OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism Reviews is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Cytochrome P450 expression and regulation in the brain	58
Pharmacology of apocynin: a natural acetophenone	42
Recent biotechnological approaches for treatment of novel COVID-19: from bench to clinical trial	36
Drug metabolic stability in early drug discovery to develop potential lead compounds	32
Toxicity mechanisms of nanoparticles in the male reproductive system	26
Pharmacogenomics in the era of next generation sequencing – from byte to bedside	22
The role of UDP-glycosyltransferases in xenobioticresistance	21
Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases	20
Recent developments inin vitroandin vivomodels for improved translation of preclinical pharmacokinetics and pharmacodynamics data	19
Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs	19
In quest of a new therapeutic approach in COVID-19: the endocannabinoid system	18
Toxicogenomics of drug induced liver injury – from mechanistic understanding to early prediction.	18
Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism	17
The relationship between UGT1A1 gene & various diseases and prevention strategies	15
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy	15
Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review	14
Molecular modeling approaches to address drug-metabolizing enzymes (DMEs) mediated chemoresistance: a review	13
Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer	13
Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer dru	12
What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism	12
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs	10
Prediction of drug-induced kidney injury in drug discovery	10
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development	10
Bioanalytical strategies in drug discovery and development	10
Rodent genetic models of Ah receptor signaling	9

In vitrocell-based models of drug-induced hepatotoxicity screening: progress and limitation	9
Transporter-mediated drug–drug interactions: advancement in models, analytical tools, and regulatory perspective	9
Targeting endothelial cell metabolism in cancerous microenvironment: a new approach for anti-angiogenic therapy	8
GSTM1 and GSTT1 polymorphisms in healthy volunteers – a worldwide systematic review	8
Metabolism of the areca alkaloids – toxic and psychoactive constituents of the areca (betel) nut	8
Pharmacokinetics, toxicological and clinical aspects of ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity	7
CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation	7
Mass spectrometry based protein biomarkers and drug target discovery and clinical diagnosis in Age-Related progressing neurodegenerative diseases	7
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	6
The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice	5
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms	5
Recent developments in predicting CYP-independent metabolism	5
Extensive metabolism of flavonoids relevant to their potential efficacy on Alzheimer’s disease	5
Biotransformation novel advances – 2021 year in review	4
Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy	4
Moonlighting in drug metabolism	4
Impact of DNA methylation on ADME gene expression, drug disposition, and efficacy	4
Novel advances in biotransformation and bioactivation research – 2020 year in review	4
Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus	4
Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition	4
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	4
Cell-Biomaterial constructs for wound healing and skin regeneration	4
Introduction to the mini special issue on next generation drug discovery and development: rethinking translational pharmacology for accelerated drug development	4