OOIR: Observatory of International Research

Papers

(The median citation count of Biochemistry and Cell Biology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Cadmium chloride generates cytotoxic reactive species that cause oxidative damage and morphological changes in human erythrocytes	38
TRAF7 inhibits proliferation and migration of esophageal squamous cell carcinoma by ubiquitination-mediated degradation of SOX12	31
NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis	30
RNA deadenylation complexes in development and diseases	21
Meeting report: 10th Annual Canadian Conference on Epigenetics	21
Retraction: MicroRNA-181 inhibits proliferation and promotes apoptosis of chondrocytes in osteoarthritis by targeting PTEN	20
Computational screening of filamin mechanical binding proteins using AlphaFold2	20
WDR4 promotes colorectal cancer progression by activating the GSK3β/β-catenin pathway	19
Distinct domain organization and diversity of 2′-5′-oligoadenylate synthetases	19
Perturbation of calcium homeostasis invokes eryptosis-like cell death in enucleated bone marrow stem cells	18
KREMEN2 promotes the proliferation and the metastasis through activating PI3K/AKT/mTOR signaling pathway in non-small cell lung cancer	17
Antibiofilm activities of lactoferricin-related Trp- and Arg-rich antimicrobial hexapeptides against pathogenic Staphylococcus aureus and Pseudomonas aeruginosa strains	16
HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury	16
Expression of concern: MicroRNA-518-3p suppresses cell proliferation, invasiveness, and migration in colorectal cancer via targeting TRIP4	15
Retraction: MiR-1180 promotes cardiomyocyte cell cycle re-entry after injury through the NKIRAS2–NFκB pathway	15
ChestCovidNet: an effective deep learning based approach for COVID-19, lung opacity, and pneumonia detection using chest radiograph images	14
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation	13
Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway	12
Bone marrow granulocytes downregulate IL-1β and TNF production and the microbicidal activity of inflammatory macrophages	11
GCN5 regulates ZBTB16 through acetylation, mediates osteogenic differentiation, and affects orthodontic tooth movement	11
Unveiling stem-like traits and chemoresistance mechanisms in ovarian cancer cells through the TGFβ1-PITX2A/B signaling axis	11
Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells	11
Characterization of cells expressing lipocalin-2 (LCN2) as a reporter	10
Correction: Ultrasound-stimulated microbubbles contributes to radiotherapy in esophageal carcinoma	10
Acyl-protein thioesterase 1 (LYPLA1) activity promotes the growth of MDA-MB-468 triple-negative breast cancer cells	10

MCPIP1 deficiency alleviates abdominal aortic aneurysm formation by inhibiting MAPK signaling	10
Bovine lactoferrin suppresses the proliferation of endometriotic stromal cells via the PI3K/Akt/mTOR pathway	10
WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells	9
O-GlcNAcylation of epidermal growth factor receptor and glucose transporter 1 prevents their intrinsic down regulation in breast cancer cells	9
Establishment of immortalized porcine intramuscular preadipocytes for the study of lipid metabolism	9
Small proline-rich protein 1A promotes lung adenocarcinoma progression and indicates unfavorable clinical outcomes	9
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori	8
Antibacterial, anti-invasive, and anti-inflammatory activity of bovine lactoferrin extracted from milk or colostrum versus whole colostrum	8
18^th International Conference of Biochemistry & Molecular Biology (18^th ICBMB)	8
An improved version of the early histone HCl extraction protocol	8
Phospholipid Externalization Blockade as an Antitumor Immunotherapy	8
Correction: Protective effect of nitronyl nitroxide against hypoxia-induced damage in PC12 cells	8
Correction: Evaluation of drug-free methods for the detection of gene silencing in S. cerevisiae	8
Study on the mechanism of USP7 promoting endometriosis by regulating DNMT1 deubiquitination level	8
Retraction: MiR-204 suppresses cell proliferation and promotes apoptosis in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome	7
How to become a successful scientist: the 2022 CSMB Arthur Wynne Gold Medal Lecture	7
Structural features, intrinsic disorder, and modularity of a pyriform spidroin 1 core repetitive domain	7
Suppression of academics and school training in Iran during the “Woman, Life, Freedom” revolution	7
Evaluation of biochemical profile and oxidative damage to lipids and proteins in patients with lysosomal acid lipase deficiency	7
Subacute exposure to aluminium chloride induces cytotoxicity and oxidative stress in rat erythrocytes: a dose-dependent study	7
Recombinant human holo-lactoferrin in complex with oleic acid suppresses the growth of solid myeloma more efficiently than its apo-form	7
HOXD-AS1 interacting with AMPK causes a disturbance in mTOR signaling, impairing ferroptosis in glioma	7
Neuroprotective effects of whey and buttermilk-based formulas on a DSS-induced colitis murine model	7
RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA	7
LMAN2 interacts with HEATR3 to expedite HER2-positive breast cancer advancement and inflammation and Akt/ERK/NF-κB signaling	6
Effects of clopidogrel bisulfate on B16-F10 cells and tumor development in a murine model of melanoma	6
A role for NFIB in SOX2 downregulation and epigenome accessibility changes due to long-term estrogen treatment of breast cancer epithelial cells	6
Doxorubicin, a DNA intercalator, inhibits transcription elongation	6
Effects of different sources of lactoferrin on cytokine response to SARS-COV-2, respiratory syncytial virus, and rotavirus infection in vitro	6
FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway	6
Neurodevelopmental functions and activities of the KAT3 class of lysine acetyltransferases	6
Structure and function of fermentation-derived bovine lactoferrin produced from Komagataella phaffii	6
Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice	6
Decreased NMIIA heavy chain phosphorylation at S1943 promotes mitoxantrone resistance by upregulating BCRP and N-cadherin expression in breast cancer cells	5
LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease	5
Hydrocortisone improves post-resuscitation myocardial dysfunction by inhibiting the NF-κB pathway	4
Mitotic bookmarking provides epigenetic persistence or plasticity for biological control and cancer	4
Chelerythrine alleviates inflammation and angiogenesis in a mouse rosacea model via suppressing the NF-κB/p38 MAPK/STAT3 pathways	4
HER2 induces cell scattering and invasion through ∆Np63α and E-cadherin	4
Retraction: Wnt5A regulates the expression of ROR2 tyrosine kinase receptor in ovarian cancer cells	4
Cell-in-cell-mediated intercellular communication exacerbates the pro-inflammatory progression in asthma	4
The regulation of m⁶A-related proteins during whole-body freezing of the freeze-tolerant wood frog	4
Characterization of IFN-γ mediated cellular responses in the HMC3 cell line	4
Note of appreciation	4
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin	4
Lactate reduces metabolic heat, enhances succinate metabolism, and improves thermal stress tolerance in Saccharomyces cerevisiae	3
Identification of critical mitochondrial hub gene for facial nerve regeneration	3
Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells	3
The journey from bench to bedside—it takes a science village	3
Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states	3

Note of appreciation	3
Naïve Bayes classifier assisted automated detection of cerebral microbleeds in susceptibility-weighted imaging brain images	3
Evolution of techniques and tools for replication fork proteome and protein interaction studies	3
A combinatorial multi-site directed mutagenesis solution for improved thermal stability of Lactobacillus plantarum tannase	3
Protamines and the sperm nuclear basic proteins Pandora’s Box of insects	3
A reliable Western blot workflow with improved dynamic range for the detection of myelin proteins in murine brain	3
Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase	3
Pristimerin alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease via inhibiting NF-κB pathway	3
Retraction: Role of the TSLP–DC–OX40L pathway in asthma pathogenesis and airway inflammation in mice	3
TMCO1 regulates energy metabolism and mitochondrial function of hepatocellular carcinoma cells through TOMM20, affecting the growth of subcutaneous graft tumors and infiltration of CAFs	3
Note of appreciation	3
Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway	3
Interconnected roles of fungal nuclear- and intron-encoded maturases: at the crossroads of mitochondrial intron splicing	3
SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55	2
Lactoferrin in the treatment of interstitial cystitis: a retrospective pilot study	2
Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1	2
How prevalent are lactoferrin receptors in Gram-negative bacteria?	2
Omega-3 polyunsaturated fatty acids modify glucose metabolism in THP-1 monocytes	2
CDHR5 splice isoform cooperation promotes apical targeting of the brush border cadherin	2
Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells	2
A novel mouse model of pulmonary fibrosis: twice-repeated oropharyngeal bleomycin administration mimicking human pathology	2
Retraction: Interaction between miR-572 and PPP2R2C, and their effects on the proliferation, migration, and invasion of nasopharyngeal carcinoma (NPC) cells	2
Retraction: Profibrogenic phenotype in caveolin-1 deficiency via differential regulation of STAT-1/3 proteins	2
Galanthamine promotes neuronal differentiation and neurite outgrowth of neural progenitor/stem cells by up-regulating IGF-2	2
An artifact of recombinatorial cloning challenges established beliefs of plasmid cotransformation, selection, and maintenance	2
Lactoferrin efficacy in treating hyperferritinemia in patients suffering from pathologies unrelated to hereditary hemochromatosis	2
Early pigment spot segmentation and classification from iris cellular image analysis with explainable deep learning and multiclass support vector machine	2
Emerging roles for heterogeneous ribonuclear proteins in normal and malignant B cells	2
LncRNAs: the good, the bad, and the unknown	2
AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer	2
Retraction: LncRNA MALAT1 regulates diabetic cardiac fibroblasts through the Hippo–YAP signaling pathway	2
GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway	2
Establishing validated RT-qPCR workflow for the analysis of oligodendrocyte gene expression in the developing murine brain	2
Comparative analysis of the effect of hypoxia in two different tumor cell models shows the differential involvement of PTEN control of proangiogenic pathways	2
Single-cell RNA sequencing analysis reveals the heterogeneity and effect of TAMs in colorectal cancer	1
Maternal use of methamphetamine alters cardiovascular function in the adult offspring	1
Single-cell genomics illustrates heterogeneous phenotypes of myocardial fibroblasts under ischemic insults	1
miR-20b-5p inhibits inflammation-induced endoplasmic reticulum stress through EIF2S1 and promotes osteogenic differentiation of bone marrow mesenchymal stem cells	1
1-Deoxynojirimycin affects high glucose-induced pancreatic beta-cell dysfunction through regulating CEBPA expression and AMPK pathway	1
Revisiting galectin-1, -3, -4, and -9 as biotargets for colorectal cancer	1
High concentrations of fructose cause brain damage in mice	1
Evaluation of drug-free methods for the detection of gene silencing in Saccharomyces cerevisiae	1
Exogenous hydrogen sulfide prevents SOD2 degradation to safeguard renal function in diabetic kidney disease	1
Mechanisms of Lycium barbarum polysaccharides in reducing radiation-induced spinal cord neuron damage	1
Divergent ERα co-factor landscapes in gynecological cancers: implications for disease progression and therapy	1
Retraction: Lentivirus-mediated angiopoietin-2 gene silencing decreases TNF-α induced apoptosis of alveolar epithelium cells	1
Equity in action: a 4-year journey towards gender parity and racial diversity in biochemistry hiring	1
Skeletal muscle mitochondrial morphology negatively affected in mice lacking Xin	1
Serum pro-surfactant protein B is correlated with clinical properties in osteosarcoma patients	1
Design and biological evaluation of novel biphenyl-dihydropyrimidinone derivatives with selective anticancer and nongenotoxic profiles	1
The biological relevance of PCSK9: when less is better…	1
Retraction: Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK–mTOR signaling pathway	1
ERCC6 plays a promoting role in the progression of non-small cell lung cancer	1
CD38 deficiency prevents diabetic nephropathy by inhibiting lipid accumulation and oxidative stress through activation of the SIRT3 pathway	1
Structural determinants for the monomeric and phospholipid-transport P4B-ATPase via comprehensive in silico analysis of P4-ATPase structures	1
Quercetin alleviates the progression of chronic rhinosinusitis by affecting nasal mucosal epithelial remodeling, inflammation, and Treg/Th17 imbalance	1
The future of scientific research—centralized expertise and specialization through full-service core facilities	1
Purification and characterization of inorganic pyrophosphatase for in vitro RNA transcription	1
Effects of the omega-3 fatty acid DHA on histone and p53 acetylation in diffuse large B cell lymphoma	1
Chromatin- and nucleosome-associated features in liquid biopsy: implications for cancer biomarker discovery	1
Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer	1
The G protein-coupled receptor GPRC5A—a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity	1
Protein arginine methyltransferase 1, a major regulator of biological processes	1
43rd International Asilomar Chromatin, Chromosomes, and Epigenetics Conference	1
The potential role of AhR/NR4A1 in androgen-dependent prostate cancer: focus on TCDD-induced ferroptosis	1
Treatment of lactoferrin and antimicrobial peptide N6 on bacterial enteritis caused by Escherichia coli in mice	1
Establishing an incentive-based multistakeholder approach to dual-use DNA screening	1
Automatic detection of Cryptosporidium in optical microscopy images using YOLOv5x: a comparative study	1
Antioxidant and migration-modulating effects of lactoferrin in human keratinocytes	1
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway	1
Yeast profilin mutants inhibit classical nuclear import and alter the balance between actin and tubulin levels	1
Proceedings of the Canadian Society for Molecular Biosciences (CSMB) 2024 Conference — Gene Regulation: From Cells to Systems	1
Retraction: PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt–β-catenin signaling pathway	1
Canada's contributions to RNA research: past, present, and future perspectives	1
Message from Dr. Philippe T. Georgel, Guest Editor for the Marshall University Collection, Brad D. Smith, President of Marshall University, and Dr. Anivandan Mukherjee, Provost of Marshall University	1