Intensive Care Medicine

Papers
(The TQCC of Intensive Care Medicine is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-09-01 to 2024-09-01.)
ArticleCitations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 20211886
Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study583
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care534
Prone position in ARDS patients: why, when, how and for whom274
Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study235
ECMO for severe ARDS: systematic review and individual patient data meta-analysis233
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies217
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis212
Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review203
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline191
Acute kidney injury in the critically ill: an updated review on pathophysiology and management190
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial173
Analgesia and sedation in patients with ARDS169
Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis165
Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study162
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus156
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19154
How the COVID-19 pandemic will change the future of critical care145
Delirium in critical illness: clinical manifestations, outcomes, and management144
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications137
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS131
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit128
COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network128
Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis119
Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19118
Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study118
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort117
Use of nasal high flow oxygen during acute respiratory failure116
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study112
Phenotypes and personalized medicine in the acute respiratory distress syndrome112
Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis112
COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland111
Extracorporeal life support for adults with acute respiratory distress syndrome107
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial104
ERC-ESICM guidelines on temperature control after cardiac arrest in adults103
Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial98
Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine 96
Intensive care unit acquired muscle weakness in COVID-19 patients96
Expanding controlled donation after the circulatory determination of death: statement from an international collaborative94
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients92
Invasive candidiasis in critical care: challenges and future directions86
ECMO for COVID-19 patients in Europe and Israel85
Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review85
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS84
Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia84
Pulmonary infections complicating ARDS83
How can assessing hemodynamics help to assess volume status?81
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians81
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study81
Bacterial and fungal superinfections in critically ill patients with COVID-1979
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial77
Management of moderate to severe traumatic brain injury: an update for the intensivist76
Neuromuscular blockade in patients with ARDS: a rapid practice guideline73
The PRICES statement: an ESICM expert consensus on methodology for conducting and reporting critical care echocardiography research studies71
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)71
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia70
Intracranial pressure: current perspectives on physiology and monitoring70
Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets69
Fluid administration and monitoring in ARDS: which management?67
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months67
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis67
How to ventilate obese patients in the ICU66
Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest66
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis65
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial64
Current practice and evolving concepts in septic shock resuscitation62
Current and evolving standards of care for patients with ARDS61
Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials60
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial58
Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial57
Development and validation of novel sepsis subphenotypes using trajectories of vital signs57
Palliative care interventions in intensive care unit patients56
Plasma exchange in the intensive care unit: a narrative review56
Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial55
Randomised clinical trials in critical care: past, present and future55
Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis54
Respiratory indications for ECMO: focus on COVID-1953
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial52
Hemoperfusion in the intensive care unit52
Ten reasons for focusing on the care we provide for family members of critically ill patients with COVID-1952
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine51
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials50
Hospital mortality in mechanically ventilated COVID-19 patients in Mexico50
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial50
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom49
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study49
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials49
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial49
Gender differences in the provision of intensive care: a Bayesian approach48
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial48
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality47
Role of total lung stress on the progression of early COVID-19 pneumonia46
Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry45
Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?44
Adjuvant therapeutic plasma exchange in septic shock44
Impact of frailty on persistent critical illness: a population-based cohort study44
Everything you need to know about deresuscitation44
High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial44
Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial43
Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review43
Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study43
Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study42
Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge c42
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study42
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study41
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia41
Cytokine adsorption in severe, refractory septic shock41
Extubation in neurocritical care patients: the ENIO international prospective study40
Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia40
Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview40
Respiratory microbiome in mechanically ventilated patients: a narrative review39
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis39
Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial39
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study39
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India39
External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals39
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis38
Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial37
Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study37
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study37
Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies36
Electroencephalogram in the intensive care unit: a focused look at acute brain injury36
How to improve intubation in the intensive care unit. Update on knowledge and devices36
Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis36
The ten reasons why corticosteroid therapy reduces mortality in severe COVID-1935
Critical illness in patients with hematologic malignancy: a population-based cohort study35
Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study33
Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS33
Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study33
Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients33
How to manage anticoagulation during extracorporeal membrane oxygenation32
Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study32
Neuroanatomical substrates of generalized brain dysfunction in COVID-1932
Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study32
COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges31
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury31
Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinica31
High-level burnout in physicians and nurses working in adult ICUs: a systematic review and meta-analysis31
(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial31
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted norm31
Predictors of death and new disability after critical illness: a multicentre prospective cohort study30
Myorelaxants in ARDS patients30
Direct assessment of microcirculation in shock: a randomized-controlled multicenter study29
Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study29
The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis29
Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial29
How to ventilate obstructive and asthmatic patients29
Sex and gender differences in intensive care medicine28
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity28
Intensive care for COVID-19 in low- and middle-income countries: research opportunities and challenges28
How to manage coagulopathies in critically ill patients28
Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis28
Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock28
Long-term mortality of elderly patients after intensive care unit admission for COVID-1928
Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline26
Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis26
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures26
Long term outcomes of critically ill COVID-19 pneumonia patients: early learning26
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings25
Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial25
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study25
SARS-CoV-2 in carotid body25
Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study25
Monitoring cerebral oxygenation in acute brain-injured patients25
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-1925
Organizational aspects of care associated with mortality in critically ill COVID-19 patients25
The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: an observational cohort study in Brazilian ICUs25
Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial24
Source control in the management of sepsis and septic shock24
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial23
Cardiac injury in COVID-1923
Imaging the acute respiratory distress syndrome: past, present and future23
Association of patient-to-intensivist ratio with hospital mortality in Australia and New Zealand23
Exploring family members’ and health care professionals’ perceptions on ICU diaries: a systematic review and qualitative data synthesis23
Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis23
Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic23
Critically ill patients with COVID-19: are they hemodynamically unstable and do we know why?23
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure22
Ten myths about albumin22
Impact of late administration of corticosteroids in COVID-19 ARDS22
Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT)22
Monitoring pain in the intensive care unit (ICU)22
The prediction of fluid responsiveness22
ICU scoring systems22
ERC-ESICM guidelines for prognostication after cardiac arrest: time for an update22
Circular material flow in the intensive care unit—environmental effects and identification of hotspots21
Poor quality data, privacy, lack of certifications: the lethal triad of new technologies in intensive care21
mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland21
Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study21
The AKI care bundle: all bundle components are created equal—are they?21
High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI21
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome21
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?21
Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study21
SAPS-3 performance for hospital mortality prediction in 30,571 patients with COVID-19 admitted to ICUs in Brazil21
Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?20
Renal outcomes following intravenous contrast administration in patients with acute kidney injury: a multi-site retrospective propensity-adjusted analysis20
One-year mortality after ICU admission due to COVID-19 infection20
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software20
Inhaled amphotericin B lipid complex for prophylaxis against COVID-19-associated invasive pulmonary aspergillosis20
COVID-19: what the clinician should know about post-mortem findings20
What’s new in ECMO for COVID-19?20
Dose of norepinephrine: the devil is in the details20
Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes19
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit19
Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study19
Airborne spread of SARS-CoV-2 while using high-flow nasal cannula oxygen therapy: myth or reality?19
Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study19
In search of the Holy Grail: identifying the best PEEP in ventilated patients19
Differences in clinical deterioration among three sub-phenotypes of COVID-19 patients at the time of first positive test: results from a clustering analysis19
Direct evidence of SARS-CoV-2 in gut endothelium19
Camostat mesylate therapy in critically ill patients with COVID-19 pneumonia19
COVID-19-associated autoimmunity as a feature of acute respiratory failure19
The physiological underpinnings of life-saving respiratory support19
How doctors manage conflicts with families of critically ill patients during conversations about end-of-life decisions in neonatal, pediatric, and adult intensive care19
ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation19
Compartmentalisation of immune responses in critical illness: does it matter?19
Psychological distress and morbidity of family members experiencing virtual visiting in intensive care during COVID-19: an observational cohort study19
Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia18
Invasive arterial pressure monitoring: much more than mean arterial pressure!18
Daily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter study18
Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study18
Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study18
Between-trial heterogeneity in ARDS research18
ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis18
Clinical practice guidelines: management of severe bronchiolitis in infants under 12 months old admitted to a pediatric critical care unit17
Prone position in mechanically ventilated patients17
The 5-year pre- and post-hospitalization treated prevalence of mental disorders and psychotropic medication use in critically ill patients: a Canadian population-based study17
Diversity and inclusivity: the way to multidisciplinary intensive care medicine in Europe17
The goal of personalized glucose control in the critically ill remains elusive17
Fatal cerebral venous sinus thrombosis after COVID-19 vaccination17
High prevalence of acute stress disorder and persisting symptoms in ICU survivors after COVID-1917
Intra-cycle power: is the flow profile a neglected component of lung protection?17
Clustering analysis of geriatric and acute characteristics in a cohort of very old patients on admission to ICU17
Climate responsibilities in intensive care medicine—let’s go green! An introduction to a new series in Intensive Care Medicine17
No clinically relevant removal of meropenem by cytokine adsorber CytoSorb® in critically ill patients with sepsis or septic shock17
Hypnotic suggestions of safety improve well-being in non-invasively ventilated patients in the intensive care unit17
The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up16
The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock16
Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience16
Effectiveness of an intensive care telehealth programme to improve process quality (ERIC): a multicentre stepped wedge cluster randomised controlled trial16
Create intensive care green teams, there is no time to waste16
How could ChatGPT impact my practice as an intensivist? An overview of potential applications, risks and limitations16
Ketamine-induced cholangiopathy in ARDS patients16
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial15
Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission15
Intracranial pressure pulse morphology: the missing link?15
Integrating palliative care into the ICU: a lasting and developing legacy15
“It was a nightmare until I saw my wife”: the importance of family presence for patients with COVID-19 hospitalized in the ICU15
Ten tips to optimize vasopressors use in the critically ill patient with hypotension15
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