Intensive Care Medicine

Article	Citations
Obituary and tribute to Professor J. Randall Curtis (Randy)	756
Weaning strategy in patients at low-to-medium risk of extubation failure	252
Workplace equity for clinicians with a disability: why it matters for all	244
Personalized oxygen targets are needed for extracorporeal membrane oxygenation	210
Preventing stress ulcer bleeding	182
Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction	165
Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease	158
The certainty of parental love vs. the uncertainty of a “best” decision	155
Pitfalls in the use of microcirculation as a resuscitation goal	149
Persistent signs of poisoning after massive drug ingestion: move the ultrasound probe to the stomach	138
Comparing intravascular and surface cooling methods: a critical look at outcomes for out-of-hospital cardiac arrest patients—author's reply	135
A double plea for dyspnea as the next great cause of all ICU professions and for caution about the dyspnea-breathlessness equivalence	132
Sequencing interventions in ARDS: the critical role of timing and order in standardized management	126
SHAP model explainability in ECMO–PAL mortality prediction: a critical analysis	119
ICU venous thromboembolism prophylaxis: revisiting external validity, vulnerable subgroups, and diagnostic standards, with future directions. Authors' reply	113
Norepinephrine dose and concentration reporting: a closer look at the fine print	111
18F-fluorodeoxyglucose positron emission tomography/computed tomography differentiates between pneumonia and atelectasis in a mechanically ventilated patient	102
Serum sickness: a mimic of septic shock	102
Hemodynamic and neurological presentations of invasive meningococcal disease in adults: a nationwide study across 100+ French ICUs	101
Family-administered delirium screening improves satisfaction among ICU caregivers: a prospective cohort study	100
Reassessing open lung ventilation in ARDS: an updated meta-analysis of the 2023 ESICM guidelines highlights risks of routine use and supports individualized strategies	99
Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study	93
Effects of PEEP on ICP in ABI patients and its relationship with etiology	89
Author Correction: Cyclosporine versus placebo pretreatment of brain-dead donors and kidney graft function (Cis-A-Rein trial): a multicenter, double-blind, randomized, controlled trial	88
No ventilation, no ARDS: insights from four-dimensional computed tomography as dynamic imaging	88

Using the helmet	87
Optimal oxygen and mean arterial blood pressure targets after cardiac arrest	85
Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	84
Correction: Expanding the role of PoCUS in tailoring diuretic strategies for congestion management in critical care	81
Frailty in intensive care medicine must be measured, interpreted and taken into account!	81
Correction to: Noninvasive respiratory support in intensive care medicine	75
Weaning of neuromuscular patients: the reality is probably somewhere in between. Author’s reply	75
Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment	74
Staircase strategy, tier-three therapies, and effects on outcome in traumatic brain injured patients: the Triple-T TBI study	69
Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions	69
Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study	67
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial	67
Measuring patient’s effort on the ventilator	67
Correspondence on “Mechanical ventilation for ICU patient with obesity: current best practices and future directions” Author’s reply	65
Beyond consensus: operationalizing gender equity and equality in intensive care medicine	63
Perioperative ARDS: beyond definitions toward etiology-driven care	62
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	62
Severe Pneumocystis jirovecii pneumonia: time to reassess our practices	62
Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE?	61
ICU communication: ‘state of the art’	60
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock	59
Lung-protective sedation: moving toward a new paradigm of precision sedation	59
The UNDERSCORE for RRT weaning prediction: promising but not yet ready to unplug. Author's reply	58
Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registry	58
The ultrasound of silence	56
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis	56
Variation in intensive care unit beds capacity in China from 2007 to 2021	56
Status epilepticus in the ICU	55
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study	55
Greenery and outdoor facilities to improve the wellbeing of critically ill patients, their families and caregivers: things to consider	55
Rapid temperature increases under isoflurane sedation	54
Dichotomy between ventilator associated-pneumonia/tracheobronchitis: did you ask the lung its opinion? Author's reply	54
“Fake” or real hypoxia?: A brainy dilemma	54
Central venous pressure not appropriate to guide volume administration in patients with high-risk pulmonary embolism	53
The role of pleural pressure and airway closure during mechanical ventilation. Author's reply	53
A call to measure family presence in the adult intensive care unit	53
NeuroWatch in acute respiratory distress syndrome: time to tune strategies	53
Should we move beyond the concept of fluid responsiveness?	52
Septic shock secondary to a rat-bite fever	51
What’s new in intensive care: disease tolerance	51
Central venous-minus-arterial PCO2 to arterial-minus-central venous O2 content ratio is tricky tool to solve the puzzle of lactate sources. Author’s reply	51
Visco-elastic testing in traumatic bleeding	51
Frailty is crucial in FORECASTing outcomes in critical care	50
Head up, face down—a practical framework for proning brain-injured patients with ARDS	50
B-ICONIC vs. Reality: The Feasibility Gap in Neuro-Ultrasound Recommendations and Achievability. Authors’ reply	50
Rethinking patient–ventilator asynchronies: toward a mechanism-based framework	50
Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable	49
Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study	48
Which issues should be addressed in future trials regarding the use of corticosteroids in community acquired pneumonia? A survey of REMAP-CAP investigators	48
From online lessons to bedside insight: learning through the ESICM fellowship experience	47

Ten myths about Albumin: don’t forget the endothelium. Author’s reply	47
Simultaneous polymicrobial obstructive pyelonephritis and gastrointestinal bleeding revealing ureteroenteric fistula	46
Less is more. Atmospheric and environmental stakes - sedate with care	46
Heart–lungs interactions in mechanically ventilated patients: physiology and clinical implications	46
Haemoglobin buffering capacity: the missing variable in transfusion physiology after acute brain injury	46
Effects of small volume resuscitation with hypertonic saline on body water distribution in ICU patients after cardiac surgery	45
Role of PEEP on the prognostic performance of the ROX index in hypoxemic respiratory failure due to COVID-19: any further gain in outcome prediction?	45
Relationship of multidrug-resistant bacterial colonization and immune status of patients in the ICU	45
Correction: Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS tria	45
Introduction to an intensive care recycling program	44
Sepsis subphenotypes, theragnostics and personalized sepsis care	43
A common longitudinal intensive care unit data format (CLIF) for critical illness research	43
Retraction Note: Influence of nimodipine and nifedipine on intrapulmonary shunting – a comparison to other vasoactive drugs	43
Management of diabetic ketoacidosis	43
How can assessing hemodynamics help to assess volume status?	42
Severe community-acquired pneumonia: current concepts and controversies	42
Epistemology of the error: Kant, Shakespeare, and the intensive care unit	42
Humanizing Delirium Care	42
Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults	42
Five-year mortality and functional trajectories in older survivors of intensive care compared to the general population	42
Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025	41
Correspondence on "Using toxidromes in the ICU"	40
High versus low positive end-expiratory pressure during noninvasive ventilation for hypoxemic respiratory failure: balancing efficacy and lung protection—author’s reply	40
Can the terms “low resource setting” and “low-income country” be used interchangeably in the context of intensive care medicine?	40
Awareness of dying: adjustments in family relationships at the end of life	40
The role of pleural pressure on fluid dynamics and responsiveness	40
Microcirculation information in clinical decision making: Rome wasn't built in a day	40
Reevaluating definitions and modifiable factors in persistent severe acute kidney injury	40
Double sequential external defibrillation for refractory ventricular fibrillation	40
Consumptive coagulopathy: how low-dose unfractionated heparin can prevent bleeding complications during extracorporeal life support	38
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	38
Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network	38
Head-to-toe bedside ultrasound for adult patients on extracorporeal membrane oxygenation	38
Ten tips on sepsis-induced thrombocytopenia	37
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial	37
ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation	37
Multiple intracardiac thrombi in a patient with extracorporeal membrane oxygenation	36
What really matters with thrombocytopenia: absolute value, timing, etiology or management? Author's reply	36
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery	36
Intensive Care admission aiming at organ donation as a duty of the intensivist: every organ, every time	36
Penicillin allergy assessment and testing: worth the risk in critically ill patients	35
Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author’s reply	35
Building a better machine learning model of extubation for neurocritical care patients. Author’s reply	35
Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice!	34
Between two worlds: from ESICM lives back to my ICU—a perspective from Tunisia	34
Correction: Association of hospital and intensive care unit occupancy and non-admission to the intensive care unit decisions: a retrospective cohort study	34
Targeting inflammation in traumatic injury: entering a new era	34
Lung and diaphragm protective ventilation guided by the esophageal pressure	34
Correction: ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	33
Caring for the dying patient in ICU	33
Long-term survival comparison of patients admitted to the intensive care unit following in-hospital cardiac arrest in perioperative and ward settings. A multicentre retrospective cohort study	33
Selective digestive decontamination- Not sure	33
Portal venous gas on point-of-care ultrasound	32
Optimising aerosolized therapies in critically ill patients	32
Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome	32
Ten reasons for the presence of pharmacy professionals in the intensive care unit	31
Long-term outcomes of intensive care unit delirium	31
Bronchoscopy for diagnosis of ventilator-associated pneumonia	31
Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL)	31
Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial	31
Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study	31
Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases	31
Restrictive nutrition in shock: reassuring renal signals—but no proof of safety	31
Bronchoscopic examination of an invasive aspergillosis in acute myeloid leukemia	30
Terlipressin use in HRS-AKI and respiratory failure	30
Integrating multidisciplinary expertise in postoperative noninvasive ventilation management. Authors’ reply	30
Critical insights into venoarterial extracorporeal membrane oxygenation outcomes in immunocompromised patients: addressing uncertainties in cause of death and treatment strategies. Author’s reply	30
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery? Author’s reply	30
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	30
Hemoadsorption in septic shock – PRO	28
Bridging the gap: implementing ESICM end-of-life care guidelines in resource-limited settings	28
Delirium in ICU and Macbeth’s dagger: author’s reply	28
On acid-base bilingualism	28
AI in neurocritical care: what to expect	28
Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply	28
Ups and downs of cerebral autoregulation in the intensive care unit: why should we care?	27
Understanding buffering of metabolic acidosis in critical illness	27
Plasma exchange in septic shock: are we ready for prime time? PRO	27
Unlocking consciousness through right median nerve stimulation. Has a potential cure arrived at our doorstep?	27
Acute kidney injury	27

Critical care in hematologic emergencies	27
Acute kidney injury and chronic kidney disease in the aging critically ill patient	27
Dr Rick van Saene 1946–2026	26
High and intermediate risk pulmonary embolism in the ICU	26
Caring for frail patients in the ICU: a multidimensional approach	26
Managing blood glucose control in the intensive care unit	26
When capacity exceeds justification: technology, proportionality, and care in the ICU	26
Current standard of care for septic shock	26
Antibiotic therapy for severe bacterial infections	26
What intensivists need to know about cytomegalovirus infection in immunocompromised ICU patients	26
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software	26
How to approach a patient hospitalized for pneumonia who is not responding to treatment?	26
Reusable versus single-use ICU equipment: what’s the environmental footprint?	26
Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis	26
Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case–control study over 5 years	26
Come hell or high water: climate change through the lens of neurocritical care	25
Analgesia as part of the orotracheal intubation induction sequence. Author's reply	25
Open-source clinical classifiers for ARDS: democratizing precision or diluting biology?	25
Massive gaseous embolism during cardiopulmonary resuscitation for massive hemoptysis in a COVID-19-associated pulmonary aspergillosis	25
Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM	25
Alveolar gas equation and its clinical implications	25
Hyperoxia and traumatic brain injury: time to stop cooking the books?	25
Driving pressure as a target for lung protective strategies: from ARDS critically-ill patients to the operating room—Lessons from the IMPROVE-2 Trial	25
Accuracy of continuous glucose monitoring systems in intensive care unit patients: a scoping review	25
Coronavirus disease 2019	24
Obituary and tribute to Professor Tobias Welte	24
Early ICU mobilisation predicting functional impairment at hospital discharge. Author's reply	24
Human albumin solution for on-pump cardiac surgery: benefit or burden? Author’s reply	24
Characteristics of co-infection and secondary infection amongst critically ill COVID-19 patients in the first two waves of the pandemic	24
Equity in patient care in the intensive care unit	23
Retraction Note: Phosphodiesterase-inhibitors enoximone and piroximone in cardiac surgery: influence on platelet count and function	23
Neuromonitoring for prognostication under ECMO	23
Author Correction: Current standard of care for septic shock	23
Standard of care for rehabilitation in critical illness	23
Clinical governance in intensive care medicine	23
Monitoring cardiac output	23
Contemporary management of major haemorrhage in critical care	23
The dawn of target trials in intensive care: time to move beyond association is not causation	23
Reconsidering transfusion thresholds in traumatic brain injury with multiple trauma: implications from the HEMOTION sub-study	23
Ceremonial purification: which rite is right in liver failure?	23
Using ultrasound in ICU	23
Heterogeneity in a meta-analysis: randomized controlled trials versus observational studies	23
Prevention of upper gastrointestinal bleeding in critical illness	23
Immunosuppressive treatment in solid organ transplant critically ill patients: still an unanswered question?	23
Challenges and strategies in the care of older adults across the continuum of intensive and post-intensive care medicine	22
Challenges for a broad international implementation of the current severe community-acquired pneumonia guidelines	22
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial	22
Delirium Related to Sedation: Prevention Strategies and Patient Perspectives	22
Central venous pressure (CVP)	22
Sex representation within intensive care trials in Australia and New Zealand	22
Deploying AI in the ICU: learning from successes and failures	22
Preventing acute kidney injury and its longer-term impact in the critically ill	22
How to optimize extubation?	22
Gymnopédie: music in the ICU	21
The role of inferior vena cava in predicting fluid responsiveness	21
Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies—author's reply	21
War, from the inside	21
Driving pressure: pitfalls of methods that do not use esophageal pressure measurement	21
The relationship of malnutrition, frailty, and sarcopenia in critical care	21
Human albumin solution for on-pump cardiac surgery: benefit or burden?	21
During the storm	21
Unraveling the enigma of genetics and phenotypes in ARDS	21
Post-sepsis recovery: perspectives on measuring what matters. Author's reply	21
Bidirectional ventricular tachycardia, a very rare and severe complication of digoxin poisoning	21
Air pollutant exposure and mortality risk of critically ill patients	20
Breaking the dogma: from contraindication to personalized prone positioning in brain-injured patients. Author’s reply	20
REMAP-CAP corticosteroids: yet, another swing of the pendulum?	20
The paradox of post-intensive care unit physical therapy	20
Correction: Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling	20
Validation of the “invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure score” (IPA-GRRR-OH score)	20
Hypervirulent Klebsiella pneumoniae: watch the eyes	20
Correction: Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study	20
Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations	19
Correction: ESICM consensus-based recommendations for the management of very old patients in intensive care	19
Onco-nephrology: what the intensivist needs to know	19
Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)	19
Alveolar gas equation: a metabolic perspective	19
Interpreting sex differences in outcomes after critical illness	19
Association between driving pressure and mortality may depend on timing since onset of acute respiratory distress syndrome	19
Author Correction: Hemoadsorption in septic shock—CON	19
Persistent severe AKI is bad—where to go now?	19
Retraction Note: The new phosphodiesterase inhibitor enoximone in patients following cardiac surgery – pharmacokinetics and influence on parameters of coagulation	19
Early biomarker detection: fundamentally disputable?	19
Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review	19
Retraction Note: Right ventricular function and cardiac surgery	19
Update on long-term physical disability after critical illness: the burden of post-intensive care syndrome	19
Correction: Variation in intensive care unit beds capacity in China from 2007 to 2021	19
Increased risk of central line-associated bloodstream infection in COVID-19 patients associated with dexamethasone but not with interleukin antagonists	19
Using diuretic therapy in the critically ill patient	19
Biomarkers and the prediction of acute kidney injury and renal replacement therapy initiation: a dream within a dream	18
HeartMate 3–related ECG artefact resolved by 40‑Hz low‑pass filtering	18
The forgotten relevance of central venous pressure monitoring	18
Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database	18
Sex and gender differences in intensive care medicine	18
The second brain in the line of fire: addressing surrogate cognitive dysautoregulation	18