Intensive Care Medicine

Article	Citations
Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China	3075
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study	2009
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target	1834
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021	1390
COVID-19 pneumonia: different respiratory treatments for different phenotypes?	1228
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)	1194
Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study	534
Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic	505
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#	486
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care	430
Critical care crisis and some recommendations during the COVID-19 epidemic in China	380
Acute kidney injury in critically ill patients with COVID-19	353
Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis	346
Ventilator-associated pneumonia in adults: a narrative review	337
Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis	314
Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China	269
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion	265
Managing ICU surge during the COVID-19 crisis: rapid guidelines	261
Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation	247
Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	241
Prone position in ARDS patients: why, when, how and for whom	232
Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study	215
ECMO for severe ARDS: systematic review and individual patient data meta-analysis	204
Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection	197
COVID-19: a novel coronavirus and a novel challenge for critical care	181

What’s new in lung ultrasound during the COVID-19 pandemic	173
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline	169
Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review	168
Lung ultrasound predicts clinical course and outcomes in COVID-19 patients	159
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis	158
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial	156
Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study	147
Analgesia and sedation in patients with ARDS	145
Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis	140
Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis	139
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19	139
Acute kidney injury in the critically ill: an updated review on pathophysiology and management	137
How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital	136
How the COVID-19 pandemic will change the future of critical care	130
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus	128
Comparative study of lung ultrasound and chest computed tomography scan in the assessment of severity of confirmed COVID-19 pneumonia	117
COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network	116
Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19	115
Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study	112
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study	111
Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19	107
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS	104
Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis	103
COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland	102
Phenotypes and personalized medicine in the acute respiratory distress syndrome	99
Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study	98
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort	97
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications	96
Use of nasal high flow oxygen during acute respiratory failure	96
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies	95
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit	95
Extracorporeal life support for adults with acute respiratory distress syndrome	94
Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis	89
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study	88
Delirium in critical illness: clinical manifestations, outcomes, and management	87
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial	86
Prediction of outcome of nasal high flow use during COVID-19-related acute hypoxemic respiratory failure	86
Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial	86
Intensive care unit acquired muscle weakness in COVID-19 patients	85
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients	84
Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial	83
Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine	82
ECMO for COVID-19 patients in Europe and Israel	81
ERC-ESICM guidelines on temperature control after cardiac arrest in adults	81
Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis	80
Expanding controlled donation after the circulatory determination of death: statement from an international collaborative	77
Clinical features and short-term outcomes of 18 patients with corona virus disease 2019 in intensive care unit	75
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS	74
Bacterial and fungal superinfections in critically ill patients with COVID-19	74
Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis	74

Early bacterial co-infection in ARDS related to COVID-19	72
Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection	71
Neuromuscular blockade in patients with ARDS: a rapid practice guideline	70
Invasive candidiasis in critical care: challenges and future directions	70
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial	69
Thrombotic events in SARS-CoV-2 patients: an urgent call for ultrasound screening	69
Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis	68
Frailty index predicts poor outcome in COVID-19 patients	68
Pulmonary infections complicating ARDS	66
The PRICES statement: an ESICM expert consensus on methodology for conducting and reporting critical care echocardiography research studies	63
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months	63
Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19	63
Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review	61
Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia	61
15-day mortality and associated risk factors for hospitalized patients with COVID-19 in Wuhan, China: an ambispective observational cohort study	61
Fluid administration and monitoring in ARDS: which management?	59
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial	59
Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression	59
Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets	58
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)	58
Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset	57
Clinicolaboratory study of 25 fatal cases of COVID-19 in Wuhan	57
Performance of a guideline-recommended algorithm for prognostication of poor neurological outcome after cardiac arrest	57
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis	57
Management of moderate to severe traumatic brain injury: an update for the intensivist	55
Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study	55
How to ventilate obese patients in the ICU	55
How can assessing hemodynamics help to assess volume status?	55
Current and evolving standards of care for patients with ARDS	54
Missed or delayed diagnosis of ARDS: a common and serious problem	53
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study	52
Lung ultrasonography versus chest CT in COVID-19 pneumonia: a two-centered retrospective comparison study from China	51
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis	50
Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest	50
Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial	50
Emerging pharmacological therapies for ARDS: COVID-19 and beyond	49
Intracranial pressure: current perspectives on physiology and monitoring	48
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial	48
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials	48
Palliative care interventions in intensive care unit patients	47
Current practice and evolving concepts in septic shock resuscitation	47
Scorpion envenomation: state of the art	46
Hospital mortality in mechanically ventilated COVID-19 patients in Mexico	46
Ten reasons for focusing on the care we provide for family members of critically ill patients with COVID-19	45
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study	45
Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials	44
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom	43
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine	43
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial	43
Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study	43
Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?	43
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials	42
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians	42
ICU capacity management during the COVID-19 pandemic using a process simulation	42
Clinical phenotypes of critically ill COVID-19 patients	42
IL-6 may be a good biomarker for earlier detection of COVID-19 progression	42
Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry	41
Role of total lung stress on the progression of early COVID-19 pneumonia	40
Adjuvant therapeutic plasma exchange in septic shock	40
Randomised clinical trials in critical care: past, present and future	40
Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis	39
The negative impact of comorbidities on the disease course of COVID-19	39
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study	39
Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: a joint ESA/ESICM guideline	39
Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial	38
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial	38
Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial	38
Machine learning in intensive care medicine: ready for take-off?	38
Respiratory indications for ECMO: focus on COVID-19	38
High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial	38
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial	37
Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS	37
The baby lung and the COVID-19 era	37
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality	37
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	37
Respiratory microbiome in mechanically ventilated patients: a narrative review	37
Imaging changes of severe COVID-19 pneumonia in advanced stage	37
Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview	37
Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy	36
Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review	36

Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis	36
Moral distress in the intensive care unit during the pandemic: the burden of dying alone	36
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial	36
Hemoperfusion in the intensive care unit	35
Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia	35
Gender differences in the provision of intensive care: a Bayesian approach	35
External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals	35
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India	35
Plasma exchange in the intensive care unit: a narrative review	35
The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19	34
Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial	34
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study	34
Recognizing and supporting morally injured ICU professionals during the COVID-19 pandemic	34
Cytokine adsorption in severe, refractory septic shock	34
Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients	33
Mechanical power and driving pressure as predictors of mortality among patients with ARDS	33
Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis	33
Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge c	33
Between-centre differences for COVID-19 ICU mortality from early data in England	33
Impact of frailty on persistent critical illness: a population-based cohort study	32
Monitoring of high-flow nasal cannula for SARS-CoV-2 severe pneumonia: less is more, better look at respiratory rate	32
Development and validation of novel sepsis subphenotypes using trajectories of vital signs	32
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study	32
Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study	31
Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	31
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study	31
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials	31
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis	31
Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study	30
Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial	30
Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies	30
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia	30
Everything you need to know about deresuscitation	30
Stages or phenotypes? A critical look at COVID-19 pathophysiology	29
First-attempt success is associated with fewer complications related to intubation in the intensive care unit	29
Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study	29
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis	29
Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study	28
Critical illness in patients with hematologic malignancy: a population-based cohort study	28
Myorelaxants in ARDS patients	28
Ten things we learned about COVID-19	28
Prothrombotic phenotype in COVID-19 severe patients	28
SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients	28
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study	27
Rapidly scalable mechanical ventilator for the COVID-19 pandemic	27
Lung ultrasound and B-lines quantification inaccuracy: B sure to have the right solution	27
Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial	27
Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinica	27
Extubation in neurocritical care patients: the ENIO international prospective study	27
Neuroanatomical substrates of generalized brain dysfunction in COVID-19	27
Predictors of death and new disability after critical illness: a multicentre prospective cohort study	27
Long-term mortality of elderly patients after intensive care unit admission for COVID-19	26
Are subpleural consolidations indicators for segmental pulmonary embolism in COVID-19?	26
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted norm	26
Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung	26
Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study	26
The novel coronavirus (SARS-CoV-2) infections in China: prevention, control and challenges	25
Intensive care for COVID-19 in low- and middle-income countries: research opportunities and challenges	25
Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial	25
Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study	25
Early mobilisation during extracorporeal membrane oxygenation was safe and feasible: a pilot randomised controlled trial	24
COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges	24
Admission chest CT score predicts 5-day outcome in patients with COVID-19	24
How to manage anticoagulation during extracorporeal membrane oxygenation	24
Long term outcomes of critically ill COVID-19 pneumonia patients: early learning	24
Hospital-level variation in the development of persistent critical illness	23
How to ventilate obstructive and asthmatic patients	23
The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: an observational cohort study in Brazilian ICUs	23
Proportional modes of ventilation: technology to assist physiology	23
Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis	23
Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis	23
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings	23
Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial	23
How to improve intubation in the intensive care unit. Update on knowledge and devices	23
(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial	22
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19	22
Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock	22
Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic	22
SARS-CoV-2 in carotid body	22
Organizational aspects of care associated with mortality in critically ill COVID-19 patients	22
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial	21
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	21
The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis	21
Impact of late administration of corticosteroids in COVID-19 ARDS	21
Monitoring cerebral oxygenation in acute brain-injured patients	21
The prevalence, risk factors and outcome of cardiac dysfunction in hospitalized patients with COVID-19	21
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure	20
COVID-19: what the clinician should know about post-mortem findings	20
Contrast-enhanced ultrasound (CEUS) of the lung reveals multiple areas of microthrombi in a COVID-19 patient	20
Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT)	20
What’s new in ECMO for COVID-19?	20
Critically ill patients with COVID-19: are they hemodynamically unstable and do we know why?	20
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity	20
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?	20
Cardiac injury in COVID-19	20