American Journal of Physiology-Cell Physiology

Article	Citations
Adipose tissue inflammation and metabolic dysfunction in obesity	727
Long-term complications of COVID-19	243
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19	157
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease	93
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons	78
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides	77
Molecular nature and physiological role of the mitochondrial calcium uniporter channel	77
In vitro and ex vivo models of adipocytes	73
Heterogeneity within molecular subtypes of breast cancer	65
The intersection of metformin and inflammation	60
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis	54
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies	52
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids	48
Factors mediating spaceflight-induced skeletal muscle atrophy	46
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo	45
Soluble ACE2 as a potential therapy for COVID-19	44
Is REDD1 a metabolic double agent? Lessons from physiology and pathology	42
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury	41
Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction	40
The glycosaminoglycan interactome 2.0	39
Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1	39
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension	38
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells	38
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity	36
Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging	35

Role of glypican-1 in regulating multiple cellular signaling pathways	35
Translating the force—mechano-sensing GPCRs	34
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions	34
Mitochondrial DNA damage as driver of cellular outcomes	34
Macrophages in myocardial infarction	34
The microRNA-29 family: role in metabolism and metabolic disease	34
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain	34
Barriers and opportunities for gemcitabine in pancreatic cancer therapy	33
Monocyte recruitment and fate specification after myocardial infarction	32
Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review	32
Burn-induced hypermetabolism and skeletal muscle dysfunction	32
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury	32
Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3	31
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG	31
G protein-coupled receptor signaling: transducers and effectors	31
Mechanisms of exercise as a preventative measure to muscle wasting	30
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection	30
Recent progress in assays for GPCR drug discovery	28
Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease	28
The importance of mitochondrial quality control for maintaining skeletal muscle function across health span	28
Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-κB signaling pathway	28
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair	28
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function	27
GPCR systems pharmacology: a different perspective on the development of biased therapeutics	27
“SLC-omics” of the kidney: solute transporters along the nephron	27
Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes	27
Sex omission and male bias are still widespread in cell experiments	27
Proteolysis: a key post-translational modification regulating proteoglycans	26
Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1	26
Coreceptor functions of cell surface heparan sulfate proteoglycans	26
Control of coronary vascular resistance by eicosanoids via a novel GPCR	25
Engineering fiber anisotropy within natural collagen hydrogels	25
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy	25
A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy	25
Neuronal G protein-gated K+ channels	25
Characterization of cellular oxidative stress response by stoichiometric redox proteomics	24
Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism	24
Regulatory networks coordinating mitochondrial quality control in skeletal muscle	24
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach	24
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease	23
Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?	23
Nonclassical monocytes in cardiovascular physiology and disease	23
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus	23
Role of SERCA and sarcolipin in adaptive muscle remodeling	23
Electrically stimulated contractile activity-induced transcriptomic responses and metabolic remodeling in C2C12 myotubes: twitch vs. tetanic contractions	23
Aquaporin water channels as regulators of cell-cell adhesion proteins	22
WNKs are potassium-sensitive kinases	22
Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease	22
Procoagulant platelets: novel players in thromboinflammation	22
Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking	22

MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1	21
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles	21
The emerging role of MEIS1 in cell proliferation and differentiation	21
Aggrecan and versican: two brothers close or apart	21
Milk exosomes in nutrition and drug delivery	21
Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent	21
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling	21
Changes in endothelial glycocalyx layer protective ability after inflammatory stimulus	21
Adaptive and maladaptive roles of lipid droplets in health and disease	20
Skeletal muscle wasting: the estrogen side of sexual dimorphism	20
Aquaporin-5 regulation of cell–cell adhesion proteins: an elusive “tail” story	20
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes	20
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis	20
Murine models of Duchenne muscular dystrophy: is there a best model?	20
Role of proton-activated G protein-coupled receptors in pathophysiology	20
Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation	19
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology	19
Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies	19
Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation	19
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells	19
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology	19
Role of metaplasia during gastric regeneration	19
The role of Cl− and K+ efflux in NLRP3 inflammasome and innate immune response activation	18
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways	18
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death	18
Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages	18
The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans	18
A semiautomated measurement of muscle fiber size using the Imaris software	18
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1	18
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature	18
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding	18
Mitochondrial ion channels in cardiac function	17
Discovery of thymosin β4 as a human exerkine and growth factor	17
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers	17
Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis	17
Chloride transport modulators as drug candidates	17
Cartilage extracellular matrix-derived matrikines in osteoarthritis	17
Alignment, cross linking, and beyond: a collagen architect’s guide to the skeletal muscle extracellular matrix	17
Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system	17
Advances in the development of novel compounds targeting cation-chloride cotransporter physiology	17
Elastin, arterial mechanics, and stenosis	17
KATP channels in lymphatic function	17
Glycosaminoglycans in cancer therapy	17
The role of PIEZO ion channels in the musculoskeletal system	16
Targeting syndecan-1: new opportunities in cancer therapy	16
Immunoengineering approaches for cytokine therapy	16
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron	16
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis	16
Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review	16
Global changes to HepG2 cell metabolism in response to galactose treatment	16
Circulating miRNAs associated with nonalcoholic fatty liver disease	16
Altered intramuscular network of lipid droplets and mitochondria in type 2 diabetes	16
Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers	16
Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle	16
Is heparan sulfate a target for inhibition of RNA virus infection?	15
Skeletal muscle memory	15
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response	15
From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function	15
Emerging roles of calcium-sensing receptor in the local regulation of intestinal transport of ions and calcium	15
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas	15
Pathophysiological impact of the adhesion G protein-coupled receptor family	15
miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition	15
Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1	15
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells	15
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia	15
Proteoglycans in Toll-like receptor responses and innate immunity	14
Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench	14
IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway	14
Role of glycolysis in the development of atherosclerosis	14
Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells	14
Moving human muscle physiology research forward: an evaluation of fiber type-specific protein research methodologies	14
The basement membrane in epidermal polarity, stemness, and regeneration	14
Distinct distribution patterns of exercise-induced natural killer cell mobilization into the circulation and tumor tissue of patients with prostate cancer	14
Therapeutic potential of antimicrobial peptides for treatment of wound infection	14
Kir6.1 and SUR2B in Cantú syndrome	14
Role of platelets in regulating activated coagulation factor XI activity	14
Protective and anti-inflammatory effects of acetylcholine in the heart	14
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging	14
Epigenetic modifications in metabolic memory: What are the memories, and can we erase them?	14
Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway	13

Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1	13
The circadian clock and extracellular matrix homeostasis in aging and age-related diseases	13
Sex differences in IL-10’s anti-inflammatory function: greater STAT3 activation and stronger inhibition of TNF-α production in male blood leukocytes ex vivo	13
The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model	13
Akt scaffold proteins: the key to controlling specificity of Akt signaling	13
Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts	13
β2 integrin activation and signal transduction in leukocyte recruitment	13
The mechanobiome: a goldmine for cancer therapeutics	13
Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease	13
Noncoding RNAs and RNA-binding proteins: emerging governors of liver physiology and metabolic diseases	13
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime	13
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation	13
Imaging microphysiological systems: a review	13
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes	13
Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1α/KCNQ1OT1 axis	13
Effect of the ketogenic diet in excitable tissues	12
Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse	12
The function of glypicans in the mammalian embryo	12
Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations	12
Mitochondrial metabolism in macrophages	12
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells	12
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle	12
Transforming nanobodies into high-precision tools for protein function analysis	12
Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1	12
Role of androgens and androgen receptor in control of mitochondrial function	12
Heparan sulfate proteoglycan in Alzheimer’s disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism	12
The role of the glypican and syndecan families of heparan sulfate proteoglycans in cardiovascular function and disease	12
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes	12
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects	12
Imoxin inhibits tunicamycin-induced endoplasmic reticulum stress and restores insulin signaling in C2C12 myotubes	12
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production	12
High glucose-induced effects on Na+-K+-2Cl− cotransport and Na+/H+ exchange of blood-brain barrier endothelial cells: involvement of SGK1, PKCβII	12
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks	12
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model	12
Physiology of chemokines in the cancer microenvironment	12
Role of mechanosensitive channels/receptors in atherosclerosis	11
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation	11
Rapid nutrient depletion to below the physiological range by cancer cells cultured in Plasmax	11
Physiological basis of brief, intense interval training to enhance maximal oxygen uptake: a mini-review	11
RNA sequencing and immunofluorescence of the myotendinous junction of mature horses and humans	11
Granzyme B in epithelial barrier dysfunction and related skin diseases	11
Essential shared and species-specific features of mammalian oocyte maturation-associated transcriptome changes impacting oocyte physiology	11
Corticosterone inhibits vagal afferent glutamate release in the nucleus of the solitary tract via retrograde endocannabinoid signaling	11
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies	11
The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome	11
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype	11
Diverse functions of apolipoprotein A-I in lung fibrosis	11
In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?	11
Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5	11
Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells	11
Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective	11
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function	11
Fibronectin isoforms in skeletal development and associated disorders	11
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis	11
The role of the tripartite synapse in the heart: how glial cells may contribute to the physiology and pathophysiology of the intracardiac nervous system	11
SOCS3 limits TNF and endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin-6 signal in human endothelial cells	11
Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function	11
Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin	11
Dynamics and physiological meaning of complexes between ion channels and integrin receptors: the case of Kv11.1	11
Thrombospondins in bone remodeling and metastatic bone disease	10
Evaluation of G protein bias and β-arrestin 2 signaling in opioid-induced respiratory depression	10
Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity	10
Docosahexaenoic and eicosapentaenoic fatty acids differentially regulate glucose and fatty acid metabolism in L6 rat skeletal muscle cells	10
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro	10
Inward rectifier potassium (Kir) channels in the retina: living our vision	10
Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response	10
Mitochondrial functional resilience after TFAM ablation in the adult heart	10
Impact of the heparan sulfate proteoglycan perlecan on human disease and health	10
Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome	10
Senescence of alveolar epithelial progenitor cells: a critical driver of lung fibrosis	10
DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition	10
Hyaluronan network: a driving force in cancer progression	10
Kir5.1 channels: potential role in epilepsy and seizure disorders	10
Characterization of TRPV4-mediated signaling pathways in an optimized human choroid plexus epithelial cell line	10
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells	10
Subcellular trafficking and endocytic recycling of KATP channels	10
Rac1 regulates nucleus pulposus cell degeneration by activating the Wnt/β-catenin signaling pathway and promotes the progression of intervertebral disc degeneration	10
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway	10
Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron	10
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation	10
Epitranscriptomics in fibroblasts and fibrosis	10
Kir7.1 disease mutant T153I within the inner pore affects K+ conduction	9
Red blood cell ATP release correlates with red blood cell hemolysis	9
Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes	9
Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts	9
Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes	9
Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography	9
Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake	9
Syndecan-1 in liver pathophysiology	9
METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis	9
Dietary fructose as a metabolic risk factor	9
Proteoglycans and glycosaminoglycans in central nervous system injury	9
Mechanics of dystrophin deficient skeletal muscles in very young mice and effects of age	9
Epigenetic regulation and targeting of ECM for cancer therapy	9
Defining the versican interactome in lung health and disease	9