Journal of Leukocyte Biology

Article	Citations
The vitals of NETs	101
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19	82
IFNγ-mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells	72
Neutrophils mediate Th17 promotion in COVID-19 patients	69
The microbiota-gut-bone axis and bone health	66
Leptin correlates with monocytes activation and severe condition in COVID-19 patients	61
Cellular immune responses in the pathophysiology of preeclampsia	57
Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis	56
Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells	51
B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19	47
Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction	45
Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients	41
Direct and indirect regulation of the tumor immune microenvironment by VEGF	40
Intersection between macrophages and periodontal pathogens in periodontitis	40
Role of IL-6 in dendritic cell functions	39
Dynamic changes in human single-cell transcriptional signatures during fatal sepsis	36
Porphyromonas gingivalisinduces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis	36
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin	33
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19	32
Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes	32
Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae	32
Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms	32
CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo	31
IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases	29
Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren’s syndrome	29

Periodontal ligament stem cells promote polarization of M2 macrophages	29
HMGB1: An overview of its roles in the pathogenesis of liver disease	27
T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination	27
Platelet extracellular vesicles in COVID-19: Potential markers and makers	27
Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation	26
The spleen: “epicenter” in malaria infection and immunity	26
Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome	26
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions	26
Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4	25
FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate-conditioned and diabetic macrophages	24
T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death	24
Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases	23
Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype	22
Role of extracellular vesicles in atherosclerosis: An update	21
MiR-155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis	21
Stem cell-like memory T cells: The generation and application	21
Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes	21
IL-38 prevents induction of trained immunity by inhibition of mTOR signaling	21
Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation	20
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain	20
LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway	19
The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment inP. gingivalis LPS-induced periodontitis mice	19
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function	19
Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation	19
The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke	19
Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin–proteasome pathway	19
Role of vitamin D in regulating COVID-19 severity—An immunological perspective	19
TCF-1 maintains CD8+ T cell stemness in tumor microenvironment	19
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells	18
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)	18
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells	18
Immunomodulatory functions of oral mesenchymal stem cells: Novel force for tissue regeneration and disease therapy	18
The regulatory role of insulin in energy metabolism and leukocyte functions	17
Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis	17
Sinomenine increases adenosine A2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR	16
Characterization of memory T cell subsets and common γ−chain cytokines in convalescent COVID-19 individuals	16
Immunopathogenesis of oral submucous fibrosis by chewing the areca nut	16
Sepsis, pyruvate, and mitochondria energy supply chain shortage	16
Circulating inflammatory cell profiling and periodontitis: A systematic review and meta-analysis	16
In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformatics	15
LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke	15
Gut microbiota shape B cell in health and disease settings	15
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease	15
Immune modulatory effects of progesterone on oxLDL-induced trained immunity in monocytes	15
Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype	15
Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways	15
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis	14
GABAergic signaling in human and murine NK cells upon challenge withToxoplasma gondii	14
Effects of mesenchymal stromal cell-derived extracellular vesicles in acute respiratory distress syndrome (ARDS): Current understanding and future perspectives	14
A novel strategy to dissect multifaceted macrophage function in human diseases	13

Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell	13
Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity	13
P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis	13
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors	13
Neutrophil subsets and their differential roles in viral respiratory diseases	13
The role of bacterial DNA containing CpG motifs in diseases	13
IL-26 promotes the pathogenesis of malignant pleural effusion by enhancing CD4+IL-22+ T-cell differentiation and inhibiting CD8+ T-cell cytotoxicity	13
K27-linked noncanonic ubiquitination in immune regulation	13
Interference with long noncoding RNA SNHG3 alleviates cerebral ischemia-reperfusion injury by inhibiting microglial activation	13
Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats	12
Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized withCandida albicansthrough inducing β-glucan exposure	12
PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA)	12
Animal models for studies of HIV-1 brain reservoirs	12
Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2	12
The effect of an isoquinoline alkaloid on treatment of periodontitis by regulating the neutrophils chemotaxis	12
Mechanisms of HIV-1 cell-to-cell transfer to myeloid cells	12
γδ T cell exhaustion: Opportunities for intervention	12
The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms	12
Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils	12
Blood tests predict the therapeutic prognosis of anti-PD-1 in advanced biliary tract cancer	12
Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD-L1	12
Tissue-specific murine neutrophil activation states in health and inflammation	11
Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs	11
HIV-1-induced type I IFNs promote viral latency in macrophages	11
Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer	11
Neutrophil-derived extracellular vesicles modulate the phenotype of naïve human neutrophils	11
Annexin A2 regulates unfolded protein response via IRE1–XBP1 axis in macrophages duringP. aeruginosainfection	11
Shock and kill within the CNS: A promising HIV eradication approach?	11
MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells	11
Serum sphingolipid profile in asthma	11
IL-17A produced by invariant natural killer T cells and CD3+CD56+αGalcer-CD1d tetramer– T cells promote liver fibrosis in patients with primary biliary cholangitis	11
Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy	11
Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia	11
Current strategies to induce selective killing of HIV-1-infected cells	10
Erythrocyte-derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4–MyD88–NF-κB–MAPK pathway	10
Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins	10
Adipose-derived stem cell-derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622-mediated transcription factor AR	10
Metabolic reprogramming of myeloid-derived suppressor cells: An innovative approach confronting challenges	10
More than neutrophils: Lin(+)Ly6G(+)IL-5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes	10
Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases	10
Dickkopf proteins in pathological inflammatory diseases	10
Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages	10
Metabolic and functional impairment of CD8+ T cells from the lungs of influenza-infected obese mice	10
The cation channel TRPM8 influences the differentiation and function of human monocytes	10
Gift bags from the sentinel cells of the immune system: The diverse role of dendritic cell-derived extracellular vesicles	10
Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice	10
Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis	10
Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL-6 production	10
A high-calorie diet aggravates LPS-induced pneumonia by disturbing the gut microbiota and Th17/Treg balance	10
Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine	10
Follicular regulatory T cell biology and its role in immune-mediated diseases	10
Divergent Golgi trafficking limits B cell-mediated IgG sialylation	9
Pan-cancer analysis of GALNTs expression identifies a prognostic of GALNTs feature in low grade glioma	9
Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes	9
Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved	9
Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators	9
Effects of serum amyloid protein A on influenza A virus replication and viral interactions with neutrophils	9
Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation	9
Human macrophage polarization shapesB. pertussisintracellular persistence	9
Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity	9
Role of macrophages in HIV pathogenesis and cure: NIH perspectives	9
A review of signaling and transcriptional control in T follicular helper cell differentiation	9
Pulmonary and blood dendritic cells from sarcoidosis patients more potently induce IFNγ-producing Th1 cells compared with monocytes	9
HDAC11 regulates expression of C/EBPβ and immunosuppressive molecules in myeloid-derived suppressor cells	9
Polymorphonuclear myeloid-derived suppressor cells link inflammation and damage response after trauma	8
Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections	8
Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction	8
Dysregulation of the IFN-I signaling pathway byMycobacterium tuberculosisleads to exacerbation of HIV-1 infection of macrophages	8
Frontline Science: The expression of integrin αDβ2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis	8
Gender-dependent frequency of unconventional T cells in a healthy adult Caucasian population: A combinational study of invariant NKT cells, γδ T cells, and mucosa-associated invariant T cells	8
LncRNA TUG1 ameliorates diabetic nephropathy via inhibition of PU.1/RTN1 signaling pathway	8
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology	8
What a difference ADA2 makes: Insights into the pathophysiology of ADA2 deficiency from single-cell RNA sequencing of monocytes	8
The role of naturally acquired antimalarial antibodies in subclinicalPlasmodiumspp. infection	8
Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients	8
Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition	8
Neutrophils vs. amoebas: Immunity against the protozoan parasiteEntamoeba histolytica	8
2022 update on the scientific premise and clinical trials for IL-15 agonists as cancer immunotherapy	8
Dysregulated Th1 cells in lung squamous cell carcinoma	7
Hepatic F4/80+CD11b+CD68– cells influence the antibacterial response in irradiated mice with sepsis by Enterococcus faecalis	7

The emerging therapeutic potential of extracellular vesicles in trauma	7
Surface translocator protein 18 kDa (TSPO) localization on immune cells upon stimulation with LPS and in ART-treated HIV+ subjects	7
IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge withP. yoelii	7
Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation	7
Analysis of potential biomarkers of response to IL-12 therapy	7
Historical Perspective: Metchnikoff and the intestinal microbiome	7
Exogenous ATP modulates PGE2 release in macrophages through sustained phosphorylation of CDK9 and p38 MAPK	7
ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection	7
LncRNA NEAT1_1 suppresses tumor-like biologic behaviors of fibroblast-like synoviocytes by targeting the miR-221-3p/uPAR axis in rheumatoid arthritis	7
Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis	7
Immune senescence and periodontitis: From mechanism to therapy	7
Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques	7
Differential expression of maturation and activation markers on NK cells in patients with active and latent tuberculosis	7
Elevated F-EDN correlates with mucosal eosinophil degranulation in patients with IBS—A possible association with microbiota?	7
Human monocytes store and secrete preformed CCL5, independent of de novo protein synthesis	7
ILC3-like ILC2 subset increases in minimal persistent inflammation after acute type II inflammation of allergic rhinitis and inhibited by Biminkang: Plasticity of ILC2 in minimal persistent inflammati	7
Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function	7
Tanshinone IIA enhances susceptibility of non-small cell lung cancer cells to NK cell-mediated lysis by up-regulating ULBP1 and DR5	7
Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles	7
Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza	7
Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood	7
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury	7
T cell activation and IFNγ modulate organ dysfunction in LPS-mediated inflammation	6
IL-7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression	6
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage	6
Clinical utility of heparin-binding protein as an acute-phase inflammatory marker in interstitial lung disease	6
Leishmania regulates host macrophage miRNAs expression by engaging transcription factor c-Myc	6
PAD4 controls chemoattractant production and neutrophil trafficking in malaria	6
Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions	6
Landscape of T Cells in NK-AML(M4/M5) Revealed by Single-Cell Sequencing	6
The molecular basis of Rac-GTP action—promoting binding of p67phoxto Nox2 by disengaging the β hairpin from downstream residues	6
BCG-trained innate immunity leads to fetal growth restriction by altering immune cell profile in the mouse developing placenta	6
Flunarizine suppressesMycobacterium tuberculosisgrowth via calmodulin-dependent phagosome maturation	6
Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies	6
Hspa8 and ICAM-1 as damage-induced mediators of γδ T cell activation	6
Atypical monocytes in COVID-19: Lighting the fire of cytokine storm?	6
High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines	6
The WASp L272P gain-of-function mutation alters dendritic cell coordination of actin dynamics for migration and adhesion	6
T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction	6
IL-17A aggravates asthma-induced intestinal immune injury by promoting neutrophil trafficking	6
The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial cell proliferation	6
Cross-reactive cellular, but not humoral, immunity is detected between OC43 and SARS-CoV-2 NPs in people not infected with SARS-CoV-2: Possible role of cTFH cells	6
Gab2 promotes acute myeloid leukemia growth and migration through the SHP2-Erk-CREB signaling pathway	6
Maintenance of gut barrier integrity after injury: Trust your gut microRNAs	6
Gut microbiota contributes to sexual dimorphism in murine autoimmune cholangitis	6
Multi-omics analysis of the expression and prognostic value of the butyrophilins in breast cancer	6
Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation	5
A novel clinically relevant graft-versus-leukemia model in humanized mice	5
Immunotherapeutic effect of adenovirus encoding antimicrobial peptides in experimental pulmonary tuberculosis	5
STAT5 promotes chronic pancreatitis by enhancing GM-CSF-dependent neutrophil augmentation	5
Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization	5
Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles	5
Activation of human γδ T cells and NK cells by Staphylococcal enterotoxins requires both monocytes and conventional T cells	5
Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology	5
Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors	5
γδ T cells: The potential role in liver disease and implications for cancer immunotherapy	5
Frontline Science: Estrogen-related receptor γ increases poly(I:C)-mediated type I IFN expression in mouse macrophages	5
Adoptive transfer of GRP78-treated dendritic cells alleviates insulitis in NOD mice	5
Oxidation of bacillithiol during killing ofStaphylococcus aureusUSA300 inside neutrophil phagosomes	5
Stabilizing the immune system by chlorogenic acid	5
Functional consequences of a close encounter between microglia and brain-infiltrating monocytes during CNS pathology and repair	5
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848	5
Fatty acids secreted from head and neck cancer induce M2-like Macrophages	5
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection	5
PD-L1 expression in peripheral blood granulocytes at diagnosis as prognostic factor in classical Hodgkin lymphoma	5
IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR	5
Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation	5
Heparanase is a regulator of natural killer cell activation and cytotoxicity	5
Acetyl-CoA carboxylase-1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO	5
Neuroimmune interactions in painful TMD: Mechanisms and treatment implications	5
A review of the mechanisms of keratinocytes damage caused byStaphylococcus aureusinfection in patients with atopic dermatitis	5
The FasLane to ocular pathology—metalloproteinase cleavage of membrane-bound FasL determines FasL function	5
DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling	5
Physiologic roles of P2 receptors in leukocytes	5
A curious case of cyclin-dependent kinases in neutrophils	5
Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants	5
Circulating B10 regulatory cells are decreased in severe and critical COVID-19	5