OOIR: Observatory of International Research

Papers

(The H4-Index of Annual Review of Pharmacology and Toxicology is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	129
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	127
Pharmacology of Intestinal Inflammation and Repair	122
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	120
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	113
How Biologics Have Changed the Drug Discovery Landscape	104
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	94
Evolving Approaches for Pharmacological Therapy of Obesity	87
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	79
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	73
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	73
E-Cigarette Toxicology	71
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	68
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	66
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	65
	63
Incretin Signaling Neighborhoods and Adverse Drug Reactions	62
The Gut Microbiome, Metformin, and Aging	61
Community Aspects of HIV Biomedical Prevention	59
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	57
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	54
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	53
Endocannabinoid-Based Therapies	52
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	52
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	51

Gβγ Signaling: Lessons Across the Cellular Multiverse	50
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	49
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	47
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	47
Health Digital Twins in Life Science and Health Care Innovation	46
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	44
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	44
RNA Splicing as a Therapeutic Target in Cancer	43
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	43
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	43
Pharmacogenetics of Antiplatelet Therapy	42