OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pineal Research is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation	202
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6	121
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis	114
Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner	111
Circadian rhythms and obesity: Timekeeping governs lipid metabolism	93
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease	82
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis	75
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2	66
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice	62
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells	59
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans	54
Clinical trial to test the efficacy of melatonin in COVID‐19	54
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis	52
Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system	51
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis	49
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma	47
Melatonin effects on bone: Implications for use as a therapy for managing bone loss	47
Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis	45
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression	45
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat	43
Melatonin receptor ligands: A pharmaco‐chemical perspective	42
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma	41
Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset	38
Melatonin controversies, an update	37
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men	35

Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia	35
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	35
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations	34
A meta‐analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment	33
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	31
The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators	31
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics	29
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	29
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5	29
S‐cone contribution to the acute melatonin suppression response in humans	28
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis	27
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase	27
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization	27
Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin?	27
Modeling melanopsin‐mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness	27
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato	26
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective	26
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer	25
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	25
The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice	24
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	23
Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population	23
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway	22
Exogenous melatonin decreases circadian misalignment and body weight among early types	22
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic	22
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism	22
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2	22
The potential remedy of melatonin on osteoarthritis	22
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis	22
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence	21
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana	21
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances	21
Melatonin promotes regeneration of injured motor axons via MT₁ receptors	20
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat	20
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H₂O₂ generation and reductive stress effects of cadmium	19
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	19
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells	19
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation	19
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight	19
Melatonin and the health of menopausal women: A systematic review	19
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings	18
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	18
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats	18
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice	18
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava	17
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	17
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses	16
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men	16
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato	15
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis	15

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	15
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults	15
Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina	15
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students	15
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery	14
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation	13
Access to electric light is associated with delays of the dim‐light melatonin onset in a traditionally hunter‐gatherer Toba/Qom community	13
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model	13
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19	13
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation	13
A novel role for the pineal gland: Regulating seasonal shifts in the gut microbiota of Siberian hamsters	13
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	13
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling	13
Enhanced anti‐angiogenic activity of novel melatonin‐like agents	13
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males	13