OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	102
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	98
CaMKII as a Therapeutic Target in Cardiovascular Disease	79
Pollution of Soil by Pharmaceuticals: Implications for Metazoan and Environmental Health	68
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	56
How Biologics Have Changed the Drug Discovery Landscape	50
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	49
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	49
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	48
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	46
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	45
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	42
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	42
Thioredoxin Reductase Inhibition for Cancer Therapy	40
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review	40
Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications	38
Endocrine-Disrupting Chemicals and Child Health	37
Alcohol Use Disorder Treatment: Problems and Solutions	36
The Nocebo Effect	36
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	34
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	34
Roadmap for Achieving Universal Antiretroviral Treatment	33
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	30
Biased Agonism: Lessons from Studies of Opioid Receptor Agonists	30
Treating Sickle Cell Disease: Gene Therapy Approaches	29

Apathy and Motivation: Biological Basis and Drug Treatment	28
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	24
Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics	24
Evolving Approaches for Pharmacological Therapy of Obesity	24
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem	23
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	23