OOIR: Observatory of International Research

Papers

(The median citation count of Biochemistry and Cell Biology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Antiviral effects of bovine lactoferrin on human norovirus	32
The N-glycans of lactoferrin: more than just a sweet decoration	30
Biological activities of commercial bovine lactoferrin sources	25
Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host’s innate immunity	23
Lactoferrin and oral pathologies: a therapeutic treatment	23
Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro	21
Formononetin protects against concanavalin-A-induced autoimmune hepatitis in mice through its anti-apoptotic and anti-inflammatory properties	19
The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1–miR-145-5p–TRPC6 pathway	19
Antibiofilm activity of lactoferrin-derived synthetic peptides against Pseudomonas aeruginosa PAO1	18
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway	18
Resveratrol upregulates miR-455-5p to antagonize cisplatin ototoxicity via modulating the PTEN–PI3K–AKT axis	18
New insights into the systemic effects of oral lactoferrin: transcriptome profiling	17
LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM	17
Amplified LncRNA PVT1 promotes lung cancer proliferation and metastasis by facilitating VEGFC expression	16
Effects of oral bovine lactoferrin on a mouse model of inflammation associated colon cancer	16
Lactoferrin receptors in Gram-negative bacteria: an evolutionary perspective	16
lncRNA CTBP1-AS2 promotes proliferation and migration of glioma by modulating miR-370-3p–Wnt7a-mediated epithelial–mesenchymal transition	15
Comparative effect of bovine buttermilk, whey, and lactoferrin on the innate immunity receptors and oxidative status of intestinal epithelial cells	15
Dose escalation study of bovine lactoferrin in preterm infants: getting the dose right	14
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1	14
Cardiovascular protective effects of GLP-1: a focus on the MAPK signaling pathway	14
A prospective on multiple biological activities of lactoferrin contributing to piglet welfare	14
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy	14
Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway	14
Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway	13

hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells	12
PCDH7 knockdown potentiates colon cancer cells to chemotherapy via inducing ferroptosis and changes in autophagy through restraining MEK1/2/ERK/c-Fos axis	12
Lactoferrin and hematoma detoxification after intracerebral hemorrhage	12
MiR-138-5p knockdown promotes osteogenic differentiation through FOXC1 up-regulation in human bone mesenchymal stem cells	11
CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis	11
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4	11
Nisin induces apoptosis in cervical cancer cells via reactive oxygen species generation and mitochondrial membrane potential changes	11
Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway	11
PDGFRβ modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K/AKT/mTOR/c-Myc pathway	11
Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced apoptosis and inflammation in human umbilical vein endothelial cells by suppressing the NF-κB signaling pathway	11
MiR-494-3p alleviates acute lung injury through regulating NLRP3 activation by targeting CMPK2	11
ELFIN, the United Kingdom preterm lactoferrin trial: interpretation and future questions	11
Knockdown of E-cadherin induces cancer stem-cell-like phenotype and drug resistance in cervical cancer cells	10
TGF-β1-containing exosomes from cardiac microvascular endothelial cells mediate cardiac fibroblast activation under high glucose conditions	10
Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells	10
Artesunate inhibits proliferation, migration, and invasion of thyroid cancer cells by regulating the PI3K/AKT/FKHR pathway	10
Bovine lactoferrin and lactoferrin peptides affect endometrial and cervical cancer cell lines	10
Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K–AKT–Nrf2 signaling pathway	9
DUSP4 inhibits autophagic cell death in PTC by inhibiting JNK–BCL2–Beclin1 signaling	9
VEGF-mediated angiogenesis in retinopathy of prematurity is co-regulated by miR-17-5p and miR-20a-5p	9
Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction	8
Reflections on antifreeze proteins and their evolution	8
Upregulation of bromodomain PHD finger transcription factor in ovarian cancer and its critical role for cancer cell proliferation and survival	8
SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation	8
Adipocyte factor CTRP6 inhibits homocysteine-induced proliferation, migration, and dedifferentiation of vascular smooth muscle cells through PPARγ/NLRP3	8
Paeonol reduces IL-β production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-κB in macrophages	8
S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine	7
Silencing LINC00511 inhibits cell proliferation, migration, and epithelial–mesenchymal transition via the PTEN–AKT–FOXO1 signaling pathway in lung cancer	7
Pristimerin alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease via inhibiting NF-κB pathway	7
Binding of lactoferrin to the surface of low-density lipoproteins modified by myeloperoxidase prevents intracellular cholesterol accumulation by human blood monocytes	7
Silencing linc00662 inhibits cell proliferation and colony formation of lung cancer cells via regulating the miR-145-5p–PAFAH1B2 axis	7
Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1	7
HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury	7
Thidiazuron suppresses breast cancer via targeting miR-132 and dysregulation of the PI3K–Akt signaling pathway mediated by the miR-202-5p–PTEN axis	7
LFchimera: a synthetic mimic of the two antimicrobial domains of bovine lactoferrin	7
SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects	7
Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin	7
Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau	7
Metformin exerts anti-tumor effects via Sonic hedgehog signaling pathway by targeting AMPK in HepG2 cells	6
Attention-based deep learning framework to recognize diabetes disease from cellular retinal images	6
Overexpression of protein disulfide isomerase enhances vitamin K epoxide reductase activity	6
Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitro	6
AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer	6
Dlx5promotes cancer progression through regulation ofCCND1in oral squamous cell carcinoma (OSCC)	6
Evidence from systematic reviews of randomized trials on enteral lactoferrin supplementation in preterm neonates	6
FOXD3 inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma through regulation of the PI3K–Akt pathway	6
NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis	6
Lactoferrin reduces mycobacterial M1-type inflammation induced with trehalose 6,6′-dimycolate and facilitates the entry of fluoroquinolone into granulomas	6
Angptl2 gene knockdown is critical for abolishing angiotensin II-induced vascular smooth muscle cell proliferation and migration	6
Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKCδ–NLRC4 axis	6

BRD4 promotes the migration and invasion of bladder cancer cells through the Sonic hedgehog signaling pathway and enhances cisplatin resistance	6
Modulating the immune system as a therapeutic target for myelodysplastic syndromes and acute myeloid leukemia	5
The endless battle between phages and CRISPR–Cas systems in Streptococcus thermophilus	5
Mitochondrial DNA methyltransferases and their regulation under freezing and dehydration stresses in the freeze-tolerant wood frog, Rana sylvatica	5
Analysis of financial challenges faced by graduate students in Canada	5
Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial–mesenchymal transition in breast cancer cells via the miR-136–Smad3 axis	5
Telomere biology and ribosome biogenesis: structural and functional interconnections	5
Hyperglycemia enhances the generation of ROS and RNS that impair antioxidant power and cause oxidative damage in human erythrocytes	5
Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states	5
Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials	5
Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells	5
A-kinase anchoring protein 5 anchors protein kinase A to mediate PLN/SERCA to reduce cardiomyocyte apoptosis induced by hypoxia and reoxygenation	5
EDTA as a chelating agent in quantitative¹H-NMR of biologically important ions	5
Attenuation of Hg(II)-induced cellular and DNA damage in human blood cells by uric acid	5
Evaluation of drug-free methods for the detection of gene silencing in Saccharomyces cerevisiae	5
Cadmium chloride generates cytotoxic reactive species that cause oxidative damage and morphological changes in human erythrocytes	5
Dexmedetomidine upregulates the expression of miR-493-5p, inhibiting growth and inducing the apoptosis of lung adenocarcinoma cells by targeting RASL11B	4
The biological relevance of PCSK9: when less is better…	4
The G protein-coupled receptor GPRC5A—a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity	4
Emerging regulatory challenges of next-generation synthetic biology	4
GCN5 enables HSP12 induction promoting chromatin remodeling, not histone acetylation	4
NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis	4
GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating theEZH2-PAX6-CXCL10pathway	4
Structural features, intrinsic disorder, and modularity of a pyriform spidroin 1 core repetitive domain	4
Dystonin loss-of-function leads to impaired autophagosome–endolysosome pathway dynamics	4
Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients — correlation with IVF parameters	4
Purification and characterization of inorganic pyrophosphatase for in vitro RNA transcription	4
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation	4
Long noncoding RNA RP11-909N17.2 promotes proliferation, invasion, and migration of hepatocellular carcinoma by regulating microRNA-767-3p	4
Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs)	4
LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease	4
Metastatic TNBC is closely associated with a fused mitochondrial morphology and a glycolytic and lipogenic metabolism	4
The role of BCL2L13 in glioblastoma: turning a need into a target	4
Ultrasound-stimulated microbubbles contributes to radiotherapy in esophageal carcinoma	4
Astrocyte-specific Ca²⁺ activity: Mechanisms of action, experimental tools, and roles in ethanol-induced dysfunction	4
Long non-coding RNA AWPPH enhances malignant phenotypes in nasopharyngeal carcinoma via silencing PTEN through interacting with LSD1 and EZH2	4
RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1	4
PUM1 modulates trophoblast cell proliferation and migration through LRP6	4
Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes	4
Protein arginine methyltransferase 1, a major regulator of biological processes	4
The nuclear receptor subfamily 4 group A1 in human disease	4
Preventive cancer vaccination with P5 HER-2/neo-derived peptide‐pulsed peripheral blood mononuclear cells in a mouse model of breast cancer	4
The let-7f-5p–Nme4 pathway mediates tumor necrosis factor α-induced impairment in osteogenesis of bone marrow-derived mesenchymal stem cells	3
Evaluation of HZX-960, a novel DCN1–UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis	3
ChestCovidNet: An Effective DL-based Approach for COVID-19, Lung Opacity, and Pneumonia Detection Using Chest Radiographs Images	3
The regulation of m⁶A-related proteins during whole-body freezing of the freeze-tolerant wood frog	3
Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice	3
RNA deadenylation complexes in development and diseases	3
Synergistic effects of autophagy inhibitors combined with cisplatin against cisplatin-resistant nasopharyngeal cancer cells	3
Nootkatone attenuates airway inflammation in asthmatic mice through repressing ROS-induced NLRP3 inflammasome activation	3
2-Undecanone alleviates asthma by inhibiting NF-κB pathway	3
HER2 induces cell scattering and invasion through ∆Np63α and E-cadherin	3
LINC00641 contributes to nasopharyngeal carcinoma cell malignancy through FOXD1 upregulation at the post-transcriptional level	3
Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer	3
HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway	3
Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development	3
LncRNAs: the good, the bad, and the unknown	3
Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway	3
Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells	3
Prognostic value and oncogenic effect of increased RBM8A expression in colon adenocarcinoma	3
Effects of the omega-3 fatty acid DHA on histone and p53 acetylation in diffuse large B cell lymphoma	3
The nuclear-localized GHR is involved in the cell proliferation of gastric cancer, and pegvisomant may be an important potential drug to inhibit the proliferation of gastric cancer cells	3