Intensive Care Medicine

Article	Citations
Obituary and tribute to Professor J. Randall Curtis (Randy)	608
Effect of proning and recruitment on physio-anatomical variables in COVID-19 pneumonia	209
Time course of physiological variables during inter-hospital helicopter transport of ventilated COVID-19 patients	194
Basic ultrasound skill for intensivists: future scope for expansion of the recommendations of the European Society of Intensive Care Medicine	183
Full enteral nutrition should be avoided among patients with high vasopressor dose and low flow state	164
Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	154
Weaning strategy in patients at low-to-medium risk of extubation failure	150
Workplace equity for clinicians with a disability: why it matters for all	149
Personalized oxygen targets are needed for extracorporeal membrane oxygenation	146
Preventing stress ulcer bleeding	145
No ventilation, no ARDS: insights from four-dimensional computed tomography as dynamic imaging	136
Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction	130
Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease	121
The certainty of parental love vs. the uncertainty of a “best” decision	116
Pitfalls in the use of microcirculation as a resuscitation goal	116
Correction to: Noninvasive respiratory support in intensive care medicine	108
ICU venous thromboembolism prophylaxis: revisiting external validity, vulnerable subgroups, and diagnostic standards, with future directions. Authors' reply	107
Norepinephrine dose and concentration reporting: a closer look at the fine print	106
Staircase strategy, tier-three therapies, and effects on outcome in traumatic brain injured patients: the Triple-T TBI study	88
Dose of norepinephrine: the devil is in the details	88
Persistent signs of poisoning after massive drug ingestion: move the ultrasound probe to the stomach	86
Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study	83
Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment	82
Comparing intravascular and surface cooling methods: a critical look at outcomes for out-of-hospital cardiac arrest patients—author's reply	82
A double plea for dyspnea as the next great cause of all ICU professions and for caution about the dyspnea-breathlessness equivalence	81

Greenery and outdoor facilities to improve the wellbeing of critically ill patients, their families and caregivers: things to consider	80
Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE?	79
Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions	79
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial	77
Correction: Expanding the role of PoCUS in tailoring diuretic strategies for congestion management in critical care	76
18F-fluorodeoxyglucose positron emission tomography/computed tomography differentiates between pneumonia and atelectasis in a mechanically ventilated patient	72
Lung-protective sedation: moving toward a new paradigm of precision sedation	71
SHAP model explainability in ECMO–PAL mortality prediction: a critical analysis	70
Serum sickness: a mimic of septic shock	70
Using the helmet	69
Anesthetic drugs for rapid sequence intubation: ketamine, but what dose?	68
Reassessing open lung ventilation in ARDS: an updated meta-analysis of the 2023 ESICM guidelines highlights risks of routine use and supports individualized strategies	66
Measuring patient’s effort on the ventilator	63
Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia	63
Hemodynamic and neurological presentations of invasive meningococcal disease in adults: a nationwide study across 100+ French ICUs	63
Variation in intensive care unit beds capacity in China from 2007 to 2021	62
The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial	60
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis	59
Weaning of neuromuscular patients: the reality is probably somewhere in between. Author’s reply	59
Status epilepticus in the ICU	59
Severe Pneumocystis jirovecii pneumonia: time to reassess our practices	58
Effects of PEEP on ICP in ABI patients and its relationship with etiology	58
Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registry	57
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock	55
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study	54
Optimal oxygen and mean arterial blood pressure targets after cardiac arrest	54
Sequencing interventions in ARDS: the critical role of timing and order in standardized management	54
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial	54
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	53
Frailty in intensive care medicine must be measured, interpreted and taken into account!	51
Towards evidence-based staffing: the promise and pitfalls of patient-to-intensivist ratios	50
B-ICONIC vs. Reality: The Feasibility Gap in Neuro-Ultrasound Recommendations and Achievability. Authors’ reply	50
Five-year mortality and functional trajectories in older survivors of intensive care compared to the general population	50
Less is more. Atmospheric and environmental stakes - sedate with care	49
Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults	48
Head up, face down—a practical framework for proning brain-injured patients with ARDS	48
Frailty is crucial in FORECASTing outcomes in critical care	48
Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study	48
Sepsis subphenotypes, theragnostics and personalized sepsis care	47
“Fake” or real hypoxia?: A brainy dilemma	47
Should we move beyond the concept of fluid responsiveness?	47
Role of PEEP on the prognostic performance of the ROX index in hypoxemic respiratory failure due to COVID-19: any further gain in outcome prediction?	46
Ten myths about Albumin: don’t forget the endothelium. Author’s reply	46
Rapid temperature increases under isoflurane sedation	45
Dichotomy between ventilator associated-pneumonia/tracheobronchitis: did you ask the lung its opinion? Author's reply	45
Central venous pressure not appropriate to guide volume administration in patients with high-risk pulmonary embolism	44
Correction: Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS tria	44
The role of pleural pressure and airway closure during mechanical ventilation. Author's reply	43
A call to measure family presence in the adult intensive care unit	43
NeuroWatch in acute respiratory distress syndrome: time to tune strategies	43

Introduction to an intensive care recycling program	43
Bone marrow necrosis induced by massive Staphylococcus aureus infiltration	43
Ten myths about albumin	42
The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute a simple solution	42
Effects of small volume resuscitation with hypertonic saline on body water distribution in ICU patients after cardiac surgery	42
Haemoglobin buffering capacity: the missing variable in transfusion physiology after acute brain injury	42
Visco-elastic testing in traumatic bleeding	42
Humanizing Delirium Care	42
Central venous-minus-arterial PCO2 to arterial-minus-central venous O2 content ratio is tricky tool to solve the puzzle of lactate sources. Author’s reply	42
Retraction Note: Influence of nimodipine and nifedipine on intrapulmonary shunting – a comparison to other vasoactive drugs	42
Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable	41
Relationship of multidrug-resistant bacterial colonization and immune status of patients in the ICU	41
Septic shock secondary to a rat-bite fever	41
Simultaneous polymicrobial obstructive pyelonephritis and gastrointestinal bleeding revealing ureteroenteric fistula	41
What’s new in intensive care: disease tolerance	40
Management of diabetic ketoacidosis	39
A common longitudinal intensive care unit data format (CLIF) for critical illness research	39
How can assessing hemodynamics help to assess volume status?	38
Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025	38
The role of pleural pressure on fluid dynamics and responsiveness	37
Correction: Association of hospital and intensive care unit occupancy and non-admission to the intensive care unit decisions: a retrospective cohort study	37
High versus low positive end-expiratory pressure during noninvasive ventilation for hypoxemic respiratory failure: balancing efficacy and lung protection—author’s reply	37
Awareness of dying: adjustments in family relationships at the end of life	36
Reevaluating definitions and modifiable factors in persistent severe acute kidney injury	36
Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice!	36
Penicillin allergy assessment and testing: worth the risk in critically ill patients	36
Double sequential external defibrillation for refractory ventricular fibrillation	35
Correspondence on "Using toxidromes in the ICU"	35
Anesthetic drugs for rapid sequence intubation: ketamine, but what dose? Author’s reply	35
Defining basic (lung) ultrasound skills; not so basic after all? Author’s reply	35
What really matters with thrombocytopenia: absolute value, timing, etiology or management? Author's reply	34
Caring for the dying patient in ICU	34
Drugs for advanced life support	34
Intensive Care admission aiming at organ donation as a duty of the intensivist: every organ, every time	34
Building a better machine learning model of extubation for neurocritical care patients. Author’s reply	33
Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome	33
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery	33
Correction: ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	33
Multiple intracardiac thrombi in a patient with extracorporeal membrane oxygenation	33
Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network	33
Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases	32
Selective digestive decontamination- Not sure	32
Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study	32
Long-term outcomes of intensive care unit delirium	31
Head-to-toe bedside ultrasound for adult patients on extracorporeal membrane oxygenation	31
Targeting inflammation in traumatic injury: entering a new era	31
Ten tips on sepsis-induced thrombocytopenia	30
Undocumented migrants in French intensive care units in 2011–2018: retrospective nationwide study	30
Ten reasons for the presence of pharmacy professionals in the intensive care unit	30
Bronchoscopy for diagnosis of ventilator-associated pneumonia	30
Optimising aerosolized therapies in critically ill patients	30
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis	30
Long-term survival comparison of patients admitted to the intensive care unit following in-hospital cardiac arrest in perioperative and ward settings. A multicentre retrospective cohort study	30
Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author’s reply	30
ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation	29
Microcirculation information in clinical decision making: Rome wasn't built in a day	29
Can the terms “low resource setting” and “low-income country” be used interchangeably in the context of intensive care medicine?	29
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	29
Lung and diaphragm protective ventilation guided by the esophageal pressure	29
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial	29
Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL)	28
Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial	28
Effect of albumin bolus therapy on vasopressor requirement after cardiac surgery? Author’s reply	28
Critical insights into venoarterial extracorporeal membrane oxygenation outcomes in immunocompromised patients: addressing uncertainties in cause of death and treatment strategies. Author’s reply	28
De-adoption of chlorhexidine oral care and ICU mortality. Authors’ reply	28
Consumptive coagulopathy: how low-dose unfractionated heparin can prevent bleeding complications during extracorporeal life support	28
Terlipressin use in HRS-AKI and respiratory failure	28
Integrating multidisciplinary expertise in postoperative noninvasive ventilation management. Authors’ reply	28
Bridging the gap: implementing ESICM end-of-life care guidelines in resource-limited settings	27
Bronchoscopic examination of an invasive aspergillosis in acute myeloid leukemia	27
Delirium in ICU and Macbeth’s dagger: author’s reply	27
On acid-base bilingualism	27
Unlocking consciousness through right median nerve stimulation. Has a potential cure arrived at our doorstep?	27
Hemoadsorption in septic shock – PRO	27
Driving pressure as a target for lung protective strategies: from ARDS critically-ill patients to the operating room—Lessons from the IMPROVE-2 Trial	26
AI in neurocritical care: what to expect	26
Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case–control study over 5 years	26
Managing blood glucose control in the intensive care unit	25
Acute kidney injury	25
Plasma exchange in septic shock: are we ready for prime time? PRO	25

Current standard of care for septic shock	25
Understanding buffering of metabolic acidosis in critical illness	25
Reusable versus single-use ICU equipment: what’s the environmental footprint?	25
Antibiotic therapy for severe bacterial infections	25
How to approach a patient hospitalized for pneumonia who is not responding to treatment?	25
Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply	25
High and intermediate risk pulmonary embolism in the ICU	25
Massive gaseous embolism during cardiopulmonary resuscitation for massive hemoptysis in a COVID-19-associated pulmonary aspergillosis	24
Caring for frail patients in the ICU: a multidimensional approach	24
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software	24
Analgesia as part of the orotracheal intubation induction sequence. Author's reply	24
Open-source clinical classifiers for ARDS: democratizing precision or diluting biology?	24
Accuracy of continuous glucose monitoring systems in intensive care unit patients: a scoping review	24
Hyperoxia and traumatic brain injury: time to stop cooking the books?	24
Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM	24
What intensivists need to know about cytomegalovirus infection in immunocompromised ICU patients	24
Retraction Note: Phosphodiesterase-inhibitors enoximone and piroximone in cardiac surgery: influence on platelet count and function	24
Confusion regarding the use of Natural Language Processing in ICU delirium assessment. Author’s reply	23
Absence of candidemia in critically ill patients with COVID-19 receiving selective digestive decontamination	23
Obituary and tribute to Professor Tobias Welte	23
Characteristics of co-infection and secondary infection amongst critically ill COVID-19 patients in the first two waves of the pandemic	23
Correction to: Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study	23
My advice to the NEXT generation	23
We are proud of you Jamie	23
Human albumin solution for on-pump cardiac surgery: benefit or burden? Author’s reply	23
Early ICU mobilisation predicting functional impairment at hospital discharge. Author's reply	23
Coronavirus disease 2019	23
Come hell or high water: climate change through the lens of neurocritical care	23
Preventing acute kidney injury and its longer-term impact in the critically ill	22
Heterogeneity in a meta-analysis: randomized controlled trials versus observational studies	22
Central venous pressure (CVP)	22
Ceremonial purification: which rite is right in liver failure?	22
Sex representation within intensive care trials in Australia and New Zealand	22
Ketamine for emergency endotracheal intubation: insights into post-induction hemodynamic instability	22
Incidence and risk factors of mental illness among the spouses of patients with sepsis: a population-based cohort study	21
The dawn of target trials in intensive care: time to move beyond association is not causation	21
Deploying AI in the ICU: learning from successes and failures	21
Monitoring cardiac output	21
How to optimize extubation?	21
Equity in patient care in the intensive care unit	21
Using ultrasound in ICU	21
Time-limited trial of intensive care is more than merely life sustaining	20
Contemporary management of major haemorrhage in critical care	20
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial	20
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial	20
Clinical governance in intensive care medicine	20
Delirium Related to Sedation: Prevention Strategies and Patient Perspectives	20
Challenges for a broad international implementation of the current severe community-acquired pneumonia guidelines	20
Prevention of upper gastrointestinal bleeding in critical illness	20
Neuromonitoring for prognostication under ECMO	20
Challenges and strategies in the care of older adults across the continuum of intensive and post-intensive care medicine	20
Author Correction: Current standard of care for septic shock	20
Correction: Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study	19
Respective roles of hypercapnia and acidosis in acute distress respiratory syndrome	19
During the storm	19
Gymnopédie: music in the ICU	19
Correction: Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling	19
Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)	19
Correction: Variation in intensive care unit beds capacity in China from 2007 to 2021	19
Unraveling the enigma of genetics and phenotypes in ARDS	19
War, from the inside	19
Driving pressure: pitfalls of methods that do not use esophageal pressure measurement	19
Post-sepsis recovery: perspectives on measuring what matters. Author's reply	18
The relationship of malnutrition, frailty, and sarcopenia in critical care	18
Retraction Note: The new phosphodiesterase inhibitor enoximone in patients following cardiac surgery – pharmacokinetics and influence on parameters of coagulation	18
Validation of the “invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure score” (IPA-GRRR-OH score)	18
Association between driving pressure and mortality may depend on timing since onset of acute respiratory distress syndrome	18
The next big epidemic? Device shutdowns	18
Human albumin solution for on-pump cardiac surgery: benefit or burden?	18
Bidirectional ventricular tachycardia, a very rare and severe complication of digoxin poisoning	18
Correction: ESICM consensus-based recommendations for the management of very old patients in intensive care	18
Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database	18
The role of inferior vena cava in predicting fluid responsiveness	18
Retraction Note: Right ventricular function and cardiac surgery	18
Author Correction: Hemoadsorption in septic shock—CON	18
Correction: Direct assessment of microcirculation in shock: a randomized-controlled multicenter study	18
Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies—author's reply	18
Air pollutant exposure and mortality risk of critically ill patients	17
Using diuretic therapy in the critically ill patient	17
The forgotten relevance of central venous pressure monitoring	17
Increased risk of central line-associated bloodstream infection in COVID-19 patients associated with dexamethasone but not with interleukin antagonists	17
The paradox of post-intensive care unit physical therapy	17
Breaking the dogma: from contraindication to personalized prone positioning in brain-injured patients. Author’s reply	17
Pv-aCO2 and Pv-aCO2/Ca-vO2 in shock resuscitation: physiologically appealing, but challenging in resource-limited ICUs	17
To mobilise or not to mobilise: is that the right question?	17
When ‘Early’ isn’t early: time to rethink the timing of mobilization in the ICU	17
REMAP-CAP corticosteroids: yet, another swing of the pendulum?	17
Hypervirulent Klebsiella pneumoniae: watch the eyes	17
Shorter might not always be better: the case for longer antibiotic therapy for Pseudomonas aeruginosa pneumonia	17
Persistent severe AKI is bad—where to go now?	16
Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations	16
Onco-nephrology: what the intensivist needs to know	16
Post-intensive care syndrome is a potential consequence of critical care: can intensivists afford to look away?	16
Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial	16
Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement	16