Genetic Epidemiology

Article	Citations
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Are trait‐associated genes clustered together in a gene network?	74
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study	39
Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes	32
Gene‐level association analysis of ordinal traits with functional ordinal logistic regressions	29
A gene‐based association test of interactions for maternal–fetal genotypes identifies genes associated with nonsyndromic congenital heart defects	25
A Brief History behind the journal Genetic Epidemiology and the International Genetic Epidemiology Society	19
Deconvolution analysis of cell‐type expression from bulk tissues by integrating with single‐cell expression reference	19
Assisted differential network analysis for gene expression data	18
The eigen higher criticism and eigen Berk–Jones tests for multiple trait association studies based on GWAS summary statistics	17
Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain	17
Bias and mean squared error in Mendelian randomization with invalid instrumental variables	17
A two‐sample robust Bayesian Mendelian Randomization method accounting for linkage disequilibrium and idiosyncratic pleiotropy with applications to the COVID‐19 outcomes	12
A Novel One‐Sample Mendelian Randomization Approach for Count‐Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects	12
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Adjusting for collider bias in genetic association studies using instrumental variable methods	12
Statistical power of transcriptome‐wide association studies	11
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Multivariable MR Can Mitigate Bias in Two‐Sample MR Using Covariable‐Adjusted Summary Associations	10
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Gene‐level association analysis of bivariate ordinal traits with functional regressions	9
Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses	9
Sensitivity analyses gain relevance by fixing parameters observable during the empirical analyses	8

Genome‐wide association studies of 27 accelerometry‐derived physical activity measurements identified novel loci and genetic mechanisms	8
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries	8
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Genome‐wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes	7
Effect of case and control definitions on genome‐wide association study (GWAS) findings	7
Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits	6
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Collider bias from selecting disease samples distorts causal inferences	6
The X factor: A robust and powerful approach to X‐chromosome‐inclusive whole‐genome association studies	5
Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels	5
Covariate adjusted inference of parent‐of‐origin effects using case–control mother–child paired multilocus genotype data	5
A Mixed‐Effect Kernel Machine Regression Model for Integrative Analysis of Alpha Diversity in Microbiome Studies	5
Control for population stratification in genetic association studies based on GWAS summary statistics	5
Integrating external controls in case–control studies improves power for rare‐variant tests	5
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Ethical, Legal, and Social Implications of Gene‐Environment Interaction Research	4
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Structured testing of genetic association with mixed clinical outcomes	4
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Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow‐Up Studies	4
Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest‐neighbor feature selection	4
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons	4
Abstracts	4
Dimension Reduction Using Local Principal Components for Regression‐Based Multi‐SNP Analysis in 1000 Genomes and the Canadian Longitudinal Study on Aging (CLSA)	3
Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid‐Related Loci as the Main Driver of Opioid Use Disorder	3
Exploring polygenic‐environment and residual‐environment interactions for depressive symptoms within the UK Biobank	3
Inverse probability weighting is an effective method to address selection bias during the analysis of high dimensional data	3
Parent‐of‐Origin Effects in Childhood Asthma at Seven Years of Age	3
The influence of unmeasured confounding on the MR Steiger approach	3
Meta‐analysis of breast cancer risk for individuals with PALB2 pathogenic variants	3
Phenotypic variance partitioning by transcriptomic gene expression levels and environmental variables for anthropometric traits using GTEx data	3
Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals	3
simmrd: An open‐source tool to perform simulations in Mendelian randomization	2
Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank	2
Comparison of regmed and BayesNetty for exploring causal models with many variables	2
Penalized mediation models for multivariate data	2
General Kernel Machine Methods for Multi‐Omics Integration and Genome‐Wide Association Testing With Related Individuals	2
Statistical learning for sparser fine‐mapped polygenic models: The prediction of LDL‐cholesterol	2
Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores	2
Improved two‐step testing of genome‐wide gene–environment interactions	2
Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data	2
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REHE: Fast variance components estimation for linear mixed models	2
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Use of genetic correlations to examine selection bias	2
Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Stu	2
Correction to “Abstracts”	2
Selection bias when inferring the effect direction in Mendelian randomization	1
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OSCAA: A two‐dimensional Gaussian mixture model for copy number variation association analysis	1

The sequence kernel association test for multicategorical outcomes	1
Genetic heterogeneity: Challenges, impacts, and methods through an associative lens	1
Data‐adaptive and pathway‐based tests for association studies between somatic mutations and germline variations in human cancers	1
Estimating Causal Effects on a Disease Progression Trait Using Bivariate Mendelian Randomisation	1
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Random effect based tests for multinomial logistic regression in genetic association studies	1
Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor	1
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Sparse group variable selection for gene–environment interactions in the longitudinal study	1
Fine‐Mapping the Results From Genome‐Wide Association Studies of Primary Biliary Cholangitis Using SuSiE and h2‐D2	1
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InTACT: An adaptive and powerful framework for joint‐tissue transcriptome‐wide association studies	1
Gene−Air Pollution Interaction and Diversity of Genetic Sampling: The Southern California Children's Health Study	1
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An exploration of linkage fine‐mapping on sequences from case‐control studies	1
Taking population stratification into account by local permutations in rare‐variant association studies on small samples	1
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Limitation of permutation‐based differential correlation analysis	1
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Bias correction for inverse variance weighting Mendelian randomization	1
Using parent‐offspring pairs and trios to estimate indirect genetic effects in education	1
Genome‐Wide Association Studies of Down Syndrome Associated Congenital Heart Defects Suggests a Genetically Heterogeneous Risk for CHD in DS	1
MR‐BOIL: Causal inference in one‐sample Mendelian randomization for binary outcome with integrated likelihood method	0
Mendelian randomization in the multivariate general linear model framework	0
Abstracts	0
Identifying genes associated with disease outcomes using joint sparse canonical correlation analysis—An application in renal clear cell carcinoma	0
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Joint analysis of multiple phenotypes for extremely unbalanced case‐control association studies	0
RoPE: A robust profile likelihood method for differential gene expression analysis	0
Statistical methods to detect mother–father genetic interaction effects on risk of infertility: A genome‐wide approach	0
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Identifying Disease Associated Multi‐Omics Network With Mixed Graphical Models Based on Markov Random Field Model	0
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RAVAQ: An integrative pipeline from quality control to region‐based rare variant association analysis	0
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Weak and pleiotropy robust sex‐stratified Mendelian randomization in the one sample and two sample settings	0
A Novel Statistical Method for Unmasking Sex‐Specific Genomics Signatures in Complex Traits	0
A Bayesian hierarchically structured prior for gene‐based association testing with multiple traits in genome‐wide association studies	0
Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models	0
A novel application of data‐consistent inversion to overcome spurious inference in genome‐wide association studies	0
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Making sense of breast cancer risk estimates	0
Powerful Rare‐Variant Association Analysis of Secondary Phenotypes	0
Hierarchical joint analysis of marginal summary statistics—Part II: High‐dimensional instrumental analysis of omics data	0
Three Loci Affecting Variance of Body Mass Index in African Americans and Sub‐Saharan Africans	0
An empirical Bayes approach to improving population‐specific genetic association estimation by leveraging cross‐population data	0
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Breast and bowel cancers diagnosed in people ‘too young to have cancer’: A blueprint for research using family and twin studies	0
Clarifying the causes of consistent and inconsistent findings in genetics	0
Gene‐based association tests in family samples using GWAS summary statistics	0
Integrative Multi‐Omics Approach for Improving Causal Gene Identification	0
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FAT4 identified as a potential modifier of orofacial cleft laterality	0
Interval estimate of causal effect in summary data based Mendelian randomization in the presence of winner's curse	0
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Proteome‐wide association study using cis and trans variants and applied to blood cell and lipid‐related traits in the Women's Health Initiative study	0
Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes	0
Testing and estimation of X‐chromosome SNP effects: Impact of model assumptions	0
Unveiling challenges in Mendelian randomization for gene–environment interaction	0
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Reference‐Based Standardization Approach Stabilizing Small Batch Risk Prediction via Polygenic Score	0
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Interaction between genetics and smoking in determining risk of coronary artery diseases	0
Sparse prediction informed by genetic annotations using the logit normal prior for Bayesian regression tree ensembles	0
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Precisely modeling zero‐inflated count phenotype for rare variants	0
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Post hoc power is not informative	0
Bayesian multivariant fine mapping using the Laplace prior	0
Refinement of a Published Gene‐Physical Activity Interaction Impacting HDL‐Cholesterol: Role of Sex and Lipoprotein Subfractions	0
Deep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK Biobank	0
Transferability of Single‐ and Cross‐Tissue Transcriptome Imputation Models Across Ancestry Groups	0

Statistical methods for Mendelian models with multiple genes and cancers	0
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Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes	0
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Haplotype reconstruction for genetically complex regions with ambiguous genotype calls: Illustration by the KIR gene region	0
A fast linkage method for population GWAS cohorts with related individuals	0
A large‐scale transcriptome‐wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine‐mapping	0
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Secondary analyses for genome‐wide association studies using expression quantitative trait loci	0
Including diverse and admixed populations in genetic epidemiology research	0
Hierarchical joint analysis of marginal summary statistics—Part I: Multipopulation fine mapping and credible set construction	0
Study of effect modifiers of genetically predicted CETP reduction	0
Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: Application of cis‐multivariable Mendelian randomization to GLP1R gene region	0
Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization	0
Benchmarking statistical methods for analyzing parent–child dyads in genetic association studies	0
Inference of causal metabolite networks in the presence of invalid instrumental variables with GWAS summary data	0
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PSAP‐Genomic‐Regions: A Method Leveraging Population Data to Prioritize Coding and Non‐Coding Variants in Whole Genome Sequencing for Rare Disease Diagnosis	0
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Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with ‘cigarette smoking initiation’ really capturing?	0
Fast and accurate recurrent event analysis for genome‐wide association studies	0
GWASBrewer: An R Package for Simulating Realistic GWAS Summary Statistics	0
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Exploring and Accounting for Genetically Driven Effect Heterogeneity in Mendelian Randomization	0
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Identifying genetic risk variants associated with brain volumetric phenotypes via K‐sample Ball Divergence method	0
A Bayesian hierarchical model for improving measurement of 5mC and 5hmC levels: Toward revealing associations between phenotypes and methylation states	0
Assumptions about frequency‐dependent architectures of complex traits bias measures of functional enrichment	0
DYNATE: Localizing rare‐variant association regions via multiple testing embedded in an aggregation tree	0
Statistical methods for cis‐Mendelian randomization with two‐sample summary‐level data	0
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RetroFun‐RVS: A Retrospective Family‐Based Framework for Rare Variant Analysis Incorporating Functional Annotations	0
Enhancing Gene Expression Predictions Using Deep Learning and Functional Annotations	0
ioSearch: An approach for identifying interacting multiomics biomarkers using a novel algorithm with application on breast cancer data sets	0
Multi‐marker genetic association and interaction tests with interval‐censored survival outcomes	0
Identifying somatic fingerprints of cancers defined by germline and environmental risk factors	0
Adaptive Bayesian variable clustering via structural learning of breast cancer data	0
Polygenic hazard score models for the prediction of Alzheimer's free survival using the lasso for Cox's proportional hazards model	0
Analysis of parent‐of‐origin effects for secondary phenotypes using case–control mother–child pair data	0
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Block coordinate descent algorithm improves variable selection and estimation in error‐in‐variables regression	0
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Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids	0
Gene–environment interaction analysis via deep learning	0
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Mediation analysis of multiple mediators with incomplete omics data	0
Ravages: An R package for the simulation and analysis of rare variants in multicategory phenotypes	0
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Revealing genomic heterogeneity and commonality: A penalized integrative analysis approach accounting for the adjacency structure of measurements	0
Additional article of this Special Issue was previously published in another issue of Genetic Epidemiology. That is:	0
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Comparing Ancestry Standardization Approaches for a Transancestry Colorectal Cancer Polygenic Risk Score	0
Interpreting disease genome‐wide association studies and polygenetic risk scores given eligibility and study design considerations	0
Predicting Lung Cancer in Korean Never‐Smokers With Polygenic Risk Scores	0
New proposal to address mediation analysis interrogations by using genetic variants as instrumental variables	0
Multitrait transcriptome‐wide association study (TWAS) tests	0
Efficient identification of trait‐associated loss‐of‐function variants in the UK Biobank cohort by exome‐sequencing based genotype imputation	0
Shared genetic risk between major orofacial cleft phenotypes in an African population	0
Uncertainty Quantification in Epigenetic Clocks via Conformalized Quantile Regression	0
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A novel transcriptional risk score for risk prediction of complex human diseases	0