American Journal of Physiology-Cell Physiology

Article	Citations
Adipose tissue inflammation and metabolic dysfunction in obesity	516
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis	240
Long-term complications of COVID-19	198
A brief history of organoids	186
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19	139
Purinergic signaling, DAMPs, and inflammation	127
Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy	121
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease	70
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain	65
In vitro and ex vivo models of adipocytes	65
Aquaporin-3 in the epidermis: more than skin deep	64
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons	64
Extracellular matrix dynamics in vascular remodeling	63
Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity	62
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides	53
Molecular nature and physiological role of the mitochondrial calcium uniporter channel	53
Extracellular vesicles as signaling mediators in type 2 diabetes mellitus	51
Wound healing and fibrosis: a contrasting role for periostin in skin and the oral mucosa	49
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation	49
Stem cells and lung regeneration	48
The intersection of metformin and inflammation	45
H2S as a potential defense against COVID-19?	45
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis	45
Soluble ACE2 as a potential therapy for COVID-19	42
Heterogeneity within molecular subtypes of breast cancer	41

Is REDD1 a metabolic double agent? Lessons from physiology and pathology	40
Integrative view of serpins in health and disease: the contribution of serpinA3	38
Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers	38
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity	37
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo	36
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury	35
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p	35
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids	34
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling	33
Factors mediating spaceflight-induced skeletal muscle atrophy	32
The glycosaminoglycan interactome 2.0	32
Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy	31
Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging	30
Advances in aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders	29
Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke	29
ARF family GTPases with links to cilia	29
Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3	29
Translating the force—mechano-sensing GPCRs	28
More than a cell biosensor: aryl hydrocarbon receptor at the intersection of physiology and inflammation	28
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension	28
Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review	28
Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1	27
Role of glypican-1 in regulating multiple cellular signaling pathways	27
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping	27
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin	27
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells	27
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury	27
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies	27
Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction	27
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair	27
Mitochondrial DNA damage as driver of cellular outcomes	27
New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease	27
LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling	25
Thrombospondin-1 in maladaptive aging responses: a concept whose time has come	25
Cardiac tissue remodeling in healthy aging: the road to pathology	25
Monocyte recruitment and fate specification after myocardial infarction	25
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG	24
Engineering fiber anisotropy within natural collagen hydrogels	24
Out of breath, out of time: interactions between HIF and circadian rhythms	23
A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy	23
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function	23
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions	23
GPCR systems pharmacology: a different perspective on the development of biased therapeutics	22
Macrophages in myocardial infarction	22
Characterization of cellular oxidative stress response by stoichiometric redox proteomics	22
Mechanisms of exercise as a preventative measure to muscle wasting	22
Alamandine enhances cardiomyocyte contractility in hypertensive rats through a nitric oxide-dependent activation of CaMKII	22
The role of the sphingolipid pathway in liver fibrosis: an emerging new potential target for novel therapies	22
Role of SERCA and sarcolipin in adaptive muscle remodeling	22
Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes	22

Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer	22
Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease	22
G protein-coupled receptor signaling: transducers and effectors	22
miRNA degradation in the mammalian brain	22
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy	22
“SLC-omics” of the kidney: solute transporters along the nephron	22
Sex omission and male bias are still widespread in cell experiments	22
Resolution of inflammation in immune and nonimmune cells by interleukin-19	21
Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes	21
Regulatory networks coordinating mitochondrial quality control in skeletal muscle	21
The importance of mitochondrial quality control for maintaining skeletal muscle function across health span	21
Coreceptor functions of cell surface heparan sulfate proteoglycans	21
Electrically stimulated contractile activity-induced transcriptomic responses and metabolic remodeling in C2C12 myotubes: twitch vs. tetanic contractions	21
Control of coronary vascular resistance by eicosanoids via a novel GPCR	21
Burn-induced hypermetabolism and skeletal muscle dysfunction	21
Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1	20
The microRNA-29 family: role in metabolism and metabolic disease	20
Aquaporin water channels as regulators of cell-cell adhesion proteins	20
Recent progress in assays for GPCR drug discovery	20
WNKs are potassium-sensitive kinases	20
3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/	20
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach	20
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus	20
Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism	19
The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility	19
The emerging role of MEIS1 in cell proliferation and differentiation	19
Aquaporin-5 regulation of cell–cell adhesion proteins: an elusive “tail” story	19
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain	19
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors	19
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology	19
Role of metaplasia during gastric regeneration	19
Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4	19
Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation	18
NAD+ precursors protect corneal endothelial cells from UVB-induced apoptosis	18
LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing	18
Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase	18
Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies	18
Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?	18
Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth	18
Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-κB signaling pathway	18
Different modalities of host cell death and their impact onMycobacterium tuberculosisinfection	18
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles	18
Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?	18
Bioprinting stem cells: building physiological tissues one cell at a time	18
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle	17
Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking	17
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function	17
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling	17
Changes in endothelial glycocalyx layer protective ability after inflammatory stimulus	17
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease	17
WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration	17
Recent progress on surfactant protein A: cellular function in lung and kidney disease development	17
Barriers and opportunities for gemcitabine in pancreatic cancer therapy	17
A semiautomated measurement of muscle fiber size using the Imaris software	17
MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1	17
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology	17
Neuronal G protein-gated K+ channels	17
Milk exosomes in nutrition and drug delivery	17
Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent	16
Discovery of thymosin β4 as a human exerkine and growth factor	16
Nonclassical monocytes in cardiovascular physiology and disease	16
Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels	16
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis	16
Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease	16
Procoagulant platelets: novel players in thromboinflammation	16
Global changes to HepG2 cell metabolism in response to galactose treatment	16
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells	15
Murine models of Duchenne muscular dystrophy: is there a best model?	15
Advances in the development of novel compounds targeting cation-chloride cotransporter physiology	15
Chloride transport modulators as drug candidates	15
The cellular and molecular basis of in vivo synaptic plasticity in rodents	15
Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review	15
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia	15
Circulating miRNAs associated with nonalcoholic fatty liver disease	15
Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation	15
Immunoengineering approaches for cytokine therapy	15
From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function	15
KATP channels in lymphatic function	14
The role of Cl−and K+efflux in NLRP3 inflammasome and innate immune response activation	14
Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages	14

Synemin-related skeletal and cardiac myopathies: an overview of pathogenic variants	14
Skeletal muscle wasting: the estrogen side of sexual dimorphism	14
Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle	14
TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens	14
Ca2+dependency of limb muscle fiber contractile mechanics in young and older adults	14
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways	14
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet	14
Proteolysis: a key post-translational modification regulating proteoglycans	14
The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules inDrosophila melanogaster	14
Microfluidic confinement enhances phenotype and function of hepatocyte spheroids	14
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding	14
TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway	14
miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition	14
Adaptive and maladaptive roles of lipid droplets in health and disease	13
Mitochondrial ion channels in cardiac function	13
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis	13
Glycosaminoglycans in cancer therapy	13
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response	13
Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers	13
Moving human muscle physiology research forward: an evaluation of fiber type-specific protein research methodologies	13
Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway	13
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers	13
The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans	13
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death	13
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes	13
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1	13
Aggrecan and versican: two brothers close or apart	13
Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells	12
Targeting syndecan-1: new opportunities in cancer therapy	12
Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells	12
Role of platelets in regulating activated coagulation factor XI activity	12
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro	12
Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway	12
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging	12
The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model	12
Active modulation of human erythrocyte mechanics	12
MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes	12
Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model	12
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells	12
Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals	12
Role of proton-activated G protein-coupled receptors in pathophysiology	12
Skeletal tissue regulation by catalase overexpression in mitochondria	11
Proteoglycans in Toll-like receptor responses and innate immunity	11
Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts	11
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function	11
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation	11
Kir6.1 and SUR2B in Cantú syndrome	11
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage	11
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes	11
The mechanobiome: a goldmine for cancer therapeutics	11
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron	11
Transforming nanobodies into high-precision tools for protein function analysis	11
Emerging roles of calcium-sensing receptor in the local regulation of intestinal transport of ions and calcium	11
β2 integrin activation and signal transduction in leukocyte recruitment	11
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes	11
Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells	10
A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics	10
Protective and anti-inflammatory effects of acetylcholine in the heart	10
Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1	10
Role of glycolysis in the development of atherosclerosis	10
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature	10
Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington’s disease	10
Essential hypertension is associated with blunted smooth muscle cell vasodilator responsiveness and is reversed by 10-20-30 training in men	10
Premature satellite cell activation before injury accelerates myogenesis and disrupts neuromuscular junction maturation in regenerating muscle	10
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production	10
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model	10
TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis	10
Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity	10
Skeletal muscle memory	10
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle	10
Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse	10
Cartilage extracellular matrix-derived matrikines in osteoarthritis	10
Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells	10
Kir5.1 channels: potential role in epilepsy and seizure disorders	10
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability	10
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells	10
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects	10
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy	10
Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells	10
Elastin, arterial mechanics, and stenosis	10
Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations	10
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation	9
Physiology of chemokines in the cancer microenvironment	9
Effect of the ketogenic diet in excitable tissues	9
Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection	9
Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes	9
Corticosterone inhibits vagal afferent glutamate release in the nucleus of the solitary tract via retrograde endocannabinoid signaling	9
Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective	9
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies	9
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway	9
Isoform-specific Na,K-ATPase and membrane cholesterol remodeling in motor endplates in distinct mouse models of myodystrophy	9
Distinct distribution patterns of exercise-induced natural killer cell mobilization into the circulation and tumor tissue of patients with prostate cancer	9
Role of mechanosensitive channels/receptors in atherosclerosis	9
Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist	9
Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease	9