OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Toxicological Sciences is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis	28
Development challenges associated with rAAV-based gene therapies	28
Mitochondrion: a sensitive target for Pb exposure	23
Microphysiological systems in early stage drug development: Perspectives on current applications and future impact	22
Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes	17
Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota	15
Environmental cadmium exposure induces kidney tubular and glomerular dysfunction in the Myanmar adults	14
Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis	14
Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing	13
Association of CYP1A1 and CYP1B1 inhibition in <i>in vitro</i> assays with drug-induced liver injury	13
Mercury, cadmium, and lead in cigarettes from international markets: concentrations, distributions and absorption ability of filters	13
Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway	12
Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter	12
Involvement of <i>Npas2</i> and <i>Per2</i> modifications in zinc-induced acute diurnal toxicity in mice	12
Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells	11
Elevated expression of miR-146 involved in regulating mice pulmonary dysfunction after exposure to PM2.5	9
Bisphenol A stabilizes Nrf2 via Ca<sup>2+</sup> influx by direct activation of the IP<sub>3</sub> receptor	9
Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated	9
Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes	9
Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat <i>in vivo</i> and <i>in vitro</i> data sets u	8
Silencing TRPV4 partially reverses the neurotoxic effects caused by excess Ketamine	7
Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations	7
Graphene oxide aggravated dextran sulfate sodium-induced colitis through intestinal epithelial cells autophagy dysfunction	7
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions	7
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner	7

Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells	7
Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice	6
Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice	6
Corilagin attenuates morphine-induced BV2 microglial activation and inflammation via regulating TLR2-mediated endoplasmic reticulum stress	6
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation	6
Lead induces a metal transporter, ZIP8, via activation of the NF-κB signaling pathway and the induction is involved in the protection against lead cytotoxicity by intracellular lead accumulation indep	6
Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry	6
Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system	5
The protective effects of miR-128-3p on sevoflurane-induced progressive neurotoxicity in rats by targeting NOVA1	5
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase	5
Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells	5
Exposure to cigarette smoke exacerbates polyhexamethylene guanidine-induced lung fibrosis in mice	5
A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats	5
Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats	5
Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal n	5
Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells	5
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway	5
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance	5
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation	4
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	4
Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1	4
Central inhibition prevents the <i>in vivo</i> acute toxicity of harmine in mice	4
Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species	4
Dose- and time-dependent systemic adverse reactions of sodium carboxy methyl cellulose after intraperitoneal application in rats	4
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	4
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice	4
Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pha	4
Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines	4
Development of <i>in silico</i> prediction models for drug-induced liver malignant tumors based on the activity of molecular initiating events: Biologically interpretable features	3
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity	3
Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells	3
Updated <i>in silico</i> prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for esti	3
MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription	3
Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity	3
Ferulic acid regulates miR-17/PTEN axis to inhibit LPS-induced pulmonary microvascular endothelial cells apoptosis through activation of PI3K/Akt pathway	3
Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice	3
Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets	3
Post-mortem interaction between methidathion and human serum albumin in blood	3
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A53/3</i>: a case report	3
Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring	3
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain	3
The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells	3
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays	3
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells	3
An investigation and assessment of the muscle damage and inflammation at injection site of aluminum-adjuvanted vaccines in guinea pigs	3
Genotoxicity and mutagenicity evaluation of isoquercitrin-γ-cyclodextrin molecular inclusion complex using Ames test and a combined micronucleus and comet assay in rats	3
MiT/TFE family members suppress L-leucyl–L-leucine methyl ester-induced cell death	3
Sodium trisulfide, a sulfane sulfur donor, stimulates bovine aortic endothelial cell proliferation in culture	3
Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells	3
Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX	2

Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells	2
Experience in the treatment of chlorfenapyr poisoning	2
Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway	2
Evaluation of neurotoxicity of anticancer drugs using nematode <i>Caenorhabditis elegans</i> as a model organism	2
Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver	2
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study	2
Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway	2
A 28-day repeated oral dose toxicity study of enniatin complex in mice	2
2,3’,4,4’,5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress	2
Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium	2
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products	2
Plasma membrane damage triggered by benzalkonium chloride and cetylpyridinium chloride induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest via Cdc6 reduction in human lung ep	2
Methyl vinyl ketone disrupts neuronal survival and axonal morphogenesis	2
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations	2
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via	2
Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells	2
Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products	2
Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense	2
Ephedrine alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and restraining NF-κB signaling	2
Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone	2
Alginate-coated activated charcoal enhances fecal excretion of 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin in mice, with fewer side effects than uncoated one	2
Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats	2
Involvement of nitrosative stress cytotoxicity induced by CdTe quantum dots in human vascular endothelial cells	2
A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes	2
Development challenges for carcinogenicity risk assessments of topical drugs	2
Transient Receptor Potential Melastatin 8, a sensor of cold temperatures mediates expression of cyclin-dependent kinase inhibitor, p21/Cip1, a regulator of epidermal cell proliferation	2
Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells	2
Hypoalgesia and recovery in methylmercury-exposed rats	2
Rapid derivatization of phosphorus-containing amino acid herbicides in plasma and urine using microwave heating	2
Knockdown of UAF1 alleviates sevoflurane-induced cognitive impairment and neurotoxicity in rats by inhibiting pro-inflammatory signaling and oxidative stress	2
Association between <i>in vitro</i> nuclear receptor-activating profiles of chemical compounds and their <i>in vivo</i> hepatotoxicity in rats	2
Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway	2
Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-	2
Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phe	1
Development of a GCN-based model to predict <i>in vitro</i> phototoxicity from the chemical structure and HOMO-LUMO gap	1
Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study	1
Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels	1
Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver	1
Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus	1
Enhancing between-facility reproducibility of the SH test as an <i>in vitro</i> skin sensitization test by the improved test method	1
Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic-associated encephalopathy classification	1
Screening and identification of differential metabolites in serum and urine of bamaxiang pigs bitten by <i>trimeresurus stejnegeri</i> based on UPLC-Q-TOF/MS metabolomics technology	1
Fetal loss due to Th1-skewed Th1/Th2 balance with increase (not decrease) of regulatory T cells in abortion-prone mouse model	1
Inhibition of autophagy with expression of NADPH oxidase subunit p22phox in preneoplastic lesions in a high-fat diet and streptozotocin-related hepatocarcinogenesis rat model	1
Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1	1
Lipopolysaccharide administration increases the susceptibility of mitochondrial permeability transition pore opening via altering adenine nucleotide translocase conformation in the mouse liver	1
Analysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs	1
Toxicological applications of human induced pluripotent stem cell-derived hepatocyte-like cells: an updated review	1
Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality	1
A simple air–liquid interface exposure system for exposing cultured human 3D epidermis and cornea to PM2.5 collected through cyclonic separation	1
Toxicological effects of two metabolites derived from <i>o</i>-toluidine and <i>o</i>-anisidine after 28-day oral administration to rats	1
Effects of early-life tosufloxacin tosilate hydrate administration on growth rate, neurobehavior, and gut microbiota at adulthood in male mice	1
Simulation-based risk assessment for the leakage of toxic substances in a chemical plant and the effects on the human body: ethanol as a working model	1
Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death	1
Detection of double-stranded DNA breaks and apoptosis induced by bleomycin in mouse intestine	1
Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance	1
Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells	1
Corneal lesions related to an anesthetic mixture of medetomidine, midazolam, and butorphanol treatment in rats	1
Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells	1
Investigation of radical scavenging effects of acetaminophen, <i>p</i>-aminophenol and their <i>O</i><i>-</i>sulfated conjugates	1
Epigenetic mutagen-like environmental chemicals alter neural differentiation of human induced pluripotent stem cells	1
Reactive oxygen species (ROS) assay-based photosafety screening for complex ingredients: Modification of the ROS assay protocol	1
False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine	1
Maternal omega-3 fatty acid supplementation against prenatal lead exposure induced cognitive impairment in offspring mice	1
CHAC1 exacerbates arsenite cytotoxicity by lowering intracellular glutathione levels	1
DTox: A deep neural network-based <i>in visio</i> lens for large scale toxicogenomics data	1
Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells	1
Involvement of <i>microRNA-4680-3p</i> against phenytoin-induced cell proliferation inhibition in human palate cells	1
Constructing a developmental and reproductive toxicity database of chemicals (DART NIHS DB) for integrated approaches to testing and assessment	1
Developing a GNN-based AI model to predict mitochondrial toxicity using the bagging method	1
Asthma attacks: Patients who survived paraquat poisoning	1
Data on long-term survival of the NOD/Shi-<i>scid</i> IL-2Rγ<sup>null</sup> (NOG) mouse in two facilities	1
Evaluation of MTT reducers and strongly colored substances in the Short Time Exposure test method for assessing eye irritation potential	1
<i>In vivo</i> analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events	1
The double-stranded RNA-dependent protein kinase inhibitor alleviates endoplasmic reticulum stress and alleviates sepsis-induced renal injury	1
Acyl-CoA:diacylglycerol acyltransferase 1 inhibition in the small intestine increases plasma transaminase activity via the activation of protein kinase C pathway	1
Neuro-protective effects of n-butylphthalide on carbon monoxide poisoning rats by modulating IL-2, AKT and BCL-2	1