Medical Hypotheses

Article	Citations
The hypothetical molecular pathways of ursolic acid to attenuate the premature ovarian failure in human	37
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	29
Exciter laser coronary atherectomy (ELCA) can be a powerful weapon in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH)	29
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	24
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	22
Editorial Board	22
Can virophages be used for management of viral infections?	21
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	20
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	20
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	19
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	19
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	17
A quantum mechanical explanation for auditory-visual hallucinations	17
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	15
Protective effect of methylene blue in iron-induced neurotoxicity	15
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	14
Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome	14
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism	14
Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain	13
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	13
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	13
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	13
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	12
Hypothesis: The triad androgen receptor, zinc finger proteins and telomeres modulates the global gene expression pattern during prostate cancer progression	12
Anticholinergic drugs versus preprocedural mouth rinses for reduction of SARS-CoV-2 load in dental aerosols	11

Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters	11
Strengthening CoViD-19 therapy via combinations of RAS modulators	11
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	10
Speechreading as a secondary diagnostic tool in bipolar disorder	10
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	10
Retraction notice to “Facemasks in the COVID-19 era: A health hypothesis” [Medical Hypotheses 146 (2021) 5]	9
Activation of resident immune cells induces enteric neuronal death	9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	9
SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells	9
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	9
Are fungi responsible for the pathogenesis of oral lichen planus?	9
The use of negative oxygen ion clusters [O2−(H2O)n] and bicarbonate ions [HCO3−] as the supportive treatment of COVID-19 infections: A possibility	9
Primary aldosteronism: A consequence of sugar and western Diet?	9
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	8
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	8
Exploring the link between sacral neuromodulation and body balance mechanism	8
Editorial Board	8
Investigating myelin oligodendrocyte glycoprotein antibodies in hereditary citrullinemia	7
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	7
Regular intake of vasodip (lercanidipine) relieves migraine attacks	7
Methylene blue: Subduing the post COVID-19 blues!	7
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	7
Hypothesis for renin-angiotensin inhibitor mitigation of COVID-19	7
Diaphragmatic speckle tracking imaging for 2D-strain assessment in mechanical ventilation weaning test	7
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	7
Editorial Board	7
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	7
Aminoglycosides and their potential as SARS-CoV-2 antivirals	6
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	6
BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients	6
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	6
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	6
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	6
Transient Receptor Potential Vanilloid 1 (TRPV1) as a plausible novel therapeutic target for treating neurological complications in ZikaVirus	6
Vitamin D may prevent COVID-19 induced pregnancy complication	6
Highly expressed ACE-2 receptors during pregnancy: A protective factor for SARS-COV-2 infection?	6
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	6
Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility	6
Age, obesity and hyperglycaemia: Activation of innate immunity initiates a series of molecular interactions involving anionic surfaces leading to COVID-19 morbidity and mortality	5
Editorial Board	5
Editorial Board	5
Tubular visual field defect relies on hyperbolic geometry spatial representations	5
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	5
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	5
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes	5
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	5
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	5
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	4

Hypothesis of subcortical visual pathway impairment in schizophrenia	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	4
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
Out of balance: the role of evolutionary mismatches in the sex disparity in autoimmune disease	4
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	4
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	4
Pathological Demand Avoidance is a result of mental process opacity	4
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	4
Bayesian interpretation of the hygiene hypothesis	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Autophagy: A self-guard against SARS-CoV-2	4
Can human metapneumovirus infection be prevented by exercise?	4
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Enhance the science of uncertainty with the art of probability	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Estimate of benefit attributable to wearing masks in Chicago during the early days of the pandemic	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Editorial Board	3
Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure	3
Prolactin and susceptibility to COVID-19 infection	3
Why is the mesencephalic nucleus of the trigeminal nerve situated inside the brain?	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Glutamine addiction in virus-infected mammalian cells: A target of the innate immune system?	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
Editorial Board	3
Whole-body vibration combined with exercise may be more effective in lowering blood pressure and arterial stiffness than exercise alone in older adults with hypertension	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	3
l-Methionine may modulate the assembly of SARS-CoV-2 by interfering with the mechanism of RNA polymerase	3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route	3
Editorial Board	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Carpal, cubital or tarsal tunnel syndrome after SARS-CoV-2 infection: A causal link?	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Editorial Board	3
Disease is essentially a biodiversity: A hypothesis	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
Erratum Regarding Previously Published Articles	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Heat shock protein 90, death-associated protein kinase 1 and other cold-induced proteins: Who’s to blame for cold-induced inflammasome activation in familial cold autoinflammatory syndromes?	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Demethyleneberberine: A possible treatment for Huntington’s disease	2
The potential role of fixation eye movements in the development of myopia	2
Gut barrier dysfunction and type 2 immunity: Implications for compulsive behavior	2
Editorial Board	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Could SARS-CoV-2 blocking of ACE2 in endothelial cells result in upregulation of CX3CL1, promoting thrombosis in COVID-19 patients?	2

Time and the body: A new approach to disease	2
The organ transplant recipient, a chimera subject, who develops a neoplastic lesion may be the suitable model to reconstruct the hierarchical organization of tumors	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
Intrathecal administration of clozapine to reduce side effects: A hypothesis	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
Do ‘nature’ mediate stem cells empowerment in women?	2
Is vestibular migraine really a separate form of migraine?	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Bridging the gap: Compressing non-unions for proper cellular signaling	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
Editorial Board	2
Adenosine deaminase and cytokines associated with infectious diseases as risk factors for inflammatory arthritis and methotrexate as a potential prophylactic agent	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia	2
Could neutrophil extracellular traps drive the development of autism?	2
Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	2
Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
Möbius strip and cancer	2
The uncoupled anterior and posterior spinal ligament tension (UAPLT) – An improvement to three-dimensional spring model of adolescent idiopathic scoliosis (AIS) pathogenesis	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity	2
The mint versus Covid hypothesis	2
Editorial Board	2
The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?	2
Regular short exposures to cold environment as an adjunct therapy for patients with sleep apnea syndrome (SAS)	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
The role of carbohydrate antigen 125 in COVID-19	2
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	2