American Journal of Physiology-Heart and Circulatory Physiology

Article	Citations
Expanding the supply of donor hearts through donation after circulatory death	89
FoxO4 controls sGCβ transcription in vascular smooth muscle	80
Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart	80
Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis	64
Central command-related increases in blood velocity of anterior cerebral artery and prefrontal oxygenation at the onset of voluntary tapping	51
The multifaceted roles of red blood cells in health and disease	50
Prenatal stress induces sex- and tissue-specific alterations in insulin pathway of Wistar rats offspring	50
Sclerostin ablation prevents aortic valve stenosis in mice	49
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction	48
Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss	47
lncRNAs in vascular senescence and microvascular remodeling	45
Reply to De Mey et al.	42
The meaning of volume responsiveness and its relationship to venous return	42
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction	41
Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function	36
The vulnerable preterm heart: tale from the two chambers	35
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure	35
Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates	33
Volume responsiveness revisited: an observational multicenter study of continuous versus binary outcomes combining echocardiography and venous return physiology	33
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum	31
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency	31
Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications	30
Guidelines for assessing ventricular pressure-volume relationships in rodents	30
Innervation of adipocytes is limited in mouse perivascular adipose tissue	29
Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life	29

Sex differences in cardiovascular disease and dysregulation in Down syndrome	29
X’s, Y’s, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging	28
Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration	28
Adverse pregnancy outcomes and renal-vascular function in the early years after delivery	28
Corrigendum for Bigler et al., volume 327, 2024, p. H1124–H1131	28
Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine	27
Corrigendum for Methawasin et al., volume 328, 2025, p. H719–H733	27
Closing the window on COVID-19 case-control studies	26
Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase	26
Role of Membrane Microdomains in Cardiac Protection: Strategies for Diabetic Cardiomyopathy	26
Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation	26
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Giα proteins and hyperproliferation of vascular smooth muscle cells	26
Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response	26
Mutation of the 5′-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice	26
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum	25
Sexual dimorphism of psychological stress-induced susceptibility to ischemic heart disease: Is the king naked?	25
Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study	25
Constipation as a new nontraditional significant contributor to cardiovascular disease	25
Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans	25
Fetal cardiac troponin I levels decline toward birth in sheep	25
Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males	25
Insights into the associations between the gut microbiome, its metabolites, and heart failure	24
Cardiac health, type I collagen, and aging in the oim/oim mouse model of osteogenesis imperfecta and a cohort of adults with OI	24
Guidelines for in vivo models of developmental programming of cardiovascular disease risk	24
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation	23
Connecting the Dots between FXR1 Isoforms and miR-1 in Pediatric Dilated Cardiomyopathy	23
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy	23
Aortic aneurysm and dissection: complement and precision medicine in aortic disease	23
Chronotype and metabolic syndrome in midlife: findings from the Northern Finland Birth Cohort 1966	23
Is a decline in myocardial citrullination in the aged female heart really PAD2 the bone?	23
Corrigendum for Ferreira et al., volume 325, 2023, p. H774–H789	23
Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function	23
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events	22
Bedding as a variable affecting fasting blood glucose and vascular physiology in mice	22
When it comes to the heart, age, and sex matter (sometimes)	22
Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk	22
Sex differences in the functional morphology of coronary arteries in embryonic mice	21
Novel role of vascular chemerin in blood vessel tone	21
Sublingual microcirculatory function as a prognostic indicator of general microvascular health	21
To err, KIR2 that is, on the side of vasodilation in aging	21
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia	21
Structural and functional adaptations of human cardiomyocytes in metabolic disease and heart failure	20
Sex as a biological variable in exercise prescription: a critical consideration in developing a road map for sex-related differences in cardiovascular research	20
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia	20
Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish	20
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading	20
Salsalate negatively impacts microvascular function in women with endometriosis	20
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells	19
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype	19
Essential contributions of the α2-Na+/K+-ATPase ouabain binding site to cardiac remodeling	19

Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy	19
Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals	19
Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?	19
Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function	19
Vascular insulin resistance as a potential mechanism of increased cardiovascular risk in gestational diabetes	18
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke	18
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity	18
Increased Adiposity Impairs Vascular Function in Postmenopausal Women in Hemodialysis	18
Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF	18
Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction	18
Ebbs and tides of endothelial K+ currents that regulate blood flow	18
A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension	18
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology	18
Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx	18
Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects	18
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep	17
Irx5 and transient outward K+ currents contribute to transmural contractile heterogeneities in the mouse ventricle	17
Functional capacity and skeletal muscle morphology are linked to N-terminal proBNP but not left ventricular ejection fraction in patients with heart failure	17
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period	17
Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension	17
Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension	17
Real-time visualization of dextran extravasation in intermittent hypoxia mice using noninvasive SWIR imaging	17
The chicken, the egg, and the elephant: eNOS and NRG1 in fibrosis	17
Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate	17
Autonomic cardiovascular control during exercise	17
Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons	16
Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction	16
Plasma levels of sTREM2 in chronic heart failure: predictors and prognostic relevance	16
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function	16
Procurement and preservation of neonatal porcine cardiac tissue	16
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure	16
Mechanical response of cardiac microtissues to acute localized injury	16
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection	16
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases	16
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes	16
Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study	16
Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population	15
Tailoring transfection for cardiomyocyte cell lines: balancing efficiency and toxicity in lipid versus polymer-based transfection methods in H9c2 and HL-1 cells	15
Adverse childhood events and cardiovascular diseases: the potential role of Sirt1	15
Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women	15
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart	15
Comprehensive ultrasound imaging of right ventricular remodeling under surgically induced pressure overload in mice	15
Hypoxic neutrophils enflame the infarcted heart	15
The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome	15
Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring	15
Trypsin cleavage of the β1-adrenergic receptor	15
Cardiovascular and Aortic Wave Reflection Responses to Evening Binge Alcohol Consumption	15
Serial blood volume measurements in patients with compensated chronic heart failure: How do volume profiles change over time?	15
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation	15
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway	15
Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research	15
Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids	14
The gut microbiome as a modulator of arterial function and age-related arterial dysfunction	14
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction	14
Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19	14
Mlc2v-Cre induces germline recombination in a sex-biased manner	14
β-Blockers are associated with increased B-type natriuretic peptide levels differently in men and women in heart failure with preserved ejection fraction	14
The role of T cells in vascular aging, hypertension, and atherosclerosis	14
Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats	13
The stronger sex, until menopause: understanding the impact of estrogen loss on heart function	13
Long-term cerebrovascular dysfunction in the offspring from maternal electronic cigarette use during pregnancy	13
Contextualization of observed racial differences in biomarkers to avoid racial essentialism	13
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy	13
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction	13
Age-related changes in left ventricular vortex and energy loss patterns: from newborns to adults	13
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model	13
Matrix anisotropy promotes angiogenesis in a density-dependent manner	13
Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study	13
Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome	13
Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury	13
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction	13
Interleukin 4/13 signaling in cardiac regeneration and repair	13
Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research	13
Racial disparity in microvascular function among women with newly diagnosed breast cancer	13
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling	13
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation	13
Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction	13
Understanding Takotsubo syndrome: first evaluate your mouse model	12
Association of right ventricular dysfunction with blood volume expansion to outcomes in chronic left-sided heart failure	12
Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress	12

High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice	12
What frozen human hearts can tell us about treating heart failure	12
Ethanol: striking the cardiovascular system by harming the gut microbiota	12
Reply to Liu et al.	12
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids	12
Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome	12
Splicing Factor Kinase SRPK1 inhibition in Monocyte: A Novel Therapeutic Approach for Peripheral Arterial Disease	12
The importance of biological sex in cardiac cachexia	12
Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications	12
Intracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity	12
A minimally invasive swine model of chronic kidney disease-associated heart failure	12
Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension	12
Computer modeling to predict balloon pulmonary angioplasty success	12
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension	12
Evolving hemodynamics in Fontan circulation: age-driven insights in patients with interrupted inferior vena cava and hepatoazygos shunt	12
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults	12
Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats	12
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles	12
Estrogen contributes to the sex difference in the occurrence of senescence-related T cells during the development of visceral adipose tissue inflammation	11
The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms	11
Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria	11
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan	11
Coronary vasodilation mediated by T cells expressing choline acetyltransferase	11
High variability in the reproducibility of key hemodynamic responses to head-up tilt	11
Differential effects of myosin activators on myocardial contractile function in nonfailing and failing human hearts	11
Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature	11
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure	11
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability	11
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice	11
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis	11
Reply to Blaustein et al.	11
Atrial pacing improves mitochondrial function in peripheral blood mononuclear cells in patients with cardiac implantable electronic devices	11
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling	11
Development and characterization of a mass cytometry panel for detecting the effect of acute doxorubicin exposure on murine cardiac nonmyocytes	11
Deletion of the Aryl Hydrocarbon Receptor in Endothelial Cells Improves Ischemic Angiogenesis in Chronic Kidney Disease	11
Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog	11
Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder	11
Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury	11
Is there an “athlete’s vein”?	10
Hippo signaling pathway and mitochondrial dysfunction in Takotsubo syndrome	10
Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice	10
The role of mechanosignaling in the control of myocardial mass	10
Glucocorticoids impair T lymphopoiesis after myocardial infarction	10
Retraction for Howard et al., volume 301, 2011, H1447–H1455	10
Understanding the molecular basis of cardiomyopathy	10
The cardiovascular subtleties of testosterone on gender-affirming hormone therapy	10
Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice	10
Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference	10
The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”	10
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults	10
Selective elevation in external carotid artery flow during acute gravitational transition to microgravity during parabolic flight	10
Sleep disturbance and sympathetic neural reactivity in postmenopausal females	10
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection	10
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease	10
Mitochondrial respiration analysis in permeabilized porcine left ventricular and human right atrial specimens with ischemia-reperfusion	10
Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study	10
Considering impact of age and sex on cardiac cytoskeletal components	9
Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation	9
PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension	9
Cardioprotective effects of exercise on ischemic heart disease: digging into the downstream signaling pathways	9
Regulation of cardiac fibroblasts by lymphocytes after a myocardial infarction: playing in the major league	9
RRAGD variants cause cardiac dysfunction in a zebrafish model	9
Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology	9
A novel TASK channel antagonist nasal spray reduces sleep apnea severity in physiological responders: a randomized, blinded, trial	9
Heartbreak to immune breakdown: myocardial infarction is causing thymic injury mediated by activation of the hypothalamus-pituitary-adrenal axis	9
Local ionotropic glutamate receptors are required to trigger and sustain ramping of sympathetic nerve activity by hypothalamic paraventricular nucleus TNFα	9
S100A1’s single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes	9
Reply to Madias	9
Sigmoidal heart rate response pattern during exercise in patients with chronic heart failure	9
Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b	9
Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice	9
Vascular regeneration: a new mechanism of glucagon-like peptide-1 receptor agonist-mediated cardioprotection?	9
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones	9
Immune cell β2-adrenergic receptors contribute to the development of heart failure	9
Cardiac energy substrate utilization in heart failure with preserved ejection fraction: reconciling conflicting evidence on fatty acid and glucose metabolism	9
(Re)modeling high-salt diet-induced hypertension in mice	9
Mueller maneuver attenuates left atrial phasic volumes and myocardial strain in healthy younger adults	9
Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension	9
Proof-of-concept for monoclonal antibody therapy in a cellular model of acquired long QT syndrome type 3	8
Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus specific	8
The two-pore K+ channel TREK-1 regulates pressure overload-induced cardiac remodeling	8
Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling	8
Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling	8
Metabolic signatures of pregnancy-induced cardiac growth	8
Hypertrophic heart failure promotes gut dysbiosis and gut leakage in interleukin 10-deficient mice	8
Multiomics analyses of the complex interplay between genetic variants, DNA methylation, and gene expression in COVID-19	8
Endothelial mechanisms for inactivation of inflammation-induced hyperpermeability	8
Impact of breakthrough COVID-19 cases during the omicron wave on vascular health and cardiac autonomic function in young adults	8
Scn1b expression in the adult mouse heart modulates Na+ influx in myocytes and reveals a mechanistic link between Na+ entry and diastolic function	8
Blunted heart rate recovery to spontaneous nocturnal arousals in short-sleeping adults	8
Sex differences in cardiovascular risk factor responses to resistance and endurance training in younger subjects	8
Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems	8
Sex matters: β-adrenergic receptor contributions to hypoxic vasodilation	8
Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy	8
Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart	8