OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Toxicological Sciences is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Development challenges associated with rAAV-based gene therapies	28
A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis	28
Mitochondrion: a sensitive target for Pb exposure	23
Microphysiological systems in early stage drug development: Perspectives on current applications and future impact	22
Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes	17
Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota	15
Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis	14
Environmental cadmium exposure induces kidney tubular and glomerular dysfunction in the Myanmar adults	14
Mercury, cadmium, and lead in cigarettes from international markets: concentrations, distributions and absorption ability of filters	13
Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing	13
Association of CYP1A1 and CYP1B1 inhibition in <i>in vitro</i> assays with drug-induced liver injury	13
Involvement of <i>Npas2</i> and <i>Per2</i> modifications in zinc-induced acute diurnal toxicity in mice	12
Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway	12
Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter	12
Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells	11
Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes	9
Elevated expression of miR-146 involved in regulating mice pulmonary dysfunction after exposure to PM2.5	9
Bisphenol A stabilizes Nrf2 via Ca<sup>2+</sup> influx by direct activation of the IP<sub>3</sub> receptor	9
Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated	9
Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat <i>in vivo</i> and <i>in vitro</i> data sets u	8
Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells	7
Silencing TRPV4 partially reverses the neurotoxic effects caused by excess Ketamine	7
Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations	7
Graphene oxide aggravated dextran sulfate sodium-induced colitis through intestinal epithelial cells autophagy dysfunction	7
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions	7

Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner	7
Lead induces a metal transporter, ZIP8, via activation of the NF-κB signaling pathway and the induction is involved in the protection against lead cytotoxicity by intracellular lead accumulation indep	6
Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry	6
Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice	6
Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice	6
Corilagin attenuates morphine-induced BV2 microglial activation and inflammation via regulating TLR2-mediated endoplasmic reticulum stress	6
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation	6
Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal n	5
Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells	5
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway	5
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance	5
Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system	5
The protective effects of miR-128-3p on sevoflurane-induced progressive neurotoxicity in rats by targeting NOVA1	5
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase	5
Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells	5
Exposure to cigarette smoke exacerbates polyhexamethylene guanidine-induced lung fibrosis in mice	5
A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats	5
Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats	5
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice	4
Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pha	4
Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines	4
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation	4
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	4
Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1	4
Central inhibition prevents the <i>in vivo</i> acute toxicity of harmine in mice	4
Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species	4
Dose- and time-dependent systemic adverse reactions of sodium carboxy methyl cellulose after intraperitoneal application in rats	4
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	4
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells	3
An investigation and assessment of the muscle damage and inflammation at injection site of aluminum-adjuvanted vaccines in guinea pigs	3
Genotoxicity and mutagenicity evaluation of isoquercitrin-γ-cyclodextrin molecular inclusion complex using Ames test and a combined micronucleus and comet assay in rats	3
MiT/TFE family members suppress L-leucyl–L-leucine methyl ester-induced cell death	3
Sodium trisulfide, a sulfane sulfur donor, stimulates bovine aortic endothelial cell proliferation in culture	3
Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells	3
Development of <i>in silico</i> prediction models for drug-induced liver malignant tumors based on the activity of molecular initiating events: Biologically interpretable features	3
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity	3
Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells	3
Updated <i>in silico</i> prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for esti	3
MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription	3
Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity	3
Ferulic acid regulates miR-17/PTEN axis to inhibit LPS-induced pulmonary microvascular endothelial cells apoptosis through activation of PI3K/Akt pathway	3
Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice	3
Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets	3
Post-mortem interaction between methidathion and human serum albumin in blood	3
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A53/3</i>: a case report	3
Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring	3
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain	3
The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells	3
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays	3