Biochemistry and Cell Biology

Article	Citations
Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK–mTOR signaling pathway	42
Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells	31
Antiviral effects of bovine lactoferrin on human norovirus	29
PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2	26
Propofol promotes apoptosis of colorectal cancer cells via alleviating the suppression of lncRNA HOXA11-AS on miRNA let-7i	24
LncRNA H19 promotes inflammatory response induced by cerebral ischemia–reperfusion injury through regulating the miR-138-5p–p65 axis	23
The N-glycans of lactoferrin: more than just a sweet decoration	22
Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway	22
LncRNA MALAT1 regulates diabetic cardiac fibroblasts through the Hippo–YAP signaling pathway	21
Protective effect of hydralazine on a cellular model of Parkinson’s disease: a possible role of hypoxia-inducible factor (HIF)-1α	21
Biological activities of commercial bovine lactoferrin sources	20
Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host’s innate immunity	19
Reversal of P-glycoprotein-mediated multidrug resistance by novel curcumin analogues in paclitaxel-resistant human breast cancer cells	19
MiR-27b-3p suppresses glioma development via targeting YAP1	19
CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT–beta-catenin signaling pathway	18
The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1–miR-145-5p–TRPC6 pathway	18
MicroRNA-1298-5p inhibits cell proliferation and the invasiveness of bladder cancer cells via down-regulation of connexin 43	17
Antibiofilm activity of lactoferrin-derived synthetic peptides against Pseudomonas aeruginosa PAO1	17
Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma	16
Lactoferrin and oral pathologies: a therapeutic treatment	16
New insights into the systemic effects of oral lactoferrin: transcriptome profiling	16
Resveratrol upregulates miR-455-5p to antagonize cisplatin ototoxicity via modulating the PTEN–PI3K–AKT axis	16
miR-628-5p promotes growth and migration of osteosarcoma by targeting IFI44L	16
Long noncoding RNA KCNQ1OT1 is correlated with human breast cancer cell development through inverse regulation of hsa-miR-107	16
Effects of oral bovine lactoferrin on a mouse model of inflammation associated colon cancer	15

LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM	15
lncRNA CTBP1-AS2 promotes proliferation and migration of glioma by modulating miR-370-3p–Wnt7a-mediated epithelial–mesenchymal transition	14
MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1	14
Amplified LncRNA PVT1 promotes lung cancer proliferation and metastasis by facilitating VEGFC expression	14
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway	14
A prospective on multiple biological activities of lactoferrin contributing to piglet welfare	14
Notch1–Nrf2 signaling crosstalk provides myocardial protection by reducing ROS formation	14
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy	13
Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway	13
PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination	13
Comparative effect of bovine buttermilk, whey, and lactoferrin on the innate immunity receptors and oxidative status of intestinal epithelial cells	13
MicroRNA-24 alleviates isoflurane-induced neurotoxicity in rat hippocampus via attenuation of oxidative stress	13
Formononetin protects against concanavalin-A-induced autoimmune hepatitis in mice through its anti-apoptotic and anti-inflammatory properties	13
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc–p21Waf1signalling pathway	13
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1	13
MicroRNA-211-5p promotes apoptosis and inhibits the migration of osteosarcoma cells by targeting proline-rich protein PRR11	13
Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro	13
Long noncoding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial–mesenchymal transition in pancreatic cancer	13
MiR-126 targets IL-17A to enhance proliferation and inhibit apoptosis in high-glucose-induced human retinal endothelial cells	13
circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth	13
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8	13
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation	12
Dose escalation study of bovine lactoferrin in preterm infants: getting the dose right	12
Exogenous ubiquitin attenuates hypoxia/reoxygenation-induced cardiac myocyte apoptosis via the involvement of CXCR4 and modulation of mitochondrial homeostasis	11
DNA methylation and regulation of DNA methyltransferases in a freeze-tolerant vertebrate	11
Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced apoptosis and inflammation in human umbilical vein endothelial cells by suppressing the NF-κB signaling pathway	11
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4	11
Lactoferrin receptors in Gram-negative bacteria: an evolutionary perspective	11
Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells	11
Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner	10
Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression	10
Atypical chromatin structure of immune-related genes expressed in chicken erythrocytes	10
Homogeneity and heterogeneity of biological characteristics in mesenchymal stem cells from human umbilical cords and exfoliated deciduous teeth	10
MiR-138-5p knockdown promotes osteogenic differentiation through FOXC1 up-regulation in human bone mesenchymal stem cells	10
Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway	10
Cardiovascular protective effects of GLP-1: a focus on the MAPK signaling pathway	10
CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis	10
LncRNA Gm4419 induces cell apoptosis in hepatic ischemia–reperfusion injury via regulating the miR-455–SOX6 axis	10
Nisin induces apoptosis in cervical cancer cells via reactive oxygen species generation and mitochondrial membrane potential changes	9
miR-140-5p targeted FGF9 and inhibited the cell growth of laryngeal squamous cell carcinoma	9
Bovine lactoferrin and lactoferrin peptides affect endometrial and cervical cancer cell lines	9
DUSP4 inhibits autophagic cell death in PTC by inhibiting JNK–BCL2–Beclin1 signaling	9
PCDH7 knockdown potentiates colon cancer cells to chemotherapy via inducing ferroptosis and changes in autophagy through restraining MEK1/2/ERK/c-Fos axis	9
PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt–β-catenin signaling pathway	9
hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells	9
Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway	9
Lactoferrin and hematoma detoxification after intracerebral hemorrhage	9
Artesunate inhibits proliferation, migration, and invasion of thyroid cancer cells by regulating the PI3K/AKT/FKHR pathway	8
ELFIN, the United Kingdom preterm lactoferrin trial: interpretation and future questions	8
SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation	8

Knockdown of E-cadherin induces cancer stem-cell-like phenotype and drug resistance in cervical cancer cells	8
PDGFRβ modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K/AKT/mTOR/c-Myc pathway	8
VEGF-mediated angiogenesis in retinopathy of prematurity is co-regulated by miR-17-5p and miR-20a-5p	8
Circ_BMP2K enhances the regulatory effects of miR-455-3p on its target gene SUMO1 and thereby inhibits the activation of cardiac fibroblasts	8
S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine	7
Chondroitin polymerizing factor (CHPF) contributes to malignant proliferation and migration of hepatocellular carcinoma cells	7
MiR-494-3p alleviates acute lung injury through regulating NLRP3 activation by targeting CMPK2	7
Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells	7
Binding of lactoferrin to the surface of low-density lipoproteins modified by myeloperoxidase prevents intracellular cholesterol accumulation by human blood monocytes	7
Glycerol kinase enhances hepatic lipid metabolism by repressing nuclear receptor subfamily 4 group A1 in the nucleus	7
Paeonol reduces IL-β production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-κB in macrophages	7
MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression	7
Silencing LINC00511 inhibits cell proliferation, migration, and epithelial–mesenchymal transition via the PTEN–AKT–FOXO1 signaling pathway in lung cancer	7
Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K–AKT–Nrf2 signaling pathway	7
Role of syndecan-1 and exogenous heparin in hepatoma sphere formation	7
LncRNA IDH1-AS1 suppresses cell proliferation and tumor growth in glioma	7
Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau	7
LFchimera: a synthetic mimic of the two antimicrobial domains of bovine lactoferrin	7
Adipocyte factor CTRP6 inhibits homocysteine-induced proliferation, migration, and dedifferentiation of vascular smooth muscle cells through PPARγ/NLRP3	7
MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia–reperfusion injury	7
MiR-1180 promotes cardiomyocyte cell cycle re-entry after injury through the NKIRAS2–NFκB pathway	7
Thidiazuron suppresses breast cancer via targeting miR-132 and dysregulation of the PI3K–Akt signaling pathway mediated by the miR-202-5p–PTEN axis	7
Silencing linc00662 inhibits cell proliferation and colony formation of lung cancer cells via regulating the miR-145-5p–PAFAH1B2 axis	6
SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects	6
Reflections on antifreeze proteins and their evolution	6
TGF-β1-containing exosomes from cardiac microvascular endothelial cells mediate cardiac fibroblast activation under high glucose conditions	6
Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA)	6
Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin	6
Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction	6
Angptl2 gene knockdown is critical for abolishing angiotensin II-induced vascular smooth muscle cell proliferation and migration	6
MicroRNA-518-3p suppresses cell proliferation, invasiveness, and migration in colorectal cancer via targeting TRIP4	6
Genes responsive to rapamycin and serum deprivation are clustered on chromosomes and undergo reorganization within local chromatin environments	6
YAP confers resistance to vandetanib in medullary thyroid cancer	5
Lactoferrin reduces mycobacterial M1-type inflammation induced with trehalose 6,6′-dimycolate and facilitates the entry of fluoroquinolone into granulomas	5
Dlx5promotes cancer progression through regulation ofCCND1in oral squamous cell carcinoma (OSCC)	5
Evidence from systematic reviews of randomized trials on enteral lactoferrin supplementation in preterm neonates	5
HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury	5
Subcellular fractionation of frozen skeletal muscle samples	5
Mistranslating tRNA identifies a deleterious S213P mutation in theSaccharomyces cerevisiaeeco1-1allele	5
Upregulation of bromodomain PHD finger transcription factor in ovarian cancer and its critical role for cancer cell proliferation and survival	5
Customizable live-cell imaging chambers for multimodal and multiplex fluorescence microscopy	5
Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials	5
Evaluation of drug-free methods for the detection of gene silencing in Saccharomyces cerevisiae	5
Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes	5
Metformin exerts anti-tumor effects via Sonic hedgehog signaling pathway by targeting AMPK in HepG2 cells	5
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K–AKT and MAPK signaling pathways in colorectal cancer	5
Overexpression of protein disulfide isomerase enhances vitamin K epoxide reductase activity	5
Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKCδ–NLRC4 axis	5
Pristimerin alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease via inhibiting NF-κB pathway	5
BRD4 promotes the migration and invasion of bladder cancer cells through the Sonic hedgehog signaling pathway and enhances cisplatin resistance	5
Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs)	4
Inhibition of brain-type glycogen phosphorylase ameliorates high glucose-induced cardiomyocyte apoptosis via Akt–HIF-1α activation	4
Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1	4
Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitro	4
GCN5 enables HSP12 induction promoting chromatin remodeling, not histone acetylation	4
Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial–mesenchymal transition in breast cancer cells via the miR-136–Smad3 axis	4
NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis	4
Preventive cancer vaccination with P5 HER-2/neo-derived peptide‐pulsed peripheral blood mononuclear cells in a mouse model of breast cancer	4
EDTA as a chelating agent in quantitative1H-NMR of biologically important ions	4
MiR-448 targets BLC2 and inhibits the growth of pituitary adenoma cells	4
FOXD3 inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma through regulation of the PI3K–Akt pathway	4
Protective effect of nitronyl nitroxide against hypoxia-induced damage in PC12 cells	4
The biological relevance of PCSK9: when less is better…	4
Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients — correlation with IVF parameters	4
Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells	4
Dystonin loss-of-function leads to impaired autophagosome–endolysosome pathway dynamics	3
The endless battle between phages and CRISPR–Cas systems in Streptococcus thermophilus	3
Emerging regulatory challenges of next-generation synthetic biology	3
Activity of fructose-1,6-bisphosphatase fromCampylobacter jejuni	3
Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells	3
Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice	3
Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells	3
The let-7f-5p–Nme4 pathway mediates tumor necrosis factor α-induced impairment in osteogenesis of bone marrow-derived mesenchymal stem cells	3
Attention-based deep learning framework to recognize diabetes disease from cellular retinal images	3
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation	3
PUM1 modulates trophoblast cell proliferation and migration through LRP6	3
LINC00641 contributes to nasopharyngeal carcinoma cell malignancy through FOXD1 upregulation at the post-transcriptional level	3
Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer	3
Long noncoding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy modulation	3
Synergistic effects of autophagy inhibitors combined with cisplatin against cisplatin-resistant nasopharyngeal cancer cells	3

A-kinase anchoring protein 5 anchors protein kinase A to mediate PLN/SERCA to reduce cardiomyocyte apoptosis induced by hypoxia and reoxygenation	3
Dexmedetomidine upregulates the expression of miR-493-5p, inhibiting growth and inducing the apoptosis of lung adenocarcinoma cells by targeting RASL11B	3
Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states	3
HER2 induces cell scattering and invasion through ∆Np63α and E-cadherin	3
Prognostic value and oncogenic effect of increased RBM8A expression in colon adenocarcinoma	3
Cadmium chloride generates cytotoxic reactive species that cause oxidative damage and morphological changes in human erythrocytes	3
The nuclear-localized GHR is involved in the cell proliferation of gastric cancer, and pegvisomant may be an important potential drug to inhibit the proliferation of gastric cancer cells	3
Metastatic TNBC is closely associated with a fused mitochondrial morphology and a glycolytic and lipogenic metabolism	3