Drug Development and Industrial Pharmacy

Article	Citations
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	55
Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant	31
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate	27
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	25
Polymeric oral fast dissolving films of metformin: fabrication, optimization, in vitro, and in vivo evalua	22
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	20
Preparation and evaluation of liposome with ropivacaine ion-pairing in local pain management	20
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	16
Microneedle-assisted transdermal delivery of amlodipine besylate loaded nanoparticles	16
Construction of albumin based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process in vivo to syne	16
Studies on ameliorative potentials of quercetin nanoparticles against imidacloprid induced subacute genotoxicity and histopathological alteration in Swiss albino mice	15
Polymyxin B and silver nanoparticles: a nanotechnology-driven approach to overcome antibiotic resistance	14
Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model	14
Ginkgolic acid as a fusion inhibitor: targeting RBD-ACE2 interaction with in silico, in vitro evidence of allosteric modulation and potent virucidal effect	14
Intranasal delivery of metal/metal oxide nanoparticles for the management of CNS-related diseases: theranostic and toxicity issues	14
Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation	14
Use of nanoemulsion for co-delivery of silibinin and cabazitaxel for prostate cancer treatment	13
Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation	13
Nicotine transport across calu-3 cell monolayer: effect of nicotine salts and flavored e-liquids	13
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	13
Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity	12
Polymorphic transformation of febuxostat after crystallization in presence of bentonite dispersion: characterization by the heat of fusion and heat of transition rule, and dissolution	12
Applications of bio-predictive dissolution tools for the development of solid oral dosage forms: current industry experience	12
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo	11
Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma	11

Network pharmacology prediction and molecular docking-based strategy to explore the pharmacodynamic substances and mechanism of “Mung Bean” against bacterial infection	11
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease	11
Correction	10
Solubility-permeability interplay of hydrotropic solubilization of piroxicam	10
The Future trends of Artificial Intelligence and innovative technologies in the new era of pharmaceutical sciences and Industry 4.0	10
Ocular delivery of sunitinib-loaded nanoparticles doped in tragacanthic acid hydrogel in treatment of diabetic retinopathy in rats	10
Assessment of Cytotoxic Effects of Quercetin Nanoemulgel on Different Skin Cancer cell lines	10
Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model	10
Development of PU foam dressings loaded with extract of Plectranthus amboinicus for burn wound healing	10
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and	10
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination	9
Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption	9
Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension	9
Comparative study between pH, time and colonic bacterial enzyme triggered polymers for colonic delivery of coated ketoprofen multi-particulates	9
An insight into molecular targets and nanotherapeutics for diabetic wound healing	9
Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery	8
The use of nanomedicines in the healthcare systems: a policy brief	8
Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system	8
pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma	8
Development and evaluation of a novel methotrexate-loaded electrospun patch to alleviate psoriasis plaques	8
Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels	8
Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice	8
Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored	8
Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application	8
Development and pharmacological evaluation of Evodia rutaecarpa extract-based transdermal gels: a novel approach for hypertension management	8
An updated review on pharmacological aspects and nanotechnological advancements of frankincense boswellic acids	8
Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography	8
Matrix metalloproteinase enzyme responsive delivery of 5-Fluorouracil using Collagen-I peptide functionalized Dendrimer-Gold nanocarrier	8
Design and optimization of venlafaxine niosomes loaded thermosensitive in-situ gel for prolonging intranasal residence in depressive disorder	7
Development of immediate release tablet formulations of lornoxicam with hot melt extrusion-based three-dimensional printing technology	7
A Novel image processing technique for weighted particle size distribution assessment	7
Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro rele	7
Unveiling the mechanistic aspect of biogenic copper oxide nanoparticles harnessing Citrus pseudolimon for eradicating multi-drug-resistant gram-negative	7
Overcoming bottlenecks in drug delivery: the promise of biomolecular and artificial molecular motors	7
Melting point depression for enhanced dissolution rate of eslicarbazepine acetate	7
Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle	7
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release	7
Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation	7
Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma	7
Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate	7
Formulation of Morus alba extract loaded solid lipid nanoparticles: in silico , characterizations, and in vitro	7
Functionalized liposomes for intranasal levodopa delivery to the brain	7
The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer	7
Silibinin solubilization: combined effect of co-solvency and inclusion complex formation	7
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	6
Enhanced photoprotection with rheum ribes -loaded solid lipid nanoparticles: a novel sunscreen gel formulation	6
Correction	6
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	6
A comprehensive review of green approaches to drug solubility enhancement	6
Q1 and Q2 selection, Q3, IVRT, IVPT, pharmacokinetic and pharmacodynamic evaluation of topical generic product	6

Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	6
Bioequivalence and pharmacokinetic prediction of oral marketed metformin extended-release tablets in Saudi Arabia	6
PEGylated drug delivery systems in the pharmaceutical field: past, present and future perspective	6
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	6
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	6
Quality by design (QbD)-driven formulation of sildenafil citrate microparticles using quasi-emulsion technique for pulmonary delivery: an in vitro study	6
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	6
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	5
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer	5
A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-acetylharpagide derived from Ajuga plan	5
Panaxadiol saponins-loaded gel for periodontitis therapy: anti-inflammatory and microbiota-modulating effects	5
Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and itsin-vitroanticancer activity	5
Green synthesis and biomedical potential of l -ascorbic acid-stabilized copper sulfide nanoparticles as antibacterial and antioxidant agents	5
A rapid solid form risk assessment workflow for ophthalmic drug candidates	5
Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib	5
Molecular dynamics and surfactant study for enhancing the formation and anti-oral cancer efficacy of D-limonene nanoemulsions	5
RETRACTED ARTICLE: Improvement of dissolution profile of eplerenone with solidified self-emulsifying drug delivery systems (S-SEDDS)	5
Ionically cross-linked pH-responsive interpenetrating polysaccharide network hydrogel tablets for colon-targeted delivery of budesonide	5
Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease	5
In vitro and in silico computational methods for assessing vaginal permeability	5
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets	5
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	5
Correction	5
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	5
Tumor microenvironment as a target for developing anticancer hydrogels	4
Potential mechanisms ofPyrrosiae Foliumin treating prostate cancer based on network pharmacology and molecular docking	4
Development of a novel human stratum corneum mimetic phospholipid ­vesicle-based permeation assay models for in vitro permeation studies	4
In vitro anticancer efficacy of Calendula Officinalis extract-loaded chitosan nanoparticles against gastric and colon cancer cells	4
Nasal residence time and rheological properties of a new bentonite-based thixotropic gel emulsion nasal spray – AM-301	4
Preparation and characterization of soluplus-based nanosuspension for dissolution enhancement of indomethacin using ultrasonic assisted precipitation method for formulation and Box-Behnken design for	4
Deoxycholic acid as a permeability enhancer of two antidiabetic drugs with distinctive biopharmaceutical properties through biological barriers	4
Gliclazide loaded spanlastic nanovesicles: empowering bioavailability and antidiabetic efficacy	4
Optimizing voriconazole-loaded thermoresponsive hydrogel: in silico tools and ex vivo studies	4
Amelioration of tableting properties and dissolution rate of naproxen co-grinded with nicotinamide: preparation and characterization of co-grinded mixture	4
Enhanced dissolution rates of glibenclamide through solid dispersions on microcrystalline cellulose and mannitol, combined with phosphatidylcholine	4
An in vitro release test method with Immersion Cells for evaluation of drug release performance of butenafine hydrochloride cream	4
Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid	4
Optimizing paracetamol-ascorbic acid effervescent tablet characteristics: a quality by design approach	4
Bicyclol alleviates high-fat diet-induced hepatic ER stress- and autophagy-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in mice	4
Synthesis and characterization of magnetic Ag–Fe 3 O 4 @polymer hybrid nanocomposite systems with promising antibacterial applicat	4
Method-dependent release kinetics of the sustained-release bolus tablets: a comparative study using daisy II incubator and continuous artificial saliva systems	4
Targeted delivery of resveratrol using PEGylated PLGA nanoparticles decorated with folic acid for cancer therapy: characterization, and in vitro studies	4
Development and validation of HPLC method for simultaneous determination of Leflunomide and folic acid in the nanoparticulate system by reversed-phase HPLC	4
The folate-linked chitosan-coated Kaempferol/HSA nano-transporters (FCKH-NTs) as the selective apoptotic inducer in human MCF-7 breast cancer cell line	4
Thermal energy and tableting effects in benznidazole product: the impacts of industrial processing	4
Nanoemulsion-based polyherbal mouthwash of cinnamon and clove oil: physicochemical characterization, molecular docking, and antimicrobial evaluations	4
Fabrication and optimization of naringin-loaded MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells	4
Emerging theranostics to combat cancer: a perspective on metal-based nanomaterials	4
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats	4
Retraction: Bioactive injectable triple acting thermosensitive hydrogel enriched with nano-hydroxyapatite for bone regeneration: in-vitro characterization, Saos-2 cell line cell viability and osteogen	4
Development and optimization of Clitoria teratea synthesized silver nanoparticles and its application to nanogel systems for wound healing	4
Emerging nanotechnology-based therapies in the treatment of diabetes: recent developments and future opinion	4
Exposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia	4
A facile one-step jet-milling approach for the preparation of proliposomal dry powder for inhalation as effective delivery system for anti-TB therapeutics	4
The role of artificial intelligence in drug development: enhancing pharmaceutical chemistry through machine learning and predictive modeling	3
Formulation, characterization and evaluation of minocycline hydrochloride loaded polyurethane/collagen nanofibers via electrospinning as wound dressings	3
Effect of PVP and HPMC on production of indomethacin amorphous nanoparticles: experiments and molecular dynamics simulations	3
Nintedanib and miR-29b co-loaded lipoplexes in idiopathic pulmonary fibrosis: formulation, characterization, and in vitro evaluation	3
Developing a rapid analytical method for simultaneous determination of apigenin and gallic acid: validation and application in a nanoliposomal formulation	3
Traditional Mongolian medicine Wu-Lan thirteen-flavor decoction protects rat from hypertension-induced renal injury via aryl hydrocarbon receptor-mediated pathway	3
Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery	3
Development and in-vitro optimization of telmisartan-curcumin solid dispersion nanoparticles for the management of diabetic nephropathy using DoE approach	3
Optimization and assessment of three generation solid dispersion for enhancement of solubility and dissolution for montelukast sodium	3
Evaluation of curcumin (CUR) loaded BSA nanoparticles for in-vitro photodynamic therapy on MCF-7 cell line	3
Correction	3
Combating breast cancer-associated metastasis using paclitaxel and tranilast-loaded human serum albumin nanoparticles	3
Study on the taste-masking effect and mechanism of Acesulfame K on berberine hydrochloride	3
Nanoformulations in the treatment of lung cancer: current status and clinical potential	3
Spray coverage analysis of topical sprays formed by cold thermoreversible hydrogels	3
Advancements in nanotechnology for targeted drug delivery in idiopathic pulmonary fibrosis: a focus on solid lipid nanoparticles and nanostructured lipid carriers	3
Formulation, optimization and full characterization of mirtazapine loaded aquasomes: a new technique to boost antidepressant effects	3
HPLC-based quantitative assessment of antiviral agents in artificial saliva	3
Microneedles assisted controlled and improved transdermal delivery of high molecular drugs viain situforming depot thermoresponsive poloxamers gels in skin microchannels	3
Computer-aided optimization of carbidopa/levodopa orally disintegrating tablets	3
Advancements in skin cancer treatment: 5-fluorouracil and carvedilol-loaded transethosomes using Lipoid S100	3
Self-nanoemulsifying drug delivery systems (SNEDDS) of anti-cancer drugs: a multifaceted nanoplatform for the enhancement of oral bioavailability	3
Development of pediatric orally disintegrating mini-tablets containing atomoxetine hydrochloride-β-cyclodextrin inclusion complex using experimental design	3
Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use	3
QbD-employed formulation and characterization of sacubitril-loaded solid lipid nanoparticles: a step forward in nanotechnology-based delivery for hypertension	3
Physicochemical interaction of rifampicin and ritonavir-lopinavir solid dispersion: an in-vitro and ex-vivo investigation	3

Hypolipidemic and HMG-CoA reductase inhibitory effects of 15-oxoursolic acid from Rhododendron arboreum : An In-vivo and In	3
Quantitative analysis of solid dosage forms of Atenolol by Raman spectroscopy	3
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly-γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC	3
Simple but novel taxifolin@pro-glycymicelles as effective treatment for acetaminophen overdose–induced hepatotoxicity: preparation, in vitro characterizations, and in vivo experimental evaluations	3
Advances in novel drug delivery systems: a focus on nanoparticles and mucoadhesive technologies	3
Applications of trimetallic nanomaterials as Non-Enzymatic glucose sensors	3
Enhanced skin penetration of Finasteride loaded DMSO-liposomes for the treatment of androgenic alopecia: comparison with conventional liposomes	3
In vivo assessment of bone repair by an injectable nanocomposite scaffold for local co-delivery of autologous platelet-rich plasma and calcitonin in a rat model	3
Biosynthesis of silver nanoparticles using Citrus hystrix leaf extract and evaluation of its anticancer efficacy against HeLa cell line	2
Box–Behnken based furosemide-nanostructured lipid carriers (NLCs) delivery system for improving oral bioavailability	2
In vitroandin vivoactivity of thermosensitive liposomes loaded with doxorubicin and cisplatin	2
Process validation and in vitro-in vivo evaluation of rosuvastatin calcium tablets	2
Retraction	2
Potent antiviral action detected in Tontelea micrantha extracts against Alphavirus chikungunya	2
Olive oil and flaxseed oil incorporating niosomes for enhanced in vivo anti-diabetic efficacy of canagliflozin	2
PEGylated solid lipid nanoparticles functionalized by aptamer for targeted delivery of docetaxel in mice bearing C26 tumor	2
Reducing residual solvent levels in poly (D, L-lactic-co-glycolic acid) microspheres: a roadmap for scalable industrial production	2
Dextran-based prodrug-nanoassemblies responsively releasing pidotimod and camptothecin for anti-breast cancer	2
Fabrication and analysis of chitosan oligosaccharide based mucoadhesive patch for oromucosal drug delivery	2
In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity	2
Design and evaluation of glimepiride hydrogel for transdermal delivery	2
Formulation of semi solid dosage forms for topical application utilizing quality by design (QbD) approach	2
Impact of actuation force on the quality assessment of pressurized metered-dose inhalers	2
Improved pharmacokinetic parameters and reduced tissue distribution of prodrug of triamcinolone acetonide in lipid nanospheres – a preliminary investigation	2
Design of a pilot plant-type pharmaceutical reactor to address the problem of interchangeability of generic semisolid formulations	2
Oral formulation of Prussian blue with improved efficacy for prophylactic use against thallium	2
Preparation and evaluation of gastrodin-ferulic acid co-loaded liposome gel patches for the treatment of migraine	2
Systems pharmacology approach to explore the mechanisms of shufeng Jiedu Capsule on treating H1N1 infection	2
In silico structural inhibition of ACE-2 binding site of SARS-CoV-2 and SARS-CoV-2 omicron spike protein by lectin antiviral dyad system to treat COVID-19	2
A new approach for the development of etodolac emulgels for rheumatic arthritis cure: in vitro and in vivo	2
Effective seed cake extract of O. sanctum inducing the p53 dependent apoptotic pathway in oral cancer cells	2
Characterization of withanolides and bacoside A-loaded proniosomes: effect on oxidative stress and survival under hypergravity in rodent model	2
Investigating the fate and toxicity of green synthesized gold nanoparticles in albino mice	2
Eutectic solutions for healing: a comprehensive review on therapeutic deep eutectic solvents (TheDES)	2
Quality by design (QbD) based approach for development of itraconazole-loaded transferosomes for skin cancer: in vitro, ex vivo and cell line studies	2
Micro-dosing of powders into capsules using a new automated micro-dosing system: effect of powder characteristics and operating conditions on the filling of 0.5 mg–100 mg weights	2
Ginkgo biloba leaves extract’s cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation	2
Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer	2
Quality-by-design driven approach in the formulation of an anti-ulcer and gastro-protective oral suspension	2
Ehretia microphylla Lam.: unveiling pharmacognostic, physicochemical, phytochemical and toxicity insights	2
Amplifying therapeutic potential through optimization of bioavailability of poorly soluble flavonols via albumin-based nanoparticles	2
Storage and in-use stability of an excipient enhanced growth (EEG) synthetic lung surfactant powder formulation	2
Antimycobacterial and autophagic activity of nebulized delamanid microemulsion targeting alveolar macrophage	2
Comparative study of Lepidium sativum orally administered seeds, hydrogel and atorvastatin on obesity of rats fed on a high fat diet	2
Skin pigmentation improvement with resveratrol microemulsion gel using polyoxyethylene hydrogenated castor oil	2
Preparation and in vitro characterization of curcumin loaded Chitosan-Hyaluronic acid polyelectrolyte complex based hydrogels	2
Green micellar liquid chromatographic analysis of alfuzosin hydrochloride and sildenafil citrate in a binary mixture compared to classical RPLC with stability indicating studies	2
Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique	2
Preparation and characterization of hydroxyapatite nanoparticles doped with nickel, tin, and molybdate ions for their antimicrobial effects	2
A novel approach of external lubrication in a rotary tablet press using electrostatics	2
Exploration of synergistically engineered invasomes of fluconazole incorporated with safranal against onychomycosis for enhanced transungual delivery	2
An insight into viscosity and conductivity in the formulation of co-axial electrospun Carica papaya leaf extract	2
Efficient drug development of oseltamivir capsules based on process control, bioequivalence and PBPK modeling	2
Enhancement of oral bioavailability and anti-colitis effect of luteolin-loaded polymer micelles with RA (rosmarinic acid)-SS-mPEG as carrier	2
Preparation and characterization of nano-emulsion formulations of Asparagus densiflorus root and aerial parts extracts: evaluation of in-vitro	2
Application of cocoa butter for formulation of fast melt tablets containing memantine hydrochloride	2
Optimization of the manufacturing process of a pediatric omeprazole enteric pellets suspension: Full Factorial Design	2
Prospects of engineered exosomes in clinical applications: a review	2