OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Nanoparticle Toxicology	163
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span	148
Arsenic: A Global Environmental Challenge	129
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	76
Preventing and Treating Anthracycline Cardiotoxicity: New Insights	75
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy	72
Thioredoxin Reductase Inhibition for Cancer Therapy	64
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	55
E-Cigarette Toxicology	55
TRP Channel Cooperation for Nociception: Therapeutic Opportunities	53
Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance	51
Antisense Drugs Make Sense for Neurological Diseases	51
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors	50
Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure	40
Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics	38
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	37
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option	37
New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders	37
Endocrine-Disrupting Chemicals and Child Health	36
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	35
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	34
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	33
Endocannabinoid-Based Therapies	33
Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics	33
Store-Operated Ca²⁺ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets	32

Mechanism of Action of TiO₂: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential	30
Pharmacologic Approach to Sinoatrial Node Dysfunction	30
Drug Target Identification in Tissues by Thermal Proteome Profiling	29
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis	29
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem	28
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond	27
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting	27
Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings	25
The Gut Microbiome, Metformin, and Aging	25
Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs	25