OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Nanoparticle Toxicology	195
Arsenic: A Global Environmental Challenge	173
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span	170
Preventing and Treating Anthracycline Cardiotoxicity: New Insights	96
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	90
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy	87
E-Cigarette Toxicology	82
Thioredoxin Reductase Inhibition for Cancer Therapy	79
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	68
TRP Channel Cooperation for Nociception: Therapeutic Opportunities	63
Antisense Drugs Make Sense for Neurological Diseases	61
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors	60
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem	56
Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance	56
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	48
Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure	47
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	46
Endocrine-Disrupting Chemicals and Child Health	46
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	45
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	42
New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders	41
Artificial Intelligence for Drug Discovery: Are We There Yet?	41
Endocannabinoid-Based Therapies	41
CaMKII as a Therapeutic Target in Cardiovascular Disease	40
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option	39

Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics	39
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting	39
Store-Operated Ca²⁺ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets	38
Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics	36
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	36
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond	36
Drug Target Identification in Tissues by Thermal Proteome Profiling	36
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis	35
Mechanism of Action of TiO₂: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential	34
The Gut Microbiome, Metformin, and Aging	34
Air Pollution–Related Neurotoxicity Across the Life Span	34
Pharmacologic Approach to Sinoatrial Node Dysfunction	34
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders	33
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	33
Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases	31
Biased Agonism: Lessons from Studies of Opioid Receptor Agonists	30
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	29
The Duality of Arsenic Metabolism: Impact on Human Health	29
Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs	28
Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings	28
Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?	28
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch	28
Models of Idiosyncratic Drug-Induced Liver Injury	27
Mechanisms of Environment-Induced Autoimmunity	25
Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications	25
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	24
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	24
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	24
Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors	24
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	24
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	23
Engineering the Microbiome to Prevent Adverse Events: Challenges and Opportunities	22
Thirty Years of Neuroscientific Investigation of Placebo and Nocebo: The Interesting, the Good, and the Bad	22
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	20
Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology	19
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	19
Health Digital Twins in Life Science and Health Care Innovation	19
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	19
PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling	18
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review	18
An Aspirin a Day: New Pharmacological Developments and Cancer Chemoprevention	18
Scavenging Reactive Lipids to Prevent Oxidative Injury	16
KCNQ Potassium Channels as Targets of Botanical Folk Medicines	16
Lipoxin Mimetics and the Resolution of Inflammation	16
Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics	16
Pharmacogenetics of Antiplatelet Therapy	15
HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction	15
Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease	15
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	14
Synthetic Retinoids Beyond Cancer Therapy	14

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy	14
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	13
Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain	13
Alcohol Use Disorder Treatment: Problems and Solutions	12
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	12
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	12
Emerging Therapeutics, Technologies, and Drug Development Strategies to Address Patient Nonadherence and Improve Tuberculosis Treatment	12