Journal of Pineal Research

Papers
(The median citation count of Journal of Pineal Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells140
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster111
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses101
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants81
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae59
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression57
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children56
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways55
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi47
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control46
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved46
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Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis42
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France41
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase39
Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells39
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model39
Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching38
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Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish36
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No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients33
Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis33
Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”32
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial32
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin31
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle30
Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health30
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial30
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota29
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence29
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart28
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure28
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland28
Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hypermethylation of promoters of protein kinase C alpha and cAMP response element‐binding28
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma28
Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD27
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes27
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics26
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Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different FecB genotypes24
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants24
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In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma22
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Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T21
Mouse Models in Circadian Rhythm and Melatonin Research20
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous Hormones20
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction20
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders20
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Melatonin as a key regulator in seed germination under abiotic stress19
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation19
Melatonin, an Antitumor Necrosis Factor Therapy18
Measuring morning melatonin levels with plasma melatonin ELISA kits is a poor choice on two levels17
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐Bmal1−/− Mice17
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges17
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐217
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock17
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer17
IAT4, a New Indolamine N‐Acetyltransferase in Saccharomyces cerevisiae Involved in Melatonin Biosynthesis17
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”17
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease16
Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways16
High sensitivity of melatonin suppression response to evening light in preschool‐aged children16
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis16
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs16
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice15
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light15
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients15
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis14
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat14
Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment14
Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response13
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming13
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis13
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Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland13
Melatonin receptor structure and signaling13
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Melatonin and Seasonal Synchrony in Mammals12
Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine12
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light12
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy12
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin12
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava12
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats11
Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views11
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial11
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Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase11
Cross‐species single‐cell landscape of vertebrate pineal gland11
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis10
Correction to “Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy”10
Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development10
Melatonin alleviates myocardial dysfunction through inhibition of endothelial‐to‐mesenchymal transition via the NF‐κB pathway10
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Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization10
OPA1 Mediated Fatty Acid β‐Oxidation in Hepatocyte: The Novel Insight for Melatonin Attenuated Apoptosis in Concanavalin A Induced Acute Liver Injury10
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Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome9
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RETRACTION: Melatonin Modulates Dysregulated Circadian Clocks in Mice With Diethylnitrosamine‐Induced Hepatocellular Carcinoma9
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Melatonin Alleviates Oxidative Stress‐Induced Mitochondrial Dysfunction Through Ameliorating NAD+ Homeostasis of hDPSCs for Cell‐Based Therapy9
Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems9
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Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease8
Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases8
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RETRACTION: Melatonin Induces Cell Cycle Arrest and Apoptosis in Hepatocarcinoma HepG2 Cell Line8
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Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers8
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases8
Identification of a COMT Gene Involved in the Biosynthesis of Melatonin Which Mediates Resistance to Citrus Canker8
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis8
Novel melatonin‐producing Bacillus safensis EH143 mitigates salt and cadmium stress in soybean7
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials7
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RP58 knockdown contributes to hypoxia‐ischemia‐induced pineal dysfunction and circadian rhythm disruption in neonatal rats7
Melatonin Protects Against Colistin‐Induced Intestinal Inflammation and Microbiota Dysbiosis7
Correction to “PP2C1 Fine‐Tunes Melatonin Biosynthesis and Phytomelatonin Receptor PMTR1 Binding to Melatonin in Cassava”7
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification7
RETRACTION: Melatonin Inhibits the Sphingosine Kinase 1/Sphingosine‐1‐Phosphate Signaling Pathway in Rabbits With Fulminant Hepatitis of Viral Origin7
Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age7
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner7
Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms7
Design, Synthesis, and Antifungal Activity of Melatonin Derivatives Containing a (Thio)Semicarbazide Group7
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction6
Mechanism of Exogenous Melatonin to Alleviate the Fermentation Performance of Saccharomyces cerevisiae Under Copper Stress6
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Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors6
Light and Temperature Coordinately Regulate Phytomelatonin Synthesis to Maintain Plant Morphogenesis via the COP1‐HY5 Module6
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)6
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Corrigendum to “melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis”6
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Relationship Between Melatonin Receptor Agonists and Parkinson's Disease5
In vitro deacetylation of N‐acetylserotonin by arylacetamide deacetylase5
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy5
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress5
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence5
Functional Characterization of GNA1 as a Serotonin N‐Acetyltransferase Reveals a Key Role in the Serotonin to Melatonin Pathway in Saccharomyces cerevisiae5
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Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport5
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Melatonin Prevents Thioacetamide–Induced Gut Leakiness and Liver Fibrosis Through the Gut–Liver Axis via Modulating Sirt1‐Related Deacetylation of Gut Junctional Complex and Hepatic Proteins5
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia4
RETRACTION: Melatonin Prevents Deregulation of the Sphingosine Kinase/Sphingosine 1‐Phosphate Signaling Pathway in a Mouse Model of Diethylnitrosamine‐Induced Hepatocellular Carcinoma4
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis4
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N1‐Acetyl‐5‐methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation4
The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland4
Melatonin Enhances Aquaporin 4 and Alpha‐Syntrophin Interaction by Inhibiting Cyclin‐Dependent Kinase 5 Activity to Preserve Glymphatic Function in Neonatal Hypoxic‐Ischemic Encephalopathy4
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RETRACTION: Melatonin Attenuates Apoptotic Liver Damage in Fulminant Hepatic Failure Induced by the Rabbit Hemorrhagic Disease Virus4
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Rational modification of melatonin for broad‐spectrum antifungal agents discovery4
Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd and Free Fatty Acid‐Induced Lipotoxicity4
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression4
Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus4
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey3
GATA3‐COMT1‐Melatonin as Upstream Signaling of ABA Participated in Se‐Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L3
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence3
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Journal of Pineal Research guidelines for authors: Melatonin studies using plants3
The potential remedy of melatonin on osteoarthritis3
Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate‐induced seizures3
Safety and efficacy of melatonin supplementation as an add‐on treatment for infantile epileptic spasms syndrome: A randomized, placebo‐controlled, double‐blind trial3
Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family‐Based Cohort Study in Northern China3
Melatonin suppression by light involves different retinal photoreceptors in young and older adults3
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Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses3
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic3
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RETRACTION: Regulation of Prostaglandin Production in Carrageenan‐Induced Pleurisy Melatonin3
Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm3
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