OOIR: Observatory of International Research

Papers

(The H4-Index of Annual Review of Pharmacology and Toxicology is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	102
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	98
CaMKII as a Therapeutic Target in Cardiovascular Disease	79
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	68
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	56
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	50
Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms	49
Pharmacology of Intestinal Inflammation and Repair	49
Pollution of Soil by Pharmaceuticals: Implications for Metazoan and Environmental Health	48
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	46
How Biologics Have Changed the Drug Discovery Landscape	45
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	42
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	42
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	40
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	40
Thioredoxin Reductase Inhibition for Cancer Therapy	38
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review	37
Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications	36
Endocrine-Disrupting Chemicals and Child Health	36
Alcohol Use Disorder Treatment: Problems and Solutions	34
The Nocebo Effect	34
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	33
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	30
Roadmap for Achieving Universal Antiretroviral Treatment	30
Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?	29

Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology