OOIR: Observatory of International Research

Papers

(The TQCC of Genetic Epidemiology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
	186
The Translational Machine: A novel machine‐learning approach to illuminate complex genetic architectures	69
Are trait‐associated genes clustered together in a gene network?	39
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study	29
Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes	28
Gene‐level association analysis of ordinal traits with functional ordinal logistic regressions	24
A gene‐based association test of interactions for maternal–fetal genotypes identifies genes associated with nonsyndromic congenital heart defects	20
A Brief History behind the journal Genetic Epidemiology and the International Genetic Epidemiology Society	19
Deconvolution analysis of cell‐type expression from bulk tissues by integrating with single‐cell expression reference	19
Assisted differential network analysis for gene expression data	17
Bias and mean squared error in Mendelian randomization with invalid instrumental variables	17
Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain	16
The eigen higher criticism and eigen Berk–Jones tests for multiple trait association studies based on GWAS summary statistics	16
Statistical power of transcriptome‐wide association studies	12
	12
Adjusting for collider bias in genetic association studies using instrumental variable methods	11
A two‐sample robust Bayesian Mendelian Randomization method accounting for linkage disequilibrium and idiosyncratic pleiotropy with applications to the COVID‐19 outcomes	11
Multivariable MR Can Mitigate Bias in Two‐Sample MR Using Covariable‐Adjusted Summary Associations	10
A Novel One‐Sample Mendelian Randomization Approach for Count‐Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects	10
	9
Issue Information	9
Issue Information	9
	9
Gene‐level association analysis of bivariate ordinal traits with functional regressions	8
Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses	8

Genome‐wide association studies of 27 accelerometry‐derived physical activity measurements identified novel loci and genetic mechanisms	8
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Collider bias from selecting disease samples distorts causal inferences	7
Genome‐wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes	7
Issue Information	7
Effect of case and control definitions on genome‐wide association study (GWAS) findings	7
Sensitivity analyses gain relevance by fixing parameters observable during the empirical analyses	7
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries	7
The X factor: A robust and powerful approach to X‐chromosome‐inclusive whole‐genome association studies	6
	6
Integrating external controls in case–control studies improves power for rare‐variant tests	5
Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels	5
Control for population stratification in genetic association studies based on GWAS summary statistics	5
Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits	5
Covariate adjusted inference of parent‐of‐origin effects using case–control mother–child paired multilocus genotype data	4
Issue Information	4
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons	4
A Mixed‐Effect Kernel Machine Regression Model for Integrative Analysis of Alpha Diversity in Microbiome Studies	4
Structured testing of genetic association with mixed clinical outcomes	4
Issue Information	4
Ethical, Legal, and Social Implications of Gene‐Environment Interaction Research	4
Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest‐neighbor feature selection	4
	4
Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow‐Up Studies	4
Meta‐analysis of breast cancer risk for individuals with PALB2 pathogenic variants	3
Exploring polygenic‐environment and residual‐environment interactions for depressive symptoms within the UK Biobank	3
Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid‐Related Loci as the Main Driver of Opioid Use Disorder	3
Abstracts	3
Inverse probability weighting is an effective method to address selection bias during the analysis of high dimensional data	3
Dimension Reduction Using Local Principal Components for Regression‐Based Multi‐SNP Analysis in 1000 Genomes and the Canadian Longitudinal Study on Aging (CLSA)	3
simmrd: An open‐source tool to perform simulations in Mendelian randomization	3
Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals	3
The influence of unmeasured confounding on the MR Steiger approach	3
Parent‐of‐Origin Effects in Childhood Asthma at Seven Years of Age	3
Phenotypic variance partitioning by transcriptomic gene expression levels and environmental variables for anthropometric traits using GTEx data	3