OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 109. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	558
Editorial Board	515
Editorial Board	457
Necroptosis in Alzheimer’s disease: Potential therapeutic target	421
Retraction notice to "Research progress of indole-fused derivatives as allosteric modulators: Opportunities for drug development" [Biomedicine & Pharmacotherapy 162 (2023) 114574]	407
Retraction notice to "Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism" [Biomedicine & Pharmacotherapy 84 (2016) 330-339]	389
Retraction notice to “Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s)” [Biomedicine & Pharmacotherapy 88 (2017) 480-487]	379
Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathw	299
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	265
Corrigendum to “I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs” [Biomed. Pharmacother. 168 (20	264
Corrigendum to “Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats” [Biomed. Pharmacother. 166 (2023), 115329]	262
Retraction notice to “CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p” [Biomed. Pharmacother. 126 (2020) 109941]	261
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis	257
Discovery of a novel NUAK1 inhibitor against pancreatic cancer	232
Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation	217
Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity	211
Between therapy effect and false-positive result in animal experimentation	209
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	208
In situ administration of temperature-sensitive hydrogel composite loading paclitaxel microspheres and cisplatin for the treatment of melanoma	207
Synergic effect of bone marrow derived mesenchymal stem cells and differentiated keratinocytes-like cells with a novel cellulose and collagen nanoscaffold on wound healing in rats	206
Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519	205
PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study	200
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease	200
Normobaric oxygen treatment in a depression-like model in male and female rats – Safety, behavioral benefits, and modulation of serotonin and inflammatory markers	197
The three dicaffeoylquinic acids of Erigeron breviscapus strengthen anticoagulation of warfarin in rats: Implications in pharmacokinetics and pharmacodynamics	196

Corrigendum to “Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways” [Biomed. Pharmacother. 141 (2021) 1–12/111874]	194
Corrigendum to “High potency of magnetic iron oxide nanoparticles covered by piroctone olamine against cystic echinococcosis” [Biomed. Pharmacother., 2023 (161) 114536]	189
Corrigendum to “Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway” [Biomed. Pharmacother. 164 (2023), 11	186
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	180
A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling	177
Editorial Board	175
Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway	174
Phenolic zingerone nanoparticles impede cell cycle progression to compete against human urothelial carcinoma	174
Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction	172
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease	172
Physiological and transcriptional profiling of surfactin exerted antifungal effect against Candida albicans	170
Role of long noncoding RNAs in pathological cardiac remodeling after myocardial infarction: An emerging insight into molecular mechanisms and therapeutic potential	169
Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice	168
AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity	167
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway	165
Cannabidiol promotes fine-tuning of natural killer and monocytic cells subsets as well as cytokine storm during chikungunya virus exposure in vitro: Insights for putative therapeutic interventions	164
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	159
The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal	153
In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response	153
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARγ levels	153
Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells	151
Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy	150
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	150
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	150
Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review	149
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	146
Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations	146
Bridging predictions with experimental reality: In vitro evaluation of phenolic natural products as SARS-CoV-2 exoribonuclease inhibitors	146
Anti-inflammatory and inflammasome-modulating effects of Jinmu-Tang, a Korean traditional medicine: Integrated network pharmacology and experimental evaluation in a DSS-induced colitis model	145
Combination of rosuvastatin and curcumin outperforms monotherapies in alleviating gentamicin-induced nephrotoxicity, audiotoxicity and vestibulotoxicity in a rat animal model	144
The role of the serotonergic system in atropine’s anti-myopic effects	143
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	141
Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia	141
The impact of curcumin on migraine: A comprehensive review	141
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	141
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	138
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis	138
Mechanistic insights and clinical implications of the S100 protein family in breast cancer	137
Retraction notice to "New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities" [Biomedicine & Pharm	136
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	135
Tea (Camellia sinensis) ameliorates DSS-induced colitis and liver injury by inhibiting TLR4/NF-κB/NLRP3 inflammasome in mice	135
Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model	133
Notoginsenoside Ft1 induces lysosomal cell death and apoptosis by inhibiting the PI3K/AKT/mTOR pathway in hepatocellular carcinoma	133
Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections	130
Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics	130
Relationship between hepatic lipid accumulation and type 2 diabetes mellitus	129
Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis	128
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells	128
Sphingolipid metabolism and insulin resistance – Does cannabigerol protect against experimental colitis induced by high-fat high-sucrose diet?	127
RETRACTED: Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	126

Discovery of a synthetic taiwaniaquinoid with potent in vitro and in vivo antitumor activity against breast cancer cells	124
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics	123
Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin	123
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy	123
Therapeutic effects of CGS21680, a selective A2A receptor agonist, via BDNF-related pathways in R106W mutation Rett syndrome model	123
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	122
Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1β signaling pathway	122
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	122
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	121
Retraction notice to “Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats” [Biomedicine & Pharmacotherapy 94 (2017) 726-741]	120
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	120
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	120
Retraction notice to "Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis" [Biomedicine & Pharmacotherapy 82 (2016) 669-676]	119
A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives	118
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons	118
Retraction notice to "Effect of nano silver on gastroprotective activity against ethanol-induced stomach ulcer in rats" [Biomedicine & Pharmacotherapy 154 (2022) 113550]	118
Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm	116
919 granules improve postpartum depression through the regulation of abnormal peripheral blood IL-1β	115
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway	114
Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2	114
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	113
Editorial Board	113
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors	112
Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis	112
Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction	112
Patient-derived tumor models in cancer research: Evaluation of the oncostatic effects of melatonin	111
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	111
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function	110
Retraction notice to "Nephroprotective potential of Panduratin A against colistin-induced renal injury via attenuating mitochondrial dysfunction and cell apoptosis" [Biomedicine & Pharmacotherapy	110
Luteolin from Lonicera japonica Thunb. restores GLUT4-mediated glucose uptake via PI3K/Akt signaling in insulin resistance	110
Aerobic conditioning and ginsenoside modulation modify molecular resilience in middle-aged rats: Differential effects of individual and combined interventions	109
Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice	109
A juglone derivative that disrupts mitochondrial redox metabolism, inhibiting the breast fibroblast-cancer cell pro-migratory signaling induced by doxorubicin	109
Unraveling the molecular and immunological landscape: Exploring signaling pathways in osteoporosis	109
A six-proline stabilized trimeric spike DNA vaccine induces robust immunity and protects against SARS-CoV-2 delta challenge in K18-hACE2 transgenic mice	109