Journal of Neurology

Article	Citations
A real-world study on the utility of regular rituximab treatment for neuromyelitis optica spectrum disorder	201
Prevalence of infratentorial superficial siderosis in a large general population sample from the UK Biobank	150
The deltoid muscle and the pattern of paresis in ALS	119
Tau levels in platelets isolated from Huntington’s disease patients serve as a biomarker of disease severity	107
A role for the Epstein–Barr virus in multiple sclerosis aetiology?	106
Pallidal deep brain stimulation for patients with myoclonus-dystonia without SGCE mutations	102
Richard Caton (1842-1926)	93
CSF biomarkers of B-cell activation in multiple sclerosis: a clinical perspective	88
Long-term outcome after decompressive hemicraniectomy for malignant middle cerebral artery infarction	85
Complications of reversible cerebral vasoconstriction syndrome in relation to age	84
Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis	81
Neuromyelitis optica spectrum disorder with a familial Mediterranean fever gene E84K mutation	81
Tacrolimus-induced Parkinsonism	77
Explaining recovery from coma with multimodal neuroimaging	77
Interpretable deep learning survival predictions in sporadic Creutzfeldt–Jakob disease	74
Different patterns of acute saccadic response to levodopa in de novo Parkinson’s disease	73
Reversible cerebral vasoconstriction syndrome after intravenous iron substitution: a case report	65
Epileptic disorders in Becker and Duchenne muscular dystrophies: a systematic review and meta-analysis	65
Neurological manifestation of HEV infection: still a rare disease entity?	62
Phenotype-driven reanalysis reveals five novel pathogenic variants in 40 exome-negative families with Charcot–Marie–Tooth Disease	61
Brain 18F-FDG PET findings and sequential vestibular testing in SCA27B: a case report	59
Correction to: Synergistic effects of vagus nerve stimulation and antiseizure medication	58
Longitudinal predictors of health-related quality of life in isolated dystonia	58
Halting progressive multifocal leukoencephalopathy with pembrolizumab: the case of a patient with multiple sclerosis under fingolimod	56
The DeMyers: Marian (1922–2012) and William (1924–2008)	55

Risk of secondary progression in patients with highly active multiple sclerosis treated with natalizumab: a real-life study	53
Incidence of Guillain–Barré syndrome in Cuba before and during the Oropouche virus emergency, 2018–2024	52
TS-HDS autoantibody: clinical characterization and utility from real-world tertiary care center experience	50
Radiation-induced intracranial vasculitis on high-resolution vessel wall MRI	49
Brain network topology and future development of freezing of gait in Parkinson’s disease: a longitudinal study	48
SARA captures disparate progression and responsiveness in spinocerebellar ataxias	46
Does visuospatial motion perception correlate with coexisting movement disorders in Parkinson’s disease?	46
Correction to: Late‑onset Huntington’s disease associated with CAG repeat lengths of 30 and 31	46
Sensory neuropathy due to RFC1 in a patient with ALS: more than a coincidence?	46
International survey on the implementation of the European and American guidelines on disorders of consciousness	45
Response to SARS-CoV-2 vaccination in multiple sclerosis patients on disease modifying therapies	45
Acute symptomatic seizures and hippocampal sclerosis: the major contributor for post-stroke epilepsy?	44
Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis	43
Historical and current issues in HIV encephalitis, and the role of neuropathology in HIV disease: a pathological perspective	43
Stroke frequency, associated factors, and clinical features in primary systemic vasculitis: a multicentric observational study	43
Correction to: Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study	43
Neural correlates of dual-task walking in people with central neurological disorders: a systematic review	43
Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies	43
Keeping an eye on Parkinson’s disease: color vision and outer retinal thickness as simple and non-invasive biomarkers	42
Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism	42
Recent applications of quantitative electroencephalography in adult intensive care units: a comprehensive review	42
A decision aid is not the quick fix for improving shared decision-making in advanced Parkinson’s disease: results of a mixed methods feasibility study	42
Exploring epigenetic modifications as potential biomarkers and therapeutic targets in amyotrophic lateral sclerosis	41
Increased aneurysm wall permeability colocalized with low wall shear stress in unruptured saccular intracranial aneurysm	40
A retrospective study of autoimmune cerebellar ataxia over a 20-year period in a single institution	40
Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension	40
Humoral response after accelerated schedule of HBV vaccination in MS patients before anti-CD20 therapy	40
Dopaminergic responsiveness and dopaminergic challenge tests of Parkinson’s disease: a systematic review and meta-analysis	40
Natalizumab-induced pneumonitis	38
Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy	38
Dystonia management across Europe within ERN-RND: current state and future challenges	38
Primary progressive aphasia: six questions in search of an answer	37
Walter Russell Brain (1895–1966)	37
eHealth tools to assess the neurological function for research, in absence of the neurologist: a systematic review, part II (hardware)	37
Retreating migraine patients in the second year with monoclonal antibodies anti-CGRP pathway: the multicenter prospective cohort RE-DO study	37
Longitudinal qualitative assessment of meaningful symptoms and relevance of WATCH-PD digital measures for people with early Parkinson’s	36
Audiovisual analysis of the diagnostic video polysomnography in patients with isolated REM sleep behavior disorder	36
The clinical phenotype of psychiatric-onset prodromal dementia with Lewy bodies: a scoping review	34
Endolymphatic space is age-dependent	34
Dysregulation of the molecular clock by blood-borne factors in Alzheimer’s disease patients	34
Present and future of the diagnostic work-up of multiple sclerosis: the imaging perspective	34
Smoking, obesity, and disability worsening in PPMS: an analysis of the INFORMS original trial dataset	34
Analyzing the relationship between specific brain structural changes and the diffusion tensor image analysis along the perivascular space index in idiopathic normal pressure hydrocephalus	34
Proposal of new diagnostic criteria for fatal familial insomnia	33
Effectiveness of rituximab vs. ocrelizumab for the treatment of primary progressive multiple sclerosis: a real-world observational study	33
Anxiety and depression in Charcot-Marie-Tooth disease: data from the Italian CMT national registry	33
Genetic modifiers of upper limb function in Duchenne muscular dystrophy	33
Adult-onset mitochondrial movement disorders: a national picture from the Italian Network	32
Procedural and Clinical Outcome of Stroke after thrombectomy according to etiology: results from a nationwide registry	32
Ultra-late response (> 24 weeks) to anti-CGRP monoclonal antibodies in migraine: a multicenter, prospective, observational study	32

Challenges in multinational rare disease clinical studies during COVID-19: regulatory assessment of cipaglucosidase alfa plus miglustat in adults with late-onset Pompe disease	31
Cavernomas: to treat or not to treat?	31
Cost effectiveness of different treatment strategies with natalizumab for pregnant women with multiple sclerosis	31
Longitudinal analysis and treatment of neuropsychiatric symptoms in post-acute sequelae of COVID-19	31
Sutton’s law applies to functional neurology	30
The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors	30
Anti-SOX1 antibody-associated acute hemorrhagic leukoencephalitis	30
Quantitative brainstem and spinal MRI in amyotrophic lateral sclerosis: implications for predicting noninvasive ventilation needs	30
Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry	30
Mismatch between clinically defined classification of ALS stage and the burden of cerebral pathology	29
Estimation of ataxia severity in children with ataxia-telangiectasia using ankle-worn sensors	29
Inflammatory neuropathy with evidence of anti-GQ1b antibodies in angioimmunoblastic T cell lymphoma (AITL): a case report	29
Neurophysiological and behavioural correlates of ocrelizumab therapy on manual dexterity in patients with primary progressive multiple sclerosis	29
Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia	29
The complex relationship between antibody titers and clinical outcome in botulinum toxin type A long-term treated patients with cervical dystonia	29
Cerebral infarctions following an increase in corticosteroids: an atypical case of reversible cerebral vasoconstriction syndrome	29
Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry	28
The impact of device-assisted therapies on the gut microbiome in Parkinson’s disease	28
Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme	28
Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study	28
Health-related quality of life in Japanese patients with multiple sclerosis	27
Air pollution, greenspace exposure and risk of Parkinson's disease: a prospective study of 441,462 participants	27
Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial	27
The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia	27
Left- vs right-sided migraine: a scoping review	27
Quantification of saccadic fatigability and diagnostic efficacy for myasthenia gravis	27
Detection of patent foramen ovale in patients with ischemic stroke on prospective ECG-gated cardiac CT compared to transthoracic echocardiography	27
Episodic symptoms caused by neurovascular conflict of vagus nerve due to hemilateral anterior inferior cerebellar artery	26
Risdiplam improves subjective swallowing quality in non-ambulatory adult patients with 5q-spinal muscular atrophy despite advanced motor impairment	26
Aphasia as a stroke mimic in older adults: a diagnostic challenge	26
Neurological update: structural and functional imaging in epilepsy surgery	26
Systematic review and evidence gap mapping of biomarkers associated with neurological manifestations in patients with COVID-19	26
Artificial intelligence in neurology: opportunities, challenges, and policy implications	26
A novel prediction score determining individual clinical outcome 3 months after juvenile stroke (PREDICT-score)	26
Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression	26
Amyotrophic lateral sclerosis stratification: unveiling patterns with virome, inflammation, and metabolism molecules	26
Vestibular function testing in patients with RFC1 mutations	26
Machine learning for adaptive deep brain stimulation in Parkinson’s disease: closing the loop	26
Regional distribution of polymorphisms associated to the disease-causing gene of spinocerebellar ataxia type 3	26
Translocator protein (TSPO)-PET as diagnostic and monitoring tool in COVID-19 related MRI-negative brainstem encephalitis: a case report	26
Encephalitis in HIV-infected adults in the antiretroviral therapy era	26
Impulse control and correlation to dopamine agonist serum concentrations in people with Parkinson's disease	25
Incidence of cerebral small vessel disease-related MR markers in the Swedish general population ‘Good Aging in Skåne’(GÅS) study	25
Motor and non-motor outcome in tremor dominant Parkinson’s disease after MR-guided focused ultrasound thalamotomy	25
Subjective and objective responses to caloric stimulation help separate vestibular migraine from other vestibular disorders	25
Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients	25
Diaschisis: a mechanism for subcortical aphasia?	25
Usefulness of subcutaneous immunoglobulin therapy in the management of myasthenia gravis: a retrospective cohort study	25
Intake reminders are effective in enhancing adherence to direct oral anticoagulants in stroke patients: a randomised cross-over trial (MAAESTRO study)	25
MRI-guided focused ultrasound: new hope for drug-resistant neurological conditions	25
Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases	25
Novel biomarkers and neuroimaging techniques in Parkinson’s disease	25
Diagnostic accuracy and confounders of vagus nerve ultrasound in amyotrophic lateral sclerosis—a single-center case series and pooled individual patient data meta-analysis	25
Rate of change in upper and lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis	24
Effect of siponimod on lymphocyte subsets in active secondary progressive multiple sclerosis and clinical implications	24
Correlation between cognitive changes and neuroradiological changes over time in multiple sclerosis: a systematic review and meta-analysis	24
Natural history of facioscapulohumeral muscular dystrophy evaluated by multiparametric quantitative MRI: a prospective cohort study	24
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson’s disease	24
The effects of dopaminergic medication and task load on trembling and akinetic freezing of gait in Parkinson’s disease	24
Impact of COVID-19 pandemic on frequency of clinical visits, performance of MRI studies, and therapeutic choices in a multiple sclerosis referral centre	24
Overcoming traps and pitfalls leading to misinterpretation of normal EEG variants and variation of the background activity	24
Dopamine transporter single photon emission computed tomography (DaT-SPECT) use in the diagnosis and clinical management of parkinsonism: an 8-year retrospective study	23
Effects of motor–cognitive training on dual-task performance in people with Parkinson’s disease: a systematic review and meta-analysis	23
Good vibrations: tactile cueing for freezing of gait in Parkinson’s disease	23
Muscle MRI as a biomarker of disease activity and progression in myotonic dystrophy type 1: a longitudinal study	23
Frequency and predictors of poststroke epilepsy after mechanical thrombectomy for large vessel occlusion stroke: results from a multicenter cohort study	23
The correlation between 9-HPT and patient-reported measures of upper limb function in multiple sclerosis: a systematic review and meta-analysis	23
The impact of spontaneous intracranial hypotension on social life and health-related quality of life	23
Systematic assessment of square-wave jerks in progressive supranuclear palsy: a video-oculographic study	23
Isolated REM sleep behaviour disorder: current diagnostic procedures and emerging new technologies	23
Beneficial effect of N-acetyl-DL-leucine on cognitive function, emotional well-being and QoL in a mentally healthy elderly person	22
A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk	22
Ocular phenotype and electroretinogram abnormalities in Lafora disease and correlation with disease stage	22
Measuring the functional impact of cognitive impairment in Huntington’s disease	22
Measuring cognitive impairment and monitoring cognitive decline in Huntington’s disease: a comparison of assessment instruments	22
How to identify insular epilepsy	22
A new genetic cause of spastic ataxia: the p.Glu415Lys variant in TUBA4A	22
Precision diagnosis and precision treatment for the genetic epilepsies	22
Quantitative whole-body muscle MRI in idiopathic inflammatory myopathies including polymyositis with mitochondrial pathology: indications for a disease spectrum	22
Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption	22

Modulation of spontaneous motor unit potentials by a new motor cortical magnetic stimulation method in amyotrophic lateral sclerosis	21
Locus coeruleus degeneration and cerebellar gray matter changes in essential tremor	21
Fingolimod-associated progressive multifocal leukoencephalopathy in a multiple sclerosis patient with a good response to filgrastim	21
Sleep-disordered breathing-related symptoms and risk of stroke: cohort study and Mendelian randomization analysis	21
Photophobia in headache disorders: characteristics and potential mechanisms	21
Recurrence and long-term outcomes of Tolosa-Hunt syndrome	21
Measurement of upper limb function in ALS: a structured review of current methods and future directions	21
The impact of the SARS-CoV-2-pandemic on patients with chronic inflammatory neuropathies: results from the German INHIBIT register	21
Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study	21
Diagnostic accuracy and usability of the EMBalance decision support system for vestibular disorders in primary care: proof of concept randomised controlled study results	21
Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4–12 years: a real-world study	21
Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis	21
Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry	21
Different approaches to test orientation of self in space: comparison of a 2D pen-and-paper test and a 3D real-world pointing task	21
Bilateral vestibulopathy decreases self-motion perception	21
Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis	21
Distal hereditary motor neuronopathy as a new phenotype associated with variants in BAG3	21
Frida Kahlo could have had cauda equina syndrome: a case report	20
Correction: Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas	20
Exploring the impact of 40 Hz multi-luminaire light exposure in Alzheimer's dementia: insights from a convenient sampling, non-randomized case–control study	20
Paroxysmal central positional nystagmus responsive to clonazepam	20
Diagnosing primary lateral sclerosis: a clinico-pathological study	20
Effectiveness of endovascular treatment for in-hospital stroke vs. community-onset stroke: a propensity score-matched analysis	20
Parkinson’s disease with hyposmia and dysautonomia: does it represent a distinct subtype?	20
Specific clinical and radiological characteristics of anti-NMDA receptor autoimmune encephalitis following herpes encephalitis	20
Unprescribed cannabinoids and multiple sclerosis: a multicenter, cross-sectional, epidemiological study in Lombardy, Italy	20
Visual quality of life in NMOSD and MOGAD: profiles, dynamics and associations with ageing and vision	20
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease	20
Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings	20
The value of magnetic resonance imaging of the optic nerve for the diagnosis of multiple sclerosis in patients with optic neuritis	19
Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces	19
Correction to: Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry	19
Optic neuritis and MOGAD	19
Upper motor neuron-predominant motor neuron disease: a novel immunotherapy-responsive association of GAD65 autoimmunity	19
Brain positron emission tomography (PET) and cognitive abnormalities one year after COVID-19	19
Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals	19
Burden of disease in myasthenia gravis: taking the patient’s perspective	19
A disproportionality analysis of surgical site infections across multiple sclerosis disease modifying therapies	19
Cognition in cerebellar disorders: What’s in the profile? A systematic review and meta-analysis	19
Effectiveness and safety of pharmacological prophylaxis for chronic migraine: a systematic review and network meta-analysis	19
Spinocerebellar ataxia 27B: a frequent and slowly progressive autosomal-dominant cerebellar ataxia—experience from an Italian cohort	19
Impacts of medication non-adherence to major modifiable stroke-related diseases on stroke prevention and mortality: a meta-analysis	19
The effect and safety of levodopa alone versus levodopa sparing therapy for early Parkinson’s disease: a systematic review and meta-analysis	19
Stroke in adults with primary intracranial tumours	19
Understanding social media: how its popularity could be used to advance medical education in stroke care?	19
Case report: cerebral sinus vein thrombosis in two patients with AstraZeneca SARS-CoV-2 vaccination	18
The impact of an MSU service on acute stroke care in a middle-sized city: a simulation-based analysis	18
A survey-based approach on restless legs syndrome: practices and perspectives among Italian neurologists	18
Louis Jacobsohn-Lask (1863–1940)	18
Prevalence, risk factors, and clinical outcomes of remote intracerebral hemorrhage after intravenous thrombolysis in acute ischemic stroke: a systematic review and meta-analysis	18
Cerebral mucormycosis: neuroimaging findings and histopathological correlation	18
Leg stereotypy syndrome: phenomenological and quantitative analysis	18
Clinical and imaging spectrum of non-congenital dominant ACTN2 myopathy	18
Frataxin analysis using triple quadrupole mass spectrometry: application to a large heterogeneous clinical cohort	18
The impact of metformin use on the outcomes of relapse-remitting multiple sclerosis patients receiving interferon beta 1a: an exploratory prospective phase II open-label randomized controlled trial	18
Epilepsy and episodic ataxia type 2: family study and review of the literature	18
COVID-19 infection after SARS-CoV-2 mRNA vaccination in Multiple Sclerosis, AQP4-antibody NMOSD and MOGAD patients during the Omicron subvariant BA.1/2 wave in Singapore	18
The phenotypic spectrum of epilepsy associated with periventricular nodular heterotopia	18
Motor function in multiple sclerosis assessed by navigated transcranial magnetic stimulation mapping	18
Correction to: DRPLA: understanding the natural history and developing biomarkers to accelerate therapeutic trials in a globally rare repeat expansion disorder	18
Cerebrospinal fluid findings in patients with neurological manifestations in post-COVID-19 syndrome	18
Resurrection of sildenafil: potential for Huntington’s Disease, too?	18
Diagnostic utility of neurofilament markers for MND is limited in restricted disease phenotype and for differentiation from compressive myeloradiculopathies	18
(William) Ritchie Russell (1903–1980)	18
Brain MRI volumetry and atrophy rating scales as predictors of amyloid status and eligibility for anti-amyloid treatment in a real-world memory clinic setting	18
Correction to: Outcomes of mechanical thrombectomy in patients with acute ischemic stroke and thrombocytopenia: systematic review and meta-analysis	18
A rare case of a wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with cutaneous lupus erythematosus after COVID-19 infection	18
Chronic vertigo and central oculomotor dysfunction with evidence of anti-ITPR1 antibodies	18
Acetyl-dl-leucine in cerebellar ataxia ([18F]-FDG-PET study): how does a cerebellar disorder influence cortical sensorimotor networks?	17
Volumetric changes and clinical trajectories in Parkinson’s disease: a prospective multicentric study	17
Altered mental status in COVID-19	17
Early therapy initiation is crucial in chronic inflammatory demyelinating polyneuropathy: prospective multimodal data from the German INHIBIT registry	17
Satralizumab as a treatment for pediatric-onset neuromyelitis optica spectrum disorder with cluster attack: a case report	17
Pathological findings in autoimmune encephalitis autopsy specimens from cases of suspected prion disease	17
Movement disorders in autoimmune encephalitis: an update	17
Time course of lesion-induced atrophy in multiple sclerosis	17
The impact of subthalamic deep-brain stimulation in restoring motor symmetry in Parkinson’s disease patients: a prospective study	17
A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility	17
Neurosarcoidosis	17
Radiologically isolated syndromes: to treat or not to treat?	17
A novel phenotype in an Italian family with a rare progranulin mutation	17
Conjugate torsional pendular nystagmus and palatal tremor after unilateral internuclear ophthalmoplegia	17
Neurological symptoms after COVID-19 vaccination: a report on the clinical presentation of the first 50 patients	17
A score to predict the stroke recurrence of patients with embolic stroke of undetermined source	17
Risk and sex-specific trends of dementia and stroke in Italy Compared to European and high-income countries and the world: global implications	17
Explaining cognitive function in multiple sclerosis through networks of grey and white matter features: a joint independent component analysis	17
Cognitive impairment associated with cerebellar volume loss in spinocerebellar ataxia type 3	17
NMOSD typical brain lesions after COVID-19 mRNA vaccination	17
Comprehensive pathological and genetic investigation of three young adult myotonic dystrophy type 1 patients with sudden unexpected death	17
Machine learning and wearable sensors for automated Parkinson’s disease diagnosis aid: a systematic review	16
Dyspnea and dystussia in Parkinson’s disease: patient-reported prevalence and determinants	16
Muscle quantitative MRI as a novel biomarker in hereditary transthyretin amyloidosis with polyneuropathy: a cross-sectional study	16
Real-life evaluation of the 2017 McDonald criteria for relapsing–remitting multiple sclerosis after a clinically isolated syndrome confirms a gain in time-to-diagnosis	16
Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area	16
Traumatic brain injury incidence and mortality: a large population-based study	16