OOIR: Observatory of International Research

Papers

(The median citation count of Cell Biology and Toxicology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Neurorescuing effect of Cinacalcet against hypercalcemia-induced nerve injury in chronic kidney disease via TRAF2/cIAP1/KLF2/SERPINA3 signal axis	115
Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway	97
The aryl hydrocarbon receptor directs the differentiation of murine progenitor blastomeres	83
Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin	77
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways	73
Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications	70
Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes	67
Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery	64
Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition	60
Transcriptional activation of budding yeast DDI2/3 through chemical modifications of Fzf1	56
Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air–liquid interface generated from induced pluripotent stem cells and primar	47
SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart	46
Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis	41
Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity	38
MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure	35
Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer	35
Caveolin-1-ACE2 axis modulates xenobiotic metabolism-linked chemoresistance in ovarian clear cell carcinoma	33
Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro	31
Reprogrammed lung epithelial cells by decrease of miR-451a in extracellular vesicles contribute to aggravation of pulmonary fibrosis	31
Correction to: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway	31
Astragalus mongholicus Bunge-Curcuma aromatica Salisb. suppresses growth and metastasis of colorectal cancer cells by inhibiting M2 macrophage polarization via a Sp1/ZFAS1/miR-153-3p/CCR5 regulatory a	29
Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer	28
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles carrying miR-655-3p inhibit the development of esophageal cancer by regulating the expression of HIF-1α via a LMO4/HDAC2-depen	25
Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation	25
Long non-coding RNA FOXP4-AS1 facilitates the biological functions of hepatocellular carcinoma cells via downregulating ZC3H12D by mediating H3K27me3 through recruitment of EZH2	25

Circ_0004676 exacerbates triple-negative breast cancer progression through regulation of the miR-377-3p/E2F6/PNO1 axis	24
A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity	23
LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p	23
Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress and causes impaired neuroprotection	22
Vitamin D3/VDR inhibits inflammation through NF-κB pathway accompanied by resisting apoptosis and inducing autophagy in abalone Haliotis discus hannai	22
Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure	22
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes	22
Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells	21
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane	21
Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced stemness and cisplatin resistance in nasopharyngeal carcinoma side population cells through the miR-579-3p/SIRT1/SSRP1 axis	21
3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway	21
AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance	21
Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway	20
CircZNF609 promotes bladder cancer progression and inhibits cisplatin sensitivity via miR-1200/CDC25B pathway	19
LINC01089, suppressed by YY1, inhibits lung cancer progression by targeting miR-301b-3p/HPDG axis	19
Novel paradigms of mitochondrial biology and function: potential clinical significance in the era of precision medicine	19
Prognostic significance of NT5E/CD73 in neuroblastoma and its function in CSC stemness maintenance	18
Induced pluripotent stem cell–derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury	18
Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM	18
Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation	18
Chemokine (C-X-C motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway	18
Cellular signaling crosstalk between Wnt signaling and gap junctions inbenzo[a]pyrene toxicity	18
The cytotoxicity of zinc oxide nanoparticles to 3D brain organoids results from excessive intracellular zinc ions and defective autophagy	18
T-cell senescence induced by peripheral phospholipids	18
Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFβR1-dependent manner	18
Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer	18
NSD1 promotes esophageal cancer tumorigenesis via HIF1α signaling	17
Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1/p-Akt/CEBPɑ axis and inducing M1 macrophage polarization	17
By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity	17
WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice	17
USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53	17
Ca2+ transfer via the ER-mitochondria tethering complex in neuronal cells contribute to cadmium-induced autophagy	17
Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer	16
USP8 inhibitor–induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma	16
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach	16
The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy	16
CircRNA_0026344 via miR-21 is involved in cigarette smoke–induced autophagy and apoptosis of alveolar epithelial cells in emphysema	16
Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer	15
A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action	15
CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression	15
Evodiamine as an anticancer agent: a comprehensive review on its therapeutic application, pharmacokinetic, toxicity, and metabolism in various cancers	15
Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis	15
CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway	14
Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery	14
Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1α/VEGFA axis by delivering microRNA-26a-5p	14
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer	13
miR-222-3p-containing macrophage-derived extracellular vesicles confer gemcitabine resistance via TSC1-mediated mTOR/AKT/PI3K pathway in pancreatic cancer	13
Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity	13
Targeting epigenetic deregulations for the management of esophageal carcinoma: recent advances and emerging approaches	13
MMP-9 reinforces radiation-induced delayed invasion and metastasis of neuroblastoma cells through second-signaling positive feedback with NFκB via both ERK and IKK activation	13

PCBP1-mediated regulation of WNT signaling is critical for breast tumorigenesis	13
microRNA-301b-3p from mesenchymal stem cells-derived extracellular vesicles inhibits TXNIP to promote multidrug resistance of gastric cancer cells	12
CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis	12
Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis	12
Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression	12
Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity	11
Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects	11
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice	11
Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy	11
Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring	11
The role of microRNAs in neurodegenerative diseases: a review	11
METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis	11
FK506-binding protein 2 (FKBP13) inhibit Bax-induced apoptosis in Saccharomyces cerevisiae (yeast)	11
Lipopolysaccharide facilitates immune escape of hepatocellular carcinoma cells via m6A modification of lncRNA MIR155HG to upregulate PD-L1 expression	11
Pulmonary fibrosis model using micro-CT analyzable human PSC–derived alveolar organoids containing alveolar macrophage-like cells	10
MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway	10
Regulation of arsenic methylation: identification of the transcriptional region of the human AS3MT gene	10
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy	10
Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production	10
CircJag1 promotes apoptosis of ethylene thiourea–exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/β-catenin pathway during the hindgut development of	10
LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway	10
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK	10
Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity	10
CCL24/CCR3 axis plays a central role in angiotensin II–induced heart failure by stimulating M2 macrophage polarization and fibroblast activation	10
RNF144A suppresses ovarian cancer stem cell properties and tumor progression through regulation of LIN28B degradation via the ubiquitin-proteasome pathway	10
The H3K27 demethylase controls the lateral line embryogenesis of zebrafish	10
YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis	9
Long non-coding RNA ZMIZ1-AS1 promotes osteosarcoma progression by stabilization of ZMIZ1	9
Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p	9
Development, scrutiny, and modulation of transient reporter gene assays of the xenobiotic metabolism pathway in zebrafish hepatocytes	9
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis	9
Correction to: Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer	9
Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells	9
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2	8
Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells	8
Oxygen toxicity: cellular mechanisms in normobaric hyperoxia	8
Molecular implications of HOX genes targeting multiple signaling pathways in cancer	8
Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms	8
Diesel exhaust exposure alters the expression of networks implicated in neurodegeneration in zebrafish brains	8
RETRACTED ARTICLE: Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway	8