Journal of Pineal Research

Article	Citations
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis	121
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease	95
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis	84
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2	73
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice	69
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells	68
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans	58
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis	56
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma	51
Melatonin effects on bone: Implications for use as a therapy for managing bone loss	50
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis	50
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression	50
Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis	47
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat	47
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma	41
Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset	41
Melatonin controversies, an update	39
Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia	38
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	37
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations	36
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	36
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men	35
The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators	35
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	34
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics	34

Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5	33
S‐cone contribution to the acute melatonin suppression response in humans	31
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis	31
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective	30
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase	30
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato	29
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization	29
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism	28
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	28
The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice	28
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	27
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer	25
The potential remedy of melatonin on osteoarthritis	24
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway	23
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis	23
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic	23
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana	23
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses	22
Exogenous melatonin decreases circadian misalignment and body weight among early types	22
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2	22
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence	22
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava	21
Melatonin and the health of menopausal women: A systematic review	21
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells	21
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation	21
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances	21
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium	20
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings	20
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight	20
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	20
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat	20
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	19
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	19
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice	19
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato	19
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	19
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats	18
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	17
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults	17
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery	16
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis	16
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation	16
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men	16
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation	15
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling	15
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy	15
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction	15
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students	15
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes—A randomized placebo‐controlled crossover trial	14
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19	14

Enhanced anti‐angiogenic activity of novel melatonin‐like agents	14
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model	14
Melatonin prevents experimental central serous chorioretinopathy in rats	13
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeas	13
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	13
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males	13
Melatonin as a key regulator in seed germination under abiotic stress	12
Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring	12
Modulations in irradiance directed at melanopsin, but not cone photoreceptors, reliably alter electrophysiological activity in the suprachiasmatic nucleus and circadian behaviour in mice	12
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	12
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data	11
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression	11
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia	11
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets	11
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin	11
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress	11
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	10
Weekly and seasonal variation in the circadian melatonin rhythm in humans: Entrained to local clock time, social time, light exposure or sun time?	10
Clock‐controlled arylalkylamine N‐acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana, via melatonin/MT2‐l	10
Effects of dynamic lighting on circadian phase, self‐reported sleep and performance during a 45‐day space analog mission with chronic variable sleep deficiency	9
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence	9
N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats	9
The pathway of melatonin biosynthesis in common wheat (Triticum aestivum)	9
The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation	9
Melatonin regulates maternal pancreatic remodeling and B‐cell function during pregnancy and lactation	9
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model	9
A hypothetical role for autophagy during the day/night rhythm‐regulated melatonin synthesis in the rat pineal gland	9
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava	8
Photoperiod integration in C3H rd1 mice	8
ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites	8
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers	8
Circadian photoperiod alters TREK‐1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling	8
The role of circadian phase in sleep and performance during Antarctic winter expeditions	8
Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression	8
Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake	8
Melatonin in food allergy: Mechanism and potential therapy	7
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis	7
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors	7
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	7
The role of homeobox gene‐encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model	6
Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems	6
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors	6
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	6
Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin‐producing enzyme	6
Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive	6
Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis	6
Measuring morning melatonin levels with plasma melatonin ELISA kits is a poor choice on two levels	6
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24‐h melatonin rhythm with antiphasic daytime and nighttime peaks	6
Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development	6
Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior	5
Daytime rest: Association with 24‐h rest–activity cycles, circadian timing and cognition in older adults	5
Circadian desynchrony and glucose metabolism	5
Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response	5
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)	5
Effects of melatonin on cardiac metabolic reprogramming in doxorubicin‐induced heart failure rats: A metabolomics study for potential therapeutic targets	5
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats	5
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Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials	5
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome	5
Melatonin use and the risk of 30‐day mortality among US veterans with sepsis: A retrospective study	5
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	5
Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload	4
The impact of daylight‐saving time (DST) on patients with delayed sleep‐wake phase disorder (DSWPD)	4
RP58 knockdown contributes to hypoxia‐ischemia‐induced pineal dysfunction and circadian rhythm disruption in neonatal rats	4
MdMPK3 and MdMPK6 fine‐tune MdWRKY17‐mediated transcriptional activation of the melatonin biosynthesis gene MdASMT7	4
The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke	4
Amelioration of gamma irradiation‐induced salivary gland damage in mice using melatonin	4
Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease	4
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Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	4
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	4
Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study	4
iMS‐Bmal1−/− mice show evident signs of sarcopenia that are counteracted by exercise and melatonin therapies	4
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart	4
Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate‐induced seizures	3
Efficacy, mechanism, and safety of melatonin‐loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design	3
No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients	3
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial	3
In vitro deacetylation of N‐acetylserotonin by arylacetamide deacetylase	3
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification	3

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double‐blind, placebo‐controlled trial	3
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	3
Melatonin improves cholestatic liver disease via the gut‐liver axis	3
Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice	3
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	3
Angiogenesis, coagulation, and fibrinolytic markers in acute promyelocytic leukemia (NB4): An evaluation of melatonin effects	3
Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism	3
Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis	3
Melatonin receptor structure and signaling	3
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	3
Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland	2
Stable indoleamines attenuate stress—A novel paradigm in tryptophan metabolism in plants	2
Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets	2
An independent comparison of the Novolytix salivary melatonin radioimmunoassay with the new Novolytix salivary melatonin enzyme‐linked immunosorbent assay	2
Safety and efficacy of melatonin supplementation as an add‐on treatment for infantile epileptic spasms syndrome: A randomized, placebo‐controlled, double‐blind trial	2
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	2
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Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hypermethylation of promoters of protein kinase C alpha and cAMP response element‐binding	2
N1‐Acetyl‐5‐methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation	2
Melatonin in energy control: Circadian time‐giver and homeostatic monitor	2
Continuous light exposure influences luteinization and luteal function of ovary in ICR mice	2
Differentiation of T cells producing interleukin‐17 (Th17) against the background of exogenous melatonin during pregnancy	2
Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression‐like behaviors	2
Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer	2