American Journal of Physiology-Cell Physiology

(The TQCC of American Journal of Physiology-Cell Physiology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Adipose tissue inflammation and metabolic dysfunction in obesity554
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis245
Long-term complications of COVID-19211
A brief history of organoids199
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19142
Purinergic signaling, DAMPs, and inflammation130
Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy128
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease76
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons68
In vitro and ex vivo models of adipocytes67
Aquaporin-3 in the epidermis: more than skin deep66
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain66
Extracellular matrix dynamics in vascular remodeling64
Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity62
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides57
Molecular nature and physiological role of the mitochondrial calcium uniporter channel57
Wound healing and fibrosis: a contrasting role for periostin in skin and the oral mucosa53
Extracellular vesicles as signaling mediators in type 2 diabetes mellitus52
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation50
The intersection of metformin and inflammation48
Stem cells and lung regeneration48
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis47
Heterogeneity within molecular subtypes of breast cancer46
H2S as a potential defense against COVID-19?45
Soluble ACE2 as a potential therapy for COVID-1942
Is REDD1 a metabolic double agent? Lessons from physiology and pathology41
Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers40
Integrative view of serpins in health and disease: the contribution of serpinA338
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo37
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids37
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity37
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury36
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p35
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling34
The glycosaminoglycan interactome 2.033
Factors mediating spaceflight-induced skeletal muscle atrophy33
Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging33
Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy32
Translating the force—mechano-sensing GPCRs31
New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease31
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells30
Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction30
Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE130
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension30
Mitochondrial DNA damage as driver of cellular outcomes29
ARF family GTPases with links to cilia29
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury29
Advances in aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders29
Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review29
Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP329
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies29
Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke29
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin28
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions28
More than a cell biosensor: aryl hydrocarbon receptor at the intersection of physiology and inflammation28
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping27
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair27
Role of glypican-1 in regulating multiple cellular signaling pathways27
Thrombospondin-1 in maladaptive aging responses: a concept whose time has come26
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG26
G protein-coupled receptor signaling: transducers and effectors25
Engineering fiber anisotropy within natural collagen hydrogels25
Cardiac tissue remodeling in healthy aging: the road to pathology25
Out of breath, out of time: interactions between HIF and circadian rhythms25
LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling25
Monocyte recruitment and fate specification after myocardial infarction25
Resolution of inflammation in immune and nonimmune cells by interleukin-1925
The importance of mitochondrial quality control for maintaining skeletal muscle function across health span24
GPCR systems pharmacology: a different perspective on the development of biased therapeutics24
Sex omission and male bias are still widespread in cell experiments24
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function23
A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy23
Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes23
Characterization of cellular oxidative stress response by stoichiometric redox proteomics23
Macrophages in myocardial infarction23
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy23
“SLC-omics” of the kidney: solute transporters along the nephron23
Control of coronary vascular resistance by eicosanoids via a novel GPCR23
Burn-induced hypermetabolism and skeletal muscle dysfunction22
Role of SERCA and sarcolipin in adaptive muscle remodeling22
Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer22
Recent progress in assays for GPCR drug discovery22
Coreceptor functions of cell surface heparan sulfate proteoglycans22
Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease22
The role of the sphingolipid pathway in liver fibrosis: an emerging new potential target for novel therapies22
miRNA degradation in the mammalian brain22
The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility22
Mechanisms of exercise as a preventative measure to muscle wasting22
Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A121
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus21
Electrically stimulated contractile activity-induced transcriptomic responses and metabolic remodeling in C2C12 myotubes: twitch vs. tetanic contractions21
Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes21
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain21
3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/21
WNKs are potassium-sensitive kinases21
Regulatory networks coordinating mitochondrial quality control in skeletal muscle21
The emerging role of MEIS1 in cell proliferation and differentiation21
The microRNA-29 family: role in metabolism and metabolic disease20
Aquaporin water channels as regulators of cell-cell adhesion proteins20
Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism20
Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?20
Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-κB signaling pathway20
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach20
Barriers and opportunities for gemcitabine in pancreatic cancer therapy20
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors20
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology19
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology19
Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase19
Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC419
Aquaporin-5 regulation of cell–cell adhesion proteins: an elusive “tail” story19
Milk exosomes in nutrition and drug delivery19
Bioprinting stem cells: building physiological tissues one cell at a time19
Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent19
Neuronal G protein-gated K+ channels19
Role of metaplasia during gastric regeneration19
Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?19
Different modalities of host cell death and their impact onMycobacterium tuberculosisinfection18
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle18
Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth18
Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies18
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling18
Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation18
Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking18
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles18
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease17
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function17
Changes in endothelial glycocalyx layer protective ability after inflammatory stimulus17
MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK117
Recent progress on surfactant protein A: cellular function in lung and kidney disease development17
Procoagulant platelets: novel players in thromboinflammation17
Nonclassical monocytes in cardiovascular physiology and disease17
WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration17
A semiautomated measurement of muscle fiber size using the Imaris software17
Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease16
Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation16
Adaptive and maladaptive roles of lipid droplets in health and disease16
Discovery of thymosin β4 as a human exerkine and growth factor16
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells16
Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels16
Murine models of Duchenne muscular dystrophy: is there a best model?16
Chloride transport modulators as drug candidates16
Global changes to HepG2 cell metabolism in response to galactose treatment16
The role of Cland K+efflux in NLRP3 inflammasome and innate immune response activation16
The cellular and molecular basis of in vivo synaptic plasticity in rodents16
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways16
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis16
From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function15
TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens15
Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review15
miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition15
KATP channels in lymphatic function15
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding15
Advances in the development of novel compounds targeting cation-chloride cotransporter physiology15
Proteolysis: a key post-translational modification regulating proteoglycans15
Circulating miRNAs associated with nonalcoholic fatty liver disease15
Immunoengineering approaches for cytokine therapy15
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia15
The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules inDrosophila melanogaster14
Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages14
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death14
Skeletal muscle wasting: the estrogen side of sexual dimorphism14
Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle14
Ca2+dependency of limb muscle fiber contractile mechanics in young and older adults14
The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans14
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes14
Mitochondrial ion channels in cardiac function14
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC114
Microfluidic confinement enhances phenotype and function of hepatocyte spheroids14
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet14
Role of proton-activated G protein-coupled receptors in pathophysiology14
TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway14
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response13
Role of platelets in regulating activated coagulation factor XI activity13
Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway13
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers13
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells13
Moving human muscle physiology research forward: an evaluation of fiber type-specific protein research methodologies13
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis13
Aggrecan and versican: two brothers close or apart13
Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers13
Targeting syndecan-1: new opportunities in cancer therapy13
Glycosaminoglycans in cancer therapy13
Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway12
Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model12
Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals12
Kir6.1 and SUR2B in Cantú syndrome12
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro12
MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes12
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas12
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature12
Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse12
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron12
Proteoglycans in Toll-like receptor responses and innate immunity12
Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells12
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging12
Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells12
The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model12
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage12
Active modulation of human erythrocyte mechanics12
Emerging roles of calcium-sensing receptor in the local regulation of intestinal transport of ions and calcium12
The role of the tripartite synapse in the heart: how glial cells may contribute to the physiology and pathophysiology of the intracardiac nervous system11
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes11
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies11
Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease11
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype11
Transforming nanobodies into high-precision tools for protein function analysis11
Altered intramuscular network of lipid droplets and mitochondria in type 2 diabetes11
Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts11
Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective11
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function11
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes11
Cartilage extracellular matrix-derived matrikines in osteoarthritis11
Elastin, arterial mechanics, and stenosis11
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks11
Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot111
β2 integrin activation and signal transduction in leukocyte recruitment11
The mechanobiome: a goldmine for cancer therapeutics11
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation11
Skeletal tissue regulation by catalase overexpression in mitochondria11
Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity10
Role of mechanosensitive channels/receptors in atherosclerosis10
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway10
Essential hypertension is associated with blunted smooth muscle cell vasodilator responsiveness and is reversed by 10-20-30 training in men10
Premature satellite cell activation before injury accelerates myogenesis and disrupts neuromuscular junction maturation in regenerating muscle10
Kir5.1 channels: potential role in epilepsy and seizure disorders10
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production10
A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics10
Protective and anti-inflammatory effects of acetylcholine in the heart10
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells10
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy10
Effect of the ketogenic diet in excitable tissues10
Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist10
Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells10
Is heparan sulfate a target for inhibition of RNA virus infection?10
Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells10
Mitochondrial metabolism in macrophages10
IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway10
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model10
Skeletal muscle memory10
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects10
Imaging microphysiological systems: a review10
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle10
Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington’s disease10
Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 110
Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells10
Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations10
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability10
TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis10
Role of glycolysis in the development of atherosclerosis10
Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome10