OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 106. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	470
Editorial Board	470
Editorial Board	380
Editorial Board	376
Editorial Board	359
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	341
PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study	322
Phenolic zingerone nanoparticles impede cell cycle progression to compete against human urothelial carcinoma	312
Sphingolipid metabolism and insulin resistance – Does cannabigerol protect against experimental colitis induced by high-fat high-sucrose diet?	308
Anti-inflammatory and inflammasome-modulating effects of Jinmu-Tang, a Korean traditional medicine: Integrated network pharmacology and experimental evaluation in a DSS-induced colitis model	270
Normobaric oxygen treatment in a depression-like model in male and female rats – Safety, behavioral benefits, and modulation of serotonin and inflammatory markers	256
The three dicaffeoylquinic acids of Erigeron breviscapus strengthen anticoagulation of warfarin in rats: Implications in pharmacokinetics and pharmacodynamics	248
Bridging predictions with experimental reality: In vitro evaluation of phenolic natural products as SARS-CoV-2 exoribonuclease inhibitors	242
919 granules improve postpartum depression through the regulation of abnormal peripheral blood IL-1β	240
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	238
The AhR/P38 MAPK pathway mediates kynurenine-induced cardiomyocyte damage: The dual role of resveratrol in apoptosis and autophagy	222
Elucidating cuproptosis in metabolic dysfunction-associated steatotic liver disease	208
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	203
Induction of JAK2/STAT3 pathway contributes to protective effects of different therapeutics against myocardial ischemia/reperfusion	200
Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin	194
Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis	193
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight	189
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	189
T helper 17 (Th17) cell responses to the gut microbiota in human diseases	185
CXCL12 inhibits hair growth through CXCR4	178

Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation	178
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	178
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	177
Glioblastoma targeting by water-soluble hypericin derivate HHL-PVP and photodynamic tumour killing	177
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	171
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	170
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	168
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	163
Corrigendum to “I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs” [Biomed. Pharmacother. 168 (20	163
Corrigendum to “Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats” [Biomed. Pharmacother. 166 (2023), 115329]	162
Retraction notice to “CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p” [Biomed. Pharmacother. 126 (2020) 109941]	161
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	160
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease	159
Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders	158
Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations	157
Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519	157
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease	154
Retraction notice to “Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats” [Biomedicine & Pharmacotherapy 94 (2017) 726-741]	153
The role of the serotonergic system in atropine’s anti-myopic effects	153
Medicinal and mechanistic overview of artemisinin in the treatment of human diseases	152
Relationship between hepatic lipid accumulation and type 2 diabetes mellitus	151
Mechanistic insights and clinical implications of the S100 protein family in breast cancer	151
Retraction notice to "New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities" [Biomedicine & Pharm	150
Tea (Camellia sinensis) ameliorates DSS-induced colitis and liver injury by inhibiting TLR4/NF-κB/NLRP3 inflammasome in mice	150
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs	148
Venetoclax in adult acute myeloid leukemia	145
Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia	144
AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity	142
Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential	141
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function	140
Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics	139
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	139
Toll-like receptor 4: A potential therapeutic target for multiple human diseases	136
Unraveling the molecular and immunological landscape: Exploring signaling pathways in osteoporosis	136
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	136
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics	135
RETRACTED: Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	135
Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling	135
Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment	134
Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction	134
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells	133
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	132
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis	131
Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics	129
Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles	128
Corrigendum to “Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway” [Biomed. Pharmacother. 164 (2023), 11	127
Basic research on curcumin in cervical cancer: Progress and perspectives	127
Cannabidiol promotes fine-tuning of natural killer and monocytic cells subsets as well as cytokine storm during chikungunya virus exposure in vitro: Insights for putative therapeutic interventions	126
Cytosolic DNA sensing pathway in senescence and aging: Underlying mechanisms and targeted interventions	126
Corrigendum to “Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways” [Biomed. Pharmacother. 141 (2021) 1–12/111874]	125

Corrigendum to “High potency of magnetic iron oxide nanoparticles covered by piroctone olamine against cystic echinococcosis” [Biomed. Pharmacother., 2023 (161) 114536]	124
Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy	123
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	123
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	122
Egg white protein hydrolysate ameliorated sepsis-induced inflammatory injuries in kidney and liver based on metabolomics analysis	120
Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice	119
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice	118
The impact of curcumin on migraine: A comprehensive review	118
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors	117
Retraction notice to "Effect of nano silver on gastroprotective activity against ethanol-induced stomach ulcer in rats" [Biomedicine & Pharmacotherapy 154 (2022) 113550]	116
Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritis	116
Injectable Gel-PEG hydrogels as promising delivery system for intravitreal PACAP release: Novel therapeutics for unilateral common carotid artery occlusion induced retinal ischemia	115
Analytical validation of a novel UHPLC-MS/MS method for 19 antibiotics quantification in plasma: Implementation in a LC-MS/MS Kit	115
Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice	114
Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity	114
Dysregulation of miR-411 in cancer: Causative factor for pathogenesis, diagnosis and prognosis	112
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	112
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway	112
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells	112
Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer	112
Between therapy effect and false-positive result in animal experimentation	111
Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway	111
Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections	111
Synergic effect of bone marrow derived mesenchymal stem cells and differentiated keratinocytes-like cells with a novel cellulose and collagen nanoscaffold on wound healing in rats	110
In situ administration of temperature-sensitive hydrogel composite loading paclitaxel microspheres and cisplatin for the treatment of melanoma	110
Patient-derived tumor models in cancer research: Evaluation of the oncostatic effects of melatonin	110
FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice	109
A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives	109
Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model	108
Clofazimine: A journey of a drug	108
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	107
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy	106
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	106
Development of alginate and alginate sulfate/polycaprolactone nanoparticles for growth factor delivery in wound healing therapy	106