OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pineal Research is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice	135
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells	70
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children	69
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses	60
Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications	54
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	54
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae	52
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways	50
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	50
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	48
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	47
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	46
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	44
Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells	43
Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching	39
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France	39
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	38
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Melatonin Enhances Peanut Productivity by Enriching Root‐Associated Nitrogen‐Fixing Bacteria	34
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase	34
Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish	34
Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis‐Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective	33
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle	33

Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis	33
No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients	32
Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”	32
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From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin	31
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	29
Relationship Between Urinary 6‐Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino‐Terminal Cross‐Linked Telopeptide of Collagen I in Blind Women	29
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	28
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart	28
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial	28
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial	28
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	27
Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health	26
In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma	24
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Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD	23
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EXPRESSION OF CONCERN: Mitochondrial Function Is Controlled by Melatonin and Its Metabolites In Vitro in Human Melanoma Cells	22
Melatonin Ameliorates Circadian Disruption‐Associated Dry Eye via Modulation of BMAL1‐REV‐ERBα‐IL‐17 Axis and Ocular Surface Microbiota Homeostasis	22
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	22
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants	21
Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different Fec^B genotypes	21
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland	21
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G_12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes	21
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Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance	20
NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation	19
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction	18
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous Hormones	18
Melatonin as a key regulator in seed germination under abiotic stress	18
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Mouse Models in Circadian Rhythm and Melatonin Research	17
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders	17
Melatonin, an Antitumor Necrosis Factor Therapy	17
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T	17
IAT4 , a New Indolamine N ‐Acetyltransferase in Saccharomyces cerevisiae Involv	16
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”	16
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	16
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	16
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice	16
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	15
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐ Bmal1 ^−/−	15
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	15
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	15
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	15
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation	15
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	14
Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways	14
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis	14

Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	14
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Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland	13
Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment	13
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients	13
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice	13
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Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine	12
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial	12
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava	12
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin	12
Cross‐species single‐cell landscape of vertebrate pineal gland	12
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Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming	12
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light	12