OOIR: Observatory of International Research

Papers

(The TQCC of Genetic Epidemiology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
	224
Are trait‐associated genes clustered together in a gene network?	89
Gene‐level association analysis of ordinal traits with functional ordinal logistic regressions	36
A gene‐based association test of interactions for maternal–fetal genotypes identifies genes associated with nonsyndromic congenital heart defects	35
Deconvolution analysis of cell‐type expression from bulk tissues by integrating with single‐cell expression reference	29
Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes	20
A Brief History behind the journal Genetic Epidemiology and the International Genetic Epidemiology Society	20
Bias and mean squared error in Mendelian randomization with invalid instrumental variables	19
	13
The eigen higher criticism and eigen Berk–Jones tests for multiple trait association studies based on GWAS summary statistics	13
A two‐sample robust Bayesian Mendelian Randomization method accounting for linkage disequilibrium and idiosyncratic pleiotropy with applications to the COVID‐19 outcomes	12
Statistical power of transcriptome‐wide association studies	12
Adjusting for collider bias in genetic association studies using instrumental variable methods	11
Issue Information	10
	10
A Novel One‐Sample Mendelian Randomization Approach for Count‐Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects	10
	9
	9
Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses	8
Issue Information	8
Gene‐level association analysis of bivariate ordinal traits with functional regressions	8
A Robust Association Test Leveraging Unknown Genetic Interactions: Application to Cystic Fibrosis Lung Disease	7
Multivariable MR Can Mitigate Bias in Two‐Sample MR Using Covariable‐Adjusted Summary Associations	6
Genome‐wide association studies of 27 accelerometry‐derived physical activity measurements identified novel loci and genetic mechanisms	6
Issue Information	6

Sensitivity analyses gain relevance by fixing parameters observable during the empirical analyses	6
Uncovering Ethnicity‐Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family‐Based WGS Analysis	5
Genome‐wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes	5
Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels	5
Collider bias from selecting disease samples distorts causal inferences	5
Effect of case and control definitions on genome‐wide association study (GWAS) findings	5
	5
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries	5
Integrating external controls in case–control studies improves power for rare‐variant tests	5
Control for population stratification in genetic association studies based on GWAS summary statistics	4
Structured testing of genetic association with mixed clinical outcomes	4
A Mixed‐Effect Kernel Machine Regression Model for Integrative Analysis of Alpha Diversity in Microbiome Studies	4
Covariate adjusted inference of parent‐of‐origin effects using case–control mother–child paired multilocus genotype data	4
Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits	4
	3
Issue Information	3
Ethical, Legal, and Social Implications of Gene‐Environment Interaction Research	3
Phenotypic variance partitioning by transcriptomic gene expression levels and environmental variables for anthropometric traits using GTEx data	3
Issue Information	3
Meta‐analysis of breast cancer risk for individuals with PALB2 pathogenic variants	3
Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow‐Up Studies	3
Genome‐Wide Association Analyses in Family Triads and Dyads Following Assisted Reproductive Technology	3
Abstracts	3
Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest‐neighbor feature selection	3
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons	3
Exploring polygenic‐environment and residual‐environment interactions for depressive symptoms within the UK Biobank	3
The influence of unmeasured confounding on the MR Steiger approach	3
Statistical learning for sparser fine‐mapped polygenic models: The prediction of LDL‐cholesterol	2
Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank	2
Comparison of regmed and BayesNetty for exploring causal models with many variables	2
Correction to “Abstracts”	2
Parent‐of‐Origin Effects in Childhood Asthma at Seven Years of Age	2
REHE: Fast variance components estimation for linear mixed models	2
Use of genetic correlations to examine selection bias	2
General Kernel Machine Methods for Multi‐Omics Integration and Genome‐Wide Association Testing With Related Individuals	2
Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid‐Related Loci as the Main Driver of Opioid Use Disorder	2
Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores	2
simmrd: An open‐source tool to perform simulations in Mendelian randomization	2
Improved two‐step testing of genome‐wide gene–environment interactions	2
	2
Issue Information	2
Dimension Reduction Using Local Principal Components for Regression‐Based Multi‐SNP Analysis in 1000 Genomes and the Canadian Longitudinal Study on Aging (CLSA)	2