Cancer Investigation

Article	Citations
Clinical Characteristics and Impact on Prognosis of Melanoma Accompanied by Multiple Primary Malignancies: A Retrospective Analysis	108
Artificial Intelligence in Cancer Clinical Research: V. What We Have Learned About Human Intelligence from Artificial Intelligence	45
Racial Diversity and Reporting in United States Food and Drug Administration Registration Trials for Thoracic Malignancies from 2006 to 2020	30
CTL-NK Signature Based on Immune Gene Profiling and IHC Predicts Clinical Outcomes in Triple-Negative Breast Cancer	25
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients	25
Adverse Events Induced by Nivolumab Plus Ipilimumab vs. Nivolumab Monotherapy among Cancer Patients: A Systematic Review and Meta-Analysis	23
Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies	23
Circulating Tumor DNA in Tracking Minimal Residual Disease and Recurrence in Ovarian Cancer: A Retrospective Cohort	22
COVID-19 Outbreak Impact on Cancer Multidisciplinary Team Meetings. A Multicenter French Experience	20
Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database	15
Clinical Analysis of the Efficacy and Safety of Different Neoadjuvant Strategies in the Treatment of Locally Advanced Rectal Cancer	14
PARP Inhibitors Rising as an Epoch-Making Strategy in First-Line Maintenance Therapy of Ovarian Cancer: A Systematic Review and Meta-Analysis	14
Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases	13
Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants	12
The Democratization of Hematology-Oncology Medical Education during the COVID-19 Pandemic	12
A Nomogram for Predicting Survival in Advanced Non-Small-Cell Lung Carcinoma Patients: A Population-Based Study	12
Gene Expression Analysis of Early Stage Changes in Pancreatic Cancer by Kras G12D Transfer in Pancreatic Progenitor-	11
Long Non-Coding RNA and Chemoresistance in Bladder Cancer – A Mini Review	11
Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance	10
Correction	10
The Relationship Between Body Image and Meaning of Life Among Women with Breast Cancer in Kerman, Iran	9
A Mechanistic Review of Methotrexate and Celecoxib as a Potential Metronomic Chemotherapy for Oral Squamous Cell Carcinoma	9
Clinical and Pathological Characteristics of the Mammary Paget’s Disease: A Single-Center Retrospective Study in Japan	9
Immunomodulatory Effect of First-Line Cisplatin Versus Carboplatin in Response to Second-Line Nivolumab Therapy in Metastatic Non-Small Cell Lung Cancer	8
Perception, Cognition and Thought: Part I Nature, Evolution and Development of Conceptual and Symbolic Processes	8

Early Changes in Lymphocyte/Monocyte Ratio on Treatment as a Prognostic Marker to Predict Overall Survival in Patients with Advanced Cancer Treated with Immune Checkpoint Inhibitors	7
Determinants of Post-Traumatic Growth and Quality of Life in Ghanaian Breast Cancer Survivors	7
A Review on Emerging Techniques for Diagnosis of Colorectal Cancer	7
Decision Aids for Decision Making about Locally Advance Breast Cancer: A Systematic Review	7
Stereotactic Body Radiation Therapy in the Management of Oligometastatic Uterine Cancer	7
Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance	7
Practice-Changing Trials in Gastrointestinal Cancers at ASCO 2025: A Critical Review and Clinical Context	7
Webinar as an Informational Resource on Trastuzumab Biosimilars: Planning, Promotion, Execution, and Evaluation	6
Dynamic Changes of Peripheral NK Cells Predict Outcome in Patients with PD-L1 Positive Non-small-cell Lung Cancer Undergoing Immune Checkpoint Inhibitors as Second-line Therapy	6
Efficacy and Safety of Different Dosages of Anlotinib Combined with PD-1 Monoclonal Antibody in the Treatment of Advanced Non-Small Cell Lung Cancer	6
Assessing Chemotherapy-Induced Peripheral Neuropathy in Postmenopausal Breast Cancer Patients Using Vibration Perception Threshold	6
Sepsis-related outcomes of patients with Philadelphia-negative myeloproliferative neoplasms	6
Tumoral Overexpression of Hepcidin is Associated with Poor Prognosis of Patients with Clear Cell Renal Cell Carcinoma	6
Correction	6
Comparative Evaluation of Serum Irisin Levels in Cancer Patients and Healthy Individuals: A Systematic Review and Meta-Analysis of Diagnostic Evidence	6
Integrative Analysis Developing and Validating Potential Candidate Biomarkers for Cancer Stemness Features of Pan-Renal Cell Carcinoma	6
Research Progress of Nutrition and Coagulation-Based Markers as Predictors for Digestive System Cancers	6
Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018	5
Turning the Tables: How Encorafenib and Binimetinib are Reshaping NSCLC Treatment	5
Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms	5
Capecitabine-Enhanced Brachytherapy in Locally Advanced Cervical Cancer: A Phase II Non-Randomized Trial on Safety and Efficacy	5
Predictors of Acute Kidney Injury in Patients Prescribed Immune Checkpoint Inhibitor Therapy and Their Association with Death: A Systematic Review and Meta-Analysis	5
The Effect of Group Counselling on Body Image and Sexual Satisfaction Among Women with Breast Cancer: A Randomized Clinical Trial	5
Differential Toxicity of Immune Checkpoint Inhibitors in Older Adults: A Large-Scale, Propensity Score-Matched Real-World Analysis	5
An Overview of Cancer Biology, Pathophysiological Development and It’s Treatment Modalities: Current Challenges of Cancer anti-Angiogenic Therapy	5
p53 Missense Mutation is Associated with Immune Cell PD-L1 Expression in Triple-Negative Breast Cancer	5
The Nature, Origin and Evolution of Life: Part II The Origin of Life	5
Fusobacterium Detected in Barrett’s Esophagus and Esophageal Adenocarcinoma Tissues	5
Analytical and Clinical Validation of a Target-Enhanced Whole Genome Sequencing-Based Comprehensive Genomic Profiling Test	5
Interplay Between ERK1/2 Signaling Pathway and Estradiol Receptor Modulates ER Targeted Genes Involved in Progression of Estrogen Responsive Breast Cancers	4
Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma	4
Recurrence Patterns and Clinical Management after a Positive Sentinel Node Biopsy in Melanoma Patients	4
Real World Presentation and Treatment Outcomes with a Predominant Induction Chemotherapy Based Approach in Nasopharyngeal Carcinoma: A Sixteen Year Report from a Teaching Hospital in India	4
Immunomodulation of the Breast Cancer Microenvironment by Tumor-Derived Exosomes: Implications for Immunotherapy	4
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: A Survey Study	4
Evaluation of High-Dimensional Data Classification for Skin Malignancy Detection Using DL-Based Techniques	4
Neoadjuvant Therapy and Axillary Lymph Node Status in HER2-Positive Breast Cancer	4
Advanced Machine Learning and Multiomics Reveal Tumor Dynamics and Therapeutic Opportunities in Glioblastoma Multiforme	4
Metagenomic Analysis of Biliary Microbial Flora in Patients with Gallbladder Cancer or Gallstones-Associated Chronic Cholecystitis	4
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: Correspondence	4
Fear of Cancer Recurrence and COVID-19 Anxiety Among Cancer Survivors: A Cross-Sectional Study in Southeast Iran	4
The Needs of Patients with Cancer Interested in Complementary and Alternative Medicine with Respect to the Physician’s Attitude and Behaviour	4
Human Mycobiota and Its Role in Cancer Progression, Diagnostics and Therapeutics: A Link Lesser-Known	4
Risk Factors and Epidemiological Trends (1990–2021) in Esophageal Cancer Across East and South Asia	4
Telomere Shortening of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese Patients	4
Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs)	4
Cancer Inducing Role of BK Polyomavirus Large T Antigen: Molecular Signaling View	4
Chemotherapy-Induced Oral Complications and Prophylaxis Strategies	3
Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model	3
A Systematic Review of the Efficacy of KRAS p.G12C Inhibitors in Metastatic Colorectal Cancer: The Current State of Science	3

Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls	3
Magnetic Resonance Imaging Guided Prostate Biopsy in Patients with ≥ One Negative Systematic Transrectal Ultrasound-Guided Biopsy: A Systemic Review and Meta-Analysis	3
Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease	3
Evidence-Based Medicine and Complementary and Alternative Medicine – Attitudes and Knowledge of German Medical Students	3
Increased Risk of Hyperglycemia in Advanced Urothelial Cancer Patients Treated with Enfortumab Vedotin: A Systematic Review and Meta-Analysis	3
Suspension of Oncology Randomized Clinical Trials during the COVID-19 Pandemic: A Cross-Sectional Evaluation of COVID-Related Suspensions	3
Role of the Family in Treatment Decision-Making for Women with Breast Cancer: a Study from China	3
Correction	3
Ethical Principles in the Analysis of Prostate Cancer Diagnostics	3
The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis	3
The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer	3
Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma	3
Flamingo Search Sailfish Optimizer Based SqueezeNet for Detection of Breast Cancer Using MRI Images	3
Gender, Bladder Cancer Healthcare and Burden of COVID-19	3
Outcomes of Cancer Patients with COVID-19: The Virginia Commonwealth University Experience	3
Trends and Projections of Stomach Cancer Incidence in Hong Kong: A Population-Based Study	3
Vitamin D Receptor Expression Is Significantly Decreased in Bone Metastases Compared to Matched Primary Breast Cancer Tumours	3
Association of XPD Gene Polymorphisms with Cutaneous Melanoma Risk: A Meta-Analysis and Trial Sequence Evaluation	3
A Systematic Review of the Treatment Outcomes among Prostate Cancer Patients in Africa	3
Evaluation of Impression Cytology for Diagnosis of Ocular Surface Squamous Neoplasia in Two Kenyan Tertiary Hospitals	3
Does Aspirin Use Reduce the Risk for Ovarian Cancer?	3
Artificial intelligence in Cancer Clinical Research: IV. Inherent Limitations of Artificial Intelligence	3
A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics	3
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/ β -Catenin Signaling Pathway	3
Modified Le-Net Model with Multiple Image Features for Skin Cancer Detection	3
Beyond the Horizon: A Cutting-Edge Review of the Latest Checkpoint Inhibitors in Cancer Treatment	3
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer	3
Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors after Standard of Care Systemic Treatment	2
Less is More? First Impressions From COSMIC-313	2
Integrated Analysis of Slow Transit Constipation and Colorectal Cancer Reveals the Co-Pathogenic Targets and Their Potential Clinical Value	2
Construction and Validation of a Prognostic Survival Prediction Model for NMIBC Patients Undergoing Radical Cystectomy	2
TTN Mutation in Endometrial Endometrioid Carcinoma Is Associated with Poor Clinical Outcomes and High Tumor Mutation Burden	2
Low Cancer Screening Rates Among Emergency Department Patients: A Multicenter Retrospective Study	2
Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis	2
CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort	2
Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review	2
Significance and Implications of Prostate Cancer: Critical Overview for Future Directions in Africa	2
Optimizing Diagnostic Tools & Outcomes Evaluation for t (9;22)-Positive Leukemias in Pediatric Low Middle-Income Country (LMIC) Patients	2
Breast Cancer Detection in Mammography Images Using Transfer Learning Model	2
Next-Generation Salivary Biomarkers for Oral Cancer: From Noninvasive Diagnostics to Public Health Impact	2
Prognostic Significance of Combining Cytokeratin-19, E-Cadherin and Ki-67 Analysis in Triple-Negative Breast Cancer with Basal-Like and Non-Basal-Like Phenotype	2
The Influence of GLP-1 Receptor Agonists on Five-Year Mortality in Colon Cancer Patients	2
Research Progress on CARM1 and its Relationship with Colorectal Cancer	2
Barthel Index and Age as Predictors of Discharge Destination in Patients with Glioblastoma	2
Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy	2
Where the Sidewalk Ends: Parenting as a Trainee during COVID-19	2
Post-Marketing Safety of Tazemetostat in Antitumor Therapy: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System	2
LDHB Mediates Histone Lactylation to Activate PD-L1 and Promote Ovarian Cancer Immune Escape	2
Investigating Breast Cancer Detection with Contextual Relationship Embedded CNN in Mammograms	2
Enhancing Chemotherapy Adherence in Cancer Management: A Quasi-Experimental Trial of a Smartphone Application	2
Thyroid Cancer Detection Using Py-SpinalNet: A Pyramid and SpinalNet Approach	2
Professional Challenges for United States Hematology/Oncology Trainees during COVID-19	2
Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation	2
The Pittsburgh Sleep Quality Index (PSQI) Applied to Cancer Patients: Psychometric Properties and Factors Affecting Sleep Quality	2
Tandem Dual CAR-T Cells Targeting HER2 and Mesothelin Enhance anti-Tumor Effects in Pancreatic Cancer	1
Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva as a Diagnostic Specimen for Rapid Classification of Oral Squamous Cell Carcinoma Using Chemometrics M	1
Decoding Cervical Cancer Biomarkers: An Integrated Framework of Bioinformatics, Machine Learning, and Experimental Confirmation	1
Viral Hepatitis in Western Patients with Advanced Intrahepatic Cholangiocarcinoma: Retrospective Assessment of Prevalence, Prognostic and Predictive Significance	1
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer	1
Identification and Validation of a Prognostic Risk-Scoring Model Based on LATS2 Expression in Acute Myeloid Leukemia	1
Poorly Controlled Diabetes Mellitus Increases the Risk of Deaths and Castration-Resistance in Locally Advanced Prostate Cancer Patients	1
Cancer Stem Cells Promote Tumorigenesis and Progression of Pancreatic Cancer Through Notch-1 Pathway	1
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity	1
Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma in Situ with Microinvasion	1
The Impact and Evaluation of Immune Checkpoint Inhibitors on Clinical Survival in Patients with Advanced Osteosarcoma: A Systematic Review and Meta-Analysis	1
Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis	1
Biomarker Potential of DNA Repair Genes XRCC1, XRCC3 and RAD51 Polymorphisms in Ovarian Cancer Patients	1
Combination Hormonal Drug Therapy Inhibits In Vitro Growth of Adult Ovarian Granulosa Tumor Cells	1
Clinical Characteristics and Prognostic Factors of Renal Sarcoma: A Japanese National Cancer Registry Study	1
Efficacy of Adjuvant First-Generation TKIs versus Chemotherapy in Patients with Completely Resected EGFR-Mutant Non-Small Cell Lung Cancer: A Meta-Analysis	1
Accuracy of the ‘CUT’ Score for Assessing Malignancy in Bethesda 3 and 4 Thyroid Nodules in North American Population: A Retrospective Study	1
Exercise interventions to combat cancer-related fatigue in cancer patients undergoing treatment: a review	1
Routine Skin Cancer Screening: Balance between Overdiagnosis and Prevention	1
The Markers Auxiliary in Differential Diagnosis of Early Melanomas and Benign Nevi Sharing Some Similar Features Potentially Leading to Misdiagnosis – A Review of Immunohistochemical Studies	1
Mutational and Expressional Deregulation of the CHEK1 Gene in Breast Cancer Patients	1
Spine Instability Neoplastic Score (SINS) as a Predictive Tool in Conventional Radiotherapy: A Narrative Review	1
Clinical Challenges and Evolving Treatments in Desmoid Fibromatosis: A Single Institution Experience	1
The Influence of Body Mass Index on Treatment Response and Survival in HER2-Positive Breast Cancer Patients	1
The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure	1
Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women	1

Lung Cancer Treatment Advances in 2022	1
Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation	1
Grade 4 Neutropenia Frequency as a Binary Risk Predictor for Adverse Clinical Consequences of Chemotherapy‑Induced Neutropenia: A Meta-analysis	1
The Journey of Resveratrol from Vineyards to Clinics	1
Artificial Intelligence in Cancer Clinical Research: II. Development and Validation of Clinical Prediction Models	1
Efficacy and Safety of Current Treatment Regimens for Acute Myeloid Leukemia in Elderly Patients	1
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma	1
Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study	1
Multi-Modal Lung Cancer Detection Using Pyramidal Cascade Neuro-Fuzzy Fractional Network	1
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma	1
Impact of the Multidisciplinary Cancer Team on the Diagnostic and Therapeutic Care Pathway of Early Breast Cancer Patients and Perception of Team Members: The Experience of a Cancer Centre in Italy	1
Ulceration vs. Mitosis in Cutaneous Melanoma: Which Is Superior for Predicting Prognosis Across Clinical Stages?	1
Once-a-Week Ablative Radiotherapy as Replacement of Prolonged Fractionation in Frail Patients: Feasibility and Toxicity Results	1
Cancer-Specific Changes in Diagnostic Activity During the COVID-19 Pandemic: An Analysis of Canadian CiNA Data	1
Predictive Modeling of Long-Term Prognosis After Resection in Typical Pulmonary Carcinoid: A Machine Learning Perspective	1
Comparative Analysis of the Chemotherapy-Related Cognitive Impairments in Patients with Breast Cancer: A Community-Based Research	1
Self-Supervised Learning Method for Breast Cancer Detection with Image Feature Set and Modified U-Net Segmentation Using Whole Slide Image	1
Metabolism-Related Programmed Cell Death: Unveiling Prognostic Biomarkers, Immune Checkpoints, and Therapeutic Strategies in Ovarian Cancer	1
Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options	1
Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules	1
AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer	1
Examining the Direct and Indirect Effects of Socioeconomic Status on Colorectal Cancer Using Structural Equation Modeling	1
Management of Non-Small Cell Lung Cancer: Updates from the European Lung Cancer Congress 2022	1
Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer	1
Anxiety, Depression, and Coping Strategies during Chemotherapy Treatment: A Comparison of Older and Younger Adults with Advanced Cancer in Brazil	1