OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	195
Pharmacology of Intestinal Inflammation and Repair	165
How Biologics Have Changed the Drug Discovery Landscape	161
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	141
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	125
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	100
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	98
Evolving Approaches for Pharmacological Therapy of Obesity	93
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	92
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	91
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	90
Incretin Signaling Neighborhoods and Adverse Drug Reactions	89
Community Aspects of HIV Biomedical Prevention	87
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	86
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	82
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	82
Gβγ Signaling: Lessons Across the Cellular Multiverse	79
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	67
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	66
Microplastics and Atherosclerosis: Mechanisms	65
Therapeutics for Alcohol-Associated Liver Disease	60
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	59
Health Digital Twins in Life Science and Health Care Innovation	57
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	56
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	54

RNA Splicing as a Therapeutic Target in Cancer	51
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	47
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	47
Pharmacogenetics of Antiplatelet Therapy	47
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	46
Translational In Vivo Assays in Behavioral Biology	44
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	43