OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	130
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	129
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	126
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	125
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	120
How Biologics Have Changed the Drug Discovery Landscape	114
Pharmacology of Intestinal Inflammation and Repair	98
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	92
Evolving Approaches for Pharmacological Therapy of Obesity	87
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	77
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	76
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	74
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	70
E-Cigarette Toxicology	67
	67
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	66
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	63
Incretin Signaling Neighborhoods and Adverse Drug Reactions	63
Community Aspects of HIV Biomedical Prevention	63
The Gut Microbiome, Metformin, and Aging	60
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	60
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	57
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	55
Endocannabinoid-Based Therapies	55
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	55

Gβγ Signaling: Lessons Across the Cellular Multiverse	54
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	53
Health Digital Twins in Life Science and Health Care Innovation	49
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	49
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	48
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	47
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	47
RNA Splicing as a Therapeutic Target in Cancer	46
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	46
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	45
Pharmacogenetics of Antiplatelet Therapy	45
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	38
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	38