Journal of Leukocyte Biology

Article	Citations
Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts	543
Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes	170
NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma	118
Natural products and their derivatives: Promising modulators of tumor immunotherapy	113
Innate immune receptors in platelets and platelet-leukocyte interactions	96
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19	92
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity	81
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex	80
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19	77
The vitals of NETs	75
Neutrophils mediate Th17 promotion in COVID-19 patients	63
Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS	62
Increasing complexity of NLRP3 inflammasome regulation	61
Leptin correlates with monocytes activation and severe condition in COVID-19 patients	58
IFNγ-mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells	56
The role of the microbiome and the NLRP3 inflammasome in the gut and lung	53
Specialized immune responses in the peritoneal cavity and omentum	53
The microbiota-gut-bone axis and bone health	51
Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions	51
Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors	49
B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19	43
Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function	43
Cellular immune responses in the pathophysiology of preeclampsia	42
Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis	42
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy	40

Notch signaling at the crossroads of innate and adaptive immunity	39
The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance	38
Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients	38
Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity	35
The neuro-immune microenvironment of acupoints—initiation of acupuncture effectiveness	34
Porphyromonas gingivalisinduces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis	34
Molecular interactions and functions of IL-32	34
Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction	33
Age-related changes in intestinal immunity and the microbiome	32
HLA-DR-expressing NK cells: Effective killers suspected for antigen presentation	32
From virus to inflammation, how influenza promotes lung damage	32
Intersection between macrophages and periodontal pathogens in periodontitis	30
Direct and indirect regulation of the tumor immune microenvironment by VEGF	30
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin	30
RAC2 and primary human immune deficiencies	29
Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions	29
Unraveling exhaustion in adaptive and conventional NK cells	29
1,25(OH)2D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation	28
Regulatory functions of NK cells during infections and cancer	28
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19	28
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer	28
PB1-F2 protein of highly pathogenic influenza A (H7N9) virus selectively suppresses RNA-induced NLRP3 inflammasome activation through inhibition of MAVS-NLRP3 interaction	26
Drug target validation in primary human natural killer cells using CRISPR RNP	26
Identification of a regulatory Vδ1 gamma delta T cell subpopulation expressing CD73 in human breast cancer	26
Changing the paradigm of IFN-γ at the interface between innate and adaptive immunity: Macrophage-derived IFN-γ	26
Dynamic changes in human single-cell transcriptional signatures during fatal sepsis	26
LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation	25
Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer	25
Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae	24
Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells	24
IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases	24
Spinal microglia-neuron interactions in chronic pain	24
Influenza A virus directly modulates mouse eosinophil responses	24
Platelet extracellular vesicles in COVID-19: Potential markers and makers	24
Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome	23
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression	23
Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy	23
Role of IL-6 in dendritic cell functions	23
T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination	23
TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models	22
Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren’s syndrome	22
Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis	22
CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4	22
Breakthrough concepts in immune-oncology: Cancer vaccines at the bedside	22
BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy	22
Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes	22
Immune system and cholangiocytes: A puzzling affair in primary biliary cholangitis	22
The spleen: “epicenter” in malaria infection and immunity	22
T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death	22
Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms	22

Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation	21
Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes	21
Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes	21
CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo	21
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance	21
Frontline Science: Dynamic cellular and subcellular features of migrating leukocytes revealed by in vivo lattice lightsheet microscopy	20
Regulatory CD4+ and CD8+ T cells are negatively correlated with CD4+/CD8+ T cell ratios in patients acutely infected with SARS-CoV-2	20
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response	20
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions	20
Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells	20
NLRC4 biology in immunity and inflammation	20
Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis	20
HMGB1: An overview of its roles in the pathogenesis of liver disease	20
Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection	19
Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype	19
Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation	19
Role of extracellular vesicles in atherosclerosis: An update	19
Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4	19
Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization and in vivo migration of neutrophils	19
Targeting NLRP3 and Staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages	19
MiR-155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis	19
Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis	18
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19	18
IL-38 prevents induction of trained immunity by inhibition of mTOR signaling	18
CD56dimCD57−NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+NKG2C+ memory-like NK cells	18
FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate-conditioned and diabetic macrophages	18
Periodontal ligament stem cells promote polarization of M2 macrophages	18
LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway	18
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)	18
IL-17a exacerbates hepatic ischemia–reperfusion injury in fatty liver by promoting neutrophil infiltration and mitochondria-driven apoptosis	17
Dengue virus-activated platelets modulate monocyte immunometabolic response through lipid droplet biogenesis and cytokine signaling	17
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis	17
Frontline Science: Two flavonoid compounds attenuate allergic asthma by regulating epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation	17
The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment inP. gingivalis LPS-induced periodontitis mice	17
Brief review on the roles of neutrophils in cancer development	16
Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation	16
The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis	16
Role of vitamin D in regulating COVID-19 severity—An immunological perspective	16
Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor	16
The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke	16
The multiple ways Wnt signaling contributes to acute leukemia pathogenesis	16
Immunomodulatory functions of oral mesenchymal stem cells: Novel force for tissue regeneration and disease therapy	16
Histone H4 directly stimulates neutrophil activation through membrane permeabilization	15
Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin–proteasome pathway	15
Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex	15
Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy	15
The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis	15
Frontline Science: Extracellular CIRP generates a proinflammatory Ly6G+CD11bhi subset of low-density neutrophils in sepsis	15
Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases	15
Mendelian diseases of dysregulated canonical NF-κB signaling: From immunodeficiency to inflammation	15
Macrophage dysfunction in cystic fibrosis: Nature or nurture?	15
Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance	15
Stem cell-like memory T cells: The generation and application	15
The regulatory role of insulin in energy metabolism and leukocyte functions	15
Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production	15
Escape of tumor cells from the NK cell cytotoxic activity	14
Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event	14
Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation	14
Sepsis, pyruvate, and mitochondria energy supply chain shortage	14
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells	14
Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency	14
TCF-1 maintains CD8+ T cell stemness in tumor microenvironment	14
Characterization of memory T cell subsets and common γ−chain cytokines in convalescent COVID-19 individuals	14
Tensile force transmitted through LFA-1 bonds mechanoregulate neutrophil inflammatory response	14
Ex-vivo drug testing predicts chemosensitivity in acute myeloid leukemia	14
Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22	14
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function	14
Sinomenine increases adenosine A2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR	14
Extracellular vesicle-mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response	13
Immune modulatory effects of progesterone on oxLDL-induced trained immunity in monocytes	13
TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies	13
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain	13
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells	13
At the Bedside: Profiling and treating patients with CXCR4-expressing cancers	13
Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis	13
The functions of EZH2 in immune cells: Principles for novel immunotherapies	13
P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis	13
Influenza A virus PB1-F2 protein: An ambivalent innate immune modulator and virulence factor	13
The mechanism of Chinese herbal formula HQT in the treatment of rheumatoid arthritis is related to its regulation of lncRNA uc.477 and miR-19b	13
Serum-borne lipids amplify TLR-activated inflammatory responses	12

The role of bacterial DNA containing CpG motifs in diseases	12
Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype	12
Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli	12
Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis	12
Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse	12
GABAergic signaling in human and murine NK cells upon challenge withToxoplasma gondii	12
Frontline Science: Activation of metabolic nuclear receptors restores periodontal tissue homeostasis in mice with leukocyte adhesion deficiency-1	12
Emerging neutrophil plasticity: Terminally differentiated cells no more	12
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors	12
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease	12
Monocyte subsets predict mortality after cardiac arrest	12
A novel strategy to dissect multifaceted macrophage function in human diseases	12
Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection	12
LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke	12
Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia	12