Cancer Investigation

Article	Citations
Clinical Characteristics and Impact on Prognosis of Melanoma Accompanied by Multiple Primary Malignancies: A Retrospective Analysis	114
Artificial Intelligence in Cancer Clinical Research: V. What We Have Learned About Human Intelligence from Artificial Intelligence	48
Racial Diversity and Reporting in United States Food and Drug Administration Registration Trials for Thoracic Malignancies from 2006 to 2020	33
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients	31
Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies	25
Quantifying the Mediation Effect of Disease Stage on Racial Disparities in Head and Neck Cancer Survival	24
Efficacy and Safety of Pembrolizumab in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis	23
CTL-NK Signature Based on Immune Gene Profiling and IHC Predicts Clinical Outcomes in Triple-Negative Breast Cancer	20
Adverse Events Induced by Nivolumab Plus Ipilimumab vs. Nivolumab Monotherapy among Cancer Patients: A Systematic Review and Meta-Analysis	18
A Comparative Analysis of TIRADS and ATA Classification Systems in Determining the Malignancy of Thyroid Nodules	16
Circulating Tumor DNA in Tracking Minimal Residual Disease and Recurrence in Ovarian Cancer: A Retrospective Cohort	15
COVID-19 Outbreak Impact on Cancer Multidisciplinary Team Meetings. A Multicenter French Experience	14
Clinical Analysis of the Efficacy and Safety of Different Neoadjuvant Strategies in the Treatment of Locally Advanced Rectal Cancer	13
Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database	13
Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases	13
A Nomogram for Predicting Survival in Advanced Non-Small-Cell Lung Carcinoma Patients: A Population-Based Study	12
Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants	12
Redefining Oligometastatic Pancreatic Ductal Adenocarcinoma: Biology, Diagnosis, and Precision Multimodal Therapy	12
The Democratization of Hematology-Oncology Medical Education during the COVID-19 Pandemic	11
Gene Expression Analysis of Early Stage Changes in Pancreatic Cancer by Kras G12D Transfer in Pancreatic Progenitor-	10
Practice-Changing Trials in Gastrointestinal Cancers at ASCO 2025: A Critical Review and Clinical Context	10
Determinants of Post-Traumatic Growth and Quality of Life in Ghanaian Breast Cancer Survivors	9
Perception, Cognition and Thought: Part I Nature, Evolution and Development of Conceptual and Symbolic Processes	8
Spatial Transcriptomics Open a New Era of Pan-Cancer Analysis	8
The Relationship Between Body Image and Meaning of Life Among Women with Breast Cancer in Kerman, Iran	8

Stereotactic Body Radiation Therapy in the Management of Oligometastatic Uterine Cancer	8
Correction	7
Immunomodulatory Effect of First-Line Cisplatin Versus Carboplatin in Response to Second-Line Nivolumab Therapy in Metastatic Non-Small Cell Lung Cancer	7
A Mechanistic Review of Methotrexate and Celecoxib as a Potential Metronomic Chemotherapy for Oral Squamous Cell Carcinoma	7
Long Non-Coding RNA and Chemoresistance in Bladder Cancer – A Mini Review	7
Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance	7
Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance	7
A Review on Emerging Techniques for Diagnosis of Colorectal Cancer	6
Efficacy and Safety of Different Dosages of Anlotinib Combined with PD-1 Monoclonal Antibody in the Treatment of Advanced Non-Small Cell Lung Cancer	6
Research Progress of Nutrition and Coagulation-Based Markers as Predictors for Digestive System Cancers	6
Clinical and Pathological Characteristics of the Mammary Paget’s Disease: A Single-Center Retrospective Study in Japan	6
Assessing Chemotherapy-Induced Peripheral Neuropathy in Postmenopausal Breast Cancer Patients Using Vibration Perception Threshold	6
Correction	6
Early Changes in Lymphocyte/Monocyte Ratio on Treatment as a Prognostic Marker to Predict Overall Survival in Patients with Advanced Cancer Treated with Immune Checkpoint Inhibitors	6
Comparative Evaluation of Serum Irisin Levels in Cancer Patients and Healthy Individuals: A Systematic Review and Meta-Analysis of Diagnostic Evidence	6
Liquid Biopsy Biomarkers as Predictors of TNBC Recurrence: A Systematic Review	6
Sepsis-related outcomes of patients with Philadelphia-negative myeloproliferative neoplasms	6
Tumoral Overexpression of Hepcidin is Associated with Poor Prognosis of Patients with Clear Cell Renal Cell Carcinoma	6
Integrative Analysis Developing and Validating Potential Candidate Biomarkers for Cancer Stemness Features of Pan-Renal Cell Carcinoma	6
Decision Aids for Decision Making about Locally Advance Breast Cancer: A Systematic Review	6
The Association Between Lymphocyte-Monocyte Ratio, Tumor-Infiltrating Lymphocytes, and Tumor-Associated Macrophages with 3-Year Progression-Free Survival in Advanced Local Stage Nasopharyngeal Cancer	5
Analytical and Clinical Validation of a Target-Enhanced Whole Genome Sequencing-Based Comprehensive Genomic Profiling Test	5
Capecitabine-Enhanced Brachytherapy in Locally Advanced Cervical Cancer: A Phase II Non-Randomized Trial on Safety and Efficacy	5
Turning the Tables: How Encorafenib and Binimetinib are Reshaping NSCLC Treatment	5
Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018	5
An Overview of Cancer Biology, Pathophysiological Development and It’s Treatment Modalities: Current Challenges of Cancer anti-Angiogenic Therapy	5
Predictors of Acute Kidney Injury in Patients Prescribed Immune Checkpoint Inhibitor Therapy and Their Association with Death: A Systematic Review and Meta-Analysis	5
Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms	5
Fusobacterium Detected in Barrett’s Esophagus and Esophageal Adenocarcinoma Tissues	5
The Effect of Group Counselling on Body Image and Sexual Satisfaction Among Women with Breast Cancer: A Randomized Clinical Trial	5
p53 Missense Mutation is Associated with Immune Cell PD-L1 Expression in Triple-Negative Breast Cancer	5
The Nature, Origin and Evolution of Life: Part II The Origin of Life	5
Differential Toxicity of Immune Checkpoint Inhibitors in Older Adults: A Large-Scale, Propensity Score-Matched Real-World Analysis	5
Evaluation of High-Dimensional Data Classification for Skin Malignancy Detection Using DL-Based Techniques	4
Neoadjuvant Therapy and Axillary Lymph Node Status in HER2-Positive Breast Cancer	4
Interplay Between ERK1/2 Signaling Pathway and Estradiol Receptor Modulates ER Targeted Genes Involved in Progression of Estrogen Responsive Breast Cancers	4
Telomere Shortening of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese Patients	4
Metagenomic Analysis of Biliary Microbial Flora in Patients with Gallbladder Cancer or Gallstones-Associated Chronic Cholecystitis	4
Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma	4
Prognostic Value of miR-145 in HER2-Positive Locally Advanced or Metastatic Urothelial Carcinoma Treated with Disitamab Vedotin	4
Human Mycobiota and Its Role in Cancer Progression, Diagnostics and Therapeutics: A Link Lesser-Known	4
Immunomodulation of the Breast Cancer Microenvironment by Tumor-Derived Exosomes: Implications for Immunotherapy	4
Real World Presentation and Treatment Outcomes with a Predominant Induction Chemotherapy Based Approach in Nasopharyngeal Carcinoma: A Sixteen Year Report from a Teaching Hospital in India	4
Advanced Machine Learning and Multiomics Reveal Tumor Dynamics and Therapeutic Opportunities in Glioblastoma Multiforme	4
The Needs of Patients with Cancer Interested in Complementary and Alternative Medicine with Respect to the Physician’s Attitude and Behaviour	4
Recurrence Patterns and Clinical Management after a Positive Sentinel Node Biopsy in Melanoma Patients	4
Cancer Inducing Role of BK Polyomavirus Large T Antigen: Molecular Signaling View	4
Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective	4
Risk Factors and Epidemiological Trends (1990–2021) in Esophageal Cancer Across East and South Asia	4
The Association of NSCLC and Dementia - A Population-Based Cohort Study in Taiwan	3

Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease	3
Artificial intelligence in Cancer Clinical Research: IV. Inherent Limitations of Artificial Intelligence	3
Evidence-Based Medicine and Complementary and Alternative Medicine – Attitudes and Knowledge of German Medical Students	3
Profiling Immune-Related Adverse Events Associated with Imatinib: A Two-Decade Real-World Safety Study Based on FDA Adverse Event Reporting System	3
A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics	3
The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis	3
Outcomes of Cancer Patients with COVID-19: The Virginia Commonwealth University Experience	3
Suspension of Oncology Randomized Clinical Trials during the COVID-19 Pandemic: A Cross-Sectional Evaluation of COVID-Related Suspensions	3
Increased Risk of Hyperglycemia in Advanced Urothelial Cancer Patients Treated with Enfortumab Vedotin: A Systematic Review and Meta-Analysis	3
Does Aspirin Use Reduce the Risk for Ovarian Cancer?	3
Magnetic Resonance Imaging Guided Prostate Biopsy in Patients with ≥ One Negative Systematic Transrectal Ultrasound-Guided Biopsy: A Systemic Review and Meta-Analysis	3
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/ β -Catenin Signaling Pathway	3
Systematic Investigation of Key Drivers of Lung Adenocarcinoma: A Focus on Genes, Pathways, and miRNAs	3
Beyond the Horizon: A Cutting-Edge Review of the Latest Checkpoint Inhibitors in Cancer Treatment	3
A Systematic Review of the Efficacy of KRAS p.G12C Inhibitors in Metastatic Colorectal Cancer: The Current State of Science	3
Modified Le-Net Model with Multiple Image Features for Skin Cancer Detection	3
Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma	3
Flamingo Search Sailfish Optimizer Based SqueezeNet for Detection of Breast Cancer Using MRI Images	3
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: A Survey Study	3
Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs)	3
Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model	3
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: Correspondence	3
The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer	3
Gender, Bladder Cancer Healthcare and Burden of COVID-19	3
Trends and Projections of Stomach Cancer Incidence in Hong Kong: A Population-Based Study	3
Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls	3
Role of the Family in Treatment Decision-Making for Women with Breast Cancer: a Study from China	2
The Influence of GLP-1 Receptor Agonists on Five-Year Mortality in Colon Cancer Patients	2
Analysis of Second Primary Tumours in Cutaneous Lymphoma Populations	2
The Pittsburgh Sleep Quality Index (PSQI) Applied to Cancer Patients: Psychometric Properties and Factors Affecting Sleep Quality	2
Low Cancer Screening Rates Among Emergency Department Patients: A Multicenter Retrospective Study	2
Association of XPD Gene Polymorphisms with Cutaneous Melanoma Risk: A Meta-Analysis and Trial Sequence Evaluation	2
Vitamin D Receptor Expression Is Significantly Decreased in Bone Metastases Compared to Matched Primary Breast Cancer Tumours	2
Evaluation of Impression Cytology for Diagnosis of Ocular Surface Squamous Neoplasia in Two Kenyan Tertiary Hospitals	2
Correction	2
Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis	2
Professional Challenges for United States Hematology/Oncology Trainees during COVID-19	2
CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort	2
TTN Mutation in Endometrial Endometrioid Carcinoma Is Associated with Poor Clinical Outcomes and High Tumor Mutation Burden	2
Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy	2
Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation	2
Research Progress on CARM1 and its Relationship with Colorectal Cancer	2
Six Years Since Selinexor Approval for Relapsed Multiple Myeloma: What Have We Learned?	2
Barthel Index and Age as Predictors of Discharge Destination in Patients with Glioblastoma	2
Enhancing Chemotherapy Adherence in Cancer Management: A Quasi-Experimental Trial of a Smartphone Application	2
Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors after Standard of Care Systemic Treatment	2
Thyroid Cancer Detection Using Py-SpinalNet: A Pyramid and SpinalNet Approach	2
Prognostic Significance of Combining Cytokeratin-19, E-Cadherin and Ki-67 Analysis in Triple-Negative Breast Cancer with Basal-Like and Non-Basal-Like Phenotype	2
Racial Differences in Outcomes Among Patients with Multiple Myeloma Treated at a Myeloma Center of Excellence: A Retrospective Cohort Study	2
Chemotherapy-Induced Oral Complications and Prophylaxis Strategies	2
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer	2
Poorly Controlled Diabetes Mellitus Increases the Risk of Deaths and Castration-Resistance in Locally Advanced Prostate Cancer Patients	1
The Heterogeneity of B Cells Potentially Contributes to Metastasis of Clear Cell Renal Cell Carcinomas	1
The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure	1
Bispecific Antibodies in Multiple Myeloma: A Concise Review of Current Treatments	1
Clinical Characteristics and Prognostic Factors of Renal Sarcoma: A Japanese National Cancer Registry Study	1
Lung Cancer Treatment Advances in 2022	1
Viral Hepatitis in Western Patients with Advanced Intrahepatic Cholangiocarcinoma: Retrospective Assessment of Prevalence, Prognostic and Predictive Significance	1
LDHB Mediates Histone Lactylation to Activate PD-L1 and Promote Ovarian Cancer Immune Escape	1
Spine Instability Neoplastic Score (SINS) as a Predictive Tool in Conventional Radiotherapy: A Narrative Review	1
Less is More? First Impressions From COSMIC-313	1
Artificial Intelligence in Cancer Clinical Research: II. Development and Validation of Clinical Prediction Models	1
Next-Generation Salivary Biomarkers for Oral Cancer: From Noninvasive Diagnostics to Public Health Impact	1
Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva as a Diagnostic Specimen for Rapid Classification of Oral Squamous Cell Carcinoma Using Chemometrics M	1
Construction and Validation of a Prognostic Survival Prediction Model for NMIBC Patients Undergoing Radical Cystectomy	1
Integrated Analysis of Slow Transit Constipation and Colorectal Cancer Reveals the Co-Pathogenic Targets and Their Potential Clinical Value	1
Grade 4 Neutropenia Frequency as a Binary Risk Predictor for Adverse Clinical Consequences of Chemotherapy‑Induced Neutropenia: A Meta-analysis	1
The Impact and Evaluation of Immune Checkpoint Inhibitors on Clinical Survival in Patients with Advanced Osteosarcoma: A Systematic Review and Meta-Analysis	1
Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma in Situ with Microinvasion	1
Metabolism-Related Programmed Cell Death: Unveiling Prognostic Biomarkers, Immune Checkpoints, and Therapeutic Strategies in Ovarian Cancer	1
Cancer Stem Cells Promote Tumorigenesis and Progression of Pancreatic Cancer Through Notch-1 Pathway	1
Self-Supervised Learning Method for Breast Cancer Detection with Image Feature Set and Modified U-Net Segmentation Using Whole Slide Image	1
Global, Regional, and National Burden of Ovarian Cancer Attributable to High Body-Mass Index Among Women Aged 55 Years and Older: A GBD 2021 Analysis	1
Efficacy and Safety of Current Treatment Regimens for Acute Myeloid Leukemia in Elderly Patients	1
Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options	1
Roles of Metastasis Associated Fibroblasts in Paclitaxel Resistance of Brain Metastatic Tumor Cells: Evaluation in Metastatic Organoids	1
The Journey of Resveratrol from Vineyards to Clinics	1
Exercise interventions to combat cancer-related fatigue in cancer patients undergoing treatment: a review	1
Optimizing Diagnostic Tools & Outcomes Evaluation for t (9;22)-Positive Leukemias in Pediatric Low Middle-Income Country (LMIC) Patients	1
Ulceration vs. Mitosis in Cutaneous Melanoma: Which Is Superior for Predicting Prognosis Across Clinical Stages?	1

Breast Cancer Detection in Mammography Images Using Transfer Learning Model	1
The Markers Auxiliary in Differential Diagnosis of Early Melanomas and Benign Nevi Sharing Some Similar Features Potentially Leading to Misdiagnosis – A Review of Immunohistochemical Studies	1
Where the Sidewalk Ends: Parenting as a Trainee during COVID-19	1
Combination Hormonal Drug Therapy Inhibits In Vitro Growth of Adult Ovarian Granulosa Tumor Cells	1
Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules	1
Impact of the Multidisciplinary Cancer Team on the Diagnostic and Therapeutic Care Pathway of Early Breast Cancer Patients and Perception of Team Members: The Experience of a Cancer Centre in Italy	1
Identification and Validation of a Prognostic Risk-Scoring Model Based on LATS2 Expression in Acute Myeloid Leukemia	1
Clinical Challenges and Evolving Treatments in Desmoid Fibromatosis: A Single Institution Experience	1
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity	1
The Influence of Body Mass Index on Treatment Response and Survival in HER2-Positive Breast Cancer Patients	1
Predictive Modeling of Long-Term Prognosis After Resection in Typical Pulmonary Carcinoid: A Machine Learning Perspective	1
Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis	1
Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women	1
Significance and Implications of Prostate Cancer: Critical Overview for Future Directions in Africa	1
Biomarker Potential of DNA Repair Genes XRCC1, XRCC3 and RAD51 Polymorphisms in Ovarian Cancer Patients	1
Post-Marketing Safety of Tazemetostat in Antitumor Therapy: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System	1
AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer	1
Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review	1
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma	1
Investigating Breast Cancer Detection with Contextual Relationship Embedded CNN in Mammograms	1
Cancer-Specific Changes in Diagnostic Activity During the COVID-19 Pandemic: An Analysis of Canadian CiNA Data	1
Comparative Analysis of the Chemotherapy-Related Cognitive Impairments in Patients with Breast Cancer: A Community-Based Research	1
Examining the Direct and Indirect Effects of Socioeconomic Status on Colorectal Cancer Using Structural Equation Modeling	1
Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation	1
Once-a-Week Ablative Radiotherapy as Replacement of Prolonged Fractionation in Frail Patients: Feasibility and Toxicity Results	1