OOIR: Observatory of International Research

Papers

(The TQCC of Heterocycles is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Chiral 1,2-Diaminocyclohexane-α-Amino Acid-Derived Amidphos/Ag(I)-Catalyzed Divergent Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides	34
Organocatalyzed Three-Component Synthesis of Isoxazol-5(4H)-ones under Aqueous Conditions	13
Environmentally Benign Synthesis of Cyclic Carbonates from Epoxides and Carbon Dioxide Using Binary and Bifunctional Catalysts	10
The Interrupted Pummerer Reaction: Design of Sulfoxides and Their Utility in Organic Synthesis	10
Microwave-Assisted Synthesis of 2-Aminothiophene Derivatives via Improved Gewald Reactions	9
Novel Heteroannulated Chromeno[2,3-b]pyridines and Related Compounds Using 6-Methylchromone-3-carbonitrile	8
Efficient and Aqoues Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-one Derivatives Using Piperazine under Green Conditions	8
Debromooscillatoxins G and I from the Cyanobacterium Moorea producens	8
Imidazole Chemistry in Crop Protection	8
Three New Anti-Rotavirus Chromeno[3,2-c]pyridines from the Whole Plant of Thalictrum scabrifolium	7
The Utility of Oxoammonium Species in Organic Synthesis: Beyond Alcohol Oxidation	6
Recent Development of Stereoselective Glycosylation Reactions	6
Synthesis and Antitumor Activity of Novel Linear Tricyclic Compounds Derived from Purine	6
An Overview of Quantitative and Qualitative Approaches on the Synthesis of Heterocyclic Kojic Acid Scaffolds through the Multi-Component Reactions	6
Reactivity of 4-Bromoacetyl-1,2,3-triazoles towards Amines and Phenols: Synthesis and Antimicrobial Activity of Novel Heterocycles	6
Synthetic Approaches for Construction of Novel 3-Heteroarylchromeno[2,3-b]pyridines and Annulated Chromenopyridopyrazolopyrimidines	6
Synthesis and Biological Activities of Some New Phosphorus Compounds Containing Pyranopyrazole Moiety	6
Combined Brønsted-Base-Mediated Direct C-H Carboxylation of Heteroarenes with CO2	6
9,9'-Bi(xanthene)-Type Hexaphenylethane Derivatives as Advanced Organic Electrochromic Systems	6
Total Synthesis of Hyalodendriol C	6
Construction and Biological Evaluations of Some Novel Chromeno[2,3-b]pyridines and Chromeno[2,3-b]quinolines Using 6-Methylchromone-3-carbonitrile	5
Recent Advances in 1,2,4-Triazole Ring Construction via Cycloaddition Reactions	5
Non-Planar Polycyclic Aromatic Molecules Including Heterole Units	5
Synthesis of Multisubstituted Benzofurans/Indoles Using Multichlorinated Phenols/Anilines via Palladium-Catalyzed Site-Selective Sonogashira Coupling	5
Preparation of 2,3-Dihydrobenzo[b]thiophene Bearing Benzylic Quaternary Carbon by Palladium-Catalyzed Cascade Reaction	5

Synthetic Approaches for Heteroannulated Chromones Fused Various Heterocyclic Systems	5
Synthesis and Biological Evaluation of New Pyrimidine Derivatives as FAK Inhibitors for Development of Antitumor Agents	5
Synthesis and Characterization of Some Novel Heteroannulated Chromeno[4,3-b]quinolines	5
On the Order of Addition of Sodium Dispersion in Reductive Diborations of Stilbene and 1,2-Diphenylcyclopropane	5
Total Synthesis of Urolithin C 3-Glucuronide	5
Chemical Reactivity of 1H-Benzimidazol-2-ylacetonitrile and Dimedone toward Simple Condensates Derived from 3-Formylchromone	4
4-Amino-3-formylcoumarin as Building Block for Construction of Novel Heteroannulated Coumarins: Synthesis, Characterization and Antimicrobial Evaluation	4
Gold-Catalyzed Formal [3+2] Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of 2,3-Dihydrobenzofuran Neolignans	4
One-Pot and Three-Component Synthesis of Some Novel Functionalized Chromonyl Pyrido[2,3-d]pyrimidines as Anticancer Agents	4
Umpolung of Electron-Rich Heteroarenes with Hypervalent Iodine Reagents	4
Synthetic Methods for Phosphorus Compounds Containing Chromone and Thiochromone Rings	4
Azido, Cyano, and Nitrato Cyclic Hypervalent Iodine(III) Reagents in Heterocycle Synthesis	4
Synthesis, Characterization, and DRAK2 Inhibitory Activities of Hydroxyaurone Derivatives	4
Synthesis of Arylideneisoxazol-5-ones Catalyzed by Sodium Cyclamate	4
Catalytic Enantioselective Oxa-Hetero-Diels-Alder Reactions of Enones with Aryl Trifluoromethyl Ketones: Synthesis of Tetrahydropyranones	4
Anti-Tobacco Mosaic Virus Isoindolin-1-ones from the Stems of Nicotiana tabacum	4
Recent Development on the Ring Transformation Reactions: Synthesis of Functionalized Benzenes, N-Heterocycles and Fused Ring Systems	4
Practical Synthesis of 1-Substituted 5-Aminopyrazolo[4,3-d]pyrimidin-7-ones Using Intramolecular Friedel–Crafts Type Cyclization and Its Application to the Synthesis of Pharmaceutically Active Compoun	3
Recent Advances in Synthetic Strategies for the C4a,C9a-Fused Tetracyclic Hydrocarbazole Core Structure of Minfiensine and Related Akuammiline Alkaloids	3
Microwave-Assisted Synthesis of Phenylisoxazole Derivatives via 1,3-Dipolar Cycloaddition	3
Inhibition of Amyloid β Aggregation by p-Terphenyl Derivatives Isolated from Boletopsis leucomelas	3
Click Chemistry toward the Synthesis of Anticancer Agents	3
Macrocarquinoid D, New Meroterpenoid from Brown Alga, Sargassum macrocarpum	3
Facile Preparation of 1-Hydroxy-1,2-Benziodoxol-3(1h)-one 1-Oxide (IBX) and Dess–Martin Reagent Using Sodium Hypochlorite under Carbon Dioxide	3
Middle-Scale IsoChichibabin Desmosine Synthesis	3
Synthesis of Roche Lactone via the Enantioselective Alcoholysis of meso-Cyclic Anhydride Strategy: A Practical Approach Employing an Efficient and Reusable Organic Microgel Auxiliaries	3
Facile Access to Highly-Substituted Dihydrofurans Using Resonated Vinylpentanedione Radicals Generated by Mn(III)-Based Oxidation	3
A Comprehensive Study of Pyrimidine and Its Medicinal Applications	3
Application of Reversible Detection Method for N-Terminus Amino Groups: Solid Phase Synthesis of Stylissatin B	3
Novel Pyrazolines and Benzothiazepines as Tubulin Polymerization Inhibitors: Synthesis, Biological Evaluation, and Molecular Docking	3
One-Pot Synthesis of Fully Substituted Oxazol-2-amines via Staudinger/Aza-Wittig/Isomerization Reaction	3
Recyclable Heterogeneous Nanocrystal Promoted Cascade Reaction in Water: An Access to Green Synthesis of Highly Functionalized 4H-Pyrans Containing Phosphonate Motif	3
Mini Review on Pyrido[2,3-c]coumarins Backbone of Santiagonamine Antibiotics	3
Elucidation of Absolute Configuration of Ophiorrhiside A by Comparison of ECD Spectra with That of Model Chiral Compound Having a 1,2,3,4-Tetrahydro-β-carbolin-3-one Skeleton	3
A New Natural Butenolide, (5R)-3-Tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella conifera	3
Briarane-Type Diterpenoids from the Cultured Octocoral Briareum stechei (Kükenthal, 1908)	3
Development of 5-Trifluoromethylpyrimidine Derivatives as Dual Inhibitors of EGFR and Src for Cancer Therapy	3
Pyrrolotetrazoles and Ring-Fused Derivatives	3
Synthesis of α-Bromomethyl Ketones in CuBr - bpy System	3
Chloroamidation of Alkenes Using Sodium Hypochlorite Pentahydrate and Its Application to Synthesis of Aziridines	3
Peniphilones A and B: Azaphilone Alkaloids from the Endophytic Fungus Penicillium maximae	3
Synthesis of Pyrrolo[2,3-c]quinoline Alkaloid Marinoquinolines	3
Metal-Free Regioselective Synthesis of 2-Nitro-3-arylimidazo[1,2-a]pyridines via Oxidative Amination under Air Using Silica Sulfuric Acid as an Effective Heterogeneous Catalyst	3
Reaction Pathway and Kinetic Study of 4,5-Dihydroxyimidazolidine-2-thione Synthesis by HPLC and NMR	2
Mechano-Biocatalytic Rapid Synthesis of 2-Amino-3-cyano-4H-pyran Derivatives	2
Mapping the Antimicrobial Activity of Indoloquinoline and Neocryptolepine Analogues	2
Total Synthesis of Natural Products and Medicinal Molecules via Chelation-Controlled Diastereoselective Hydride Reduction of Amino Ketones	2
Concise Synthesis of an Amide-Functionalized [7]Helicene-like Molecule via Intramolecular Amidation	2
Chemical Modifications of N,N-Dimethylalkylamino-Substituted 2-Chlorophenothiazine and Their Electrochemical Behavior	2
New Sugar Based γ-Amino Silyl Ether Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins	2

Metal-Free sp3 C-H Bond Oxidation and Functionalization of α-Bromoketones to Quinoxalinone, Benzoxazinone, and Benzothiazinone Heterocyclic Compounds	2
A One-Pot Approach to Construct 3-(2-Methoxypyridin-3-yl)-4H-chromen-4-ones via Meinwald Rearrangement/Intramolecular Demethylation Annulation of Epoxides	2
Synthesis and Antitumor Activity of Heterocylic Aurone and Its Analogue Indanone Derivatives	2
Synthesis of 1-Azaazulenes Using Ring-Opening Cyclization of Spirocyclopropane with Amine	2
Preparation of Optically Pure Dinuclear Cobalt(III) Complex with Λ-Configuration as a Dianionic Chiral Catalyst	2
Iodine-Containing 4,7-Dihalobenzo[b]thiophene Building Blocks and Related Iodobenzo[b]thiophenes: Promising Molecular Scaffolds for Bio-Inspired Molecular Architecture	2
Synthesis of 1-Methoxy-1H-indoles with a Heterocyclic Moiety via Unstable Indole Isothiocyanate by Using Enzyme from Brassicaceae Plant	2
Synthetic Approaches toward Certain Structurally Related Antimicrobial Thiazole Derivatives (2010-2020)	2
Nucleophilic Substitution of 2,2-Bis(arylthio)-4,4,6,6-tetrachlorocyclotriphosphazene with Ammonia, Phenoxide, and Thiophenoxide	2
Systematic Search for Transition States in Complex Molecules: Computational Analyses of Regio- and Stereoselective Interflavan Bond Formation in Flavan-3-ols	2
Coniferains C and D, New Eunicellin-Based Diterpenoids from Cladiella conifera	2
The Fascinating Chemistry of Mesoionic 4-Trifluoroacetyl-1,3-oxazolium-5-olates and Related Compounds	2
Alkaloids and Alkaloid-Like Compounds are Potential Scaffolds of Antiviral Agents against SARS-CoV-2 (COVID-19) Virus	2
Divergent Total Synthesis of Azalamellarins D and N	2
Synthesis, Cytotoxicity and Docking Simulation of Bioactive [1,2,4]Triazolo[3,4-α]dihydroisoquinoline Chalcone Derivatives	2
Total Synthesis of (−)-Exiguolide, a Potent Anticancer Marine Macrolide	2
Recent Progress on Synthesis of Spirochromanone and Spirochromane Derivatives	2
Concise Synthesis of Eutigoside C	2
Studies on Rotational Stability of 2-Aryl-3-(2-Fluorophenyl)Quinazolin-4-One Derivatives	2
Synthesis of Novel 2,3-Disubstituted Thiophenes via Tandem Thia-Michael/Aldol Reaction of Allenyl Esters	2
Regiodivergent Ring Opening Reactions of 2-Arylated 3-Nitrocyclopropane-1,1-dicarboxylates Leading to Polyfunctionalized Dipoles	2
Recent Advances in Synthetic Transformations with Robust Yet Reactive B(Dan) Moiety	2
Highly Oxidized γ-Lactam-Containing Natural Products: Total Synthesis and Biological Evaluation	2
Mini Review: Antioxidant Application of Metal-Organic Frameworks and Their Composites	2
Design and One-Pot Synthesis of Some New [3,5-Di(4’,5’-diphenyl-2’-substituted)-1H-imidazol-1-yl)]-1H-1,2,4-triazole Derivatives: in silico ADMET and Docking Study, Antibacterial and Antifungal Activi	2
Synthesis, Photochemical Properties, and Cytotoxicity of 10-Alkylphenazin-2(10H)-ones	2
Fasciospyrinadinone and Fasciospyrinadinol, Novel 3-Alkylpyridine Sesquiterpenoids from an Indonesian Marine Sponge, as Selective Growth Inhibitors of the Cancer Cells under Nutrient Starvation	2
Detection of New 3,4-Dimethylpyrrole Derivatives upon the Incubation of Exogenous Amines with Extract of Onion (Allium cepa) and Crude Alliinase from Garlic (A. sativum)	2
Synthesis, Characterization, Antibacterial and Cytotoxic Evaluation of New 6-(Chlorothiophenyl)-2-(2-oxopropoxy)pyridine-3-carbonitrile Derivatives and Their Corresponding Furo[2,3-b]pyridine Derivati	2
Rhodium-Catalyzed Crossed [2+2+2] Cycloaddition with Ynamides: Key-Strategy for the Concise Total Synthesis of 3-Oxygenated Carbazole Alkaloids	2
Heterocycles Award	2
New and Practical Synthesis of GS-441524, the Key Intermediate of Remdesivir	2
Synthetic Approaches for Nitrogen Bridgehead Pyrido-[1,2-b][1,2,4]triazepines and Annulated Compounds Using 4-(8-Allylchromon-3-yl)-1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile	2
Probing the Reaction of N,N-Dimethyformamide Dimethyl Acetal with p-tert-Butylthiacalix[4]arene Tetrahydrazides: A Facile Approach for the Synthesis and Application of Novel Metal Receptors	2
3-Trifluoromethanesulfonyloxy-4,7-dihydropyrazolo[1,5-a]pyridine via Ring-Closing Metathesis: Synthesis and Transformation to Withasomnine Homologs	2
Unusual Cembrane Diterpenoid Isolated from the Japanese Soft Coral Genus Sinularia	2
Liquid-Assisted Mechanosynthesis of trans-2,3-Dihydropyrroles from Chalcones and Enaminones	2
Recent Achievements in the Synthesis of Heterocyclic Compounds by Phthalhydrazide-Based Multicomponent Reactions	2
Stereoselective Synthesis of Diastereomeric Berberine Alkaloids, O-Methylcorytenchirine and Coralydine	2
Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation	2
Thermally-Induced Doping of the Regioregular Polythiophene Bearing Alkylene Spacered Benzene sulfonate Group at the Side Chain	2
Metal-Free C3-H Hydrazination of Imidazo[1,2-a]pyridine with Azodiformates in Water at Room Temperature	2
Polyfluoroarene-Capped Thiophene Derivatives via Fluoride-Catalyzed Nucleophilic Aromatic Substitution	2
Attractive Organic Cocrystal Materials in Optics	2
An Efficient SeO2/FeCl3 Promoted Acylation:Intramolecular Friedel-Crafts Reaction Leading to a One-Pot Synthesis of Wrightiadione and Its Derivatives	2
Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives	2
A Simple Route for Synthesis and Evaluation of Antioxidant Activity of (Guaiazulen-1-yl)furans	2
Synthesis, Structures, and Interactions with CT-DNA/BSA of Three New Acylhydrazones Containing Oxazole Ring	2
Advances on Catalytic Approaches towards the Synthesis of Quinoline Derivatives Using Povarov Reaction	2
Diterpenoid Alkaloids from Aconitum Leucostomum and Their Antifeedant Activity	2
Direct Arylation of Furoxan Using Potassium Aryltrifluoroborates	2
Synthesis and Enzyme Inhibitory Properties of Quinoxaline Bridged Bis(imidazolium) Salts	2
Antimicrobial Activities of Heliciopsis terminalis Trunk Extract	2
Deprotection of the Carbazole PMB Group Using Hypervalent Iodine Reagent Combined with N-Hydroxyphthalimide	2
Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines	2
Synthesis, Antimicrobial and Antitumor Study of New Pyrido[2,1-a]isoquinolines via Isoquinoline-1-acetonitrile	2
Direct β-Alkenylation of Thiophenes with Alkenyl Halides Catalyzed by a Dinuclear Palladium Complex	2
Optimization of NAMPT (Nicotinamide Phosphoribosyltransferase) Activators: Discovery of N,N-Diethyl-1,2-benzoxazole-3-carboxamide Derivatives as Potent NAMPT Activators with Mitigated Mutagenic Risks	2
Aryne-Mediated Synthesis of Oxygen Heterocycles and Application to Cysteine-Selective Trapping	2
An Arylative Aziridination Process toward Aspidosperma Alkaloids	2
A Simple Route for Synthesis of New Triazole Derivatives via Reaction between Arylglyoxals, Acetylacetone and Sodium Azide	2
Facile Protocol for the Synthesis of Electron-Rich Benzimidazole Derivatives	2
Isolation of Peptidolipin NA Derivatives from the Culture of Nocardia arthritidis IFM10035T in the Presence of Mouse Macrophage Cells	2
When Hydrazonoyl Chlorides Meet Allenes: a Site- and Regio-Selective Copper(I)-Catalysed Approach to 5-Substituted Pyrazoles	2