OOIR: Observatory of International Research

Papers

(The H4-Index of Annual Review of Pharmacology and Toxicology is 35. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Pharmacology of Intestinal Inflammation and Repair	125
How Biologics Have Changed the Drug Discovery Landscape	124
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	117
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	112
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	104
Evolving Approaches for Pharmacological Therapy of Obesity	95
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	94
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	79
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	78
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	71
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	69
E-Cigarette Toxicology	69
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	65
	63
Community Aspects of HIV Biomedical Prevention	62
The Gut Microbiome, Metformin, and Aging	60
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	58
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	57
Endocannabinoid-Based Therapies	56
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	55
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	52
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	51
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	51
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	50
Gβγ Signaling: Lessons Across the Cellular Multiverse	48

G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	48
Health Digital Twins in Life Science and Health Care Innovation	47
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	45
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	45
RNA Splicing as a Therapeutic Target in Cancer	42
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	42
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	41
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	41
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	41
Pharmacogenetics of Antiplatelet Therapy	40
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	35