OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Labelled Compounds & Radiopharmaceuticals is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Thorium chelators for targeted alpha therapy: Rapid chelation of thorium‐226	17
Use of radioiodine in nuclear medicine—A brief overview	17
Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties	16
Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [¹¹C]Tolebrutinib, via palladium‐NiXantphos‐mediated carbonylation	15
Radioiodination of balsalazide, bioevaluation, and characterization as a highly selective radiotracer for imaging of ulcerative colitis in mice	13
Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [¹⁸F]PM‐PBB3 for clinical applications	13
A ⁶⁴Cu‐porphyrin‐based dual‐modal molecular probe with integrin α_vβ₃ targeting function for tumour imaging	13
Production of [⁸⁹Zr]Oxinate₄ and cell radiolabeling for human use	11
Enantioselective synthesis of tri‐deuterated (–)‐geosmin to be used as internal standard in quantitation assays	9
Production of [⁶⁸Ga]Ga‐PSMA: Comparing a manual kit‐based method with a module‐based automated synthesis approach	8
Automated synthesis of ⁶⁸Ga/¹⁷⁷Lu‐PSMA on the Trasis miniAllinOne	8
Automated radiosynthesis of [⁶⁸Ga]Ga‐PSMA‐11 and [¹⁷⁷Lu]Lu‐PSMA‐617 on the iPHASE MultiSyn module for clinical applications	8
Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a ^99mTc targeting receptor for cancer diagnostic imaging	7
Fully automated production of the fibroblast activation protein radiotracer [¹⁸F]FAPI‐74	7
New synthesis of 6″‐[¹⁸F]fluoromaltotriose for positron emission tomography imaging of bacterial infection	7
A novel ^99mTc‐diester complex as tumor targeting agent: Synthesis, radiolabeling, and biological distribution study	7
Positron emission tomography imaging of a novel Anxa1‐targeted peptide ¹⁸F‐Al‐NODA‐Bn‐p‐SCN‐GGGRDN‐IF7 in A431 cancer mouse models	6
A one‐pot radiosynthesis of [¹⁸F]PARPi	6
Review: Self‐radiolysis of compounds containing tritium and carbon‐14	6
Automated GMP production and long‐term experience in radiosynthesis of CB₁ tracer [¹⁸F]FMPEP‐d₂	6
Copper‐mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide	6
Dual‐labeled prostate‐specific membrane antigen (PSMA)‐targeting agent for preoperative molecular imaging and fluorescence‐guided surgery for prostate cancer	6
Development of an automated production process of [⁶⁴Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications	5
Development of a fully automated low‐pressure [¹¹C]CO carbonylation apparatus	5
Arabinofuranose‐derived positron‐emission tomography radiotracers for detection of pathogenic microorganisms	5

A practical approach to the optimization of positron emission tomography imaging agents for the central nervous system	5
Strategies for designing novel positron emission tomography (PET) radiotracers to cross the blood–brain barrier	5
Evaluating N‐difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [¹⁸F]fluoroform	4
Radiolabeled (R)‐(–)‐5‐iodo‐3′‐O‐[2‐(ε‐guanidinohexanoyl)‐2‐phenylacetyl]‐2′‐deoxyuridine: A new theranostic for neuroblastoma	4
Synthesis of a deuterated 6‐AmHap internal standard for the determination of hapten density in a heroin vaccine drug product	4
Preclinical evaluation of anti‐VEGFR2 monoclonal antibody ramucirumab labelled with zirconium‐89 for tumour imaging	4
Carbon‐11 carboxylation of terminal alkynes with [¹¹C]CO₂	4
Synthesis of deuterium‐labeled cinnamic acids: Understanding the volatile benzenoid pathway in the flowers of the Japanese loquat Eriobotrya japonica	4
Radiolabeled hormones in insulin research, a minireview	3
Facile synthesis of 2‐deoxy‐2‐[¹⁸F]fluorosorbitol using sodium borohydride on aluminum oxide	3
Synthesis and analysis of isotopically stable labeled nitrosamines as mass spectrometry standards for drug impurity quality control	3
Selective synthesis of L‐2‐[¹⁸F]fluoro‐alpha‐methylphenylalanine via copper‐mediated ¹⁸F‐fluorination of (mesityl)(aryl)iodonium salt	3
Radiosynthesis, in vitro and preliminary biological evaluation of [¹⁸F]2‐amino‐4‐((2‐((3‐fluorobenzyl)oxy)benzyl)(2‐((3‐(fluoromethyl)benzyl)oxy)benzyl)amino)butanoic acid, a novel alanine	3
Synthesis of ¹³C‐labelled cutin and suberin monomeric dicarboxylic acids of the general formula HO₂¹³C‐(CH₂)_n‐¹³CO₂H (n<	3
Synthesis of [H‐3]‐ and [C‐14]‐labeled elagolix	3
Detailed radiosynthesis of [¹⁸F]mG4P027 as a positron emission tomography radiotracer for mGluR4	3
An improved one‐pot preparation of [¹⁸F]FMISO based on solid phase extraction purification: Pitfalls on the analytical method reported in the Ph.Eur.'s monograph	3
Exploration of alcohol‐enhanced Cu‐mediated radiofluorination toward practical labeling	3
Production of the next‐generation positron nuclide zirconium‐89 (⁸⁹Zr) guided by Monte Carlo simulation and its good quality for antibody labeling	3
Isotopically labelled compounds in research projects of life sciences	3
The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects	3
Novel developed HPLC analyses of [⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu‐EDTMP and [⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu‐DOTA‐Zoledronate	2
Study of the ^99mTc‐labeling conditions of 6‐hydrazinonicotinamide‐conjugated peptides from a new perspective: Introduction to the term radio‐stoichiometry	2
Iodination of CART(61‐102) peptide: Preserved binding and anorexigenic activity in mice	2
Development of an automated, GMP compliant FASTlab™ radiosynthesis of [¹⁸F]GE‐179 for the clinical study of activated NMDA receptors	2
Development of a ⁶⁸Ga‐labelled PET tracer for carbonic anhydrase IX‐overexpressed tumors using the artificial sweetener saccharin	2
Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites	2
Radiosynthesis of ³H‐ and ¹⁴C‐labeled Veliparib	2
Synthesis of ¹⁸F‐radiolabeled organophosphine fluorides for thiol‐chemoselective peptide conjugation	2
Improved protocol for the radiosynthesis of [¹⁸F]FTC‐146: A potent and selective sigma‐1 receptor radioligand	2
S‐(4‐nitrobenzyl)‐6‐thioinosine: Tritium labelling at high specific activity	2
Automated radiosynthesis of 1‐(2‐[¹⁸F]fluoroethyl)‐L‐tryptophan ([¹⁸F]FETrp) for positron emission tomography (PET) imaging of cancer in humans	2
Enzymatic synthesis of halogen derivatives of L‐phenylalanine and phenylpyruvic acid stereoselectively labeled with hydrogen isotopes in the side chain	2
Peptides for trans‐blood–brain barrier delivery	2
High‐yield synthesis of a tau PET radioligand and its nonradioactive ligand using an alternative protection and deprotection strategy	2
Synthesis of [¹³C₆]‐ibrutinib	2
Process validation, current good manufacturing practice production, dosimetry, and toxicity studies of the carbonic anhydrase IX imaging agent [¹¹¹In]In‐XYIMSR‐01 for phase I regulatory app	2
Synthesis of isotopically labelled αCGRP_8‐37 and its lipidated analogue	2
Synthesis and automated fluorine‐18 radiolabeling of new PSMA‐617 derivatives with a CuAAC radiosynthetic approach	2
Carbon‐13 synthesis and NMR spectroscopic geometric isomer evaluation to support the filing of teriflunomide	2
An updated synthesis of N₁′‐([¹¹C]methyl)naltrindole for positron emission tomography imaging of the delta opioid receptor	2
Comparison of three different methods in [⁶⁸Ga]Ga‐PSMA11 radiolabeling	2
Exploring the enzyme‐catalyzed synthesis of isotope labeled cyclopropanes	1
Copper‐mediated nucleophilic radiofluorination of [¹⁸F]β‐CFT for positron emission tomography imaging of dopamine transporter	1
Synthesis and radiolabeling of a polar [¹²⁵I]I‐1,2,4,5‐tetrazine	1
Synthesis of a dual carbon‐14‐labeled calcitonin gene‐related peptide receptor antagonist for use in a human absorption–distribution–metabolism–elimination study	1
Development of a novel [¹⁸F]fluorobenzyl derivative of the AT₁ receptor antagonist Candesartan	1
Benzylic deuteration of alkylnitroaromatics via amine‐base catalysed exchange with deuterium oxide	1
Preparation, quality control, and biodistribution assessment of [¹¹¹In]In‐DOTA‐PR81 in BALB/c mice bearing breast tumors	1
Synthesis of [4S‐²H]NADH, [4R‐²H]NADH, [4‐²H₂]NADH and [4‐²H]NAD⁺ cofactors through heterogeneous biocatalysis in heavy	1

Ultra‐fast liquid chromatography method coupled with ultraviolet detection to quantify dimethylsulfoxide, dimethylformamide and dimethylacetamide in short half‐lives radiopharmaceuticals	1
Determination of isotope abundance for deuterium‐labeled compounds by quantitative ¹H NMR + ²H NMR	1
Fluorine‐18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein	1
Highly selective catalytic transfer hydrodeuteration of cyclic alkenes	1
In vivo and in vitro binding of [¹²⁵I]I‐R‐(+)‐TISCH: A dopamine D₁ receptor ligand for studying pancreatic β‐cell mass	1
Automated radiosynthesis of [¹¹C]MTP38—a phosphodiesterase 7 imaging tracer—using [¹¹C]hydrogen cyanide for clinical applications	1
The synthesis of one H‐2 labeled and two H‐3 labeled leukotriene C4 synthase inhibitors	1
An improved synthesis of [¹⁸F]VAT and its precursor	1
Low‐scale syringe‐made synthesis of ¹⁵N‐labeled oligonucleotides	1
Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry	1
Automated synthesis of (R)‐[¹⁸F]MH.MZ on the iPhase Flexlab reaction platform	1
A comparative study on Suzuki‐type ¹¹C‐methylation of aromatic organoboranes performed in two reaction media	1
Simplified and accessible [¹⁸F]F‐AraG synthesis procedure for preclinical PET	1
Hydrogen isotope exchange labelling: A brief update	1
An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters	1
A practical and environmentally friendly protocol for synthesis of α‐deuterated carboxylic acids	1
Site‐specifically radiolabeled nanobodies for imaging blood‐brain barrier penetration and targeting in the brain	1
Synthesis of [²H₅]baricitinib via [²H₅]ethanesulfonyl chloride	1
A facile synthesis of isotope labeled acylcarnitines	1
Issue Information	1
Research on preparation and in vitro evaluation of the dendrimer–peptide nuclear acid conjugate for amplification pretargeting	1
Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro‐compounds with deuterium gas over palladium catalysts	1
Automated radiochemical synthesis of pharmaceutical grade [¹⁸F]FLT using 3‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine precursor and its Sep‐Pak® purification employing selective elutio	1
Efficient synthesis of carbon‐14 labeled metabolites of the strobilurin fungicide mandestrobin using biomimetic iron‐porphyrin catalyzed oxidation	1
Automated radiosynthesis of the adenosine A_2A receptor‐targeting radiotracer [¹⁸F]FLUDA	1