OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Toxicological Sciences is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis	27
Development challenges associated with rAAV-based gene therapies	23
Mitochondrion: a sensitive target for Pb exposure	19
Microphysiological systems in early stage drug development: Perspectives on current applications and future impact	16
Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota	14
Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes	14
Environmental cadmium exposure induces kidney tubular and glomerular dysfunction in the Myanmar adults	13
Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis	12
Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter	11
Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing	11
Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway	10
Elevated expression of miR-146 involved in regulating mice pulmonary dysfunction after exposure to PM2.5	9
Mercury, cadmium, and lead in cigarettes from international markets: concentrations, distributions and absorption ability of filters	9
Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated	9
Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells	8
Bisphenol A stabilizes Nrf2 via Ca<sup>2+</sup> influx by direct activation of the IP<sub>3</sub> receptor	8
Involvement of <i>Npas2</i> and <i>Per2</i> modifications in zinc-induced acute diurnal toxicity in mice	8
Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat <i>in vivo</i> and <i>in vitro</i> data sets u	8
Association of CYP1A1 and CYP1B1 inhibition in <i>in vitro</i> assays with drug-induced liver injury	8
Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations	7
Silencing TRPV4 partially reverses the neurotoxic effects caused by excess Ketamine	7
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions	7
Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes	7
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner	6
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation	6

Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice	6
Graphene oxide aggravated dextran sulfate sodium-induced colitis through intestinal epithelial cells autophagy dysfunction	6
Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats	5
Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry	5
Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells	5
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase	5
Exposure to cigarette smoke exacerbates polyhexamethylene guanidine-induced lung fibrosis in mice	4
A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats	4
Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice	4
The protective effects of miR-128-3p on sevoflurane-induced progressive neurotoxicity in rats by targeting NOVA1	4
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway	4
Lead induces a metal transporter, ZIP8, via activation of the NF-κB signaling pathway and the induction is involved in the protection against lead cytotoxicity by intracellular lead accumulation indep	4
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice	4
Post-mortem interaction between methidathion and human serum albumin in blood	3
Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells	3
MiT/TFE family members suppress L-leucyl–L-leucine methyl ester-induced cell death	3
Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells	3
Sodium trisulfide, a sulfane sulfur donor, stimulates bovine aortic endothelial cell proliferation in culture	3
Dose- and time-dependent systemic adverse reactions of sodium carboxy methyl cellulose after intraperitoneal application in rats	3
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance	3
Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system	3
MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription	3
Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species	3
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain	3
Development of <i>in silico</i> prediction models for drug-induced liver malignant tumors based on the activity of molecular initiating events: Biologically interpretable features	3
Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets	3
Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1	3
Central inhibition prevents the <i>in vivo</i> acute toxicity of harmine in mice	3
Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring	3
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation	3
Ferulic acid regulates miR-17/PTEN axis to inhibit LPS-induced pulmonary microvascular endothelial cells apoptosis through activation of PI3K/Akt pathway	3
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays	3
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	3
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity	3
Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells	2
An investigation and assessment of the muscle damage and inflammation at injection site of aluminum-adjuvanted vaccines in guinea pigs	2
Genotoxicity and mutagenicity evaluation of isoquercitrin-γ-cyclodextrin molecular inclusion complex using Ames test and a combined micronucleus and comet assay in rats	2
Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium	2
Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX	2
Involvement of nitrosative stress cytotoxicity induced by CdTe quantum dots in human vascular endothelial cells	2
Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells	2
Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells	2
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells	2
Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal n	2
Updated <i>in silico</i> prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for esti	2
A 28-day repeated oral dose toxicity study of enniatin complex in mice	2
Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity	2
Alginate-coated activated charcoal enhances fecal excretion of 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin in mice, with fewer side effects than uncoated one	2
Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice	2
Transient Receptor Potential Melastatin 8, a sensor of cold temperatures mediates expression of cyclin-dependent kinase inhibitor, p21/Cip1, a regulator of epidermal cell proliferation	2

Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells	2
Methyl vinyl ketone disrupts neuronal survival and axonal morphogenesis	2
Corilagin attenuates morphine-induced BV2 microglial activation and inflammation via regulating TLR2-mediated endoplasmic reticulum stress	2
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A53/3</i>: a case report	2
Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pha	2
Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats	2
Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells	2
A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes	2
Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver	2
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via	2
Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway	1
Evaluation of neurotoxicity of anticancer drugs using nematode <i>Caenorhabditis elegans</i> as a model organism	1
Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells	1
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	1
The double-stranded RNA-dependent protein kinase inhibitor alleviates endoplasmic reticulum stress and alleviates sepsis-induced renal injury	1
False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine	1
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations	1
Simulation-based risk assessment for the leakage of toxic substances in a chemical plant and the effects on the human body: ethanol as a working model	1
Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway	1
Enhancing between-facility reproducibility of the SH test as an <i>in vitro</i> skin sensitization test by the improved test method	1
Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death	1
Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance	1
Screening and identification of differential metabolites in serum and urine of bamaxiang pigs bitten by <i>trimeresurus stejnegeri</i> based on UPLC-Q-TOF/MS metabolomics technology	1
<i>In vivo</i> analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events	1
Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1	1
2,3’,4,4’,5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress	1
The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells	1
Maternal omega-3 fatty acid supplementation against prenatal lead exposure induced cognitive impairment in offspring mice	1
Constructing a developmental and reproductive toxicity database of chemicals (DART NIHS DB) for integrated approaches to testing and assessment	1
Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products	1
Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic-associated encephalopathy classification	1
Association between <i>in vitro</i> nuclear receptor-activating profiles of chemical compounds and their <i>in vivo</i> hepatotoxicity in rats	1
Corneal lesions related to an anesthetic mixture of medetomidine, midazolam, and butorphanol treatment in rats	1
Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone	1
Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-	1
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products	1
Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality	1
Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines	1
Toxicological effects of two metabolites derived from <i>o</i>-toluidine and <i>o</i>-anisidine after 28-day oral administration to rats	1
Development challenges for carcinogenicity risk assessments of topical drugs	1
Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus	1