Toxicology Letters

Article	Citations
Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review	49
Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants	49
Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor	47
The influence of air pollution on respiratory microbiome: A link to respiratory disease	46
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice	40
Cadmium and breast cancer – Current state and research gaps in the underlying mechanisms	39
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity	35
Predicting the reproductive toxicity of chemicals using ensemble learning methods and molecular fingerprints	34
Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice	34
Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis	34
Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson’s disease model	31
Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways	30
Repeated radon exposure induced lung injury and epithelial–mesenchymal transition through the PI3K/AKT/mTOR pathway in human bronchial epithelial cells and mice	29
Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk assessment	29
Evaluating the effect of ozone in UV induced skin damage	28
Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin	28
CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis	28
Ocular toxicity of mustard gas: A concise review	27
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss	26
Acrylamide induces ferroptosis in HSC-T6 cells by causing antioxidant imbalance of the XCT-GSH-GPX4 signaling and mitochondrial dysfunction	24
Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells	24
Changes and relationship of N6-methyladenosine modification and long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells	22
In vivo and in vitro α-amanitin metabolism studies using molecular networking	21
Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors	21
Lead exposure induces metabolic reprogramming in rat models	20

LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling	20
Differential susceptibility of rat primary neurons and neural stem cells to PFOS and PFOA toxicity	19
The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells	19
The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways	19
Doxorubicin induces arterial stiffness: A comprehensive in vivo and ex vivo evaluation of vascular toxicity in mice	18
Zinc oxide nanoparticle causes toxicity to the development of mouse oocyte and early embryo	18
Disruption of normal adipocyte development and function by methyl- and propyl- paraben exposure	18
Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice	18
Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring	18
AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209)	18
Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes	17
The disruption and hyperpermeability of blood-labyrinth barrier mediates cisplatin-induced ototoxicity	17
Glutathione is a potential therapeutic target for acrolein toxicity in the cornea	17
The mycotoxin beauvericin impairs development, fertility and life span in the nematode Caenorhabditis elegans accompanied by increased germ cell apoptosis and lipofuscin accumulation	17
MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression	17
iTRAQ-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals perfluorooctanoic acid-induced lipid metabolism and urea cycle dysfunction	17
Anticoagulant Micrurus venoms: Targets and neutralization	17
Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients	17
Short-term exposure of decabromodiphenyl ether in female adult Balb/c mice: Immune toxicity and self-recovery	17
The development of an in vitro 3D model of goblet cell hyperplasia using MUC5AC expression and repeated whole aerosol exposures	16
Optimization of aqueous aerosol extract (AqE) generation from e-cigarettes and tobacco heating products for in vitro cytotoxicity testing	16
Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats	16
In vivo treatment with varespladib, a phospholipase A2 inhibitor, prevents the peripheral neurotoxicity and systemic disorders induced by Micrurus corallinus (coral snake) venom in rats	16
Dual role of cadmium in rat liver: Inducing liver injury and inhibiting the progression of early liver cancer	16
Shp2 regulates PM2.5-induced airway epithelial barrier dysfunction by modulating ERK1/2 signaling pathway	16
Human Variability in Carboxylesterases and carboxylesterase-related Uncertainty Factors for Chemical Risk Assessment	16
Energy disorders caused by mitochondrial dysfunction contribute to α-amatoxin-induced liver function damage and liver failure	16
Depletion of serotonin relieves concanavalin A-induced liver fibrosis in mice by inhibiting inflammation, oxidative stress, and TGF-β1/Smads signaling pathway	15
Exploration study on serum metabolic profiles of Chinese male patients with artificial stone silicosis, silicosis, and coal worker's pneumoconiosis	15
Melamine impairs working memory and reduces prefrontal activity associated with inhibition of AMPA receptor GluR2/3 subunit expression	15
Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam	15
Environmental factors in Parkinson’s disease: New insights into the molecular mechanisms	15
Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: Gefitinib and afatinib	15
Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A	15
Copper exposure disrupts ovarian steroidogenesis in human ovarian granulosa cells via the FSHR/CYP19A1 pathway and alters methylation patterns on the SF-1 gene promoter	15
In vivo toxicity assessment of four types of graphene quantum dots (GQDs) using mRNA sequencing	15
Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity	15
The potential diagnostic and therapeutic applications of exosomes in drug-induced liver injury	14
Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling	14
A suitable silicosis mouse model was constructed by repeated inhalation of silica dust via nose	14
Immunotoxicity and uterine transcriptome analysis of the effect of zearalenone (ZEA) in sows during the embryo attachment period	14
Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms	14
Extended regorafenib treatment can be linked with mitochondrial damage leading to cardiotoxicity	13
Cadmium causes hepatopathy by changing the status of DNA methylation in the metabolic pathway	13
JUUL e-liquid exposure elicits cytoplasmic Ca2+ responses and leads to cytotoxicity in cultured airway epithelial cells	13
Modes of action considerations in threshold expectations for health effects of benzene	13
Paraquat mediates BV-2 microglia activation by raising intracellular ROS and inhibiting Akt1 phosphorylation	13
The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice	13
Vitamin D3 protects against nitrogen mustard-induced apoptosis of the bronchial epithelial cells via activating the VDR/Nrf2/Sirt3 pathway	13
Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats	13

Evaluation of a high-throughput in vitro endothelial cell migration assay for the assessment of nicotine and tobacco delivery products	13
Tissue-specific expression and activity of cytochrome P450 1A and 3A in rainbow trout (Oncorhynchus mykiss)	12
Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway	12
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced immunosuppression in mice spleen	12
MicroRNA-363-3p promotes apoptosis in response to cadmium-induced renal injury by down-regulating phosphoinositide 3-kinase expression	12
iPSC-derived cortical neurons to study sporadic Alzheimer disease: A transcriptome comparison with post-mortem brain samples	12
The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets	12
The unreliability of the reliability criteria in the estimation of QSAR for skin sensitivity: A pun or a reliable law?	12
Tumorigenic response in lung tumor susceptible A/J mice after sub-chronic exposure to calcium chromate or iron (III) oxide	12
Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium	12
Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-β-independent, endoplasmic reticulum stress induced pathway	12
Advances in sulfur mustard-induced DNA adducts: Characterization and detection	12
A versatile toxicity evaluation of ethyl carbamate (urethane) on zebrafish embryos: Morphological, physiological, histopathological, immunohistochemical, transcriptional and behavioral approaches	12
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles	12
Exposure to traffic-generated air pollution promotes alterations in the integrity of the brain microvasculature and inflammation in female ApoE-/- mice	12
Suppression of Th2 cytokines as a potential mechanism for reduced antibody response following PFOA exposure in female B6C3F1 mice	12
Effect of PM10 on pulmonary immune response and fetus development	12
Analysis of serum metabolome of workers occupationally exposed to hexavalent chromium: A preliminary study	11
Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum	11
Theoretical modeling of structure-toxicity relationship of cyanides	11
Cigarette smoke upregulates Notch-1 signaling pathway and promotes lung adenocarcinoma progression	11
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation	11
3-Monochloropropane-1,2-diol causes spermatogenesis failure in male rats via Sertoli cell dysfunction but not testosterone reduction	11
Therapeutic measures for sulfur mustard-induced ocular injury	11
DNA adduct formation and reduced EIF4A3expression contributes to benzo[a]pyrene-induced DNA damage in human bronchial epithelial BEAS-2B cells	11
Short-term exposure to acrylamide exacerbated metabolic disorders and increased metabolic toxicity susceptibility on adult male mice with diabetes	11
Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom	11
Favipiravir induces oxidative stress and genotoxicity in cardiac and skin cells	11
Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR	11
Arsenic exposure impairs intestinal stromal cells	11
Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway	11
Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing	11
An in vitro study on the transport and phase II metabolism of the mycotoxin alternariol in combination with the structurally related gut microbial metabolite urolithin C	11
The Precision Toxicology initiative	11
Refinement of health-based guidance values for cadmium in the French population based on modelling	11
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway	10
Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-κB, and AhR	10
Toxicity prediction using target, interactome, and pathway profiles as descriptors	10
Transfer of α-synuclein from neurons to oligodendrocytes triggers myelin sheath destruction in methamphetamine administration mice	10
Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway	10
Paternal nicotine exposure promotes hepatic fibrosis in offspring	10
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice	10
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment	10
Application of ToxTracker for the toxicological assessment of tobacco and nicotine delivery products	10
Nickel chloride regulates ANGPTL4 via the HIF-1α-mediated TET1 expression in lung cells	10
Cigarette smoke-induced extracellular vesicles from dendritic cells alter T-cell activation and HIV replication	10
PPARγ mediates the anti-pulmonary fibrosis effect of icaritin	10
Mechanism of LncRNA XIST/ miR-101–3p/ZEB1 axis in EMT associated with silicosis	10
Metabolism of glyphosate by the human fecal microbiota	10
The mouse Anxa6/miR-9-5p/Anxa2 axis modulates TGF-β1-induced mouse hepatic stellate cell (mHSC) activation and CCl4-caused liver fibrosis	10
Hepatic bile acid synthesis and secretion: Comparison of in vitro methods	10
Danio rerio as an alternative vertebrate model for jellyfish venom study: The toxinological aspects of Nemopilema nomurai venom	10
A 3D in vitro comparison of two undiluted e-cigarette aerosol generating systems	10
Applying Bayesian forecasting to predictive toxicology: The probability of innate carcinogenicity to humans of colorants synthesized from benzidine	10
Myricetin and M10, a myricetin-3-O-β-d-lactose sodium salt, modify composition of gut microbiota in mice with ulcerative colitis	10
Effects of prenatal chlorocholine chloride exposure on pubertal development and reproduction of male offspring in rats	10
TP53-induced glycolysis and apoptosis regulator (TIGAR) ameliorates lysosomal damage in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-mediated mouse model of Parkinson’s disease	10
Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window	10
LncRNA Meg3-mediated regulation of the Smad pathway in atRA-induced cleft palate	10
The MIR100HG/miR-29a-3p/Tab1 axis modulates TGF-β1-induced fibrotic changes in type II alveolar epithelial cells BLM-caused lung fibrogenesis in mice	10
Alpha-lipoic acid attenuates silica-induced pulmonary fibrosis by improving mitochondrial function via AMPK/PGC1α pathway activation in C57BL/6J mice	10
Platelets prevent the development of monocrotaline-induced liver injury in mice	10
Role of endothelial biomarkers in predicting acute kidney injury in Bothrops envenoming	10
Integration of data from the in vitro long-term exposure study on human endothelial cells and the in silico analysis: A case of dibutyl phthalate-induced vascular dysfunction	10
Ppic modulates CCl4-induced liver fibrosis and TGF-β-caused mouse hepatic stellate cell activation and regulated by miR-137-3p	9
Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals	9
A genome-wide screen for differentially methylated long noncoding RNAs identified that lncAC007255.8 is regulated by promoter DNA methylation in Beas-2B cells malignantly transformed by NNK	9
NFATc4 mediates ethanol-triggered hepatocyte senescence	9
The combined effect of deoxynivalenol and Fumonisin B1 on small intestinal inflammation mediated by pyroptosis in vivo and in vitro	9
Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway	9
Maternal smoking during pregnancy aggravated muscle phenotype in FHL1 offspring mice similar to congenital clubfoot through P2RX7-mediated pyroptosis	9
In vitro inhibition of human UDP-glucuronosyltransferase (UGT) 1A1 by osimertinib, and prediction of in vivo drug-drug interactions	9
The fungicide Tebuconazole induces electromechanical cardiotoxicity in murine heart and human cardiomyocytes derived from induced pluripotent stem cells	9
Mitochondrial dysfunction, oxidative stress, ER stress and mitochondria-ER crosstalk alterations in a chemical rat model of Huntington's disease: Potential benefits of bezafibrate	9
Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools	9
Application of HepG2/C3A liver spheroids as a model system for genotoxicity studies	9
Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via α7nAChR-mediated JAK2/STAT3 signaling pathway in rats	9
Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model	9
PGAM5 regulates DRP1-mediated mitochondrial fission/mitophagy flux in lipid overload-induced renal tubular epithelial cell necroptosis	9
Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity	9

Uremic endothelial-derived extracellular vesicles: Mechanisms of formation and their role in cell adhesion, cell migration, inflammation, and oxidative stress	9
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine	9
Age-related tolerance to paraquat-induced parkinsonism in Drosophila melanogaster	9
OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations	9
A critical review of microplastics toxicity and potential adverse outcome pathway in human gastrointestinal tract following oral exposure	9
Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk	9
Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis	9
p62/sequestosome 1 attenuates methylmercury-induced endoplasmic reticulum stress in mouse embryonic fibroblasts	8
Antimony-induced astrocyte activation via mitogen-activated protein kinase activation-dependent CREB phosphorylation	8
FG-4592 alleviates radiation-induced intestinal injury by facilitating recovery of intestinal stem cell and reducing damage of intestinal epithelial	8
In ovo exposure to cadmium causes right ventricle hyperplasia due to cell proliferation of cardiomyocytes	8
Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single poi	8
Monomethylated arsenic was the Major methylated arsenic in Red blood cells of acute promyelocytic leukemia patients treated with arsenic trioxide	8
Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation	8
PXR-mediated expression of FABP4 promotes valproate-induced lipid accumulation in HepG2 cells	8
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p–HIF3A axis	8
Potential toxicity evaluation and comparison within multiple mice organs after repeat injections of linear versus macrocyclic gadolinium-based contrast agents: A comprehensive and time course study	8
A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers	8
Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition	8
Pubertal exposure to acrylamide disrupts spermatogenesis by interfering with meiotic progression in male mice	8
HBM4EU chromates study – the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe	8
Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice	8
Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model	8
The main mechanisms of trimethyltin chloride-induced neurotoxicity: Energy metabolism disorder and peroxidation damage	8
In vitro human skin decontamination efficacy of MOF-808 in decontamination lotion following exposure to the nerve agent VX	8
Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration	8
Targeting SLC1A5 blocks cell proliferation through inhibition of mTORC1 in arsenite-treated human uroepithelial cells	8
The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity	8
Food additive sodium bisulfite induces intracellular imbalance of biothiols levels in NCM460 colonic cells to trigger intestinal inflammation in mice	8
FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway	8
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures	8
High concentrations of ammonia induced cytotoxicity and bronchoconstriction in a precision-cut lung slices rat model	8
Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary rat Leydig cells	8
Tris(1,3-dichloro-2-propyl) phosphate is a metabolism-disrupting chemical in male mice	8
Upregulation of hepatic CD36 via glucocorticoid receptor activation contributes to dexamethasone-induced liver lipid metabolism disorder in mice	8
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review	8
Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker®	8
Downregulation of hERG channel expression by tyrosine kinase inhibitors nilotinib and vandetanib predominantly contributes to arrhythmogenesis	7
Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung	7
Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice	7
Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat	7
Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues	7
Time-course transcriptome analysis of lungs from mice exposed to ricin by intratracheal inoculation	7
Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro	7
Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neur	7
Skin biological responses to urban pollution in an ex vivo model	7
Little in vitro effect of remdesivir on mitochondrial respiration and monoamine oxidase activity in isolated mitochondria	7
Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling	7
Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis	7
Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin	7
Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats	7
Neuroligin-1 plays an important role in methamphetamine-induced hippocampal synaptic plasticity	7
Changes in the renal function after acute mercuric chloride exposure in the rat are associated with renal vascular endothelial dysfunction and proximal tubule NHE3 inhibition	7
Up-regulation of microRNA-34a mediates ethanol-induced impairment of neural crest cell migration in vitro and in zebrafish embryos through modulating epithelial-mesenchymal transition by targeting Sna	7
Low dose of fire retardant, 2,2’,4,4’-tetrabromodiphenyl ether (BDE47), stimulates the proliferation and differentiation of progenitor Leydig cells of male rats during prepuberty	7
Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats	7
Repeated low-dose exposures to sarin disrupted the homeostasis of phospholipid and sphingolipid metabolism in guinea pig hippocampus	7
Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair	7
JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma	7
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action	7
Toxicity profiles and protective effects of antifreeze proteins from insect in mammalian models	7
Triphenyltin (TPT) exposure causes SD rat liver injury via lipid metabolism disorder and ER stress revealed by transcriptome analysis	7
Exogenous activation of toll-like receptor 5 signaling mitigates acetaminophen-induced hepatotoxicity in mice	7
Energy metabolism disorders and oxidative stress in the SH-SY5Y cells following PM2.5 air pollution exposure	7
Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model	7
Exposure to 4-bromodiphenyl ether during pregnancy blocks testis development in male rat fetuses	7
Cylindrospermopsin impairs vascular smooth muscle cells by P53-mediated apoptosis due to ROS overproduction	7
Cylindrospermopsin impairs tubular transport function in kidney cells LLC-PK1	7
Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats	7
miR-345–5p curbs hepatic stellate cell activation and liver fibrosis progression by suppressing hypoxia-inducible factor-1alpha expression	7
Effect of the dose on the toxicokinetics of a quaternary mixture of rare earth elements administered to rats	7
Macrophage-derived exosomal lncRNA MSTRG.91634.7 inhibits fibroblasts activation by targeting PINK1 in silica-induced lung fibrosis	7
Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques	6
Prenatal cyanuric acid exposure depresses hippocampal synaptic plasticity and induces spatial learning and memory deficits	6
In vitro enantioselective inhibition of the main human CYP450 enzymes involved in drug metabolism by the chiral pesticide tebuconazole	6
Does fluoride exposure impact on the human microbiome?	6
Involvement of a novel regulatory cascade consisting of SET-H3K18ac/H3K27ac-53BP1 in Cr(VI)-induced malignant transformation of 16HBE cells	6
Effects of the chelating agent DTPA on naturally accumulating metals in the body	6
Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis	6
The role of Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis in vivo and in vitro	6
The screening of the safety profile of polymeric based amoxicillin nanoparticles in various test systems	6
Shedding new light on methylmercury-induced neurotoxicity through the crosstalk between autophagy and apoptosis	6
Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo	6
Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes	6
In vitro Phase I metabolism of newly identified plasticizers using human liver microsomes combined with high resolution mass spectrometry and based on non-targeted and suspect screening workflows	6
A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity	6
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells	6
PPARγ activation inhibits endocytosis of claudin-4 and protects against deoxynivalenol-induced intestinal barrier dysfunction in IPEC-J2 cells and weaned piglets	6
Neuronal growth and synaptogenesis are inhibited by prenatal methamphetamine exposure leading to memory impairment in adolescent and adult mice	6
Analysis of the microRNA and mRNA expression profile of ricin toxin-treated RAW264.7 cells reveals that miR-155-3p suppresses cell inflammation by targeting GAB2	6
First insight on in vitro metabolism of three newly identified aryl organophosphate esters via a suspect coupled with nontarget screening approach	6
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor	6
Hypercholesterolemia reduces the expression and function of hepatic drug metabolizing enzymes and transporters in rats	6
The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity	6
Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a/C3aR complement system	6