OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARγ levels	324
Editorial Board	297
Editorial Board	284
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	275
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma	248
Editorial Board	243
Editorial Board	240
Between therapy effect and false-positive result in animal experimentation	240
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	239
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	230
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	226
A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling	219
Emerging role of carbon monoxide in intestinal transplantation	217
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	214
Editorial Board	208
Advances in the role and mechanism of miRNA in inflammatory pain	195
Induction of JAK2/STAT3 pathway contributes to protective effects of different therapeutics against myocardial ischemia/reperfusion	193
Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats	187
Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis	184
Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF)	181
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	178
Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period	175
Cervical carcinoma high expressed 1 (CCHE1): An oncogenic lncRNA in diverse neoplasms	174
Role of long noncoding RNAs in pathological cardiac remodeling after myocardial infarction: An emerging insight into molecular mechanisms and therapeutic potential	172
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	165

Analytical validation of a novel UHPLC-MS/MS method for 19 antibiotics quantification in plasma: Implementation in a LC-MS/MS Kit	164
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	163
Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis	160
Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study	158
Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing	157
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	149
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	145
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	144
Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation	142
Expression of concern: MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5- dependent PPAR signaling pathway [Bi	139
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	139
Expression of concern: miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1 [Biomedicine & Pharmacotherapy 106 (2018) 1072–1081]	139
Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biome	137
Retraction notice to “Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210” [Biomed. Pharmacother. 108 (2018) 1679–1685]	136
Retraction notice to “Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells” [Biomed. Pharmacother. 103 (2018) 947–954]	134
Editorial Board	133
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	132
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	129
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	126
Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity	125
Multi-omics study reveals associations among neurotransmitter, extracellular vesicle-derived microRNA and psychiatric comorbidities during heroin and methamphetamine withdrawal	124
Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications	124
Polyphenol-enriched Desmodium elegans DC. ameliorate scopolamine-induced amnesia in animal model of Alzheimer’s disease: In Vitro, In Vivo and In Silico approaches	123
Cuproptosis in cancers: Function and implications from bench to bedside	123
Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice	121
Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses	121
Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin	120
Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice	117
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	117
Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo	117
Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics	117
Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism	117
Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice	115
Tea (Camellia sinensis) ameliorates DSS-induced colitis and liver injury by inhibiting TLR4/NF-κB/NLRP3 inflammasome in mice	114
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	113
Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models	112
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	109
T helper 17 (Th17) cell responses to the gut microbiota in human diseases	109
Injectable Gel-PEG hydrogels as promising delivery system for intravitreal PACAP release: Novel therapeutics for unilateral common carotid artery occlusion induced retinal ischemia	109
Granulocyte colony-stimulating factor in reproductive-related disease: Function, regulation and therapeutic effect	108
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	108
Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential	107
Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction	107
Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction	107
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy	107
Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties	106
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	106
Clofazimine: A journey of a drug	106
Egg white protein hydrolysate ameliorated sepsis-induced inflammatory injuries in kidney and liver based on metabolomics analysis	104
Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2	103

CXCL12 inhibits hair growth through CXCR4	103
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice	103
Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	103
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	102
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	102
Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia	102
Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?	101
The AhR/P38 MAPK pathway mediates kynurenine-induced cardiomyocyte damage: The dual role of resveratrol in apoptosis and autophagy	100
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs	100
Glioblastoma targeting by water-soluble hypericin derivate HHL-PVP and photodynamic tumour killing	99
Synergic effect of bone marrow derived mesenchymal stem cells and differentiated keratinocytes-like cells with a novel cellulose and collagen nanoscaffold on wound healing in rats	99
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells	98
Squalene nanoemulsion reinforces mucosal and immunological fingerprints following intravaginal delivery	98
Discovery of a synthetic taiwaniaquinoid with potent in vitro and in vivo antitumor activity against breast cancer cells	97
Discovery of a novel NUAK1 inhibitor against pancreatic cancer	97
Effective-component compatibility of Bufei Yishen formula alleviates chronic obstructive pulmonary disease inflammation by regulating GSK3β-mediated NLRP3 inflammasome activation	96
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	96
The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal	95
AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity	94
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis	94
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease	94