OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pineal Research is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)

Article	Citations
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease	95
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis	84
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice	79
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2	79
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells	73
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis	62
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans	58
Melatonin effects on bone: Implications for use as a therapy for managing bone loss	54
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma	51
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis	50
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression	50
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat	48
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma	44
Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset	41
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	40
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	40
Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia	38
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	37
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations	36
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men	35
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics	34
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5	33
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism	32
S‐cone contribution to the acute melatonin suppression response in humans	31
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis	31

Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective	30
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase	30
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization	29
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato	29
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	28
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	27
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer	25
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic	24
The potential remedy of melatonin on osteoarthritis	24
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana	23
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis	23
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway	23
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2	22
Exogenous melatonin decreases circadian misalignment and body weight among early types	22
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses	22
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence	22
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat	22
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava	21
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances	21
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells	21
Melatonin and the health of menopausal women: A systematic review	21
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation	21
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation	21
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight	20
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings	20
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H₂O₂ generation and reductive stress effects of cadmium	20
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	20
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato	19
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	19
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	19
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	19
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice	19
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats	18
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults	17
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy	17
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	17
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling	16
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis	16
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation	16
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery	16
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men	16
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction	15
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students	15
Enhanced anti‐angiogenic activity of novel melatonin‐like agents	14
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model	14
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes—A randomized placebo‐controlled crossover trial	14
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19	14
Melatonin prevents experimental central serous chorioretinopathy in rats	13
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	13
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males	13

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeas	13
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	12
Modulations in irradiance directed at melanopsin, but not cone photoreceptors, reliably alter electrophysiological activity in the suprachiasmatic nucleus and circadian behaviour in mice	12
Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring	12
Melatonin as a key regulator in seed germination under abiotic stress	12
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α₂β₁ expression	11
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data	11
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets	11
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia	11
Melatonin alleviates PM_2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress	11
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin	11