Intensive Care Medicine

Article	Citations
Obituary and tribute to Professor J. Randall Curtis (Randy)	798
Weaning strategy in patients at low-to-medium risk of extubation failure	260
Workplace equity for clinicians with a disability: why it matters for all	252
Personalized oxygen targets are needed for extracorporeal membrane oxygenation	217
Preventing stress ulcer bleeding	189
Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction	173
Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease	163
The certainty of parental love vs. the uncertainty of a “best” decision	159
Pitfalls in the use of microcirculation as a resuscitation goal	152
Persistent signs of poisoning after massive drug ingestion: move the ultrasound probe to the stomach	144
Comparing intravascular and surface cooling methods: a critical look at outcomes for out-of-hospital cardiac arrest patients—author's reply	140
A double plea for dyspnea as the next great cause of all ICU professions and for caution about the dyspnea-breathlessness equivalence	139
Sequencing interventions in ARDS: the critical role of timing and order in standardized management	123
SHAP model explainability in ECMO–PAL mortality prediction: a critical analysis	120
ICU venous thromboembolism prophylaxis: revisiting external validity, vulnerable subgroups, and diagnostic standards, with future directions. Authors' reply	113
Serum sickness: a mimic of septic shock	105
Norepinephrine dose and concentration reporting: a closer look at the fine print	105
Hemodynamic and neurological presentations of invasive meningococcal disease in adults: a nationwide study across 100+ French ICUs	103
Reassessing open lung ventilation in ARDS: an updated meta-analysis of the 2023 ESICM guidelines highlights risks of routine use and supports individualized strategies	102
Family-administered delirium screening improves satisfaction among ICU caregivers: a prospective cohort study	102
Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study	98
Using the helmet	93
No ventilation, no ARDS: insights from four-dimensional computed tomography as dynamic imaging	93
Optimal oxygen and mean arterial blood pressure targets after cardiac arrest	91
Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	90

Correction: Expanding the role of PoCUS in tailoring diuretic strategies for congestion management in critical care	88
Weaning of neuromuscular patients: the reality is probably somewhere in between. Author’s reply	87
Correction to: Noninvasive respiratory support in intensive care medicine	85
Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions	84
Measuring patient’s effort on the ventilator	83
Beyond consensus: operationalizing gender equity and equality in intensive care medicine	81
Severe Pneumocystis jirovecii pneumonia: time to reassess our practices	80
Perioperative ARDS: beyond definitions toward etiology-driven care	73
Variation in intensive care unit beds capacity in China from 2007 to 2021	72
Greenery and outdoor facilities to improve the wellbeing of critically ill patients, their families and caregivers: things to consider	71
Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registry	69
Author Correction: Cyclosporine versus placebo pretreatment of brain-dead donors and kidney graft function (Cis-A-Rein trial): a multicenter, double-blind, randomized, controlled trial	69
The UNDERSCORE for RRT weaning prediction: promising but not yet ready to unplug. Author's reply	68
The ultrasound of silence	68
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	67
18F-fluorodeoxyglucose positron emission tomography/computed tomography differentiates between pneumonia and atelectasis in a mechanically ventilated patient	65
Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment	63
Correspondence on “Mechanical ventilation for ICU patient with obesity: current best practices and future directions” Author’s reply	63
Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE?	62
ICU communication: ‘state of the art’	62
Vitamin C appears harmful in patients after out-of-hospital cardiac arrest treated in the intensive care unit	61
Effects of PEEP on ICP in ABI patients and its relationship with etiology	61
Lung-protective sedation: moving toward a new paradigm of precision sedation	61
Frailty in intensive care medicine must be measured, interpreted and taken into account!	60
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock	59
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis	59
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study	58
Status epilepticus in the ICU	58
Staircase strategy, tier-three therapies, and effects on outcome in traumatic brain injured patients: the Triple-T TBI study	58
Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study	57
Dichotomy between ventilator associated-pneumonia/tracheobronchitis: did you ask the lung its opinion? Author's reply	57
“Fake” or real hypoxia?: A brainy dilemma	57
The role of pleural pressure and airway closure during mechanical ventilation. Author's reply	56
Central venous pressure not appropriate to guide volume administration in patients with high-risk pulmonary embolism	56
Rapid temperature increases under isoflurane sedation	56
Should we move beyond the concept of fluid responsiveness?	55
A call to measure family presence in the adult intensive care unit	55
NeuroWatch in acute respiratory distress syndrome: time to tune strategies	55
Septic shock secondary to a rat-bite fever	54
Central venous-minus-arterial PCO2 to arterial-minus-central venous O2 content ratio is tricky tool to solve the puzzle of lactate sources. Author’s reply	54
B-ICONIC vs. Reality: The Feasibility Gap in Neuro-Ultrasound Recommendations and Achievability. Authors’ reply	53
Head up, face down—a practical framework for proning brain-injured patients with ARDS	52
Which issues should be addressed in future trials regarding the use of corticosteroids in community acquired pneumonia? A survey of REMAP-CAP investigators	51
Relationship of multidrug-resistant bacterial colonization and immune status of patients in the ICU	50
Heart–lungs interactions in mechanically ventilated patients: physiology and clinical implications	50
Haemoglobin buffering capacity: the missing variable in transfusion physiology after acute brain injury	50
Effects of small volume resuscitation with hypertonic saline on body water distribution in ICU patients after cardiac surgery	50
Simultaneous polymicrobial obstructive pyelonephritis and gastrointestinal bleeding revealing ureteroenteric fistula	50
Role of PEEP on the prognostic performance of the ROX index in hypoxemic respiratory failure due to COVID-19: any further gain in outcome prediction?	49
Correction: Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS tria	49

Management of diabetic ketoacidosis	47
Publisher Correction: Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome	47
Retraction Note: Influence of nimodipine and nifedipine on intrapulmonary shunting – a comparison to other vasoactive drugs	47
How can assessing hemodynamics help to assess volume status?	47
From online lessons to bedside insight: learning through the ESICM fellowship experience	47
Visco-elastic testing in traumatic bleeding	47
Frailty is crucial in FORECASTing outcomes in critical care	46
Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study	46
Less is more. Atmospheric and environmental stakes - sedate with care	45
Epistemology of the error: Kant, Shakespeare, and the intensive care unit	45
What’s new in intensive care: disease tolerance	44
Rethinking patient–ventilator asynchronies: toward a mechanism-based framework	44
Humanizing Delirium Care	44
How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support	44
A common longitudinal intensive care unit data format (CLIF) for critical illness research	43
Five-year mortality and functional trajectories in older survivors of intensive care compared to the general population	43
Sepsis subphenotypes, theragnostics and personalized sepsis care	42
Severe community-acquired pneumonia: current concepts and controversies	42
Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults	42
Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable	42
Burden of and risk factors for neurological complications in critical illness	41
Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025	41
Introduction to an intensive care recycling program	41
The role of pleural pressure on fluid dynamics and responsiveness	40
High versus low positive end-expiratory pressure during noninvasive ventilation for hypoxemic respiratory failure: balancing efficacy and lung protection—author’s reply	40
Reevaluating definitions and modifiable factors in persistent severe acute kidney injury	39
Correspondence on "Using toxidromes in the ICU"	38
Awareness of dying: adjustments in family relationships at the end of life	38
Can the terms “low resource setting” and “low-income country” be used interchangeably in the context of intensive care medicine?	37
Intensive Care admission aiming at organ donation as a duty of the intensivist: every organ, every time	37
What really matters with thrombocytopenia: absolute value, timing, etiology or management? Author's reply	37
Double sequential external defibrillation for refractory ventricular fibrillation	37
Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network	37
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery	37
Microcirculation information in clinical decision making: Rome wasn't built in a day	37
Ten tips on sepsis-induced thrombocytopenia	37
Multiple intracardiac thrombi in a patient with extracorporeal membrane oxygenation	37
Building a better machine learning model of extubation for neurocritical care patients. Author’s reply	36
Penicillin allergy assessment and testing: worth the risk in critically ill patients	36
Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author’s reply	36
Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice!	35
Lung and diaphragm protective ventilation guided by the esophageal pressure	35
Caring for the dying patient in ICU	34
Portal venous gas on point-of-care ultrasound	34
Selective digestive decontamination- Not sure	34
Long-term survival comparison of patients admitted to the intensive care unit following in-hospital cardiac arrest in perioperative and ward settings. A multicentre retrospective cohort study	34
Restrictive nutrition in shock: reassuring renal signals—but no proof of safety	34
Correction: Association of hospital and intensive care unit occupancy and non-admission to the intensive care unit decisions: a retrospective cohort study	34
Correction: ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	34
Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial	33
Ten reasons for the presence of pharmacy professionals in the intensive care unit	33
Bronchoscopy for diagnosis of ventilator-associated pneumonia	33
Optimising aerosolized therapies in critically ill patients	33
Between two worlds: from ESICM lives back to my ICU—a perspective from Tunisia	32
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	32
ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation	31
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial	31
Long-term outcomes of intensive care unit delirium	31
Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases	30
Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL)	30
Head-to-toe bedside ultrasound for adult patients on extracorporeal membrane oxygenation	30
Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study	30
Targeting inflammation in traumatic injury: entering a new era	29
Critical insights into venoarterial extracorporeal membrane oxygenation outcomes in immunocompromised patients: addressing uncertainties in cause of death and treatment strategies. Author’s reply	29
Integrating multidisciplinary expertise in postoperative noninvasive ventilation management. Authors’ reply	29
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	29
Terlipressin use in HRS-AKI and respiratory failure	29
Bronchoscopic examination of an invasive aspergillosis in acute myeloid leukemia	29
Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome	29
Consumptive coagulopathy: how low-dose unfractionated heparin can prevent bleeding complications during extracorporeal life support	29
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery? Author’s reply	29
Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply	28
Delirium in ICU and Macbeth’s dagger: author’s reply	28
AI in neurocritical care: what to expect	28
Hemoadsorption in septic shock – PRO	28
Bridging the gap: implementing ESICM end-of-life care guidelines in resource-limited settings	28
Unlocking consciousness through right median nerve stimulation. Has a potential cure arrived at our doorstep?	27
Is acute respiratory distress syndrome a preventable disease?	27
Acute kidney injury and chronic kidney disease in the aging critically ill patient	27
Dynamic indices of fluid responsiveness: physiological basis and clinical limits	27

Driving pressure as a target for lung protective strategies: from ARDS critically-ill patients to the operating room—Lessons from the IMPROVE-2 Trial	27
Dr Rick van Saene 1946–2026	27
Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis	27
On acid-base bilingualism	27
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software	27
Plasma exchange in septic shock: are we ready for prime time? PRO	27
When capacity exceeds justification: technology, proportionality, and care in the ICU	27
Accuracy of continuous glucose monitoring systems in intensive care unit patients: a scoping review	26
Ups and downs of cerebral autoregulation in the intensive care unit: why should we care?	26
Alveolar gas equation and its clinical implications	26
High and intermediate risk pulmonary embolism in the ICU	26
What intensivists need to know about cytomegalovirus infection in immunocompromised ICU patients	26
Acute kidney injury	26
How to approach a patient hospitalized for pneumonia who is not responding to treatment?	26
Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM	26
Open-source clinical classifiers for ARDS: democratizing precision or diluting biology?	26
Managing blood glucose control in the intensive care unit	26
Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case–control study over 5 years	26
Critical care in hematologic emergencies	26
Current standard of care for septic shock	26
Caring for frail patients in the ICU: a multidimensional approach	25
Reusable versus single-use ICU equipment: what’s the environmental footprint?	25
Coronavirus disease 2019	25
Antibiotic therapy for severe bacterial infections	25
Hyperoxia and traumatic brain injury: time to stop cooking the books?	25
Massive gaseous embolism during cardiopulmonary resuscitation for massive hemoptysis in a COVID-19-associated pulmonary aspergillosis	25
Understanding buffering of metabolic acidosis in critical illness	25
Analgesia as part of the orotracheal intubation induction sequence. Author's reply	25
Come hell or high water: climate change through the lens of neurocritical care	25
Monitoring cardiac output	24
Retraction Note: Phosphodiesterase-inhibitors enoximone and piroximone in cardiac surgery: influence on platelet count and function	24
Deploying AI in the ICU: learning from successes and failures	24
Human albumin solution for on-pump cardiac surgery: benefit or burden? Author’s reply	24
Obituary and tribute to Professor Tobias Welte	24
Sex representation within intensive care trials in Australia and New Zealand	24
Characteristics of co-infection and secondary infection amongst critically ill COVID-19 patients in the first two waves of the pandemic	24
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial	24
Heterogeneity in a meta-analysis: randomized controlled trials versus observational studies	23
The dawn of target trials in intensive care: time to move beyond association is not causation	23
Immunosuppressive treatment in solid organ transplant critically ill patients: still an unanswered question?	23
Clinical governance in intensive care medicine	23
How to optimize extubation?	23
Equity in patient care in the intensive care unit	23
Ceremonial purification: which rite is right in liver failure?	23
Neuromonitoring for prognostication under ECMO	23
Author Correction: Current standard of care for septic shock	23
Prevention of upper gastrointestinal bleeding in critical illness	23
Delirium Related to Sedation: Prevention Strategies and Patient Perspectives	22
Challenges for a broad international implementation of the current severe community-acquired pneumonia guidelines	22
Source control following traumatic gastric perforation : not so easy	22
Standard of care for rehabilitation in critical illness	22
Preventing acute kidney injury and its longer-term impact in the critically ill	22
Using ultrasound in ICU	22
Central venous pressure (CVP)	22
Challenges and strategies in the care of older adults across the continuum of intensive and post-intensive care medicine	22
Contemporary management of major haemorrhage in critical care	22
Reconsidering transfusion thresholds in traumatic brain injury with multiple trauma: implications from the HEMOTION sub-study	22
During the storm	21
The role of inferior vena cava in predicting fluid responsiveness	21
EIT in ARDS: what we know and what we still do not	21
Gymnopédie: music in the ICU	21
The relationship of malnutrition, frailty, and sarcopenia in critical care	21
War, from the inside	21
Driving pressure: pitfalls of methods that do not use esophageal pressure measurement	21
Unraveling the enigma of genetics and phenotypes in ARDS	21
Post-sepsis recovery: perspectives on measuring what matters. Author's reply	20
Air pollutant exposure and mortality risk of critically ill patients	20
Breaking the dogma: from contraindication to personalized prone positioning in brain-injured patients. Author’s reply	20
The paradox of post-intensive care unit physical therapy	20
Bidirectional ventricular tachycardia, a very rare and severe complication of digoxin poisoning	20
Validation of the “invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure score” (IPA-GRRR-OH score)	20
REMAP-CAP corticosteroids: yet, another swing of the pendulum?	20
Human albumin solution for on-pump cardiac surgery: benefit or burden?	20
Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies—author's reply	20
Hypervirulent Klebsiella pneumoniae: watch the eyes	20
Correction: Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling	20
Correction: Variation in intensive care unit beds capacity in China from 2007 to 2021	19
Persistent severe AKI is bad—where to go now?	19
Author Correction: Hemoadsorption in septic shock—CON	19
Onco-nephrology: what the intensivist needs to know	19
Correction: Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study	19
Retraction Note: Right ventricular function and cardiac surgery	19
Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)	19
Correction: ESICM consensus-based recommendations for the management of very old patients in intensive care	19
Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations	18
The second brain in the line of fire: addressing surrogate cognitive dysautoregulation	18
What is the most appropriate next step in a patient with progressive subcutaneous emphysema and hemodynamic deterioration?	18
HeartMate 3–related ECG artefact resolved by 40‑Hz low‑pass filtering	18
Post-intensive care syndrome is a potential consequence of critical care: can intensivists afford to look away?	18
Pv-aCO2 and Pv-aCO2/Ca-vO2 in shock resuscitation: physiologically appealing, but challenging in resource-limited ICUs	18
Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database	18
Correction: Direct assessment of microcirculation in shock: a randomized-controlled multicenter study	18
Retraction Note: The new phosphodiesterase inhibitor enoximone in patients following cardiac surgery – pharmacokinetics and influence on parameters of coagulation	18
When the heart goes to the wrong side	18
Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial	18