OOIR: Observatory of International Research

Papers

(The TQCC of Intensive Care Medicine is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study	2015
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021	1465
COVID-19 pneumonia: different respiratory treatments for different phenotypes?	1231
Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study	543
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#	495
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care	445
Acute kidney injury in critically ill patients with COVID-19	355
Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis	323
Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China	272
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion	270
Managing ICU surge during the COVID-19 crisis: rapid guidelines	261
Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation	248
Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	243
Prone position in ARDS patients: why, when, how and for whom	240
Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study	218
ECMO for severe ARDS: systematic review and individual patient data meta-analysis	207
Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection	198
What’s new in lung ultrasound during the COVID-19 pandemic	173
Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review	172
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline	172
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis	169
Lung ultrasound predicts clinical course and outcomes in COVID-19 patients	161
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial	159
Analgesia and sedation in patients with ARDS	151
Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study	149

Acute kidney injury in the critically ill: an updated review on pathophysiology and management	146
Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis	144
Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis	141
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19	141
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus	134
How the COVID-19 pandemic will change the future of critical care	132
Comparative study of lung ultrasound and chest computed tomography scan in the assessment of severity of confirmed COVID-19 pneumonia	117
COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network	116
Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19	115
Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study	113
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study	111
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies	111
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS	109
Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19	109
COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland	106
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications	106
Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis	106
Phenotypes and personalized medicine in the acute respiratory distress syndrome	104
Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study	101
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit	101
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort	100
Use of nasal high flow oxygen during acute respiratory failure	98
Extracorporeal life support for adults with acute respiratory distress syndrome	97
Delirium in critical illness: clinical manifestations, outcomes, and management	94
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study	94
Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis	91
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial	89
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients	87
Prediction of outcome of nasal high flow use during COVID-19-related acute hypoxemic respiratory failure	87
Intensive care unit acquired muscle weakness in COVID-19 patients	86
Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial	86
ERC-ESICM guidelines on temperature control after cardiac arrest in adults	85
Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis	85
Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial	84
Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine	83
ECMO for COVID-19 patients in Europe and Israel	81
Expanding controlled donation after the circulatory determination of death: statement from an international collaborative	79
Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis	78
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS	77
Bacterial and fungal superinfections in critically ill patients with COVID-19	74
Invasive candidiasis in critical care: challenges and future directions	73
Early bacterial co-infection in ARDS related to COVID-19	72
Pulmonary infections complicating ARDS	71
Neuromuscular blockade in patients with ARDS: a rapid practice guideline	71
Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection	71
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial	70
Thrombotic events in SARS-CoV-2 patients: an urgent call for ultrasound screening	69
Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia	68
Frailty index predicts poor outcome in COVID-19 patients	68
The PRICES statement: an ESICM expert consensus on methodology for conducting and reporting critical care echocardiography research studies	65

Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19	64
Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review	64
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months	63
15-day mortality and associated risk factors for hospitalized patients with COVID-19 in Wuhan, China: an ambispective observational cohort study	63
Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets	61
Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression	61
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial	60
Fluid administration and monitoring in ARDS: which management?	60
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)	59
Performance of a guideline-recommended algorithm for prognostication of poor neurological outcome after cardiac arrest	58
Clinicolaboratory study of 25 fatal cases of COVID-19 in Wuhan	57
How can assessing hemodynamics help to assess volume status?	57
Management of moderate to severe traumatic brain injury: an update for the intensivist	57
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis	57
How to ventilate obese patients in the ICU	57
Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset	57
Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study	56
Missed or delayed diagnosis of ARDS: a common and serious problem	55
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis	54
Current and evolving standards of care for patients with ARDS	54
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study	53
Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial	52
Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest	51
Lung ultrasonography versus chest CT in COVID-19 pneumonia: a two-centered retrospective comparison study from China	51
Intracranial pressure: current perspectives on physiology and monitoring	51
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial	50
Palliative care interventions in intensive care unit patients	50
Emerging pharmacological therapies for ARDS: COVID-19 and beyond	50
Current practice and evolving concepts in septic shock resuscitation	50
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study	50
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials	49
Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials	49
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians	46
Hospital mortality in mechanically ventilated COVID-19 patients in Mexico	46
Ten reasons for focusing on the care we provide for family members of critically ill patients with COVID-19	45
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom	44
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine	44
Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?	43
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials	43
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial	43
Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study	43
Clinical phenotypes of critically ill COVID-19 patients	42
IL-6 may be a good biomarker for earlier detection of COVID-19 progression	42
ICU capacity management during the COVID-19 pandemic using a process simulation	42
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study	42
Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry	42
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	41
Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis	41
Adjuvant therapeutic plasma exchange in septic shock	41
Randomised clinical trials in critical care: past, present and future	41
Machine learning in intensive care medicine: ready for take-off?	41
Role of total lung stress on the progression of early COVID-19 pneumonia	41
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality	40
High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial	40
Respiratory indications for ECMO: focus on COVID-19	39
The negative impact of comorbidities on the disease course of COVID-19	39
Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial	39
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial	39
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial	39
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial	38
Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview	38
Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial	38
Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review	38
Gender differences in the provision of intensive care: a Bayesian approach	37
Moral distress in the intensive care unit during the pandemic: the burden of dying alone	37
Respiratory microbiome in mechanically ventilated patients: a narrative review	37
Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis	37
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study	37
Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy	37
Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS	37
The baby lung and the COVID-19 era	37
Hemoperfusion in the intensive care unit	36
Plasma exchange in the intensive care unit: a narrative review	36
Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis	36
Development and validation of novel sepsis subphenotypes using trajectories of vital signs	36
Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia	36
Cytokine adsorption in severe, refractory septic shock	35
Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge c	35
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study	35
External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals	35

Mechanical power and driving pressure as predictors of mortality among patients with ARDS	35
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India	35
Monitoring of high-flow nasal cannula for SARS-CoV-2 severe pneumonia: less is more, better look at respiratory rate	35
Recognizing and supporting morally injured ICU professionals during the COVID-19 pandemic	35
The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19	35
Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study	34
Everything you need to know about deresuscitation	34
Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial	34
Impact of frailty on persistent critical illness: a population-based cohort study	34
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia	33
Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients	33
Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial	33
Between-centre differences for COVID-19 ICU mortality from early data in England	33
Critical illness in patients with hematologic malignancy: a population-based cohort study	32
Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies	32
Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study	32
Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study	31
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis	31
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study	31
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials	31
Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	31
Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study	30
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis	30
Neuroanatomical substrates of generalized brain dysfunction in COVID-19	29
Prothrombotic phenotype in COVID-19 severe patients	29
Stages or phenotypes? A critical look at COVID-19 pathophysiology	29
Extubation in neurocritical care patients: the ENIO international prospective study	29
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study	29
First-attempt success is associated with fewer complications related to intubation in the intensive care unit	29
Ten things we learned about COVID-19	28
Myorelaxants in ARDS patients	28
Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial	28
SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients	28
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted norm	28
Rapidly scalable mechanical ventilator for the COVID-19 pandemic	27
Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial	27
Predictors of death and new disability after critical illness: a multicentre prospective cohort study	27
Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinica	27
Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study	26
Are subpleural consolidations indicators for segmental pulmonary embolism in COVID-19?	26
Long-term mortality of elderly patients after intensive care unit admission for COVID-19	26
Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung	26
Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study	26
How to manage anticoagulation during extracorporeal membrane oxygenation	25
Intensive care for COVID-19 in low- and middle-income countries: research opportunities and challenges	25
Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock	25
Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis	25
COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges	25
How to ventilate obstructive and asthmatic patients	25
Admission chest CT score predicts 5-day outcome in patients with COVID-19	24
The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: an observational cohort study in Brazilian ICUs	24
Monitoring cerebral oxygenation in acute brain-injured patients	24
Electroencephalogram in the intensive care unit: a focused look at acute brain injury	24
Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial	24
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	24
The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis	24
Long term outcomes of critically ill COVID-19 pneumonia patients: early learning	24
How to improve intubation in the intensive care unit. Update on knowledge and devices	24
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings	23
Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis	23
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19	23
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial	23
Proportional modes of ventilation: technology to assist physiology	23
Hospital-level variation in the development of persistent critical illness	23
Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic	22
Impact of late administration of corticosteroids in COVID-19 ARDS	22
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure	22
Organizational aspects of care associated with mortality in critically ill COVID-19 patients	22
(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial	22
Critically ill patients with COVID-19: are they hemodynamically unstable and do we know why?	22
SARS-CoV-2 in carotid body	22
Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT)	21
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study	21
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity	21
The prevalence, risk factors and outcome of cardiac dysfunction in hospitalized patients with COVID-19	21
Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline	21
COVID-19: what the clinician should know about post-mortem findings	20
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures	20
Contrast-enhanced ultrasound (CEUS) of the lung reveals multiple areas of microthrombi in a COVID-19 patient	20
Differential pathophysiologic phenotypes of hypoxic ischemic brain injury: considerations for post-cardiac arrest trials	20
ICU scoring systems	20
ERC-ESICM guidelines for prognostication after cardiac arrest: time for an update	20
What’s new in ECMO for COVID-19?	20
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?	20
Cardiac injury in COVID-19	20
How to manage coagulopathies in critically ill patients	19
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome	19
Ten myths about albumin	19
Association of patient-to-intensivist ratio with hospital mortality in Australia and New Zealand	19
Monitoring patient–ventilator interaction by an end-expiratory occlusion maneuver	19
Airborne spread of SARS-CoV-2 while using high-flow nasal cannula oxygen therapy: myth or reality?	19
Poor quality data, privacy, lack of certifications: the lethal triad of new technologies in intensive care	19
Source control in the management of sepsis and septic shock	19
Artificial intelligence in intensive care medicine	19
Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial	19