OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Cell Physiology is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-05-01 to 2023-05-01.)

Article	Citations
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke	340
The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA	98
Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction	92
ROS-induced autophagy regulates porcine trophectoderm cell apoptosis, proliferation, and differentiation	81
Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury	79
Oral squamous cell carcinoma-derived exosomes promote M2 subtype macrophage polarization mediated by exosome-enclosed miR-29a-3p	78
Copper transporters and copper chaperones: roles in cardiovascular physiology and disease	73
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling	70
Endoplasmic reticulum proteostasis: a key checkpoint in cancer	65
Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy	61
Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells	60
Gut organoids: mini-tissues in culture to study intestinal physiology and disease	59
Non-coding RNAs in kidney injury and repair	58
Cell type- and tissue-specific functions of ecto-5′-nucleotidase (CD73)	52
Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining	52
Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology	51
Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity	51
Autophagy in chronic liver diseases: the two faces of Janus	50
E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation	48
mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling	48
Roles of blood-brain barrier integrins and extracellular matrix in stroke	46
ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway in preeclampsia	45
Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis	45
TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts	45
Genetic and pharmacological inactivation of apical Na⁺-K⁺-2Cl⁻cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporte	43

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration	43
Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance	42
Autophagy, apoptosis, and mitochondria: molecular integration and physiological relevance in skeletal muscle	40
The role of coagulation and platelets in colon cancer-associated thrombosis	39
Role of extracellular vesicles in stem cell biology	38
Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT₁R/ROS/p38 MAPK/ADAM17 pathway	35
Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion	34
Matrix stiffness regulates microvesicle-induced fibroblast activation	32
Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway	32
MicroRNAs in brain development and cerebrovascular pathophysiology	30
A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes	29
Stem cells and lung regeneration	29
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells	29
MicroRNA-150 suppresses epithelial-mesenchymal transition, invasion, and metastasis in prostate cancer through the TRPM4-mediated β-catenin signaling pathway	28
Stroke and the neurovascular unit: glial cells, sex differences, and hypertension	27
Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1	27
Dopamine promotes colonic mucus secretion through dopamine D₅receptor in rats	26
Long non-coding RNA HOXA11-AS induces type I collagen synthesis to stimulate keloid formation via sponging miR-124-3p and activation of Smad5 signaling	25
MicroRNA-146a-5p enhances radiosensitivity in hepatocellular carcinoma through replication protein A3-induced activation of the DNA repair pathway	25
Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes	24
Let-7c regulates proliferation and osteodifferentiation of human adipose-derived mesenchymal stem cells under oxidative stress by targeting SCD-1	23
Stem cells and extracellular vesicles: biological regulators of physiology and disease	23
Electrical stimulation facilitates the angiogenesis of human umbilical vein endothelial cells through MAPK/ERK signaling pathway by stimulating FGF2 secretion	23
Long noncoding RNA MEG3 prevents vascular endothelial cell senescence by impairing miR-128-dependent Girdin downregulation	23
Roles of exosomes in metastatic colorectal cancer	23
Plant MIR156 regulates intestinal growth in mammals by targeting the Wnt/β-catenin pathway	22
On the role of tubulin, plectin, desmin, and vimentin in the regulation of mitochondrial energy fluxes in muscle cells	22
MicroRNA-488 inhibits progression of colorectal cancer via inhibition of the mitogen-activated protein kinase pathway by targeting claudin-2	22
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p	22
Inhibition of Smurf2 translation by miR-322/503 protects from ischemia-reperfusion injury by modulating EZH2/Akt/GSK3β signaling	22
TRIM27 promotes IL-6-induced proliferation and inflammation factor production by activating STAT3 signaling in HaCaT cells	21
Resident muscle stem cells are not required for testosterone-induced skeletal muscle hypertrophy	21
Physiological roles of non-coding RNAs	21
Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway	20
Everolimus induces G₁ cell cycle arrest through autophagy-mediated protein degradation of cyclin D1 in breast cancer cells	20
Cytokine and inflammatory mediator effects on TRPV4 function in choroid plexus epithelial cells	20
A central core disease mutation in the Ca²⁺-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation	19
Support of bone mineral deposition by regulation of pH	19
SMCHD1 terminates the first embryonic genome activation event in mouse two-cell embryos and contributes to a transcriptionally repressive state	19
Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency	19
Cold acclimation enhances UCP1 content, lipolysis, and triacylglycerol resynthesis, but not mitochondrial uncoupling and fat oxidation, in rat white adipocytes	19
HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension	19