OOIR: Observatory of International Research

Papers

(The TQCC of Fundamental & Clinical Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities	40
Antiviral therapies: advances and perspectives	38
Chemsex practice in France: An update in Addictovigilance data	34
In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease	32
Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities	30
Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications	30
Poster Abstracts	29
A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS‐CoV‐2	28
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice	28
Poster Abstracts	27
Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?	27
Is lithium neuroprotective? An updated mechanistic illustrated review	22
The clinical meaning of levodopa equivalent daily dose in Parkinson's disease	21
Psychoactive substance use among students: A cross‐sectional analysis	20
The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences	20
Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma	18
Anti‐inflammatory effect of amitriptyline in a rat model of acetic acid‐induced colitis: the involvement of the TLR4/NF‐kB signaling pathway	17
Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions	17
Poster Abstracts	17
Exploring the beneficial role of ROCK inhibitors in sepsis‐induced cerebral and cognitive injury in rats	16
Rapamycin attenuates depression and anxiety‐like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole‐kindled male Wistar rats	15
Development of pyrazole derivatives in the management of inflammation	15
Melatonin has an inhibitory effect on MCF‐7 and MDA‐MB‐231 human breast cancer cell lines by inducing autophagy and apoptosis	14
Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats	13
Gemfibrozil, a lipid‐lowering drug, reduces anxiety, enhances memory, and improves brain oxidative stress in d‐galactose‐induced aging mice	13

Improvement of cognitive function, glucose and lipid homeostasis and serum osteocalcin levels by liraglutide in diabetic rats	13
Drug adulteration of sexual enhancement supplements: a worldwide insidious public health threat	11
Dexamethasone and p38 MAPK inhibition of cytokine production from human lung fibroblasts	11
Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol‐induced myocardial injury	11
Advances on pharmacology and toxicology of aconitine	11
COVID‐19 in DMARD‐treated patients with inflammatory rheumatic diseases: Insights from an analysis of the World Health Organization pharmacovigilance database	11
The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease	11
Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis	11
Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors	10
An overview of ongoing clinical trials assessing pharmacological therapeutic strategies to manage chemotherapy‐induced peripheral neuropathy, based on preclinical studies in rodent models	10
Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II‐induced hypertension	10
Tyrosine kinase inhibitors and direct oral anticoagulants: In vitro evaluation of drug–drug interaction mediated by P‐glycoprotein	10
N‐(benzylidene)‐2‐((2‐hydroxynaphthalen‐1‐yl)diazenyl)benzohydrazides (1‐2) (NCHDH and NTHDH) attenuate DMBA‐induced breast cancer via Nrf2/NF‐κB/apoptosis signaling	10
Safety concerns on the abuse potential of esketamine: Multidimensional analysis of a new anti‐depressive drug on the market	10
Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review	10
Doctor shopping for methylphenidate as a proxy for misuse and potential abuse in the 67 million inhabitants in France	9
Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori‐related diseases	9
Study of prescription‐indication of tetracyclines in a population in Colombia	9
The HIV reverse transcriptase Inhibitor Tenofovir suppressed DMH/HFD‐induced colorectal cancer in Wistar rats	9
K_ATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury	8
Homoarginine in the cardiovascular system: Pathophysiology and recent developments	8
Vortioxetine as an analgesic in preclinical inflammatory pain models: Mechanism of action	8
Spermidine reduced neuropathic pain in chronic constriction injury‐induced peripheral neuropathy in rats	8
Effect of sacubitril/valsartan on cognitive impairment in colchicine‐induced Alzheimer's model in rats	8
Medication non‐adherence after allogeneic hematopoietic cell transplantation in adult and pediatric recipients: a cross sectional study conducted by the Francophone Society of Bone Marrow Transplantat	8
Targeting cannabinoid receptor 2 (CB2) limits collagen production—An in vitro study in a primary culture of human fibroblasts	8
Na⁺, K⁺‐ATPase participates in the protective mechanism of rat cerebral ischemia‐reperfusion through the interaction with glutamate transporter‐1	8
Pro‐inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis	7
Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments	7
Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging	7
Function of intestinal barrier protected by regulating the miR‐199a‐3p in ulcerative colitis: Modulation of IL‐23/IL‐17A axis	7
Vasorelaxant effect of trans‐4‐chloro‐β‐nitrostyrene, a synthetic nitroderivative, in rat thoracic aorta	7
Inhibition MNK‐eIF4E‐β‐catenin preferentially sensitizes gastric cancer to chemotherapy	7
NVX‐Cov2373 Novavax Covid‐19 vaccine: A further analysis of its efficacy using multiple modes of expression	7
Anisomycin sensitizes non‐small‐cell lung cancer cells to chemotherapeutic agents and epidermal growth factor receptor inhibitor via suppressing PI3K/Akt/mTOR	7
Safety profile of hydroxychloroquine used off‐label for the treatment of patients with COVID‐19: A descriptive study based on EudraVigilance data	7
Adverse effects of gender‐affirming hormonal therapy in transgender persons: Assessing reports in the French pharmacovigilance database	7
Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice	7
Short‐chain fatty acids increase intracellular calcium levels and enhance gut hormone release from STC‐1 cells via transient receptor potential Ankyrin1	7
Efficacy of COVID‐19 vaccines: Several modes of expression should be presented in scientific publications	7
Viral target and metabolism‐based rationale for combined use of recently authorized small molecule COVID‐19 medicines: Molnupiravir, nirmatrelvir, and remdesivir	7
Ferulic acid improves glucose homeostasis by modulation of key diabetogenic activities and restoration of pancreatic architecture in diabetic rats	7
Effect of dapagliflozin and/or L‐arginine on solid tumor model in mice: The interaction between nitric oxide, transforming growth factor‐beta 1, autophagy, and apoptosis	7
Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway	7
Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus	7
Effects of physical activity on cell‐to‐cell communication during type 2 diabetes: A focus on miRNA signaling	7
Evaluating and modulating TFEB in the control of autophagy: toward new treatments in CNS disorders	7
Orexin receptors: Targets and applications	7
UPLC‐MS analysis and network pharmacology‐based investigation into the active ingredients and molecular mechanisms of anti‐fatigue of male flowers with Eucommia ulmoides Oliv.	6
Therapeutic potentials of melatonin in the treatment of lymphoma: A review of current evidence	6

Inhibitory effects and molecular mechanisms of ginsenoside Rg1 on the senescence of hematopoietic stem cells	6
Can chronopharmacology improve the therapeutic management of neurological diseases?	6
Inhibition of eukaryotic initiation factor 4E by tomivosertib suppresses angiogenesis, growth, and survival of glioblastoma and enhances chemotherapy's efficacy	6
The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats	6
Phosphatidylinositol 3‐kinase signaling pathway and inflammatory bowel disease: Current status and future prospects	6
Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia‐induced experimental vascular cognitive impairment and dementia	6
Cluster headache: state of the art of pharmacological treatments and therapeutic perspectives	6
Antinociceptive, anxiolytic, and depression‐like effects of hydrogen sulfide, nitric oxide, and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity	6
Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma	6
An insight into the pharmacological and analytical potential of Andrographolide	6
Simvastatin–Ezetimibe enhances growth factor expression and attenuates neuron loss in the hippocampus in a model of intracerebral hemorrhage	6
Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways	6
A comprehensive view on the quercetin impact on bladder cancer: Focusing on oxidative stress, cellular, and molecular mechanisms	6
Increased risk of urinary tract infection and pyelonephritis under concomitant use of sodium‐dependent glucose cotransporter 2 inhibitors with antidiabetic, antidyslipidemic, and antihypertensive drug	6
Animal models for the evaluation of antipsychotic agents	5
Effects of 27 CYP3A4 protein variants on saxagliptin metabolism in vitro	5
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini‐review on availability and limitations	5
Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets	5
Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein	5
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model	5
Molecular toxicological alterations in the mouse hearts induced by sub‐chronic thiazolidinedione drugs administration	5
Chemsex in HIV pre‐exposure prophylaxis users: Assessment of mood disorders and addictive behavior	5
Beta‐glucan suppresses high‐fat‐diet‐induced obesity by attenuating dyslipidemia and modulating obesogenic marker expressions in rats	5
The cyclin‐dependent kinase inhibitor AT7519 augments cisplatin's efficacy in ovarian cancer via multiple oncogenic signaling pathways	5
Ten‐year trends in hospitalizations related to cocaine abuse in France	5
Neuroprotective effect of sumatriptan in pentylenetetrazole‐induced seizure is mediated through N‐methyl‐D‐aspartate/nitric oxide and cAMP response element‐binding protein signaling pathway	5
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review	5
Variability of rituximab and tocilizumab trough concentrations in patients with rheumatoid arthritis	5
Lacosamide‐induced personality changes: An unexpected adverse effect	5
Absence of ethnic difference on single‐dose pharmacokinetics of rivoceranib between healthy male Caucasian, Japanese, and Chinese subjects	5
Advances in the phytochemical screening and biological potential of propolis	5
Vitamin D modulates hepatic microRNAs and mitigates tamoxifen‐induced steatohepatitis in female rats	5
Optimization of application schedule of camphecene, a novel anti‐influenza compound, based on its pharmacokinetic characteristics	5
Impact of anesthetics on oncogenic signaling network: a review on propofol and isoflurane	5
Tramadol‐induced hypoglycemia: A pharmacovigilance study	5
Sakuranetin exerts anticonvulsant effect in bicuculline‐induced seizures	5
Pentosan polysulfate exerts anti‐inflammatory effect and halts albuminuria progression in diabetic nephropathy: Role of combined losartan	5
Dihydroartemisinin inhibits angiogenesis in breast cancer via regulating VEGF and MMP‐2/‐9	5
Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model	4
Roflumilast improves resolution of sepsis‐induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments	4
The effect of microglial inhibition on the expression of BDNF, KCC2, and GABAA receptor before and after the establishment of CCI‐induced neuropathic pain model	4
MNK/eIF4E inhibition overcomes anlotinib resistance in non‐small cell lung cancer	4
Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology	4
What changes in prescription patterns of antiemetic medications in pregnant women in France?	4
Effect of food on the single‐dose pharmacokinetics and tolerability of savolitinib in Chinese healthy volunteers	4
Metformin potentiates the chemotherapeutic effects of doxorubicin on 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5b] pyridine‐induced Mammary Carcinoma in rats	4
Inflammatory molecules facilitate the development of docetaxel‐resistant prostate cancer cells in vitro and in vivo	4
Investigating the link between drug consumption and adverse events reporting in France	4
Role of angiotensin receptor blockers in the context of Alzheimer's disease	4
Enhancement of nerve regeneration with nimodipine treatment after sciatic nerve injury	4
Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?	4
Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs	4
Patch testing versus interferon‐gamma release assay in evaluation of drug eruptions	4
Therapeutic effects and the impact of statins in the prevention of ulcerative colitis in preclinical models: A systematic review	4
Everolimus: A potential therapeutic agent targeting PI3K/Akt pathway in brain insulin system dysfunction and associated neurobehavioral deficits	4
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains	4
Transforming growth factor‐β1 inhibits interleukin‐1β‐induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells	4
Chronic polypharmacy at all age: A population‐based drug utilization study	4
Is the human model RPTEC/TERT1 a relevant model for assessing renal drug efflux?	4
Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization	4
Antioxidant activities of artesunate–procyanidin hybrid compound in erythrocyte and liver of Plasmodium berghei NK65‐infected mice	4
Risk factors for and characteristics of community‐ and hospital‐acquired drug‐induced acute kidney injuries	4
A mini‐review on anticancer‐related properties of azithromycin and its potential activities in overcoming the challenges of glioblastoma	4
Trends in the use of antihistamines with reference to drivers between 2015 and 2019: A population‐based registry analysis	4
Inhibitory effects of fluoxetine and duloxetine on the pharmacokinetics of metoprolol in vivo and in vitro	4
Antidepressants abuse in subjects with opioid use disorders: A 10‐year study in the French OPPIDUM program	4