OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARγ levels	347
Editorial Board	315
Editorial Board	313
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	265
Editorial Board	259
Between therapy effect and false-positive result in animal experimentation	251
Editorial Board	251
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	249
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	248
Emerging role of carbon monoxide in intestinal transplantation	242
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	230
Editorial Board	220
Cervical carcinoma high expressed 1 (CCHE1): An oncogenic lncRNA in diverse neoplasms	219
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	205
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	201
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	198
Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study	196
Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing	189
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	183
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	181
Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation	179
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	174
Expression of concern: MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5- dependent PPAR signaling pathway [Bi	173
Expression of concern: miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1 [Biomedicine & Pharmacotherapy 106 (2018) 1072–1081]	172
Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biome	168

Retraction notice to “Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210” [Biomed. Pharmacother. 108 (2018) 1679–1685]	167
Retraction notice to “Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells” [Biomed. Pharmacother. 103 (2018) 947–954]	165
Editorial Board	161
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	153
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	150
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	146
Editorial Board	143
Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis	143
Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity	143
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis	142
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease	140
Corrigendum to “Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats” [Biomed. Pharmacother. 166 (2023), 115329]	139
Hyperbranched polymer dots enhance hair follicle regeneration via Wnt/β-catenin activation: A drug-free nanozyme-based approach to hair growth therapy	139
Corrigendum to “I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs” [Biomed. Pharmacother. 168 (20	136
Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review	134
CXCL12 inhibits hair growth through CXCR4	130
Notoginsenoside Ft1 induces lysosomal cell death and apoptosis by inhibiting the PI3K/AKT/mTOR pathway in hepatocellular carcinoma	130
Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia	129
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	129
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	128
Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?	127
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs	125
The AhR/P38 MAPK pathway mediates kynurenine-induced cardiomyocyte damage: The dual role of resveratrol in apoptosis and autophagy	125
Glioblastoma targeting by water-soluble hypericin derivate HHL-PVP and photodynamic tumour killing	123
Synergic effect of bone marrow derived mesenchymal stem cells and differentiated keratinocytes-like cells with a novel cellulose and collagen nanoscaffold on wound healing in rats	122
Squalene nanoemulsion reinforces mucosal and immunological fingerprints following intravaginal delivery	121
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells	120
Effective-component compatibility of Bufei Yishen formula alleviates chronic obstructive pulmonary disease inflammation by regulating GSK3β-mediated NLRP3 inflammasome activation	119
Discovery of a synthetic taiwaniaquinoid with potent in vitro and in vivo antitumor activity against breast cancer cells	119
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	118
Cuproptosis in cancers: Function and implications from bench to bedside	117
Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice	117
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease	117
Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction	115
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	114
Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice	113
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	113
Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models	111
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	111
Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin	111
Patient-derived tumor models in cancer research: Evaluation of the oncostatic effects of melatonin	110
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	110
Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells	110
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons	109
Therapeutic effects of CGS21680, a selective A2A receptor agonist, via BDNF-related pathways in R106W mutation Rett syndrome model	109
FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice	109
919 granules improve postpartum depression through the regulation of abnormal peripheral blood IL-1β	108
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway	108
PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study	107
Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury	106

Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm	106
Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model	105
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway	104
Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy	104
Whole-exome sequencing reveals genetic variations in humans with differential sensitivity to sevoflurane：A prospective observational study	104
Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis	102
Cinnarizine dissolving microneedles against microwave-induced brain injury	101
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis	101
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells	100
Sesquiterpene lactones as potential therapeutic agents against Naegleria fowleri	100
Development of alginate and alginate sulfate/polycaprolactone nanoparticles for growth factor delivery in wound healing therapy	100
CircRNA: An emerging star in the progression of glioma	99
Salvadora persica attenuates DMBA-induced mammary cancer through downregulation oxidative stress, estrogen receptor expression and proliferation and augmenting apoptosis	99
In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response	99
Beneficial effects of carvedilol modulating potassium channels on the control of glucose	99
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function	98
Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway	97
Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection	96
Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders	96
Seroprevalence of SARS-CoV-2-specific antibodies and vaccination-related adverse events in systemic lupus erythematosus and rheumatoid arthritis	96
Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses	95
Physiological and transcriptional profiling of surfactin exerted antifungal effect against Candida albicans	95
Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2	95
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma p	95