Medical Hypotheses

Article	Citations
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	38
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	17
A quantum mechanical explanation for auditory-visual hallucinations	16
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	14
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	13
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	12
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	12
Acupressure at LI4 and LU10 as a modulator of cortical microstates and autonomic tone: a hypothetical mechanism	12
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	12
Post-menopause cardiovascular risk – lack of hormones or bleeding? – Increased blood viscosity due to cessation in menstrual bleeding	12
Editorial Board	12
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	11
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	11
Can virophages be used for management of viral infections?	10
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	10
Protective effect of methylene blue in iron-induced neurotoxicity	10
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	10
The mechanical protector paradox: a hypothesis linking transition zone enlargement, urethral angle, and carcinogenesis via intraprostatic reflux	10
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	9
Trained immunity in diabetic kidney disease: a hypothesis for metabolic memory and therapeutic targeting	8
Editorial Board	8
Integration of parenteral nutrition with galactose may improve neurodevelopmental outcomes for preterm newborns	7
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	7
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	7
Editorial Board	7

A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	7
Exploring the link between sacral neuromodulation and body balance mechanism	7
Activation of resident immune cells induces enteric neuronal death	6
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	6
Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?	6
Acute diffuse brain swelling during surgery — Hypothalamic injury or the “dual-switch” hypothesis	6
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	6
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	6
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	6
Local hematoma may be a cause of peripheral fusion after spinal surgery	6
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	6
Development of a novel mucosal multi-epitope subunit vaccine against Clostridioides difficile, incorporating recombinant Outer membrane Vesicles and spores	5
Iron chelators reduce prostaglandins and leukotrienes by inhibiting cyclooxygenase and lipoxygenase: A hypothesis to attenuate PPARγ transcriptional activity in prostate cancer	5
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	5
Parkinson’s disease as a superposition of wake and sleep states: a hypothesis of vicious cycle neurodegeneration	5
Cigarette smoke as a superspreading vector of SARS-CoV-2, measles virus, and influenza virus: A hypothesis on virus-laden aerosol formation and transport	5
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	5
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data	5
Editorial Board	5
Controlled intracranial pressure elevation via cerebrospinal fluid infusion: a novel hemostatic hypothesis for hematoma expansion in traumatic brain contusion	5
Editorial Board	5
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	5
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	5
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	5
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	5
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	5
Molecular hydrogen and heat-stressed exercise: a mechanistic hypothesis and framework for future investigation	5
Endocrine–mechanical coupling in physiologic lumina: a hypothesis for episodic obstruction across organs	5
Regular intake of vasodip (lercanidipine) relieves migraine attacks	5
The hypothesis – A dual-front attack on TB: Vitamin D–fluoroquinolone conjugates as next generation therapeutic strategy against drug-resistant Mycobacterium tuberculosis	5
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	5
A novel hypothesis on the pathogenesis of knee osteoarthritis: the muscle weakness-joint instability and stress overload – uneven bone settlement cascade	5
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Bayesian interpretation of the hygiene hypothesis	4
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	4
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	4
Editorial Board	4
Nasal breathing and brain Function: A hypothesis of nasal cavity as a localized interface for gas exchange	4
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
Speed as a compensatory stabilizer: the momentum-dependent hypothesis of pediatric gait maturation and its implications for hidden motor deficits	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
Species-specific biofilm traits and virulence gene expression in recurrent vulvovaginal candidiasis: a translational hypothesis	4
Autophagy: A self-guard against SARS-CoV-2	4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease	4
Is iron dysregulation in the mirror motor cortex associated with misophonia?	4
Tubular visual field defect relies on hyperbolic geometry spatial representations	4
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	4

Non-secretor status as a saliva-based risk marker for cancer susceptibility: a hypothesis	4
Pathological Demand Avoidance is a result of mental process opacity	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
A papain protease-window hypothesis for ulcerative colitis: controlled local proteolysis to modulate inflammatory amplification and epithelial barrier repair	4
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	4
Can human metapneumovirus infection be prevented by exercise?	4
RETRACTED: Sickle Cell Crisis – Home Oxygen in the Golden Half Hour, can prevent or stop a crisis, prevent complications and change the trajectory of disease	4
Embolization-assisted intra-arterial steroid delivery (EAIS) for synovitis-driven osteoarthritis and monoarticular arthritis: A mechanistic hypothesis	4
Editorial Board	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	4
Exercise may enhance the anti-metastatic effects of cyclooxygenase 1 inhibitors	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	3
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	3
Hybrid GAN–P-TransUNet framework for alveolar bone regeneration in dental implant planning: A hypothesis	3
Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
Editorial Board	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Handgrip exercise: An innovative non-pharmacological strategy for chronic hypertension in pregnancy	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
Delayed acclimatization and persistent hyperdynamic circulation amplify capillary stress in severe high-altitude illness	3
Editorial Board	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Osteoclasts may play key roles in initiating vascular calcification during atherosclerosis	3
Editorial Board	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
A diametrically opposed view of the role of glucocorticoids in central serous chorioretinopathy	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	3
A neurophysiological model of patellofemoral pain: The role of cortical and spinal mechanisms − A theoretical model	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	3
COUP-TFII as a potential therapeutic target for metabolic dysfunction-associated steatotic liver disease	3
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy	3
HIV-induced neuroinflammation may influence an increase in sexual behavior: A testable hypothesis	3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	3
Editorial Board	3
Metabolic dysfunction associated steatotic liver disease as a disorder of hepatic bioenergetic timing	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Late intraocular lens dislocation arises from two independent biomechanical pathways: Structural failure and interface fatigue	3
Targeting conserved dynamic regions of SARS-CoV-2 spike protein identified by normal mode analysis for broad-spectrum antiviral therapy	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
A substrate-competition hypothesis for type 2 diabetes driven by nutrient excess rather than a primary insulin-signaling defect	3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	3
Stress-conditioned small extracellular vesicles from young cells to restore resilience in aging	3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	3
Editorial Board	3
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
The development and evolution of inner speech: Hippocampal contribution	2
Brainstem dysfunction as a potential etiology of ME/CFS and long COVID: A mechanical basis	2
Enhancing the effects of mindfulness in migraine patients through transcranial magnetic stimulation: A plausible hypothesis	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Asymmetric mechanical stress on both sides of the spine – Based on human functional chiral asymmetry – May constitute the underlying Pathomechanism of adolescent idiopathic scoliosis (AIS)	2
Premaxilla and incisive papilla as a nasopalatine sensory gateway: A developmental hypothesis linking trigeminal V2 afference to brainstem state calibration, oral posture, breathing mode, and childhoo	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
Möbius strip and cancer	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2

The postulated role of brain pulsations and arachnoid membranes in cerebrospinal fluid circulation, ventriculomegaly and related CSF disorders	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
The digestive Enzyme-Based nasal dysbiosis in Empty nose Syndrome: A theory	2
The mint versus Covid hypothesis	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
A combined surgical approach using oral mucosa and allo-SLET to promote corneal epithelial phenotype restoration: a hypothesis	2
A novel strategy combining high-intensity interval training and exogenous ketone supplementation for obesity treatment	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
Red blood cells as intelligent antioxidant carriers to rescue sperm in in vitro fertilization (IVF): A hypothesis	2
The Stage 1 Plus hypothesis in status epilepticus: predicting resistance before it happens	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
Creatine insufficiency as an energetic amplifier of brainstem dysfunction in ME/CFS and long COVID	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
Intrathecal administration of clozapine to reduce side effects: A hypothesis	2
Editorial Board	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Complement overactivation: A potential mechanistic bridge between immunothrombosis and thromboinflammation in venous thromboembolism	2
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Comment on: Could the administration of SGLT2i agents serve as a viable prophylactic approach against CNI-induced toxicities?	2
Time and the body: A new approach to disease	2
Potential health risks of mRNA-based vaccine therapy: A hypothesis	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Growth differentiation factor 15 activation of AMPK modulates choline/TMAO‑driven calcific aortic valve disease: a novel therapeutic strategy for aortic stenosis	2
Could neutrophil extracellular traps drive the development of autism?	2
3D Doppler territorial vascular mapping as a prognostic tool in uterine EMV/AVM	2
Editorial Board	2
Could dysbiosis of urban air microbiota be an overlooked contributor to pediatric asthma and neurodevelopmental disorders?	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Is vestibular migraine really a separate form of migraine?	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
Do ‘nature’ mediate stem cells empowerment in women?	2
The potential role of fixation eye movements in the development of myopia	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Unilateral multifidus hypoplasia as a potential cause of adolescent idiopathic scoliosis: A hypothesis	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
SARS-CoV-2 aerosols: A physical bridge linking upper respiratory infection to lung pathology — A pathological transmission hypothesis	2
Moderate-intensity exercise as a preventive strategy against dopaminergic dysfunction in Long COVID: A mechanistic hypothesis	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
“Idiopathic” adhesive capsulitis is caused by reactivation of latent neurotrophic virus involving peripheral nerves around the shoulder capsule: A hypothesis	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Mitochondrial silencing as an apoptosis-evasive metabolic state preceding senescence fixation: A hypothesis	2