OOIR: Observatory of International Research

Papers

(The TQCC of Drug Metabolism Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Drug transporters in drug disposition – the year 2022 in review	53
CYP24A1: the pivotal regulator of vitamin D homeostasis, pathophysiology in metabolic and genetic disease, and emerging target for precision medicine	43
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	41
Phase II metabolism in xenobiotic biotransformation: general mechanisms and the underestimated role of microbial systems	35
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	22
Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids	22
An in-depth review of PPARγ modulators as anti-diabetes therapeutics	20
Mechanisms of intestinal pharmacokinetic natural product-drug interactions	18
A critical review of analytical tools for the detection of spironolactone and its metabolites	17
Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism	16
Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations	15
Multimolecular interactions from Chinese medicines activate nuclear receptor conformational changes: a potential strategy for anti-inflammatory therapy	15
Redox enzyme networks shaping cancer drug metabolism and therapeutic resistance	14
Biopolymers as promising vehicles for drug delivery to the brain	13
Drug transporters in drug disposition – highlights from the year 2024	12
Metabolism of new drug modalities research advances – 2024 year in review	11
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state o	11
Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature	11
Clinical pharmacokinetics of nebivolol: a systematic review	11
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	11
A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	10
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	10
Molecular insights into doxorubicin-induced cardiotoxicity and phytochemical-based cardioprotection: challenges and future strategies	10
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods	9