Biomedicine & Pharmacotherapy

Papers
(The TQCC of Biomedicine & Pharmacotherapy is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
The emerging role of ferroptosis in inflammation335
Cancer immunotherapy: Pros, cons and beyond315
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management284
The role of IL-1β and TNF-α in intervertebral disc degeneration267
Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases251
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols250
Type II diabetes mellitus: a review on recent drug based therapeutics234
Adipose tissue and insulin resistance in obese229
EMT, cancer stem cells and autophagy; The three main axes of metastasis219
Isorhamnetin: A review of pharmacological effects210
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system209
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition194
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management185
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19172
H19 lncRNA: Roles in tumorigenesis171
WNT/β-catenin signaling in the development of liver cancers168
Lipase Inhibitors for Obesity: A Review167
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease161
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators159
Antiviral activities of flavonoids153
Myricetin: A review of the most recent research151
Role of lncRNA LUCAT1 in cancer150
Anticancer activities of TCM and their active components against tumor metastasis148
Antiproliferative and palliative activity of flavonoids in colorectal cancer148
Natural carbon-based quantum dots and their applications in drug delivery: A review147
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation145
The role of curcumin in aging and senescence: Molecular mechanisms143
Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model137
Resveratrol (RV): A pharmacological review and call for further research136
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms131
Oxindole and its derivatives: A review on recent progress in biological activities129
Role of microbiota-derived short-chain fatty acids in cancer development and prevention127
Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice126
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role126
Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake123
Role of the NLRP3 inflammasome in autoimmune diseases120
Immune boosting functional foods and their mechanisms: A critical evaluation of probiotics and prebiotics118
Monoclonal antibody as a potential anti-COVID-19117
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review116
The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway113
A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications112
Immune defence to invasive fungal infections: A comprehensive review111
MicroRNA: A signature for cancer progression110
Mechanistic insights and perspectives involved in neuroprotective action of quercetin110
Natural history of COVID-19 and current knowledge on treatment therapeutic options109
Lipocalin-2: Structure, function, distribution and role in metabolic disorders109
Probiotics for cancer alternative prevention and treatment104
Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways102
Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing101
Innate and adaptive immune responses against coronavirus101
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities100
Flavonoids against the SARS-CoV-2 induced inflammatory storm100
Role of microbiota-derived short-chain fatty acids in nervous system disorders100
NF-κB inhibitors in treatment and prevention of lung cancer94
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-293
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence93
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation91
A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects90
Potential inhibitory effect of lycopene on prostate cancer90
Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming90
Pleotropic Effects of Polyphenols in Cardiovascular System89
Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect89
Gestational diabetes mellitus - A metabolic and reproductive disorder88
Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway88
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease88
CAR-macrophage: A new immunotherapy candidate against solid tumors88
Novel advances in inhibiting advanced glycation end product formation using natural compounds87
Phytochemicals of garlic: Promising candidates for cancer therapy87
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress86
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents85
Progress of exosomes in the diagnosis and treatment of lung cancer85
A comprehensive review on Pueraria: Insights on its chemistry and medicinal value84
Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment84
Mechanisms of blue light-induced eye hazard and protective measures: a review84
Polymer-hybrid nanoparticles: Current advances in biomedical applications84
Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential82
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages81
Traditional Chinese medicine and lung cancer——From theory to practice81
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms81
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)79
Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway78
Pharmacological basis and new insights of taxifolin: A comprehensive review77
Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet77
Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives77
Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully77
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets77
Emerging role of NRF2 in ROS-mediated tumor chemoresistance76
Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism76
EF24 induces ferroptosis in osteosarcoma cells through HMOX176
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling76
Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics76
IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway76
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines76
Safety profile of the antiviral drug remdesivir: An update75
The links between gut microbiota and obesity and obesity related diseases75
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities75
MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets75
Recent progress in TGF-β inhibitors for cancer therapy75
The role of Interleukin 6 inhibitors in therapy of severe COVID-1975
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects75
Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system74
Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential74
Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy74
The role of miRNAs in colorectal cancer progression and chemoradiotherapy74
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size73
Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial73
Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement72
Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis72
The emerging roles of artificial intelligence in cancer drug development and precision therapy72
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family70
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway70
Silica nanoparticles: Biomedical applications and toxicity70
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role70
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs70
Principles of RNA methylation and their implications for biology and medicine69
Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin68
Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement68
Anti prostate cancer therapy: Aptamer-functionalized, curcumin and cabazitaxel co-delivered, tumor targeted lipid-polymer hybrid nanoparticles68
The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-1968
The antioxidant potential of different edible and medicinal mushrooms68
A review on development of MUC1-based cancer vaccine68
Non-coding RNAs participate in the ischemia-reperfusion injury68
Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression67
The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment67
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway66
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions66
Oxidative stress – Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders66
CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis65
Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota65
Small rodent models of atherosclerosis65
Dual role of microbiota-derived short-chain fatty acids on host and pathogen65
Diets and drugs for weight loss and health in obesity – An update64
Role of miRNA and lncRNAs in organ fibrosis and aging64
Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice63
Curcumin and cardiovascular diseases: Focus on cellular targets and cascades63
Gene therapy clinical trials, where do we go? An overview63
Exploring the multifocal role of phytochemicals as immunomodulators63
Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-263
Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling63
Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis63
The effects of metformin on autophagy62
The potential of photodynamic therapy in current breast cancer treatment methodologies62
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis62
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation62
Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential62
When science goes viral: The research response during three months of the COVID-19 outbreak62
Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review61
Natural components in sunscreens: Topical formulations with sun protection factor (SPF)61
An updated role of astragaloside IV in heart failure61
HDAC11: a rising star in epigenetics60
Emerging pharmacotherapies for COVID-1960
Nanomedicines: Redefining traditional medicine60
RNA-based pharmacotherapy for tumors: From bench to clinic and back60
Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics59
Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine59
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators59
The effect of Berberine on weight loss in order to prevent obesity: A systematic review59
Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes59
The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression59
Targeting SARS-CoV2 Spike Protein Receptor Binding Domain by Therapeutic Antibodies59
Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4+/Nanog+ NSCLC cells59
The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression59
Aptamers used for biosensors and targeted therapy59
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease59
Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment59
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges58
Nanotechnology-based drug delivery for central nervous system disorders58
Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail58
G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy58
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability57
Plant-derived bioactive compounds in colon cancer treatment: An updated review57
RETRACTED: Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model57
Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology57
Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression57
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases57
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-1957
Extraction, structure, and activity of polysaccharide from Radix astragali57
Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level57
Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety56
Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice56
Breakthrough in targeted therapy for non-small cell lung cancer56
Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease56
Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells56
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver56
A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds56
Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms55
Research progress of traditional Chinese medicine against COVID-1955
Macrophages in pancreatitis: Mechanisms and therapeutic potential55
Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model55
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?55
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways55
A cross-talk between gut microbiome, salt and hypertension55
Recent advances in fructose intake and risk of hyperuricemia54
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors54
Targets and strategies for vaccine development against SARS-CoV-254
COVID-19 challenges and its therapeutics54
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy53
Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction53
Advances in the relationship between coronavirus infection and cardiovascular diseases53
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications53
Synergic effect of PD-1 blockade and endostar on the PI3K/AKT/mTOR-mediated autophagy and angiogenesis in Lewis lung carcinoma mouse model53
The molecular mechanisms of ferroptosis and its role in cardiovascular disease53
Tetramethylpyrazine: A review on its mechanisms and functions53
Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase53
Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review53
Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer53
Therapeutic potential of CAR T cell in malignancies: A scoping review53
Animal models of cerebral ischemia: A review52
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study52
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases52
Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia52
The oncogenic role of Jagged1/Notch signaling in cancer51
MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration51
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms51
The current understanding on the impact of KRAS on colorectal cancer51
Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway51
Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook51
The pharmacological properties of chrysophanol, the recent advances51
Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment51
Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota50
Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization50
Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise50
Recent advances in management of COVID-19: A review50
SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia50
The emerging role of XBP1 in cancer50
Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats50
Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities50
Clusterin: Always protecting. Synthesis, function and potential issues49
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review49
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke49
Betulinic acid in the treatment of tumour diseases: Application and research progress49
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action49
Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease49
HCG18/miR-34a-5p/HMMR axis accelerates the progression of lung adenocarcinoma49
Non-small cell lung cancer combination therapy: Hyaluronic acid modified, epidermal growth factor receptor targeted, pH sensitive lipid-polymer hybrid nanoparticles for the delivery of erlotinib plus 49
An update review of emerging small-molecule therapeutic options for COVID-1949
Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application49
Marine-derived drugs: Recent advances in cancer therapy and immune signaling48
Evidence and perspectives of cell senescence in neurodegenerative diseases48
Regulatory role of microRNAs on PTEN signaling48
Long non-coding RNA in cervical cancer: From biology to therapeutic opportunity48
MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients48
Advances in developing therapeutic strategies for Alzheimer's disease48
Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine48
The potential use of simvastatin for cancer treatment: A review48
Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance48
The gut microbiome-bile acid axis in hepatocarcinogenesis48
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights48
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids48
The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer48
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