Fundamental & Clinical Pharmacology

Article	Citations
Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?	51
Location matters: Overlooked ethnic‐geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in	50
Changes in digoxin pharmacokinetics associated with hepatic P‐glycoprotein upregulation in rats with non‐alcoholic fatty liver disease	49
In vitro evidence that the vasorelaxant effects of 2‐nitro‐1‐phenyl‐1‐propanol on rat coronary arteries involve cyclic nucleotide pathways	48
Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin	37
Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors	29
Can cannabidiol have an analgesic effect?	28
Effect of ceftriaxone on intestinal transit time	27
Improvement of cognitive dysfunction by a novel phosphodiesterase type 5 inhibitor, Tadalafil	27
Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats	20
Efficacy of COVID‐19 vaccines: Several modes of expression should be presented in scientific publications	19
Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.	17
Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage	17
Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines	17
Roflumilast improves resolution of sepsis‐induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments	17
Novel ginsenoside monomer RT4 promotes colitis repair in mice by regulating miR‐144‐3p/SLC7A11 signaling pathway	16
MiR‐199a‐3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury	16
Relative bioavailability and pharmacokinetic comparison of a fixed‐dose combination tablet of mosapride, pancreatin, and simethicone relative to single‐component mosapride tablets in healthy Mexican s	15
Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy	14
Treatment implications of augmented renal clearance in a critically ill COVID‐19 patient: A case report	14
Cell therapy procedure using anti‐inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta‐a	14
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Precipitation of sugammadex with nicardipine and labetalol: A laboratory research	14
Metformin improves neurobehavioral impairments of streptozotocin‐treated and western diet‐fed mice: Beyond glucose‐lowering effects	12
Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model	12

Issue Information	12
In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease	12
Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging	11
Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non‐small cell lung cancer	11
The protective effect of α7‐nACh receptor and its interaction with 5‐HT1B/1D receptors in acute intestinal ischemia‐reperfusion injury in rats	11
Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights	11
Population pharmacokinetics of mycophenolate in patients treated for interstitial lung disease (EVER‐ILD study)	10
Spontaneous reporting of adverse drug reactions as an outlet for patient dismay? The case of Levothyrox® change of excipients	10
Master 2 Award	10
Cover Image, Volume 36, Issue 1	10
Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia‐reperfusion necrosis in rats	10
Vestibular disorders following BNT162b2 mRNA COVID‐19 vaccination: A retrospective case series	10
Sakuranetin exerts anticonvulsant effect in bicuculline‐induced seizures	10
Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway	9
Chlorogenic acid co‐administration alleviates cisplatin‐induced peripheral neuropathy in rats	9
UPLC‐MS analysis and network pharmacology‐based investigation into the active ingredients and molecular mechanisms of anti‐fatigue of male flowers with Eucommia ulmoides Oliv.	9
Kappa‐opioid receptor‐mediated thermal analgesia evoked by the intrathecal administration of the chemokine CCL1 in mice	9
Issue Information	9
Acetazolamide suppresses the progression of hepatocellular carcinoma induced by diethylnitrosamine in Wistar albino rats	9
Issue Information	9
Issue Information	8
Histamine H1‐ and H2‐receptors participate to provide metabolic energy differently	8
Discussed Poster Abstracts	8
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Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities	8
Issue Information	7
A novel naphthylchalcone ([E]‐4‐(3‐[naphthalen‐2‐yl]‐3‐oxoprop‐1‐en‐1‐yl) induces intrinsic and extrinsic apoptosis in human acute leukemia cell lines	7
The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats	7
Chemsex practice in France: An update in Addictovigilance data	7
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats	7
Animal models for the evaluation of antipsychotic agents	7
Advances in the phytochemical screening and biological potential of propolis	7
A comprehensive view on the quercetin impact on bladder cancer: Focusing on oxidative stress, cellular, and molecular mechanisms	7
Inhibition of plasminogen suppresses fibrosis and macrophage foaming in a nonalcoholic steatohepatitis mouse model	7
Use of real‐world evidence in translational pharmacology research	7
Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria	7
Inhibition of kidney potassium channels by fluoxetine: In vivo and in vitro studies	7
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Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis	7
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Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers	7
Capivasertib augments chemotherapy via Akt inhibition in preclinical small cell lung cancer models	7
Necrostatin‐1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice	7
Vitamin D3 potentiates the nephroprotective effects of vildagliptin–metformin combination in a rat model of metabolic syndrome	7
Bupivacaine inhibits the TLR4‐ and TLR2‐Myd88/NF‐κB pathways in human leukocytes	7
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Anti‐oxidative and anti‐neuroinflammatory role of Necrostatin‐1s and docosahexaenoic acid in RIP‐1‐mediated neurotoxicity in MPTP‐induced Parkinson's disease model	7
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Effect of a high‐fat meal on the relative bioavailability of HMPL‐689 in Chinese healthy volunteers	6
Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency	6

Discussed Poster Abstracts – PM2	6
COVID‐19 in DMARD‐treated patients with inflammatory rheumatic diseases: Insights from an analysis of the World Health Organization pharmacovigilance database	6
Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori‐related diseases	6
Antihypertensive and lipid‐lowering drugs usage after primary stroke in a large representative sample of the French population	6
Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting	6
Chronic polypharmacy at all age: A population‐based drug utilization study	5
Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers	5
Discussed Poster Abstracts – PM1	5
Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)‐1‐(4‐aminophenyl)‐3‐(4‐fluorophenyl)prop‐2‐en‐1‐one	5
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Recognition of potential therapeutic role of 2‐hydroxy‐3‐methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis	5
Involvement of different K+ channel subtypes in hydrogen sulfide‐induced vasorelaxation of human internal mammary artery	5
Prevalence of medication administration errors in hospitalized adults: A systematic review and meta‐analysis up to 2017 to explore sources of heterogeneity	5
Update on monkeypox virus infection: Focusing current treatment and prevention approaches	5
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model	5
Immunomodulator FTY720 improves glucose homeostasis and diabetic complications by rejuvenation of β‐cell function in nonhuman primate model of diabetes	5
Drug news and therapeutic news	5
LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice	5
The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized clinical trial	5
A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case	5
Lacosamide use during breastfeeding: A case report and a literature review	5
Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats	5
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Oral Communication Abstracts	5
Issue Information	5
Drug‐induced radiation recall reactions and non‐anticancer drugs: A descriptive analysis from VigiBase®	5
Probing polypharmacy, ageing and sex effects on physical function using different tests	5
Atorvastatin ameliorates α‐KGDH and GDH functions in rats with diet‐induced hypercholesterolemia	5
Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats	5
Master 2 award	5
Inflammatory molecules facilitate the development of docetaxel‐resistant prostate cancer cells in vitro and in vivo	4
ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus	4
Interaction of buspirone and its major metabolites with human organic cation transporters	4
Combination of human papillomaviruses L1 and L2 multiepitope constructs protects mice against tumor cells	4
Knockdown of RFC3 enhances the sensitivity of colon cancer cells to oxaliplatin by inducing ferroptosis	4
In vitro evidence that the anti‐inflammatory effect of synthetic cinnamate‐derived dienes is directly linked to a macrophage repolarization	4
Second primary cancers and hormonal therapies for prostate cancer: A nested case–control study	4
Afatinib triggers a Ni2+‐resistant Ca2+ influx pathway in A549 non‐small cell lung cancer cells	4
Development of a Bayesian estimation tool to determine the optimal duration of apixaban discontinuation before a high‐bleeding risk procedure	4
Vortioxetine improved schizophrenia‐like behavioral deficits in a Poly I:C‐induced maternal immune activation model of schizophrenia in rats	4
Population pharmacokinetics of sivelestat in Chinese patients with severe pneumonia	4
Trends in adverse drug reactions related to oral weak opioid analgesics in therapeutic use in adults: A 10‐year French vigilances retrospective study	4
Issue Information	4
Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma	4
Mechanism research on microRNA‐669f‐5p/deoxycytidylate deaminase axis mediating sevoflurane‐induced cognitive dysfunction in aged mice	4
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains	4
Thesis awards	4
JAK/STAT inhibitors mitigate sepsis‐associated cerebral and cognitive injury	4
Angiotensin receptor–neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury	4
Is lithium neuroprotective? An updated mechanistic illustrated review	4
Buprenorphine exposures in adolescents and adults: A 10‐year experience of a French Poison Control Center	4
Issue Information	4
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice	4
Issue Information	4
Antimanic‐like effect of dipyridamole in the methylphenidate‐induced hyperlocomotion	4
A mini‐review on anticancer‐related properties of azithromycin and its potential activities in overcoming the challenges of glioblastoma	4
Analgesic switching in chronic users of dextropropoxyphene in France	4
Issue Information	3
Pro‐inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis	3
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Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus	3
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Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia	3
Photobiological effect of eugenol‐derived 3‐benzoylcoumarin associated with led lights against MDR microorganisms	3
The role of β‐adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β‐adrenergic receptor agonists and antagonists protect the heart?	3
Issue Information	3
Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function	3
Latest advances in the reversal strategies for direct oral anticoagulants	3
Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug‐induced liver injury	3
Bezafibrate mitigates oxidized‐low density lipoprotein (ox‐LDL)‐induced the attachment of monocytes to endothelial cells: An implication in atherosclerosis	3
Effects of the nerve growth factor and its carrier protein on the inflammatory response from human monocytes	3
Pre‐treatment or post‐treatment with hydroxychloroquine demonstrates neuroprotective effects in cerebral ischemia/reperfusion	3
Thesis Awards	3
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Role of biomarkers and molecular signaling pathways in acute lung injury	3
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Pentosan polysulfate exerts anti‐inflammatory effect and halts albuminuria progression in diabetic nephropathy: Role of combined losartan	3
Fundamental and Clinical Pharmacology of drug repositioning	3
Intradermal testing of iodinated contrast media: Should we test up to pure or with diluted compounds only?	3
Issue Information	3

Study of prescription‐indication of tetracyclines in a population in Colombia	3
Patch testing versus interferon‐gamma release assay in evaluation of drug eruptions	3
Pharmacological treatment for mental health illnesses in adults receiving dialysis: A scoping review	3
Investigating the link between drug consumption and adverse events reporting in France	3
Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways	3
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Advances on pharmacology and toxicology of aconitine	3
Sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) plus glucagon‐like peptide type 1 receptor combination is more effective than SGLT2i plus dipeptidyl peptidase‐4 inhibitor combination in treating obe	3
FKA‐A NPs enhances PTX‐A NPs efficacy to suppress ovarian cancer via regulating Skp2/YAP pathway	3
Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis	3
(−)‐Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high‐fat diet	3
KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury	3
Antinociceptive, anxiolytic, and depression‐like effects of hydrogen sulfide, nitric oxide, and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity	3
Author index	2
Themed series on neuropharmacology	2
Issue Information	2
The protective effect of pregabalin and xanthenone on testicular ischemia/reperfusion injury in rats	2
Repurposing bosentan as an anticancer agent: EGFR/ERK/c‐Jun modulation inhibits NSCLC tumor growth	2
Issue Information	2
Gout and Levodopa: An unknown adverse effect?	2
Breastfeeding and contrast agents—A critical review and presentation of new aspects	2
Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization	2
Isobolographic analysis of the ciprofloxacin–gentamicin combination against beta‐lactamase‐producing Staphylococcus aureus	2
The state of astragaloside IV research: A bibliometric and visualized analysis	2
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Sodium hypochlorite accident diagnosis and management: Analysis from the literature and the French pharmacovigilance database	2
Efficacy and safety of topiramate for reducing impulsivity: A transdiagnostic systematic review and meta‐analysis of a common clinical use	2
Telmisartan: An angiotensin receptor blocker regulates osteoclastogenesis via inhibition of the ERK triggering in osteoporotic male rats	2
Heterogeneity in protocols and outcomes to study the effect of renin‐angiotensin system blockers in inflammatory bowel disease: A systematic review	2
Theme and main topic index	2
MNK/eIF4E inhibition overcomes anlotinib resistance in non‐small cell lung cancer	2
Opening of mitochondrial permeability transition pore in cardiomyocytes: Is ferutinin a suitable tool for its assessment?	2
Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction	2
Towards therapeutic drug monitoring of mycophenolic acid in mucous membrane pemphigoid: A retrospective single‐centre study	2
Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review	2
Issue Information	2
Induction of Ca2+ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca2+ chelati	2
Effects of 27 CYP3A4 protein variants on saxagliptin metabolism in vitro	2
Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology	2
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini‐review on availability and limitations	2
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats	2
Exploring the therapeutic potential of Modafinil in mitigating renal ischemia–reperfusion injury in rats	2
Myrtenal exhibits cardioprotective effects by attenuating the pathological progression associated with myocardial infarction	2
Orexin receptors: Targets and applications	2
Alterations in the gene expression of SARS‐COV‐2 entry receptors and enzymes in lungs and hearts of controlled and uncontrolled diabetic mice	2
Effects of acute ethanol and/or diazepam exposure on immediate and delayed hippocampal metabolite levels in rats anesthetized with isoflurane	2
Discussed Poster Abstracts – PM1	2
Issue Information	2
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approac	2
Chemsex in HIV pre‐exposure prophylaxis users: Assessment of mood disorders and addictive behavior	2
Author Index	2
Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs	2
Discussed Poster Abstracts	2
Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant‐induced arthritis in rats: Involvement of inflammatory mediators	1
Sitagliptin ameliorates diabetic nephropathy by upregulating renal nephrin and podocin expression through modulation of adipokines levels	1
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Evaluation of combination therapies with colistin in an experimental mouse pneumonia model induced by carbapenem‐resistant Acinetobacter baumannii strain	1
Homoarginine treatment of rats improves cardiac function and remodeling in response to pressure overload	1
Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)‐3‐(4‐(dimethylamino)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐one: An in v	1
Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus	1
Rapid high performance liquid chromatography method for erlotinib quantification in vitro: Application to study the effect of resveratrol on metabolism and cellular uptake of erlotinib	1
Antimalarial activities of benzothiazole analogs: A systematic review	1
Neuroprotective effect of sumatriptan in pentylenetetrazole‐induced seizure is mediated through N‐methyl‐D‐aspartate/nitric oxide and cAMP response element‐binding protein signaling pathway	1
Issue Information	1
Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease	1
Exogenous GalR2‐specific peptide agonist as a tool for treating myocardial ischemia/reperfusion injury	1
Role of apoptosis and autophagy in folic acid‐induced cytotoxicity of human breast cancer cells in vitro	1
Role of angiotensin receptor blockers in the context of Alzheimer's disease	1
Preliminary evaluation of the efficacy and safety of brimonidine for deep sedation	1
Optimization of application schedule of camphecene, a novel anti‐influenza compound, based on its pharmacokinetic characteristics	1
Issue Information	1
Drug–drug interactions of protein kinase inhibitors in chronic myeloid leukaemia patients: A study using the French health insurance database	1
Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview	1
Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats	1
Adverse effects of gender‐affirming hormonal therapy in transgender persons: Assessing reports in the French pharmacovigilance database	1
Metabolic reprogramming regulates microglial polarization and its role in cerebral ischemia reperfusion	1
RETRACTION: Mineralocorticoid receptor antagonist‐mediated cognitive improvement in a mouse model of Alzheimer's type: possible involvement of BDNF‐H2S‐Nrf2 signaling	1
Long‐term evaluation of rheumatoid arthritis activity with erythrocyte methotrexate‐polyglutamate 3	1
Effect of food intake on the pharmacokinetics of rivoceranib in healthy subjects	1
Activation of spinal ephrin‐B3/EphBs signaling induces hyperalgesia through a PLP‐mediated mechanism	1
The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent	1
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Fundamental and clinical neuropharmacology, a terra incognita with constantly expanding frontiers	1
Repurposing synthetic and natural derivatives induces apoptosis in an orthotopic glioma‐induced xenograft model by modulating WNT/β‐catenin signaling	1
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model	1
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Sodium thiosulfate mitigates PM2.5‐induced cardiotoxicity by preservation of mitochondrial function	1
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review	1
The comparison of the antidiabetic effects of exenatide, empagliflozin, quercetin, and combination of the drugs in type 2 diabetic rats	1
Inhibitory effects and molecular mechanisms of ginsenoside Rg1 on the senescence of hematopoietic stem cells	1
Discussed Poster Abstracts	1
Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis	1
Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics	1
Wnt/beta‐catenin modulation: A promising frontier in chronic kidney disease management	1
Molecular toxicological alterations in the mouse hearts induced by sub‐chronic thiazolidinedione drugs administration	1