OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	528
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARγ levels	521
Editorial Board	355
Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm	285
Editorial Board	267
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells	261
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease	232
Cervical carcinoma high expressed 1 (CCHE1): An oncogenic lncRNA in diverse neoplasms	219
Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2	216
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	215
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma	212
Whole-exome sequencing reveals genetic variations in humans with differential sensitivity to sevoflurane：A prospective observational study	212
Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy	212
Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury	211
Egg white protein hydrolysate ameliorated sepsis-induced inflammatory injuries in kidney and liver based on metabolomics analysis	209
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	205
Editorial Board	195
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication	179
Therapeutic efficacy of 3,4-Diaminopyridine phosphate on neuromuscular junction in Pompe disease	178
Editorial Board	170
Between therapy effect and false-positive result in animal experimentation	169
Salvadora persica attenuates DMBA-induced mammary cancer through downregulation oxidative stress, estrogen receptor expression and proliferation and augmenting apoptosis	168
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons	165
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease	159
Injectable Gel-PEG hydrogels as promising delivery system for intravitreal PACAP release: Novel therapeutics for unilateral common carotid artery occlusion induced retinal ischemia	158

Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	156
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	156
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	155
Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation	150
A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling	145
Venetoclax in adult acute myeloid leukemia	144
Emerging role of carbon monoxide in intestinal transplantation	144
“Aducanumab” making a comeback in Alzheimer’s disease: An old wine in a new bottle	143
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	140
FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice	135
Editorial Board	135
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors	130
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	129
Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection	129
Patient-derived tumor models in cancer research: Evaluation of the oncostatic effects of melatonin	126
Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential	125
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	123
Development of alginate and alginate sulfate/polycaprolactone nanoparticles for growth factor delivery in wound healing therapy	122
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	120
Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction	119
RETRACTED: mPEG-b-P(Glu-co-Phe) nanoparticles increase gastric retention time and gastric ulcer treatment efficacy of 20(S)-ginsenoside Rg3	119
Exploring the anticancer effects of standardized extracts of poplar-type propolis: In vitro cytotoxicity toward cancer and normal cell lines	117
Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis	117
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice	116
Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing	115
Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study	115
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	115
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	113
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	112
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy	110
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	109
Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation	109
The role of ubiquitin-specific peptidases in glioma progression	109
Resveratrol supplementation and acute pancreatitis: A comprehensive review	109
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	108
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function	108
Combinatorial delivery of antigen and TLR agonists via PLGA nanoparticles modulates Leishmania major-infected-macrophages activation	107
Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy	106
The interaction between ETS transcription factor family members and microRNAs: A novel approach to cancer therapy	104
Expression of concern: MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5- dependent PPAR signaling pathway [Bi	103
Expression of concern: miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1 [Biomedicine & Pharmacotherapy 106 (2018) 1072–1081]	103
Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis	103
Retraction notice to “Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210” [Biomed. Pharmacother. 108 (2018) 1679–1685]	102
A fungus-derived purpactin A as an inhibitor of TMEM16A chloride channels and mucin secretion in airway epithelial cells	102
Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biome	102
Retraction notice to “Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells” [Biomed. Pharmacother. 103 (2018) 947–954]	102
Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses	99
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	98
Editorial Board	98
Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models	98

Therapeutic effects of CGS21680, a selective A2A receptor agonist, via BDNF-related pathways in R106W mutation Rett syndrome model	96
Diabetes and hypertension: Pivotal involvement of purinergic signaling	96
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	95
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	94
Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice	93
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	93
Physiological and transcriptional profiling of surfactin exerted antifungal effect against Candida albicans	93
Parecoxib improves atherosclerotic plaque stability by suppressing inflammation and inhibiting matrix metalloproteinases production	93
Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathw	92
Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	92
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway	92
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	91
Tea (Camellia sinensis) ameliorates DSS-induced colitis and liver injury by inhibiting TLR4/NF-κB/NLRP3 inflammasome in mice	91
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma p	90
Beneficial effects of carvedilol modulating potassium channels on the control of glucose	90
In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response	90