Journal of Pineal Research

Papers
(The median citation count of Journal of Pineal Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation172
Melanopic illuminance defines the magnitude of human circadian light responses under a wide range of conditions124
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6102
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis95
Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway92
Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner89
Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner88
Melatonin confers cadmium tolerance by modulating critical heavy metal chelators and transporters in radish plants83
Daily rhythms of phytomelatonin signaling modulate diurnal stomatal closure via regulating reactive oxygen species dynamics in Arabidopsis78
Circadian rhythms and obesity: Timekeeping governs lipid metabolism76
Melatonin ameliorates aluminum toxicity through enhancing aluminum exclusion and reestablishing redox homeostasis in roots of wheat68
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease67
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies61
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis58
Measuring melatonin by immunoassay54
Clinical trial to test the efficacy of melatonin in COVID‐1953
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF252
Melatonin‐stimulated exosomes enhance the regenerative potential of chronic kidney disease‐derived mesenchymal stem/stromal cells via cellular prion proteins50
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells47
Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system46
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice44
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis44
Melatonin effects on bone: Implications for use as a therapy for managing bone loss41
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans41
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma40
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis39
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression39
Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis39
Melatonin receptor ligands: A pharmaco‐chemical perspective36
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat36
Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease34
Melatonin controversies, an update34
Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss34
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men34
Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells33
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure32
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma32
Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset32
A meta‐analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment31
The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators29
Melatonin restores the pluripotency of long‐term‐cultured embryonic stem cells through melatonin receptor‐dependent m6A RNA regulation28
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta‐analysis28
Modeling melanopsin‐mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness27
Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin?27
Melatonin‐triggered post‐transcriptional and post‐translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma27
Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway27
S‐cone contribution to the acute melatonin suppression response in humans26
The association between melatonin and episodic migraine: A pilot network meta‐analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and 26
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase26
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations26
Melatonin improves uterine‐conceptus interaction via regulation of SIRT1 during early pregnancy26
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics26
The dual roles of melatonin biosynthesis enzymes in the coordination of melatonin biosynthesis and autophagy in cassava26
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 525
Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins24
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer24
Journal of Pineal Research guideline for authors: Measuring melatonin in humans24
Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia23
Immune‐pineal axis protects rat lungs exposed to polluted air23
Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population23
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective23
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport23
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization22
Extracellular vesicles and melatonin benefit embryonic develop by regulating reactive oxygen species and 5‐methylcytosine22
The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice22
The potential remedy of melatonin on osteoarthritis22
Melatonin protects the retina from experimental nonexudative age‐related macular degeneration in mice21
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato21
Exogenous melatonin decreases circadian misalignment and body weight among early types21
Melatonin promotes regeneration of injured motor axons via MT1 receptors20
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells19
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis19
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana19
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic18
High sensitivity of melatonin suppression response to evening light in preschool‐aged children18
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model18
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway18
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis18
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings17
Dysfunction of serotonergic activity and emotional responses across the light‐dark cycle in mice lacking melatonin  MT2 receptors17
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐216
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence16
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma16
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism16
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat16
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium15
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances15
Melatonin and the health of menopausal women: A systematic review15
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats15
Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1/MT2 receptor knockout mice15
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight14
Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina14
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice14
Decreased melatonin secretion in patients with glaucoma: Quantitative association with glaucoma severity in the LIGHT study14
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase14
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men14
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation14
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults13
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants13
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis13
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐1913
Modulations in irradiance directed at melanopsin, but not cone photoreceptors, reliably alter electrophysiological activity in the suprachiasmatic nucleus and circadian behaviour in mice12
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner12
A novel role for the pineal gland: Regulating seasonal shifts in the gut microbiota of Siberian hamsters12
Enhanced anti‐angiogenic activity of novel melatonin‐like agents12
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava11
Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3‐phosphoinositides11
Melatonin rhythm and other outputs of the master circadian clock in the desert goat (Capra hircus) are entrained by daily cycles of ambient temperature11
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model11
Cancer, hear my battle CRY10
Access to electric light is associated with delays of the dim‐light melatonin onset in a traditionally hunter‐gatherer Toba/Qom community10
Deconstructing circadian disruption: Assessing the contribution of reduced peripheral oscillator amplitude on obesity and glucose intolerance in mice10
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation10
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males10
Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation9
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets9
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy9
Clock‐controlled arylalkylamine N‐acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana, via melatonin/MT2‐l9
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression9
Weekly and seasonal variation in the circadian melatonin rhythm in humans: Entrained to local clock time, social time, light exposure or sun time?9
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery9
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses9
Angelman syndrome and melatonin: What can they teach us about sleep regulation9
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students9
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato9
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes—A randomized placebo‐controlled crossover trial8
Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring8
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia8
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers8
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin8
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeas8
Circadian photoperiod alters TREK‐1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling8
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data8
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock8
The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle8
Melatonin recovers sleep phase delayed by MK‐801 through the melatonin MT2 receptor‐ Ca2+‐CaMKII‐CREB pathway in the ventrolateral preoptic nucleus8
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis7
Melatonin prevents experimental central serous chorioretinopathy in rats7
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs7
Photoperiod integration in C3H rd1 mice7
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation7
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction7
What time is it? A tale of three clocks, with implications for personalized medicine7
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model6
The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation6
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress6
Melatonin regulates maternal pancreatic remodeling and B‐cell function during pregnancy and lactation6
Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake6
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors6
A PERIOD3 variable number tandem repeat polymorphism modulates melatonin treatment response in delayed sleep‐wake phase disorder6
Measuring morning melatonin levels with plasma melatonin ELISA kits is a poor choice on two levels6
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence6
A hypothetical role for autophagy during the day/night rhythm‐regulated melatonin synthesis in the rat pineal gland6
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster6
Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive5
The role of circadian phase in sleep and performance during Antarctic winter expeditions5
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The role of homeobox gene‐encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model5
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome5
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Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24‐h melatonin rhythm with antiphasic daytime and nighttime peaks5
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis5
Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis5
Effects of dynamic lighting on circadian phase, self‐reported sleep and performance during a 45‐day space analog mission with chronic variable sleep deficiency4
N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats4
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling4
The pathway of melatonin biosynthesis in common wheat (Triticum aestivum)4
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials4
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota4
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