Annual Review of Pharmacology and Toxicology

Papers
(The TQCC of Annual Review of Pharmacology and Toxicology is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets117
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays111
How Biologics Have Changed the Drug Discovery Landscape103
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease92
Pharmacology of Intestinal Inflammation and Repair88
Evolving Approaches for Pharmacological Therapy of Obesity66
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology66
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities63
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?62
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development61
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”60
E-Cigarette Toxicology58
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”56
55
The Gut Microbiome, Metformin, and Aging53
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer52
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases51
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss48
Endocannabinoid-Based Therapies47
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges47
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders46
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory44
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery44
Health Digital Twins in Life Science and Health Care Innovation44
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon42
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview41
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies39
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation38
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments36
Pharmacogenetics of Antiplatelet Therapy34
Prospects for Disease Slowing in Parkinson Disease30
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy30
Translational In Vivo Assays in Behavioral Biology30
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment30
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