Biomedicine & Pharmacotherapy

Article	Citations
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management	453
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management	406
Adipose tissue and insulin resistance in obese	360
The role of IL-1β and TNF-α in intervertebral disc degeneration	335
Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases	329
Type II diabetes mellitus: a review on recent drug based therapeutics	327
EMT, cancer stem cells and autophagy; The three main axes of metastasis	284
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition	270
Antiviral activities of flavonoids	205
Resveratrol (RV): A pharmacological review and call for further research	203
Anticancer activities of TCM and their active components against tumor metastasis	201
WNT/β-catenin signaling in the development of liver cancers	201
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms	199
Role of lncRNA LUCAT1 in cancer	197
Myricetin: A review of the most recent research	189
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19	189
The role of curcumin in aging and senescence: Molecular mechanisms	187
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators	181
Antiproliferative and palliative activity of flavonoids in colorectal cancer	179
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease	178
Natural carbon-based quantum dots and their applications in drug delivery: A review	178
Role of microbiota-derived short-chain fatty acids in cancer development and prevention	174
Oxindole and its derivatives: A review on recent progress in biological activities	166
Lipocalin-2: Structure, function, distribution and role in metabolic disorders	164
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review	164

MicroRNA: A signature for cancer progression	155
Mechanistic insights and perspectives involved in neuroprotective action of quercetin	148
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation	145
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents	140
Gestational diabetes mellitus - A metabolic and reproductive disorder	136
Role of microbiota-derived short-chain fatty acids in nervous system disorders	134
Novel advances in inhibiting advanced glycation end product formation using natural compounds	125
CAR-macrophage: A new immunotherapy candidate against solid tumors	124
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities	122
Silica nanoparticles: Biomedical applications and toxicity	118
The links between gut microbiota and obesity and obesity related diseases	117
Innate and adaptive immune responses against coronavirus	117
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis	115
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects	115
Gene therapy clinical trials, where do we go? An overview	114
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease	113
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence	112
Traditional Chinese medicine and lung cancer——From theory to practice	112
Cellular Red-Ox system in health and disease: The latest update	111
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs	108
Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives	108
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities	108
A comprehensive review on Pueraria: Insights on its chemistry and medicinal value	106
Polymer-hybrid nanoparticles: Current advances in biomedical applications	106
Pharmacological basis and new insights of taxifolin: A comprehensive review	106
Progress of exosomes in the diagnosis and treatment of lung cancer	106
Flavonoids against the SARS-CoV-2 induced inflammatory storm	105
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms	105
Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential	105
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2	104
Emerging role of NRF2 in ROS-mediated tumor chemoresistance	102
Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis	101
Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression	101
Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway	97
EF24 induces ferroptosis in osteosarcoma cells through HMOX1	96
Recent progress in TGF-β inhibitors for cancer therapy	96
Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully	95
MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets	95
Plant-derived bioactive compounds in colon cancer treatment: An updated review	95
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway	95
The initiation of oxidative stress and therapeutic strategies in wound healing	94
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling	91
Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism	90
Oxidative stress – Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders	90
Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential	89
The role of miRNAs in colorectal cancer progression and chemoradiotherapy	89
Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin	88
Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential	88
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway	88
The antioxidant potential of different edible and medicinal mushrooms	88

Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement	88
Pharmacological effects and mechanisms of tannic acid	87
Role of miRNA and lncRNAs in organ fibrosis and aging	86
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets	86
Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial	85
Aptamers used for biosensors and targeted therapy	85
A review on development of MUC1-based cancer vaccine	85
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke	84
Exploring the multifocal role of phytochemicals as immunomodulators	84
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation	84
Tetramethylpyrazine: A review on its mechanisms and functions	84
Dual role of microbiota-derived short-chain fatty acids on host and pathogen	84
Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota	83
Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review	83
The effects of metformin on autophagy	83
Principles of RNA methylation and their implications for biology and medicine	83
The role of Interleukin 6 inhibitors in therapy of severe COVID-19	81
The potential of photodynamic therapy in current breast cancer treatment methodologies	80
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy	80
Nanotechnology-based drug delivery for central nervous system disorders	79
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases	79
Natural components in sunscreens: Topical formulations with sun protection factor (SPF)	79
Anti-inflammatory and immunoregulatory effects of icariin and icaritin	78
Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis	78
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines	78
Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders	77
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role	77
The molecular mechanisms of ferroptosis and its role in cardiovascular disease	77
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size	76
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications	76
The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19	76
Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2	76
Curcumin and cardiovascular diseases: Focus on cellular targets and cascades	76
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?	75
Macrophages in pancreatitis: Mechanisms and therapeutic potential	75
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions	74
The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment	74
Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine	74
Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics	74
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges	73
Nanomedicines: Redefining traditional medicine	73
Recent advances in fructose intake and risk of hyperuricemia	73
Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: A review	72
Diets and drugs for weight loss and health in obesity – An update	72
The current understanding on the impact of KRAS on colorectal cancer	72
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids	72
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability	72
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators	72
Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review	71
Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail	71
HDAC11: a rising star in epigenetics	71
Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review	71
Extraction, structure, and activity of polysaccharide from Radix astragali	71
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors	71
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease	71
Mechanism of chromium-induced toxicity in lungs, liver, and kidney and their ameliorative agents	70
The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression	70
RETRACTED: Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model	70
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms	69
Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance	69
Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges	69
Therapeutic potential of CAR T cell in malignancies: A scoping review	68
Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application	68
Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design	68
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver	68
Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis	68
COVID-19 challenges and its therapeutics	67
Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease	67
Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats	67
Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes	67
Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment	66
The roles and mechanism of m6A RNA methylation regulators in cancer immunity	66
Animal models of cerebral ischemia: A review	66
Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities	66
Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia	66
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways	66
A cross-talk between gut microbiome, salt and hypertension	66
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19	65
Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice	65
G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy	65

The biological activities of butyrylcholinesterase inhibitors	65
Roles of melatonin in the field of reproductive medicine	65
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets	65
Betulinic acid in the treatment of tumour diseases: Application and research progress	64
Research progress of traditional Chinese medicine against COVID-19	64
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study	64
Inhibiting RRM2 to enhance the anticancer activity of chemotherapy	64
Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise	64
Breakthrough in targeted therapy for non-small cell lung cancer	64
Evidence and perspectives of cell senescence in neurodegenerative diseases	64
Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy	63
Protective effects of curcumin against traumatic brain injury	63
The potential use of simvastatin for cancer treatment: A review	63
A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds	63
MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration	63
Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron	63
Paxlovid (Nirmatrelvir/Ritonavir): A new approach to Covid-19 therapy?	63
3D printing promotes the development of drugs	63
Marine-derived drugs: Recent advances in cancer therapy and immune signaling	62
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen	62
The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma	62
Hydroxytyrosol alleviate intestinal inflammation, oxidative stress and apoptosis resulted in ulcerative colitis	62
The emergence of metal oxide nanoparticles (NPs) as a phytomedicine: A two-facet role in plant growth, nano-toxicity and anti-phyto-microbial activity	61
Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase	61
Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway	61
Arginase: An emerging and promising therapeutic target for cancer treatment	60
Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer	60
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review	60
Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling	60
The role of natural antioxidants in cisplatin-induced hepatotoxicity	60
Antioxidant properties of flavonoid metal complexes and their potential inclusion in the development of novel strategies for the treatment against neurodegenerative diseases	60
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights	60
Postbiotics as potential new therapeutic agents for metabolic disorders management	60
Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages	60
Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na+]c/ROS-pathway in human endothelial cells	60
Progress in the treatment of diabetic peripheral neuropathy	60
Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy	60
Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models	59
Regulatory role of microRNAs on PTEN signaling	59
Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization	59
Advances in developing therapeutic strategies for Alzheimer's disease	59
Traditional Chinese medicine for precancerous lesions of gastric cancer: A review	59
Effects of Polygonatum sibiricum saponin on hyperglycemia, gut microbiota composition and metabolic profiles in type 2 diabetes mice	59
Targeting PI3K/AKT signaling pathway in obesity	59
MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients	59
Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook	58
Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges	58
Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism	57
Advances and challenges in the treatment of lung cancer	57
Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo	57
The role of SARS-CoV-2 accessory proteins in immune evasion	57
Recent advances in management of COVID-19: A review	57
The involvement of noncanonical Wnt signaling in cancers	57
Pharmacological and clinical application of heparin progress: An essential drug for modern medicine	56
Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances	56
Targets and strategies for vaccine development against SARS-CoV-2	56
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action	56
Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action	56
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics	56
Diacerein: Recent insight into pharmacological activities and molecular pathways	56
Topical nanocarriers for management of Rheumatoid Arthritis: A review	56
Compound sophorae decoction enhances intestinal barrier function of dextran sodium sulfate induced colitis via regulating notch signaling pathway in mice	56
An update on potential biomarkers for diagnosing diabetic foot ulcer at early stage	56
Anti-tumor activities and mechanisms of Traditional Chinese medicines formulas: A review	55
New understanding of the pathogenesis and treatment of stroke-related sarcopenia	55
Microbiota alteration and modulation in Alzheimer's disease by gerobiotics: The gut-health axis for a good mind	55
Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications − A review	55
Mechanism and application of metformin in kidney diseases: An update	55
Nrf2 a molecular therapeutic target for Astaxanthin	55
Clusterin: Always protecting. Synthesis, function and potential issues	55
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis	54
Recent advances in regenerative medicine strategies for cancer treatment	54
Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus	54
Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways	54
Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia	53
RdRp inhibitors and COVID-19: Is molnupiravir a good option?	53
The gut microbiome-bile acid axis in hepatocarcinogenesis	53
cGAS-STING signaling in cancer immunity and immunotherapy	53
Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer	53
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways	53
Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway	53
EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions	53
Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies	53
Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway	53
Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity	53
Emerging impact of quercetin in the treatment of prostate cancer	52
An update review of emerging small-molecule therapeutic options for COVID-19	52
Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation	52
LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma	52
Diabetic nephropathy: Focusing on pathological signals, clinical treatment, and dietary regulation	52
SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines	52
Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine	52
Preparation, structure and activity of polysaccharide phosphate esters	52
Fe3O4@piroctone olamine magnetic nanoparticles: Synthesize and therapeutic potential in cutaneous leishmaniasis	52
Integrative toxicogenomics: Advancing precision medicine and toxicology through artificial intelligence and OMICs technology	52