OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Nanoparticle Toxicology	177
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span	158
Arsenic: A Global Environmental Challenge	150
Preventing and Treating Anthracycline Cardiotoxicity: New Insights	85
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	83
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy	79
Thioredoxin Reductase Inhibition for Cancer Therapy	70
E-Cigarette Toxicology	67
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	60
TRP Channel Cooperation for Nociception: Therapeutic Opportunities	58
Antisense Drugs Make Sense for Neurological Diseases	57
Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance	53
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors	52
Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure	44
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	43
Endocrine-Disrupting Chemicals and Child Health	42
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	41
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	41
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem	40
New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders	39
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option	39
Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics	39
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	37
Endocannabinoid-Based Therapies	37
Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics	34

Pharmacologic Approach to Sinoatrial Node Dysfunction	34
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond	34
Store-Operated Ca²⁺ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets	33
Mechanism of Action of TiO₂: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential	32
Drug Target Identification in Tissues by Thermal Proteome Profiling	32
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis	32
CaMKII as a Therapeutic Target in Cardiovascular Disease	31
The Gut Microbiome, Metformin, and Aging	30
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting	30