OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 98. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Editorial Board	368
Editorial Board	364
Therapeutic strategies targeting synovial cells to treat osteoarthritis	331
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	307
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	294
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	279
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	277
Editorial Board	268
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	259
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	247
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	243
Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice	233
Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection	232
Editorial Board	221
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	219
Editorial Board	212
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	207
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	204
Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles	199
Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathw	196
Effective-component compatibility of Bufei Yishen formula alleviates chronic obstructive pulmonary disease inflammation by regulating GSK3β-mediated NLRP3 inflammasome activation	192
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight	181
Advances in the role and mechanism of miRNA in inflammatory pain	180
Imbalance of gut microbiota is involved in the development of chronic obstructive pulmonary disease: A review	177
The significance of dysregulated serine metabolism in depression	165

Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction	164
Retraction notice to “CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p” [Biomed. Pharmacother. 126 (2020) 109941]	163
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma	155
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	152
Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders	152
Glioblastoma targeting by water-soluble hypericin derivate HHL-PVP and photodynamic tumour killing	151
Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations	148
Role of long noncoding RNAs in pathological cardiac remodeling after myocardial infarction: An emerging insight into molecular mechanisms and therapeutic potential	148
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells	147
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy	146
Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model	144
Clofazimine: A journey of a drug	142
Unraveling the molecular and immunological landscape: Exploring signaling pathways in osteoporosis	140
Between therapy effect and false-positive result in animal experimentation	140
Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway	139
Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics	138
Toll-like receptor 4: A potential therapeutic target for multiple human diseases	137
Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis	137
Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice	137
Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1β signaling pathway	137
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs	134
Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment	133
Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective	133
Beneficial effects of carvedilol modulating potassium channels on the control of glucose	133
Necroptosis in Alzheimer’s disease: Potential therapeutic target	133
Targeting the STAT3 oncogenic pathway: Cancer immunotherapy and drug repurposing	131
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway	130
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	128
Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519	128
Identification of early diagnostic biomarkers via WGCNA in gastric cancer	127
Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application	126
Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritis	123
Effects of cPIP2 peptide and rosuvastatin on TLR4 signaling and cardiac remodeling in an acute myocardial infarction model	123
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities	122
Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF)	122
Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases	121
Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications	121
Notoginsenoside Ft1 induces lysosomal cell death and apoptosis by inhibiting the PI3K/AKT/mTOR pathway in hepatocellular carcinoma	120
Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections	120
Hyperbranched polymer dots enhance hair follicle regeneration via Wnt/β-catenin activation: A drug-free nanozyme-based approach to hair growth therapy	119
Optimizing mesenchymal stromal cells priming strategies for tailored effects on the secretome	119
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	119
Corrigendum to “Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats” [Biomed. Pharmacother. 166 (2023), 115329]	118
Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism	116
Corrigendum to “I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs” [Biomed. Pharmacother. 168 (20	116
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	115
The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal	113
Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2	112
The AhR/P38 MAPK pathway mediates kynurenine-induced cardiomyocyte damage: The dual role of resveratrol in apoptosis and autophagy	111
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis	111

Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells	109
Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice	107
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	106
Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction	106
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	106
Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy	104
Injectable Gel-PEG hydrogels as promising delivery system for intravitreal PACAP release: Novel therapeutics for unilateral common carotid artery occlusion induced retinal ischemia	104
Medicinal and mechanistic overview of artemisinin in the treatment of human diseases	104
AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity	103
Discovery of a synthetic taiwaniaquinoid with potent in vitro and in vivo antitumor activity against breast cancer cells	102
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease	102
Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis	101
Therapeutic effects of CGS21680, a selective A2A receptor agonist, via BDNF-related pathways in R106W mutation Rett syndrome model	101
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs	101
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons	101
FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice	101
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	100
A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling	100
Analytical validation of a novel UHPLC-MS/MS method for 19 antibiotics quantification in plasma: Implementation in a LC-MS/MS Kit	100
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	99
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice	99
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	99
The pharmacokinetic property and pharmacological activity of acteoside: A review	98
Phytochemicals targeting mitophagy: Therapeutic opportunities and prospects for treating Alzheimer’s disease	98
Venetoclax in adult acute myeloid leukemia	98