American Journal of Physiology-Heart and Circulatory Physiology

Article	Citations
Sex differences in cardiovascular disease and dysregulation in Down syndrome	120
Expanding the supply of donor hearts through donation after circulatory death	84
Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss	80
Find the stimulus, save the heart: a heroes’ story	71
Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart	68
FoxO4 controls sGCβ transcription in vascular smooth muscle	62
Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis	53
Central command-related increases in blood velocity of anterior cerebral artery and prefrontal oxygenation at the onset of voluntary tapping	51
Sclerostin ablation prevents aortic valve stenosis in mice	47
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction	47
Prenatal stress induces sex- and tissue-specific alterations in insulin pathway of Wistar rats offspring	46
Reply to De Mey et al.	45
The meaning of volume responsiveness and its relationship to venous return	43
Adverse pregnancy outcomes and renal-vascular function in the early years after delivery	43
The multifaceted roles of red blood cells in health and disease	41
Guidelines for assessing ventricular pressure-volume relationships in rodents	40
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency	40
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction	40
Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications	39
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum	38
Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates	37
Volume responsiveness revisited: an observational multicenter study of continuous versus binary outcomes combining echocardiography and venous return physiology	35
The Vulnerable Preterm Heart: Tale from the Two Chambers	33
LncRNAs in vascular senescence and microvascular remodeling	32
Sustained Tenascin-C Expression Drives Neointimal Hyperplasia and Promotes Aortocaval Fistula Failure	30

Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function	30
Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life	28
Innervation of adipocytes is limited in mouse perivascular adipose tissue	28
X’s, Y’s, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging	27
Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans	27
Corrigendum for Bigler et al., volume 327, 2024, p. H1124–H1131	27
Cardiac health, type I collagen, and aging in the oim/oim mouse model of osteogenesis imperfecta and a cohort of adults with OI	27
Mutation of the 5′-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice	26
Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine	26
Insights into the associations between the gut microbiome, its metabolites, and heart failure	26
Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric intrauterine growth restriction or cardiovascular risk induced by placental ischemia in the rat	26
Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function	26
Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase	25
Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation	25
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Giα proteins and hyperproliferation of vascular smooth muscle cells	25
Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response	25
Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males	24
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy	24
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum	24
Constipation as a new nontraditional significant contributor to cardiovascular disease	24
Closing the window on COVID-19 case-control studies	24
Chronotype and metabolic syndrome in midlife: findings from the Northern Finland Birth Cohort 1966	24
Sexual dimorphism of psychological stress-induced susceptibility to ischemic heart disease: Is the king naked?	23
Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration	23
Guidelines for in vivo models of developmental programming of cardiovascular disease risk	23
Fetal cardiac troponin I levels decline toward birth in sheep	23
Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk	23
Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study	23
Corrigendum for Ferreira et al., volume 325, 2023, p. H774–H789	23
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading	22
Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF	22
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation	22
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype	22
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events	22
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology	21
Guidelines for the measurement of vascular function and structure in isolated arteries and veins	21
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells	21
Structural and Functional Adaptations of Human Cardiomyocytes in Metabolic Disease and Heart Failure	21
Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?	21
Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx	21
Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function	21
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke	21
Sublingual microcirculatory function as a prognostic indicator of general microvascular health	20
Novel role of vascular chemerin in blood vessel tone	20
Aortic aneurysm and dissection: complement and precision medicine in aortic disease	20
Sex differences in the functional morphology of coronary arteries in embryonic mice	20
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia	20
Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals	20
To err, KIR2 that is, on the side of vasodilation in aging	20
When it comes to the heart, age, and sex matter (sometimes)	20

Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction	19
Delineating racial and socioeconomic-related health disparities in end-stage heart failure: insight from cardiac DNA methylation	19
Salsalate negatively impacts microvascular function in women with endometriosis	19
Essential contributions of the α2-Na+/K+-ATPase ouabain binding site to cardiac remodeling	19
Vascular insulin resistance as a potential mechanism of increased cardiovascular risk in gestational diabetes	19
Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish	19
A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension	19
Sex as a biological variable in exercise prescription: a critical consideration in developing a road map for sex-related differences in cardiovascular research	19
Bedding as a variable affecting fasting blood glucose and vascular physiology in mice	18
Procurement and preservation of neonatal porcine cardiac tissue	18
Ebbs and tides of endothelial K+ currents that regulate blood flow	18
Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy	18
Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons	18
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia	18
Irx5 and transient outward K+ currents contribute to transmural contractile heterogeneities in the mouse ventricle	17
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period	17
Real-time visualization of dextran extravasation in intermittent hypoxia mice using noninvasive SWIR imaging	17
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection	17
The chicken, the egg, and the elephant: eNOS and NRG1 in fibrosis	17
Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects	17
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep	17
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure	17
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity	17
Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension	16
Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension	16
Extracellular vesicle interplay in cardiovascular pathophysiology	16
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function	16
Plasma levels of sTREM2 in chronic heart failure: predictors and prognostic relevance	16
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases	16
Mechanical response of cardiac microtissues to acute localized injury	16
Adverse childhood events and cardiovascular diseases: the potential role of Sirt1	16
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes	16
Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate	16
Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study	16
Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction	16
Autonomic cardiovascular control during exercise	16
β-Blockers are associated with increased B-type natriuretic peptide levels differently in men and women in heart failure with preserved ejection fraction	15
Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population	15
Hypoxic neutrophils enflame the infarcted heart	15
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation	15
Serial blood volume measurements in patients with compensated chronic heart failure: How do volume profiles change over time?	15
The gut microbiome as a modulator of arterial function and age-related arterial dysfunction	15
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction	15
Tailoring transfection for cardiomyocyte cell lines: balancing efficiency and toxicity in lipid versus polymer-based transfection methods in H9c2 and HL-1 cells	15
Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research	15
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart	15
Comprehensive ultrasound imaging of right ventricular remodeling under surgically induced pressure overload in mice	15
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction	15
The stronger sex, until menopause: understanding the impact of estrogen loss on heart function	14
Cardiac nicotinic receptors show β-subunit-dependent compensatory changes	14
The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome	14
Mlc2v-Cre induces germline recombination in a sex-biased manner	14
Splicing Factor Kinase SRPK1 inhibition in Monocyte: A Novel Therapeutic Approach for Peripheral Arterial Disease	14
Matrix anisotropy promotes angiogenesis in a density-dependent manner	14
Long-term electronic cigarette exposure induces cardiovascular dysfunction similar to tobacco cigarettes: role of nicotine and exposure duration	14
Trypsin cleavage of the β1-adrenergic receptor	14
TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest	14
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway	14
Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women	14
Contextualization of observed racial differences in biomarkers to avoid racial essentialism	14
Age-related changes in left ventricular vortex and energy loss patterns: from newborns to adults	14
Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19	14
Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring	14
The role of T cells in vascular aging, hypertension, and atherosclerosis	14
Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids	14
Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction	14
Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury	13
Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research	13
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation	13
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy	13
Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress	13
Long-term cerebrovascular dysfunction in the offspring from maternal electronic cigarette use during pregnancy	13
Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study	13
Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome	13
Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome	13
Ignoring a basic pathophysiological mechanism of heart failure progression will not make it go away	13
Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats	13
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction	13
Ifetroban reduces coronary artery dysfunction in a mouse model of Duchenne muscular dystrophy	13
Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis	13

Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure	12
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles	12
Cardiac myosin binding protein-C phosphorylation accelerates β-cardiac myosin detachment rate in mouse myocardium	12
The importance of biological sex in cardiac cachexia	12
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids	12
Coronary vasodilation mediated by T cells expressing choline acetyltransferase	12
Understanding Takotsubo syndrome: first evaluate your mouse model	12
High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice	12
Computer modeling to predict balloon pulmonary angioplasty success	12
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model	12
Reply to Blaustein et al.	12
Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension	12
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling	12
Interleukin 4/13 signaling in cardiac regeneration and repair	12
Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder	12
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability	12
Deletion of the Aryl Hydrocarbon Receptor in Endothelial Cells Improves Ischemic Angiogenesis in Chronic Kidney Disease	12
Reply to Liu et al.	11
What frozen human hearts can tell us about treating heart failure	11
Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature	11
Sigmoidal heart rate response pattern during exercise in patients with chronic heart failure	11
Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in Col4a3−/− Alport mice	11
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling	11
Moderate aerobic exercise prevents matrix degradation and death in a mouse model of aortic dissection and aneurysm	11
Differential effects of myosin activators on myocardial contractile function in nonfailing and failing human hearts	11
The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms	11
Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria	11
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension	11
A minimally invasive swine model of chronic kidney disease-associated heart failure	11
Ethanol: striking the cardiovascular system by harming the gut microbiota	11
Intracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity	11
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis	11
Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications	11
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults	11
Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats	11
Reply to Madias	11
RRAGD variants cause cardiac dysfunction in a zebrafish model	11
Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog	11
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice	11
Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury	11
High variability in the reproducibility of key hemodynamic responses to head-up tilt	11
Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice	10
Is there an “athlete’s vein”?	10
Atrial pacing improves mitochondrial function in peripheral blood mononuclear cells in patients with cardiac implantable electronic devices	10
Cardiac Energy Substrate Utilization in Heart Failure with Preserved Ejection Fraction: Reconciling Conflicting Evidence on Fatty Acid and Glucose Metabolism	10
Thioredoxin-interacting protein (Txnip): more than its name	10
Glucocorticoids impair T lymphopoiesis after myocardial infarction	10
What keeps us up at night? The cardiovascular impact of nighttime arousals from sleep	10
Hippo signaling pathway and mitochondrial dysfunction in Takotsubo syndrome	10
Mitochondrial respiration analysis in permeabilized porcine left ventricular and human right atrial specimens with ischemia-reperfusion	10
S100A1’s single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes	10
Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice	10
The cardiovascular subtleties of testosterone on gender-affirming hormone therapy	10
Development and characterization of a mass cytometry panel for detecting the effect of acute doxorubicin exposure on murine cardiac nonmyocytes	10
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection	10
Structural and functional remodeling of the female Apoe−/− mouse aorta due to chronic cigarette smoke exposure	10
Understanding the molecular basis of cardiomyopathy	10
Immune cell β2-adrenergic receptors contribute to the development of heart failure	10
Unraveling the thread of uncontrolled immune response in COVID-19 and STEMI: an emerging need for knowledge sharing	10
Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study	10
(Re)modeling high-salt diet-induced hypertension in mice	10
Corrigendum for Nawaito et al., volume 316, 2019, p. H1281–H1296	10
Estrogen contributes to the sex difference in the occurrence of senescence-related T cells during the development of visceral adipose tissue inflammation	10
Cardioprotective effects of exercise on ischemic heart disease: digging into the downstream signaling pathways	10
Selective elevation in external carotid artery flow during acute gravitational transition to microgravity during parabolic flight	10
The role of mechanosignaling in the control of myocardial mass	10
The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”	10
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease	10
Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference	10
Sleep disturbance and sympathetic neural reactivity in postmenopausal females	10
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults	10
Vascular regeneration: a new mechanism of glucagon-like peptide-1 receptor agonist-mediated cardioprotection?	9
Mueller maneuver attenuates left atrial phasic volumes and myocardial strain in healthy younger adults	9
Considering impact of age and sex on cardiac cytoskeletal components	9
Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice	9
Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension	9
Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats	9
K+ currents in ventricular cardiomyocytes of p.N98S-calmodulin mutant mice	9
Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b	9
Local ionotropic glutamate receptors are required to trigger and sustain ramping of sympathetic nerve activity by hypothalamic paraventricular nucleus TNFα	9
The critical role of microvesicles in the modulation of renin-angiotensin-aldosterone system in endothelial homeostasis	9
Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation	9
Antecubital Venous Endothelial ETB Receptor Protein Expression is Preserved with Aging in Men	9
Calcification prevalence in different vascular zones and its association with demographics, risk factors, and morphometry	9
Sympathetic determinants of resting blood pressure in males and females	9
Heartbreak to immune breakdown: myocardial infarction is causing thymic injury mediated by activation of the hypothalamus-pituitary-adrenal axis	9
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones	9
Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice	9
Regulation of cardiac fibroblasts by lymphocytes after a myocardial infarction: playing in the major league	9
A novel TASK channel antagonist nasal spray reduces sleep apnea severity in physiological responders: a randomized, blinded, trial	9
Impact of COVID-19 on cardiac autonomic function in healthy young adults: potential role of symptomatology and time since diagnosis	9
Exercise for chronic kidney disease: effects on vascular and cardiopulmonary function	9
Carotid artery stiffness mechanisms, heart failure events, and atrial fibrillation in MESA: the Multi-Ethnic Study of Atherosclerosis	9
Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans	8
Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart	8