Archives of Toxicology

Article	Citations
Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice	2077
A modular strategy for the testing and assessment of non-genotoxic carcinogens	1016
NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite	661
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypo	608
Sex-specific differences in toxicology: does the sex make the poison?	218
Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors	204
The effects of nanoplastics on toxicity of metals and metal nanoparticles: molecular mechanisms and health effects	141
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro	131
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin	122
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice	113
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs	112
Green tea catechins: protectors or threats to DNA? A review of their antigenotoxic and genotoxic effects	93
Whole cigarette smoke condensates of heated tobacco products disrupt cell adhesion and induce anoikis in human bronchial epithelial cells	90
miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity	89
Construction of testicular organoids and their applications in the field of toxicology	88
Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity	87
Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models	86
Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression	85
Oxidative stress-mediated DNA fragmentation involved in STING-dependent apoptosis in human keratinocytes by 5-amino-2-methylphenol under ambient UVB exposure	85
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells	83
Biodistribution and pulmonary toxicity of branched polyethyleneimine in rats following intratracheal and intravenous exposure	80
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)	80
Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern	79
THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics	74
Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS	61

Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium	57
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases	57
Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged CD-1 male mice	56
Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts	52
In vitro evidence for estrogen receptor activity of selected phase II isoflavone metabolites	51
Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice	51
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity	50
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells	47
In vitro-in silico analysis reveals that loss of tankyrase1/2 improves bile acid handling in genetically engineered HepG2 cultures	46
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglob	44
Effects of low concentrations of ozone gas exposure on percutaneous oxygen saturation and inflammatory responses in a mouse model of Dermatophagoides farinae-induced asthma	44
Classification of industrial chemicals for respiratory chemosensory irritation using the TRPV1-expressing neuronal SH-SY5Y cell model and machine learning	43
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro	43
Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination	42
What do we currently know about Novichoks? The state of the art	41
Toxicokinetics of benzotriazole UV stabilizer UV-P in humans after single oral administration	40
Development of a transcriptome-based determination of innate immune suppressor (TDIS) assay as an in vitro test for immunotoxicity	39
In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin	39
N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes	39
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation	37
Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling	36
Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma	36
Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells	36
Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness	36
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review	36
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis	35
Identification, synthesis and quantification of eutylone consumption markers in a chemsex context	35
PFAS-like behavior of alkylimidazolium ionic liquids: chain-length–dependent toxicokinetics and PBTK-based risk implications	35
Evaluation of the toxicity of combustion smokes at the air–liquid interface: a comparison between two lung cell models and two exposure methods	34
Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4	33
Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects	33
Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3	33
Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells	33
In vitro toxicity assessment of graphene quantum dots using a 3D HepG2 model	32
Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models	32
Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)	31
Canine coronavirus infection is intensified by 2,3,7,8-tetrachlorodibenzo-p-dioxin	31
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS	31
Development of a novel in vitro respiratory sensitization assay and its application in an integrated testing strategy (ITS)	30
Response to 10.1007/s00204-022-03330-1 by Prof. D.A. Ribeiro ‘What are the criteria and conditions for performing the micronucleus assay in oral exfoliated cells from children continuously exposed to	30
Molecular docking and molecular dynamics simulations revealed interaction mechanism of acetylcholinesterase with organophosphorus pesticides and their alternatives	30
A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells	30
Correction to: Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure	29
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters	29
Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways	28
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice	28
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging	28
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment	28
Toxicity of fentanyl (CAS: 437-38-7) and valerylfentanyl (CAS: 122882-90-0): the first integrative in silico toxicology study with clinical and forensic implications	27
A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation	27

Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning	27
Evaluating the stability of synthetic cathinones in liquid urine and dried urine spots: impact of pH and storage conditions	26
Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review	26
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents	26
Integrated transcriptomic and variant analysis reveals molecular mechanisms of pyrethroid resistance in a genetically homogenized Cas9 strain of Aedes aegypti	26
Human metabolism and excretion kinetics of Bronopol after oral administration	26
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury	26
Pathophysiology of reactive oxygen species (ROS)	25
The use of new approach methodologies (high-throughput transcriptomics) to study nanoagrochemicals: mechanisms of toxicity of a commercial copper oxychloride to soil model invertebrates (Enchytraeus c	25
Toxicity of ACP-105: a substance used as doping in sports: application of in silico methods for prediction of selected toxicological endpoints	25
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller’s fruit fly findings, and Muller fails to cite Snell’s findings	25
Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model	25
Targeting MLKL ameliorates T-2 toxin-induced cartilage damage by inhibiting chondrocyte death and matrix degradation in mice	25
Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology	25
Protein covalent modification and hepatic cytotoxicity of atorvastatin resulting from its metabolic activation	25
Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs)	25
Translational medicine protocol for proteomics clinical research on snakebite envenoming: contributions for develop studies in mechanisms and new biomarkers	24
Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults	24
Post-mortem evidence of microplastic bioaccumulation in human organs: insights from advanced imaging and spectroscopic analysis	24
Evaluating CYP enzyme induction by cigarette smoking: a new in vitro approach using primary human hepatocytes	24
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene	23
The presence of carcinogenic compounds in gene-edited NGOs causes cancer in humans	23
Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)	23
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs	23
Improving how we use workshops when solving complex research problems: reflections from the CHANGE project	23
Bats, bugs, and babies: why stringent guidelines are needed for cause-and-effect interpretation in epidemiological studies	23
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model	22
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro	22
Therapeutic potential of 4-phenylbutyric acid against methylmercury-induced neuronal cell death in mice	22
TRACT assay-based in vitro characterization of substituted cathinones: inhibition and release at the serotonin transporter	22
Metabolism study of two phenethylamine − derived new psychoactive substances using in silico, in vivo, and in vitro approaches	21
Human metabolism and excretion kinetics of the surfactant 2,4,7,9-tetramethyl-5-decyne-4,7-diol (TMDD) after oral and dermal administration	21
Delayed complications of sulfur mustard poisoning: a focus on inflammation and telomere footprint	21
Correction: Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes	21
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity	21
Prioritisation of co-formulants and plant protection products for non-dietary risk assessment using NAMs	21
A recent decade update on combating doxorubicin-induced toxicities	21
Development of an integrated physiologically based toxicokinetic-toxicodynamic model for quantitative prediction of polyhexamethylene guanidine-induced human toxicity	21
Associations among global long interspersed nuclear element-1 DNA methylation, metal exposure, and chronic kidney disease	21
Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling	20
Tat_BioV: tattoo ink exposure and biokinetics of selected tracers in a short-term clinical study of 24 subjects	20
Reassessing the carcinogenic potential of dibutyl hydrogen phosphate: new insight from repeated-dose toxicity studies	20
Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk	20
Flavonoids commonly induce hormetic responses	20
A comparison of the chemo- and radiotoxicity of thorium and uranium at different enrichment grades	20
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forens	20
Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop	20
AHAK: a new effective medical countermeasure against percutaneous intoxication by Novichok chemical warfare agents	19
Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes	19
High molecular weight polycyclic aromatic hydrocarbon (HMW-PAH) isomers: unveiling distinct toxic effects from cytotoxicity to oxidative stress-induced DNA damage	19
Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice	19
Exploring the multifaceted impact of bisphosphonates on bone graft integration: transitioning from in vivo insights to clinical applications	18
Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)*	18
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism	18
T-2 toxin-induced splenic injury by disrupting the gut microbiota–spleen axis via promoting IL-6/JAK/STAT1 signaling-mediated inflammation and apoptosis and its mitigation by elemental nano-selenium	18
Bridging approaches to facilitate innovation: building an approach for heated tobacco products from case studies in the food and drug domains a comparative review	18
Is there a relationship between orthodontic treatment and DNA damage? The relevance of metal ion accumulation in oral mucosa cells	18
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors	17
Comparative toxicity of plant protection products, their active substances and mixtures in zebrafish embryos and HepaRG cells	17
Developmental vulnerability to fluoride toxicity: enamel and clearance differences in adolescent versus mature mice	17
In silico & in vitro approaches suggest osteoclastogenesis induction underlying fractures in Entrectinib-treated children	17
YES1 as a potential target to overcome drug resistance in EGFR-deregulated non-small cell lung cancer	17
A study of the pharmacokinetics of clozapine and its metabolites by the dynamics of its distribution in the oral fluid of healthy volunteers	16
Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity	16
Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments	16
Proteomic diversity of Russell's viper venom: exploring PLA2 isoforms, pharmacological effects, and inhibitory approaches	16
Vernonia amygdalina displays otoprotective effects via antioxidant pathway on cisplatin-induced hair cell loss in zebrafish	16
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo	16
A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats	16
Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations	16
In silico prediction of parkinsonian motor deficits-related neurotoxicants based on the adverse outcome pathway concept	16
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells	16
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells	16
The alarming consequences of workforce reductions at the FDA, EPA, NIH and CDC in the United States	15
A urinary biomarker for monitoring exposures to 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate in rats	15
A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals	15
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by Polygonum multiflorum	15
Hepatotoxicity of chlorinated organophosphate flame retardants (Cl-OPFRs): a comprehensive review	15
Gestational vortioxetine exposure impairs pregnancy outcomes and fetal brain development via modulation of BDNF/Bax-Bcl2/5-HT pathways in rats	15
Extension and validation of a physiologically based toxicokinetic model for risk assessment of aluminium exposure in humans	15

Plasma biomarkers TAP, CPA1, and CPA2 for the detection of pancreatic injury in rat: the development of a novel multiplex IA-LC-MS/MS assay and biomarker performance evaluation	15
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)	15
In vitro metabolism of Benzyl-4CN-BUTINACA and MDMB-4CN-BUTINACA using human hepatocytes and LC-QToF-MS analysis	15
Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride	15
Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays	15
Genetic alterations in coronary cell lines exposed to sirolimus and paclitaxel	15
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro	15
Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress	14
Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presentin	14
Systematic review of genotoxicity induced by occupational exposure to antineoplastic drugs	14
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insigh	14
The toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), 1-valeryl-LSD (1V-LSD) and 1-cyclopropylmethanoyl-LSD (1cP-LSD)—prediction of toxi	14
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice	14
Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review	14
Sex-specific toxicity targets of aristolochic acids: nephrotoxicity in males, hepatotoxicity in females	14
Possum: identification and interpretation of potassium ion inhibitors using probabilistic feature vectors	14
Modular air–liquid interface aerosol exposure system (MALIES) to study toxicity of nanoparticle aerosols in 3D-cultured A549 cells in vitro	14
Effects of micro- and nano-plastics exposure on cellular senescence: an overview	14
Molecular dosimetry of estragole and 1′-hydroxyestragole-induced DNA adduct formation, clastogenicity and cytotoxicity in human liver cell models	14
Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis	14
PEGylated liposomal fluopsin C triggers cuproptosis and ferroptosis pathways and suppresses 3D tumor spheroid growth in NCI-H460 cells	13
Cardiovascular toxicity of ethyl maltol exposure: a comprehensive investigation from virtual screening to experimental validation	13
Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy	13
Comparison of comet-based approaches to assess base excision repair	13
Drug-induced hepatic sinusoidal obstruction syndrome: current advances and future perspectives	13
In vitro comparative assessment of metabolic stability and structure–metabolism relationships of five fentanyl analogs with varying N-acyl side chain lengths	13
Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhydrocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by para-tert-butyl- b	13
Exploiting TRP channel diversity in insects: a pathway to next-generation pest management	13
Substance abuse and neurodegenerative diseases: focus on ferroptosis	13
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions	13
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level	13
Metabolism of alcohol ethoxylates (AEs) in rat, hamster, and human hepatocytes and liver S9: a pilot study for metabolic stability, metabolic pathway, and metabolites identification in vitro and in si	13
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man	13
The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns	13
The hepatoprotective potential of ferulic acid against a spectrum of pharmaceuticals and toxic compounds	13
Rat and human primary proximal tubule epithelial cells allow for cross-species comparisons of drug-induced nephrotoxicity in vitro	13
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes	13
Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity	13
Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics	13
Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins	13
Long-term TCDD oral exposure changes gut microbial glycosylation patterns in female but not male C57BL/6 mice	12
Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method	12
Replication stress: an early key event in ochratoxin a genotoxicity?	12
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives	12
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure	12
Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review	12
Application of in silico methods to predict the acute toxicity of bicyclic organophosphorus compounds as potential chemical weapon	12
Immunomodulation and exposure to per- and polyfluoroalkyl substances: an overview of the current evidence from animal and human studies	12
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and auto	12
Unanticipated differences in the rat plasma metabolome of genistein and daidzein	12
Impact of physical activity on ethoxy- and propoxypropanol human toxicokinetics in vivo	12
Paternal lipopolysaccharide exposure induced intrauterine growth restriction via the inactivation of placental MEST/PI3K/AKT pathway in mice	12
In silico analysis decodes transthyretin (TTR) binding and thyroid disrupting effects of per- and polyfluoroalkyl substances (PFAS)	12
Heavy metals: toxicity and human health effects	12
In vitro approaches to investigate the effect of chemicals on antibody production: the case study of PFASs	12
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects	12
Characterization of pathological changes in the olfactory system of mice exposed to methylmercury	12
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures	12
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis	12
Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT	11
Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system	11
Letter to the editor regarding “Bichlmaier, I. Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings. Arch	11
Dexamethasone alters the cornea transcriptome to confer protection against ocular sulfur mustard exposure via regulating NFκB and TGFβ signaling in an in vivo rabbit model	11
SIRT3 regulates PFKFB3-mediated glycolysis to attenuate cisplatin-induced ototoxicity both in vivo and in vitro	11
High-throughput transcriptomics analysis of equipotent and human relevant mixtures of BPA alternatives reveal additive effects in vitro	11
Correction: Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters	11
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins	11
How to avoid misinterpretation of dual reporter gene assay data affected by cell damage	11
Role of paraoxonase 1 in organophosphate G-series nerve agent poisoning and future therapeutic strategies	11
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms	11
Fast and reliable in vitro activity-based detection of synthetic cannabinoid receptor agonists in e-liquids	11
Compromised blood–bile barrier after acetaminophen overdose	11
Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review	11
Polychlorinated biphenyls (PCBs) interact with drug metabolism in vivo	11
Characterizing the in vitro metabolic features of seven α-pyrrolidinophenone-derived synthetic cathinone-type new psychoactive substances	11
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation	11
Predicting the developmental toxicity of 8-methyl-benzo[a]pyrene (BaP) by physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry and read-across from BaP	11
PFAS and One Health: integrating human, animal, and environmental perspectives	10
Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes	10
Comparison of ex vivo placenta perfusion and in vitro BeWo b30 cell models for assessing transfer of developmental and reproductive toxic compounds	10
From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping	10
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells	10
Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis	10
Correction to: Toxicological profiling of venoms from ten major chinese snakes: a mass spectrometry-based proteomic and multiroute assessment	10
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)	10
The role of oxidative stress and antioxidant therapy in cisplatin neurotoxicity: preclinical evidence in the last decade	10
Human metabolism and excretion kinetics of benzotriazole UV stabilizer UV-327 after single oral administration	10
Identification of key neuronal mechanisms triggered by dimethyl fumarate in SH-SY5Y human neuroblastoma cells through a metabolomic approach	10
Chikungunya: global epidemiology, clinical spectrum, and vector control-lessons for China from the 2025 Guangdong outbreak	10
In silico prediction of the interaction of legacy and novel per- and poly-fluoroalkyl substances (PFAS) with selected human transporters and of their possible accumulation in the human body	10
Simulations of radioiodine exposure and protective thyroid blocking in a new biokinetic model of the mother–fetus unit at different pregnancy ages	10
The immunogenic potential of AZD1402 (Elarekibep) T-cell epitopes in healthy volunteers and drug-exposed clinical trial participants	10
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes	10
Pro-inflammatory response of human iPSC-derived intestinal epithelial monolayers towards microbial toxins LPS and nigericin	10
Long noncoding RNAs at the crossroads of smoking, oxidative stress, inflammation, and lung disease	10