Annual Review of Pharmacology and Toxicology

Papers
(The TQCC of Annual Review of Pharmacology and Toxicology is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
How Biologics Have Changed the Drug Discovery Landscape122
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease119
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays112
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets104
Pharmacology of Intestinal Inflammation and Repair96
Evolving Approaches for Pharmacological Therapy of Obesity93
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities85
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology75
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”74
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development69
E-Cigarette Toxicology67
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?66
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”61
60
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer60
The Gut Microbiome, Metformin, and Aging57
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges56
Community Aspects of HIV Biomedical Prevention56
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss55
Endocannabinoid-Based Therapies52
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders51
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases51
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory49
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery49
Health Digital Twins in Life Science and Health Care Innovation48
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview46
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies46
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon44
RNA Splicing as a Therapeutic Target in Cancer41
Pharmacogenetics of Antiplatelet Therapy40
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation40
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments40
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment38
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