OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-09-01 to 2024-09-01.)

Article	Citations
Nanoparticle Toxicology	192
Arsenic: A Global Environmental Challenge	170
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span	167
Preventing and Treating Anthracycline Cardiotoxicity: New Insights	95
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	88
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy	84
E-Cigarette Toxicology	79
Thioredoxin Reductase Inhibition for Cancer Therapy	78
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	67
TRP Channel Cooperation for Nociception: Therapeutic Opportunities	60
Antisense Drugs Make Sense for Neurological Diseases	60
Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance	55
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors	55
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	47
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem	46
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	46
Endocrine-Disrupting Chemicals and Child Health	45
Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure	44
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	43
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	42
New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders	41
Endocannabinoid-Based Therapies	41
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option	39
Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics	39
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting	38

CaMKII as a Therapeutic Target in Cardiovascular Disease	37
Store-Operated Ca²⁺ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets	36
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond	36
Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics	36
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis	35
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	35
The Gut Microbiome, Metformin, and Aging	34
Artificial Intelligence for Drug Discovery: Are We There Yet?	34
Pharmacologic Approach to Sinoatrial Node Dysfunction	34
Drug Target Identification in Tissues by Thermal Proteome Profiling	34
Mechanism of Action of TiO₂: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential	33
Air Pollution–Related Neurotoxicity Across the Life Span	32
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	31
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	29
The Duality of Arsenic Metabolism: Impact on Human Health	29
Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases	29
Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings	27
Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs	27
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders	27
Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?	27
Models of Idiosyncratic Drug-Induced Liver Injury	26
Biased Agonism: Lessons from Studies of Opioid Receptor Agonists	26
Mechanisms of Environment-Induced Autoimmunity	25
Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications	25
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	24
Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors	24
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch	24
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	23
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	22
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	22
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	22
Engineering the Microbiome to Prevent Adverse Events: Challenges and Opportunities	21
Thirty Years of Neuroscientific Investigation of Placebo and Nocebo: The Interesting, the Good, and the Bad	21
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	20
Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology	19
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	19
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	19
Health Digital Twins in Life Science and Health Care Innovation	18
An Aspirin a Day: New Pharmacological Developments and Cancer Chemoprevention	18
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review	17
PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling	16
Scavenging Reactive Lipids to Prevent Oxidative Injury	16
Lipoxin Mimetics and the Resolution of Inflammation	16
HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction	15
Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics	15
KCNQ Potassium Channels as Targets of Botanical Folk Medicines	15
Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease	15