a mouse model of myocardial infarction	5
Eicosapentaenoic Acid Alleviates Inflammatory Response and Insulin Resistance in Pregnant Mice With Gestational Diabetes Mellitus	5
Cardiovascular Changes During Phototherapy in Newborns	5
Arecoline Hydrobromide Enhances Jejunum Smooth Muscle Contractility via Voltage-Dependent Potassium Channels in W/Wv Mice	5
Short-Term Arterial Compliance Changes in the Context of Systolic Blood Pressure Influence	5
Fibroblast Growth Factor 23 and Klotho Are Associated With Trabecular Bone Score but Not Bone Mineral Density in the Early Stages of Chronic Kidney Disease: Results of the Cross-Sectional Study	5
Nutrition and Bone Marrow Adiposity in Relation to Bone Health	5
The Role of Connexin 37 Polymorphism in Spontaneous Abortion	5
Baicalin Ameliorates Cartilage Injury in Rats With Osteoarthritis via Modulating miR-766-3p/AIFM1 Axis	5
Decellularization techniques of human foreskin for tissue engineering application	5
Modern Perspective of Lactate Metabolism	5
Aspalathin Alleviates Skeletal Muscle Insulin Resistance and Mitochondrial Dysfunction	5
The Role of Pulmonary Artery Wedge Pressure on the Incidence of Atrial Fibrillation and Atrial Tachycardias in Patients With Isolated Pre-capillary Pulmonary Hypertension	5
Is there a Need to Change the Basic Principles of Histology? Educational, Functional and Embryological Perspective	5
Effects of Acute Pump Speed Changes on Cerebral Hemodynamics in Patients With an Implantable Continuous-Flow Left Ventricular Assist Devices	5
Steroidogenic Enzyme Gene Expression and Testosterone Production are Developmentally Modulated by Bone Morphogenetic Protein Receptor-1B in Mouse Testis	5
Chronic Venous Disease and Its Intersections With Diabetes Mellitus	5
Genistein does not Inhibit TGF-β1-Induced Conversion of Human Dermal Fibroblasts to Myofibroblasts	5
Comprehensive Genomic Profiling in Predictive Testing of Cancer	5
Berberine Exerts Neuroprotective Effects in Alzheimer’s Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling	5
Hydrolat of Helichrysum Italicum promotes tissue regeneration during wound healing	4
Progesterone Inhibitory Role on Gastrointestinal Motility	4
High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats	4
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity – A Pilot Study: Part 2 – Biliopancreatic Diversion	4
Biomarkers of the Physical Function Mobility Domains Among Patients Hospitalized in Internal Medicine	4
Impairment of Endogenous H2S Pathway due to Aging and Endothelium Denudation in Mouse Isolated Thoracic Aorta	4
Effects of total intravenous anesthesia with etomidate and propofol on postoperative cognitive dysfunction	4
Endothelial-Mesenchymal Transition or Functional Tissue Regeneration – Two Outcomes of Heart Remodeling	4
Metabolic Syndrome in Hypertriglyceridemic Rats: Effects of Antioxidants	4
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences	4
The Severity of Muscle Performance Deterioration in Sarcopenia Correlates With Circulating Muscle Tissue-Specific miRNAs	4
The potential applications of artificial intelligence in drug discovery and development	4
Interplay Between Astroglial Endocannabinoid System and the Cognitive Dysfunction in Alzheimer's Disease	4
The Expression Level of Inflammation-Related Genes in Patients With Bone Nonunion and the Effect of BMP-2 Infected Mesenchymal Stem Cells Combined With nHA/PA66 on the Inflammation Level of Femoral Bo	4
miR-491-5p Inhibits Emilin 1 to Promote Fibroblasts Proliferation and Fibrosis in Gluteal Muscle Contracture via TGF-β1/Smad2 Pathway	4
Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension	4
Valsartan prevented neointimal hyperplasia and inhibited SRSF1 expression and the TLR4–iNOS–ERK–AT1 receptor pathway in the balloon-injured rat aorta	4
Cadmium-Induced Hepatotoxicity in Mice – Prophylactic Supplementation of Quercetin Exerts Hepatoprotective Effect by Modulating PI3K/Akt/NF-κB Signaling Pathway	4
Protection of Toll-Like Receptor 9 Against Lipopolysaccharide-Induced Inflammation and Oxidative Stress of Pulmonary Epithelial Cells via MyD88-Mediated Pathways	4
Association of Polymorphisms in Endothelin-1 and Endothelin Receptor A Genes With Vasovagal Syncope	4
Is Apelin a new biomarker in patients with polycystic ovary syndrome?	4
Androgens in SARS-CoV-2 Coronavirus Infections	4
Clinical Efficacy of Blood Ultrafiltration Therapy in Patients with Acute Decompensated Chronic Heart Failure	4
Parvalbumin - Positive Neurons in the Neocortex: A Review	4
Hyperbaric Oxygen Enhances Collagen III Formation in Wound of ZDF Rat	4
Ginsenoside-MC1 Alleviates Stroke by Modulating AMPK/SIRT1 Pathway in a Rat Model	4
Research on Experimental Hypertension in Prague (1966-2009)	4
Effect of Laparoscopic Sleeve Gastrectomy on Serum Adipokine Levels	4
The Assessment of Plasma Fatty Acid Profiles in Newly Diagnosed Treatment-Naïve Paediatric Crohn’s Disease	4
Dihydromyricetin Inhibits Ferroptosis to Attenuate Cisplatin-Induced Muscle Atrophy	4
Circulating Exosomal miRNAs as a Promising Diagnostic Biomarker in Cancer	4
Differential Mitochondrial Adaptation of the Slow and Fast Skeletal Muscles by Endurance Running Exercise in Streptozotocin-Induced Diabetic Mice	4
Ca2+ Depletion in the ER Causes Store-Operated Ca2+ Entry via the TRPC6 Channel in Mouse Brown Adipocytes	4
Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study	4