Journal of Pineal Research

Papers
(The median citation count of Journal of Pineal Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6134
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis119
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease95
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis84
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF273
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice69
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells68
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans58
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis56
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma51
Melatonin effects on bone: Implications for use as a therapy for managing bone loss50
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression50
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis50
Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis47
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat46
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma41
Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset41
Melatonin controversies, an update39
Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia38
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure37
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations36
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport36
The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators35
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men35
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics34
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model34
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 533
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis31
S‐cone contribution to the acute melatonin suppression response in humans31
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective30
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase30
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization29
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato29
The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice28
High sensitivity of melatonin suppression response to evening light in preschool‐aged children28
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism28
Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin?28
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma27
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer25
The potential remedy of melatonin on osteoarthritis24
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis23
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic23
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana23
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway23
Exogenous melatonin decreases circadian misalignment and body weight among early types22
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐222
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence22
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses22
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells21
Melatonin and the health of menopausal women: A systematic review21
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances21
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava21
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation21
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium20
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings20
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight20
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase20
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat20
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato19
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice19
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner19
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants19
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats18
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs18
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster17
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults17
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery16
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis16
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation16
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men16
A novel role for the pineal gland: Regulating seasonal shifts in the gut microbiota of Siberian hamsters15
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction15
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students15
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation15
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy15
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling15
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model14
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes—A randomized placebo‐controlled crossover trial14
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐1914
Enhanced anti‐angiogenic activity of novel melatonin‐like agents14
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males13
Melatonin prevents experimental central serous chorioretinopathy in rats13
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis12
Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring12
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeas12
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock12
Modulations in irradiance directed at melanopsin, but not cone photoreceptors, reliably alter electrophysiological activity in the suprachiasmatic nucleus and circadian behaviour in mice12
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data12
Melatonin as a key regulator in seed germination under abiotic stress12
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression11
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin11
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets11
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia11
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress11
Angelman syndrome and melatonin: What can they teach us about sleep regulation10
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota10
Weekly and seasonal variation in the circadian melatonin rhythm in humans: Entrained to local clock time, social time, light exposure or sun time?10
Clock‐controlled arylalkylamine N‐acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana, via melatonin/MT2‐l10
Effects of dynamic lighting on circadian phase, self‐reported sleep and performance during a 45‐day space analog mission with chronic variable sleep deficiency9
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence9
N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats9
The pathway of melatonin biosynthesis in common wheat (Triticum aestivum)9
The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation9
Melatonin regulates maternal pancreatic remodeling and B‐cell function during pregnancy and lactation9
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model9
A hypothetical role for autophagy during the day/night rhythm‐regulated melatonin synthesis in the rat pineal gland9
Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake8
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava8
Photoperiod integration in C3H rd1 mice8
ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites8
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers8
Circadian photoperiod alters TREK‐1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling8
The role of circadian phase in sleep and performance during Antarctic winter expeditions8
Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression8
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors7
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression7
Melatonin in food allergy: Mechanism and potential therapy7
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis7
Measuring morning melatonin levels with plasma melatonin ELISA kits is a poor choice on two levels6
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24‐h melatonin rhythm with antiphasic daytime and nighttime peaks6
Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development6
The role of homeobox gene‐encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model6
Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems6
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors6
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease6
Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin‐producing enzyme6
Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive6
Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis6
Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior5
Daytime rest: Association with 24‐h rest–activity cycles, circadian timing and cognition in older adults5
Circadian desynchrony and glucose metabolism5
Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response5
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)5
Effects of melatonin on cardiac metabolic reprogramming in doxorubicin‐induced heart failure rats: A metabolomics study for potential therapeutic targets5
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats5
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi5
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials5
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome5
Melatonin use and the risk of 30‐day mortality among US veterans with sepsis: A retrospective study5
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Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study4
iMS‐Bmal1−/− mice show evident signs of sarcopenia that are counteracted by exercise and melatonin therapies4
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart4
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved4
The impact of daylight‐saving time (DST) on patients with delayed sleep‐wake phase disorder (DSWPD)4
RP58 knockdown contributes to hypoxia‐ischemia‐induced pineal dysfunction and circadian rhythm disruption in neonatal rats4
MdMPK3 and MdMPK6 fine‐tune MdWRKY17‐mediated transcriptional activation of the melatonin biosynthesis gene MdASMT74
The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke4
Amelioration of gamma irradiation‐induced salivary gland damage in mice using melatonin4
Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease4
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Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload4
Melatonin improves cholestatic liver disease via the gut‐liver axis3
Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice3
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control3
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification3
Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate‐induced seizures3
Efficacy, mechanism, and safety of melatonin‐loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design3
No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients3
Melatonin receptor structure and signaling3
In vitro deacetylation of N‐acetylserotonin by arylacetamide deacetylase3
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges3
Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double‐blind, placebo‐controlled trial3
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence3
Melatonin action in Plasmodium infection: Searching for molecules that modulate the asexual cycle as a strategy to impair the parasite cycle3
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial3
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light3
Angiogenesis, coagulation, and fibrinolytic markers in acute promyelocytic leukemia (NB4): An evaluation of melatonin effects3
Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism3
Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis3
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