American Journal of Physiology-Cell Physiology

Article	Citations
Adipose tissue inflammation and metabolic dysfunction in obesity	604
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis	255
Long-term complications of COVID-19	223
A brief history of organoids	223
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19	148
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease	83
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons	72
In vitro and ex vivo models of adipocytes	70
Molecular nature and physiological role of the mitochondrial calcium uniporter channel	69
Extracellular matrix dynamics in vascular remodeling	65
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides	65
Heterogeneity within molecular subtypes of breast cancer	56
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation	53
Stem cells and lung regeneration	52
The intersection of metformin and inflammation	52
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis	49
H2S as a potential defense against COVID-19?	46
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids	44
Soluble ACE2 as a potential therapy for COVID-19	43
Integrative view of serpins in health and disease: the contribution of serpinA3	43
Is REDD1 a metabolic double agent? Lessons from physiology and pathology	41
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury	38
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies	38
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo	38
Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction	37

Drivers of dynamic intratumor heterogeneity and phenotypic plasticity	37
Factors mediating spaceflight-induced skeletal muscle atrophy	36
The glycosaminoglycan interactome 2.0	35
Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging	33
Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy	33
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension	32
Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1	32
Translating the force—mechano-sensing GPCRs	32
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells	32
Thrombospondin-1 in maladaptive aging responses: a concept whose time has come	32
Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review	32
ARF family GTPases with links to cilia	31
Advances in aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders	30
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury	30
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions	30
Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3	30
Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke	30
Monocyte recruitment and fate specification after myocardial infarction	29
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG	29
Mitochondrial DNA damage as driver of cellular outcomes	29
Role of glypican-1 in regulating multiple cellular signaling pathways	29
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin	28
Out of breath, out of time: interactions between HIF and circadian rhythms	28
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection	28
G protein-coupled receptor signaling: transducers and effectors	28
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain	28
Burn-induced hypermetabolism and skeletal muscle dysfunction	27
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair	27
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping	27
Cardiac tissue remodeling in healthy aging: the road to pathology	27
Macrophages in myocardial infarction	27
“SLC-omics” of the kidney: solute transporters along the nephron	26
GPCR systems pharmacology: a different perspective on the development of biased therapeutics	26
Sex omission and male bias are still widespread in cell experiments	26
The microRNA-29 family: role in metabolism and metabolic disease	26
Resolution of inflammation in immune and nonimmune cells by interleukin-19	26
Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease	25
Engineering fiber anisotropy within natural collagen hydrogels	25
The importance of mitochondrial quality control for maintaining skeletal muscle function across health span	25
Mechanisms of exercise as a preventative measure to muscle wasting	25
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function	25
LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling	25
A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy	24
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy	24
Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-κB signaling pathway	24
Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes	24
Control of coronary vascular resistance by eicosanoids via a novel GPCR	24
Coreceptor functions of cell surface heparan sulfate proteoglycans	24
Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer	24
Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes	23

Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1	23
Characterization of cellular oxidative stress response by stoichiometric redox proteomics	23
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus	23
Regulatory networks coordinating mitochondrial quality control in skeletal muscle	23
Recent progress in assays for GPCR drug discovery	23
WNKs are potassium-sensitive kinases	22
miRNA degradation in the mammalian brain	22
Electrically stimulated contractile activity-induced transcriptomic responses and metabolic remodeling in C2C12 myotubes: twitch vs. tetanic contractions	22
Role of SERCA and sarcolipin in adaptive muscle remodeling	22
Barriers and opportunities for gemcitabine in pancreatic cancer therapy	21
The emerging role of MEIS1 in cell proliferation and differentiation	21
Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism	21
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease	21
Aquaporin water channels as regulators of cell-cell adhesion proteins	21
Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking	21
Neuronal G protein-gated K+ channels	21
3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/	21
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach	21
Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent	21
Recent progress on surfactant protein A: cellular function in lung and kidney disease development	20
Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?	20
Aquaporin-5 regulation of cell–cell adhesion proteins: an elusive “tail” story	20
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors	20
Procoagulant platelets: novel players in thromboinflammation	20
Nonclassical monocytes in cardiovascular physiology and disease	19
Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation	19
Milk exosomes in nutrition and drug delivery	19
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis	19
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology	19
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles	19
Role of metaplasia during gastric regeneration	19
Bioprinting stem cells: building physiological tissues one cell at a time	19
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology	19
Murine models of Duchenne muscular dystrophy: is there a best model?	19
Proteolysis: a key post-translational modification regulating proteoglycans	19
Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase	19
WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration	18
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling	18
Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation	18
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle	18
A semiautomated measurement of muscle fiber size using the Imaris software	18
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function	18
Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies	18
Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth	18
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells	18
Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease	17
Changes in endothelial glycocalyx layer protective ability after inflammatory stimulus	17
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways	17
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes	17
MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1	17
Adaptive and maladaptive roles of lipid droplets in health and disease	17
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1	16
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers	16
Advances in the development of novel compounds targeting cation-chloride cotransporter physiology	16
Discovery of thymosin β4 as a human exerkine and growth factor	16
The role of Cl− and K+ efflux in NLRP3 inflammasome and innate immune response activation	16
Immunoengineering approaches for cytokine therapy	16
Global changes to HepG2 cell metabolism in response to galactose treatment	16
Role of proton-activated G protein-coupled receptors in pathophysiology	16
KATP channels in lymphatic function	16
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis	16
Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review	16
Chloride transport modulators as drug candidates	16
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding	15
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet	15
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro	15
Mitochondrial ion channels in cardiac function	15
Circulating miRNAs associated with nonalcoholic fatty liver disease	15
Aggrecan and versican: two brothers close or apart	15
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature	15
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death	15
Skeletal muscle wasting: the estrogen side of sexual dimorphism	15
miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition	15
Microfluidic confinement enhances phenotype and function of hepatocyte spheroids	15
The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans	15
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia	15
Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle	15
From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function	15
Targeting syndecan-1: new opportunities in cancer therapy	15
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells	14

Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers	14
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas	14
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response	14
Cartilage extracellular matrix-derived matrikines in osteoarthritis	14
Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages	14
Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells	14
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron	14
Is heparan sulfate a target for inhibition of RNA virus infection?	13
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging	13
Glycosaminoglycans in cancer therapy	13
Proteoglycans in Toll-like receptor responses and innate immunity	13
Kir6.1 and SUR2B in Cantú syndrome	13
Altered intramuscular network of lipid droplets and mitochondria in type 2 diabetes	13
Pathophysiological impact of the adhesion G protein-coupled receptor family	13
The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model	13
Moving human muscle physiology research forward: an evaluation of fiber type-specific protein research methodologies	13
Emerging roles of calcium-sensing receptor in the local regulation of intestinal transport of ions and calcium	13
Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts	13
β2 integrin activation and signal transduction in leukocyte recruitment	13
Elastin, arterial mechanics, and stenosis	13
Role of platelets in regulating activated coagulation factor XI activity	13
Active modulation of human erythrocyte mechanics	12
Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench	12
Protective and anti-inflammatory effects of acetylcholine in the heart	12
Distinct distribution patterns of exercise-induced natural killer cell mobilization into the circulation and tumor tissue of patients with prostate cancer	12
Imaging microphysiological systems: a review	12
The mechanobiome: a goldmine for cancer therapeutics	12
Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease	12
Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway	12
Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model	12
Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system	12
Therapeutic potential of antimicrobial peptides for treatment of wound infection	12
Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals	12
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage	12
Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway	12
Skeletal muscle memory	12
Epigenetic modifications in metabolic memory: What are the memories, and can we erase them?	12
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle	12
Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse	12
Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1	11
Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective	11
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function	11
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes	11
Imoxin inhibits tunicamycin-induced endoplasmic reticulum stress and restores insulin signaling in C2C12 myotubes	11
Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells	11
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production	11
Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1	11
TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis	11
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability	11
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes	11
Role of glycolysis in the development of atherosclerosis	11
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies	11
Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells	11
Transforming nanobodies into high-precision tools for protein function analysis	11
MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes	11
High glucose-induced effects on Na+-K+-2Cl− cotransport and Na+/H+ exchange of blood-brain barrier endothelial cells: involvement of SGK1, PKCβII	11
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model	11
Mitochondrial metabolism in macrophages	11
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks	11
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects	11
The circadian clock and extracellular matrix homeostasis in aging and age-related diseases	11
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype	11
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation	11
Skeletal tissue regulation by catalase overexpression in mitochondria	11
Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1	11
Premature satellite cell activation before injury accelerates myogenesis and disrupts neuromuscular junction maturation in regenerating muscle	11
Noncoding RNAs and RNA-binding proteins: emerging governors of liver physiology and metabolic diseases	11
The role of the tripartite synapse in the heart: how glial cells may contribute to the physiology and pathophysiology of the intracardiac nervous system	11
IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway	11
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells	10
Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin	10
Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity	10
Role of mechanosensitive channels/receptors in atherosclerosis	10
Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington’s disease	10
Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1α/KCNQ1OT1 axis	10
The basement membrane in epidermal polarity, stemness, and regeneration	10
The role of the glypican and syndecan families of heparan sulfate proteoglycans in cardiovascular function and disease	10
Akt scaffold proteins: the key to controlling specificity of Akt signaling	10
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation	10
Rac1 regulates nucleus pulposus cell degeneration by activating the Wnt/β-catenin signaling pathway and promotes the progression of intervertebral disc degeneration	10
Effect of the ketogenic diet in excitable tissues	10
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway	10
Rapid nutrient depletion to below the physiological range by cancer cells cultured in Plasmax	10
Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations	10
Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response	10
Heparan sulfate proteoglycan in Alzheimer’s disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism	10
Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome	10
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells	10
Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist	10
Sex differences in IL-10’s anti-inflammatory function: greater STAT3 activation and stronger inhibition of TNF-α production in male blood leukocytes ex vivo	10
Kir5.1 channels: potential role in epilepsy and seizure disorders	10