American Journal of Physiology-Heart and Circulatory Physiology

Article	Citations
Expanding the supply of donor hearts through donation after circulatory death	109
The multifaceted roles of red blood cells in health and disease	103
lncRNAs in vascular senescence and microvascular remodeling	93
The meaning of volume responsiveness and its relationship to venous return	62
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction	59
Prenatal stress induces sex- and tissue-specific alterations in insulin pathway of Wistar rats offspring	57
Innervation of adipocytes is limited in mouse perivascular adipose tissue	55
Farther and faster: enhancing skeletal muscle performance	53
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction	52
Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm	48
Adverse pregnancy outcomes and renal-vascular function in the early years after delivery	47
Volume responsiveness revisited: an observational multicenter study of continuous versus binary outcomes combining echocardiography and venous return physiology	45
Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications	43
Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium	40
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency	40
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure	39
The vulnerable preterm heart: tale from the two chambers	38
Reply to De Mey et al.	36
Modifying the electrical excitability of cardiomyocytes in rainbow trout ( Oncorhynchus mykiss ) through exercise training	36
Sex differences in cardiovascular disease and dysregulation in Down syndrome	33
Sclerostin ablation prevents aortic valve stenosis in mice	32
Guidelines for assessing ventricular pressure-volume relationships in rodents	31
Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function	31
FoxO4 controls sGCβ transcription in vascular smooth muscle	31
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum	31

Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males	30
Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis	30
Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates	30
Constipation as a new nontraditional significant contributor to cardiovascular disease	30
Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss	30
Fetal cardiac troponin I levels decline toward birth in sheep	29
Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation	29
Closing the window on COVID-19 case-control studies	28
Guidelines for in vivo models of developmental programming of cardiovascular disease risk	27
Corrigendum for Methawasin et al., volume 328, 2025, p. H719–H733	27
Connecting the dots between FXR1 isoforms and miR-1 in pediatric dilated cardiomyopathy	27
Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy	27
Is a decline in myocardial citrullination in the aged female heart really PAD2 the bone?	26
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum	26
X’s, Y’s, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging	26
Reply to Skalidis et al.	26
Corrigendum for Bigler et al., volume 327, 2024, p. H1124–H1131	26
Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans	25
Sexual dimorphism of psychological stress-induced susceptibility to ischemic heart disease: Is the king naked?	25
Cardiac health, type I collagen, and aging in the oim/oim mouse model of osteogenesis imperfecta and a cohort of adults with OI	25
Mechanisms matter: a powerful example of insights gained through computational physiology	25
Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine	25
Insights into the associations between the gut microbiome, its metabolites, and heart failure	25
Exercise as a Vital Sign in Cardiopulmonary Disease: Insights from Wave Intensity Analysis	25
Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function	25
Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase	25
Chronotype and metabolic syndrome in midlife: findings from the Northern Finland Birth Cohort 1966	24
Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration	24
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy	24
Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study	24
Corrigendum for Ferreira et al., volume 325, 2023, p. H774–H789	23
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation	23
Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk	23
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia	22
When it comes to the heart, age, and sex matter (sometimes)	22
Advanced phenotyping in patients with a Fontan circulation uncovers effects of pulmonary vascular disease	22
To err, KIR2 that is, on the side of vasodilation in aging	22
Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx	21
Increased adiposity impairs vascular function in postmenopausal women in hemodialysis	21
Novel role of vascular chemerin in blood vessel tone	21
Vascular insulin resistance as a potential mechanism of increased cardiovascular risk in gestational diabetes	21
Beyond the QT interval: how QT/RR hysteresis may reveal a sex-dependent hidden risk for cardiac arrhythmias	21
Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals	21
Essential contributions of the α2-Na+/K+-ATPase ouabain binding site to cardiac remodeling	20
Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?	20
Differential right ventricular afterload during exercise in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension	20
Sublingual microcirculatory function as a prognostic indicator of general microvascular health	20
Structural and functional adaptations of human cardiomyocytes in metabolic disease and heart failure	20
Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility	19
Sex as a biological variable in exercise prescription: a critical consideration in developing a road map for sex-related differences in cardiovascular research	19

Detecting rapid elevations in blood pressure using a novel pulse arrival time and machine learning technique	19
Salsalate negatively impacts microvascular function in women with endometriosis	19
Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish	19
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading	19
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia	19
Sex differences in the functional morphology of coronary arteries in embryonic mice	19
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells	19
Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction	18
Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation	18
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke	18
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology	18
Sugar-coating the endothelium: Adaptive or maladaptive?	18
Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy	18
The role of α 2 -adrenergic mechanisms in sympathetic baroreflex control of human blood pressure	18
Echocardiographic Imaging in Conscious, Unsedated Sheep: A Novel Approach Enabling Apical Views for Advanced Cardiac Assessment	18
Accelerating systematic reviews: a novel 1-wk screening protocol using rule-based automation with AI-assisted Python coding	18
Bedding as a variable affecting fasting blood glucose and vascular physiology in mice	18
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events	18
Aortic aneurysm and dissection: complement and precision medicine in aortic disease	17
Plasma levels of sTREM2 in chronic heart failure: predictors and prognostic relevance	17
Real-time visualization of dextran extravasation in intermittent hypoxia mice using noninvasive SWIR imaging	17
Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons	17
Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension	17
Ebbs and tides of endothelial K+ currents that regulate blood flow	17
Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF	17
Functional capacity and skeletal muscle morphology are linked to N-terminal proBNP but not left ventricular ejection fraction in patients with heart failure	17
Procurement and preservation of neonatal porcine cardiac tissue	17
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep	16
Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction	16
Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension	16
Cardiovascular and aortic wave reflection responses to evening binge alcohol consumption	16
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function	16
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity	16
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases	16
Autonomic cardiovascular control during exercise	16
Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects	16
Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study	16
Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate	16
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes	16
Mechanical response of cardiac microtissues to acute localized injury	16
Irx5 and transient outward K+ currents contribute to transmural contractile heterogeneities in the mouse ventricle	16
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period	16
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection	16
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure	16
Tailoring transfection for cardiomyocyte cell lines: balancing efficiency and toxicity in lipid versus polymer-based transfection methods in H9c2 and HL-1 cells	15
β-Blockers are associated with increased B-type natriuretic peptide levels differently in men and women in heart failure with preserved ejection fraction	15
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction	15
Editorial Board	15
Comprehensive ultrasound imaging of right ventricular remodeling under surgically induced pressure overload in mice	15
Hypoxic neutrophils enflame the infarcted heart	15
Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring	15
Mlc2v-Cre induces germline recombination in a sex-biased manner	15
Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women	15
Serial blood volume measurements in patients with compensated chronic heart failure: How do volume profiles change over time?	15
Trypsin cleavage of the β1-adrenergic receptor	15
Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research	15
The role of T cells in vascular aging, hypertension, and atherosclerosis	15
Racial disparity in microvascular function among women with newly diagnosed breast cancer	14
Association of right ventricular dysfunction with blood volume expansion to outcomes in chronic left-sided heart failure	14
Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction	14
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway	14
The gut microbiome as a modulator of arterial function and age-related arterial dysfunction	14
The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome	14
The stronger sex, until menopause: understanding the impact of estrogen loss on heart function	14
MRI assessed cardiac structure and function in young adult offspring of hypertensive pregnancies: a 27-year prospective follow-up birth cohort	14
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction	14
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart	14
Acute vascular function responses predict chronic vascular function changes to heating and exercise interventions in young, healthy recreationally active adults	14
Contextualization of observed racial differences in biomarkers to avoid racial essentialism	14
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation	14
Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19	14
Acute Binge Alcohol Increases Risk of Arrhythmias and Myocardial Fibrosis in a Mouse Model of Arrhythmogenic Cardiomyopathy	14
Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population	14
Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis	13
Splicing factor kinase SRPK1 inhibition in monocyte: a novel therapeutic approach for peripheral arterial disease	13
Corrigendum for Robinson et al., volume 319, 2020, p. H306–H319	13
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling	13
Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance	13
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction	13
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model	13

Persisting elevation of total hemoglobin mass after altitude training in elite swimmers: a potential role of prolonged erythrocyte survival	13
Matrix anisotropy promotes angiogenesis in a density-dependent manner	13
Age-related changes in left ventricular vortex and energy loss patterns: from newborns to adults	13
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy	13
Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome	13
The neurovascular unit in type 2 diabetes: a tale of two sexes	13
Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome	13
Interleukin 4/13 signaling in cardiac regeneration and repair	13
Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury	13
What frozen human hearts can tell us about treating heart failure	12
High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice	12
High variability in the reproducibility of key hemodynamic responses to head-up tilt	12
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles	12
Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension	12
Intracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity	12
Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder	12
Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress	12
Evolving hemodynamics in Fontan circulation: age-driven insights in patients with interrupted inferior vena cava and hepatoazygos shunt	12
Dual effects of the small-conductance Ca 2+ -activated K + current on human atrial electrophysiolo	12
Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats	12
A minimally invasive swine model of chronic kidney disease-associated heart failure	12
Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications	12
Understanding Takotsubo syndrome: first evaluate your mouse model	12
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability	12
Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury	12
The importance of biological sex in cardiac cachexia	11
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan	11
Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia	11
Deletion of the Aryl Hydrocarbon Receptor in Endothelial Cells Improves Ischemic Angiogenesis in Chronic Kidney Disease	11
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure	11
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice	11
Collagen VIII: A New Guardian of Endothelial Cell Identity in Atherosclerosis	11
Reply to Liu et al.	11
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis	11
Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation	11
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids	11
Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature	11
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults	11
Reply to Blaustein et al.	11
The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms	11
Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice	11
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling	11
Differential effects of myosin activators on myocardial contractile function in nonfailing and failing human hearts	11
Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria	11
Sigmoidal heart rate response pattern during exercise in patients with chronic heart failure	10
Estrogen contributes to the sex difference in the occurrence of senescence-related T cells during the development of visceral adipose tissue inflammation	10
Cigarette exposure lights the NLPR3 inflammasome pathway to atrial fibrillation	10
Mitochondrial respiration analysis in permeabilized porcine left ventricular and human right atrial specimens with ischemia-reperfusion	10
The cardiovascular subtleties of testosterone on gender-affirming hormone therapy	10
Is there an “athlete’s vein”?	10
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension	10
Hippo signaling pathway and mitochondrial dysfunction in Takotsubo syndrome	10
Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice	10
Chloride/bicarbonate exchange adversely modifies cardiovascular responses to traumatic brain injury	10
Atrial pacing improves mitochondrial function in peripheral blood mononuclear cells in patients with cardiac implantable electronic devices	10
PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension	10
(Re)modeling high-salt diet-induced hypertension in mice	10
The role of mechanosignaling in the control of myocardial mass	10
Selective elevation in external carotid artery flow during acute gravitational transition to microgravity during parabolic flight	10
Reply to Madias	10
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection	10
Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study	10
The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”	10
Retraction for Howard et al., volume 301, 2011, H1447–H1455	10
Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice	10
Cardioprotective effects of exercise on ischemic heart disease: digging into the downstream signaling pathways	10
Association between blood pressure and invasive hemodynamic measures in myocardial bridging	10
Development and characterization of a mass cytometry panel for detecting the effect of acute doxorubicin exposure on murine cardiac nonmyocytes	10
Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference	10
Understanding the molecular basis of cardiomyopathy	9
Impact of COVID-19 on cardiac autonomic function in healthy young adults: potential role of symptomatology and time since diagnosis	9
A novel TASK channel antagonist nasal spray reduces sleep apnea severity in physiological responders: a randomized, blinded, trial	9
TREK-1: a Janus-faced and subcellular location-based regulator of cardiac remodeling in heart failure	9
Connecting postmenopausal vasomotor symptoms and blood pressure regulation: a role for the autonomic nervous system?	9
Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice	9
Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology	9
Sleep disturbance and sympathetic neural reactivity in postmenopausal females	9
S100A1’s single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes	9
Carotid artery stiffness mechanisms, heart failure events, and atrial fibrillation in MESA: the Multi-Ethnic Study of Atherosclerosis	9
Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension	9
Persistence of cardiac malprogramming in late gestational fetal sheep by early to midgestational testosterone excess	9
Antecubital Venous Endothelial ETB Receptor Protein Expression is Preserved with Aging in Men	9
Regulation of cardiac fibroblasts by lymphocytes after a myocardial infarction: playing in the major league	9
Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice	9
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults	9
Bridging the Gap: Connexin 43 at the Frontline of Endothelial Repair	9
Heartbreak to immune breakdown: myocardial infarction is causing thymic injury mediated by activation of the hypothalamus-pituitary-adrenal axis	9
Exercise for chronic kidney disease: effects on vascular and cardiopulmonary function	9
Sympathetic determinants of resting blood pressure in males and females	9
Clinical significance and correlation of microRNA-21 expression in patients undergoing transcatheter aortic valve replacement	9
Macro- and microinjury define the heart failure progression after permanent coronary ligation or ischemia-reperfusion in young healthy mice	9
Are E-Cigarettes a Safer Alternative? Revisiting the Cardiovascular Cost of Nicotine Delivery	9
Mechanisms that limit regression of myocardial fibrosis following removal of left ventricular pressure overload	9
Glucocorticoids impair T lymphopoiesis after myocardial infarction	9
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease	9