OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Toxicological Sciences is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Glasgow coma scale may be a predictive factor for delayed neurological sequelae after carbon monoxide poisoning: a retrospective analysis of a nationwide multicenter observational registry in Japan	15
Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice	14
Per- and polyfluoroalkyl substances: toxicokinetics, exposure and health risks	13
Histological differences between the central and peripheral areas of the testes of busulfan-administered mice	13
An exploratory study of sex differences in thallium-induced nephrotoxicity in rats	11
Neuro-protective effects of n-butylphthalide on carbon monoxide poisoning rats by modulating IL-2, AKT and BCL-2	10
Neurotoxicity of acrylamide in wild-type and TNF-α depletion mice: possible alternative role of IL-6 and dipolar effects of TNF-α depletion on oxidative stress pathway	10
Characterization of the toxicological findings from 90-day and 2-year repeated-dose toxicity studies of pesticides in rats	10
Variation and classification of chemically-induced zebrafish malformations for the ICH S5 (R3) guideline: an atlas for zebrafish teratogenesis	9
Identification of postmortem product of amlodipine decomposition by hemoglobin with LC-Q-Orbitrap-MS	9
A preliminary evaluation of the applicability of the <i>in vitro</i> to <i>in vivo</i> extrapolation approach to quantitative risk assessment	9
Activation of the arylhydrocarbon receptor through maternal beta-naphthoflavone exposure in the neonatal kidney	9
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	9
Diphenylarsinic acid induced astrocyte-preferential cell-type-specific aberrant activation of signal transduction related to oxidative stress, MAP kinase activation, transcription factor regulation, a	9
Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells	8
Considerations for infection risks identified in target safety review	8
<i>In vivo</i> analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events	8
Protective effects of retinoic acid on cadmium toxicity in human proximal tubular epithelial cells	8
Evaluation of circulating miR-216a and miR-217 as biomarkers of pancreatic damage in the L-arginine-induced acute pancreatitis mouse model	8
Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis	7
Male rat-specific fatty change in liver by DS-1971a: Elevation in phospholipids and adenosine as early responses to the fatty change in male rat-derived primary hepatocytes	7
Methylthioacetic acid, a derivative of aroma compounds from <i>Cucumis melo</i> var. <i>conomon</i> dose-dependently triggers differentiation and apoptosis of RCM-1 human color	7
Comparison of the acceptable surface limits derived from the skin sensitization potency for workers and swab residue limits determined from the permitted daily exposure derived from the systemic effec	7
Quantitative analysis of Cyp1a2 expression and temporal characterization of zonation structure formation during mouse liver development	6
Comprehensive molecular docking on the AlphaFold-predicted protein structure proteome: identifying target protein candidates for puberulic acid	6

Anticancer agent doxorubicin toxicity to <i>in vitro X. laevis</i> tadpole organ heart and mature frog heart and liver mitochondria	6
Dabrafenib stimulates autophagy in thyroid carcinoma cells via HMGB-1	6
Investigation of additional suitable positive controls in the human Cell Line Activation Test	5
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS	5
Evaluation of neurotoxicity of anticancer drugs using nematode <i>Caenorhabditis elegans</i> as a model organism	5
Dihydropyrazine activates the CAMKK2-AMPK-ULK1 signaling pathway in human hepatoma HepG2 cells	5
Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study	5
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	5
Potential of connexin 32 as a predictive marker for drug-induced cholestatic liver injury in a collagen vitrigel-culture model of HepG2-NIAS cells, a new subline of HepG2 cells, with bile canaliculus-	5
Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels	5
Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver	5
Prevention of prolactin reduction: a novel strategy countering multi-generational growth retardation caused by maternal exposure to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin	5
Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells	4
<i>Drosophila melanogaster</i> as potential alternative animal model for evaluating acute inhalation toxicity	4
Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study	4
Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B	4
Successful multimodal treatment of venlafaxine overdose-induced catecholamine-refractory shock: a case report	4
Paternal methamphetamine exposure differentially affects first and second generations in mice	4
Differential effects of different time windows of postnatal perfluorooctane sulfonate exposure on cognitive development in mouse hippocampus	4
Plasma membrane damage triggered by benzalkonium chloride and cetylpyridinium chloride induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest via Cdc6 reduction in human lung ep	4
Induction of systemic inflammation by welding fume exposure in office workers as well as welders in welding factories	4
Transcriptome analysis in various cell lines exposed to nitric oxide	4
Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion	4
Toxicological effects of Sb(III), Sb(V), and NMG-Sb(V) in human lung, kidney, and liver cells: cytotoxicity and fibrotic factor induction	4
Lipopolysaccharide administration increases the susceptibility of mitochondrial permeability transition pore opening via altering adenine nucleotide translocase conformation in the mouse liver	4
Effects of food restriction on toxicological parameters in juvenile rats	4
Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons	4
Optimisation of Photo-KeratinoSens™ for <i>in vitro</i> photoallergenicity assessment	4
Slow-releasing hydrogen sulfide donor GYY4137 induces epithelial-mesenchymal transition in A549 human lung adenocarcinoma cells	3
Integrating mathematical approaches (IMAS): Novel methodology for predicting dermal absorption rates of chemicals under finite dose conditions	3
An update on ototoxicity: from a genetic perspective	3
Lidocaine induces neurotoxicity in spinal cord neurons in Goto-Kakizaki rats via AMPK-mediated mitophagy	3
Pathogenesis of selective damage of granule cell layer in cerebellum of rats exposed to methylmercury	3
Small noncoding RNA dysregulation is implicated in manganism in a rat model of methylcyclopentadienyl manganese tricarbonyl-induced unrepaired striatum damage	3
Testosterone contributes sex differences of urinary biomarkers for nephrotoxicity in rats	3
Prenatal low-dose MeHg exposure leads to proteomic and transcriptomic alterations consistent with neurodegenerative disease in the cerebellum of C57BL/6 mice	3
Incorporation of target safety review in drug discovery	3
Bridging toxicological properties of environmental chemicals between animals and humans using healthy organoid systems	3
Resin monomers induce apoptosis of the pulp–dentin complex through the mitochondrial pathway	3
Development of an AI algorithm for the automatic detection and classification of rat bone marrow cells	3
A probabilistic approach for estimating human exposure to polychlorinated biphenyls via tuna consumption	3
Methylmercury-induced brain neuronal death in CHOP-knockout mice	3
Developing a GNN-based AI model to predict mitochondrial toxicity using the bagging method	3
Renal effects of excessive fructose intake in Spontaneously Diabetic Torii-<i>Lepr</i>fa (SDT fatty) rats	3
Toxicity of the novel mercury species α-mercuri-acetaldehyde and α-mercuri-acetic acid, in comparison with that of methylmercury, in rats	3
Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells	3
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled car	3
Transcriptome analysis of cultured human vascular endothelial cells after γ-ray irradiation and correlation analysis with ATP, ADP, and adenosine as secondary soluble factors	3
Breast milk-mediated exposure to dioxins and antigen in infancy enhances antigen-specific antibody production capacity in adulthood in mice	3
Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model	3

DTox: A deep neural network-based <i>in visio</i> lens for large scale toxicogenomics data	3
Ephedrine alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and restraining NF-κB signaling	3
Potential involvement of the endoplasmic reticulum stress response in the development of cisplatin-induced muscle atrophy	2
Rodent-specific induction of cholestasis and cholangioma through the reduction of bile salt export pump by bardoxolone methyl	2
Protection of cultured vascular endothelial cells against cadmium cytotoxicity by simultaneous treatment or pretreatment with manganese	2
Determination of putrefactive amine and ammonia concentrations around decomposed corpses	2
Activator protein-1 mediates blue light-induced phototoxicity in retinal pigment epithelial cells	2
Preclinical <i>in vitro</i> evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody	2
Triphenyl phosphate-induced cell injury through endoplasmic reticulum stress in human kidney cells	2
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products	2
Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids	2
Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX	2
Construction and evaluation of an open-source database for inhalation-based physiologically based kinetic modeling of selected categories for industrial chemicals	2
Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams	2
Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells	2
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations	2
Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1	2
Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells	2
miRNA-214-3p targets BNIP3 to affect autophagy and thus drive gastric cancer progression	2
Carcinogenicity of butyraldehyde in rats by a two-year inhalation study	2
Impact of variability of <i>in silico</i> and <i>in vitro</i> octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiolo	2
Possible involvement of tubular interleukin-34 in macrophage recruitment during colistin-induced nephrotoxicity in rats	2
Retraction: MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription	2
Effect of the barrier function of stratum corneum and viable epidermis and dermis on the skin concentration of topically applied chemicals	1
Behavioral effects induced by the oral administration of acetamiprid in male mice during the postnatal lactation period or adulthood	1
MiR-98-3p alleviates lipopolysaccharide-induced pulmonary microvascular endothelial barrier dysfunction by targeting DKK3 in sepsis-induced acute lung injury	1
Simulation-based risk assessment for the leakage of toxic substances in a chemical plant and the effects on the human body: ethanol as a working model	1
Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells	1
Estimation of intravenous TTC (TTCiv) for Extractables and Leachables (E&Ls) by applying a modifying factor based on blood concentration predicted using an open-source PBPK model	1
Differential response of SNU-1826 colon cells on the autophagy, ER stress, and inflammation during the regulation of microplastic internalization	1
Alteration of bile acid composition is a possible risk factor for antibiotics-induced liver injury	1
Caffeine potentiates the dependence induced by central nervous system depressants contained in over-the-counter medications in mice	1
Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells	1
Predicting nucleic acid drug-induced nephrotoxicity using a 3D human renal proximal tubule spheroid model	1
Development of a risk assessment method for the detailed consideration of the effects of liquid toxic substance leakage incidents on the human body: ethanol as a model substance	1
Epigenetic mutagen-like environmental chemicals alter neural differentiation of human induced pluripotent stem cells	1
Simultaneous analysis of caffeine and paraxanthine provides potentially useful indexes in the treatment of acute caffeine intoxication	1
Clinical features and outcomes of acute paracetamol poisoning in a resource-limited setting: observations from 96 patients in Vietnam	1
Effects of early-life tosufloxacin tosilate hydrate administration on growth rate, neurobehavior, and gut microbiota at adulthood in male mice	1
A single dose of clothianidin exposure induces varying sex-specific behavioral changes in adulthood depending on the developmental stage of its administration	1
Effects of inhalation of multi-walled carbon nanotube (MWCNT) on respiratory syncytial virus (RSV) infection in mice	1
Evaluation of toxicokinetic interactions mediated by plasma protein binding during amoxapine intoxication	1
Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice	1
Discovery and development of COVID-19 vaccines and therapeutics: nonclinical perspectives	1
Methylmercury induces ferroptosis by suppressing GPX4 protein levels in C17.2 mouse neural stem cells	1
Experience in the treatment of chlorfenapyr poisoning	1
Oral exposure to polystyrene nanoplastics induces anxiety-like behavior and cognitive deficit accompanied with alteration of neuroimmune markers in rats	1
Comparative cytotoxicity of novel mercury species α-mercuri-acetaldehyde and α-mercuri-acetic acid versus methylmercury in SH-SY5Y cells	1
Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice	1
Corilagin attenuates morphine-induced BV2 microglial activation and inflammation via regulating TLR2-mediated endoplasmic reticulum stress	1
Ionic liquid cytotoxicity in mouse macrophage J774.1 cells: Effects of alkyl chain length, cation core, and anion type	1
Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells	1
Elemental impurities in Yataprasen Thai Polyherbal Formulation: source-dependent variation, and analytical method validation	1
Evaluation of rewarding effects of nitazene analogs: results from conditioned place preference tests and <i>in vivo</i> microdialysis experiments in mice	1