OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	140
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	140
How Biologics Have Changed the Drug Discovery Landscape	139
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	138
Pharmacology of Intestinal Inflammation and Repair	136
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	126
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	104
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	96
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	96
Evolving Approaches for Pharmacological Therapy of Obesity	82
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	79
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	77
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	75
	72
E-Cigarette Toxicology	72
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	69
Community Aspects of HIV Biomedical Prevention	68
Incretin Signaling Neighborhoods and Adverse Drug Reactions	68
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	67
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	66
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	66
The Gut Microbiome, Metformin, and Aging	66
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	60
Endocannabinoid-Based Therapies	60
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	59

Gβγ Signaling: Lessons Across the Cellular Multiverse	57
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	57
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	56
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	55
Health Digital Twins in Life Science and Health Care Innovation	52
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	52
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	51
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	50
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	50
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	47
RNA Splicing as a Therapeutic Target in Cancer	47
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	40
Pharmacogenetics of Antiplatelet Therapy	39
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	38
Translational In Vivo Assays in Behavioral Biology	37
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	36
Prospects for Disease Slowing in Parkinson Disease	36
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	35
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	35
Drug Target Identification in Tissues by Thermal Proteome Profiling	35
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	32
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	30
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology	30
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	28
Targeting Efferocytosis in Inflammaging	28
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	28
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	26
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	26
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	26
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	25
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	24
Alcohol Use Disorder Treatment: Problems and Solutions	24
Treating Sickle Cell Disease: Gene Therapy Approaches	24
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	23
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	23
From Fundamental Biology to Toxicology by Way of an Accident	22
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	22
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	22
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	21
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	20
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	19
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	18
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	17
Dengue Fever Vaccines: Progress and Challenges	17
Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies	16
Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure	16
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	15
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging	15
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	15
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	14

LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	14
Decoding the Therapeutic Target SVEP1: Harnessing Molecular Trait GWASs to Unravel Mechanisms of Human Disease	14
Endocrine-Disrupting Chemicals and Child Health	14
CaMKII as a Therapeutic Target in Cardiovascular Disease	14