Medical Hypotheses

Article	Citations
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	42
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	32
A quantum mechanical explanation for auditory-visual hallucinations	28
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	21
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	21
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	16
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	15
Exciter laser coronary atherectomy (ELCA) can be a powerful weapon in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH)	15
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	14
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	13
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	12
Protective effect of methylene blue in iron-induced neurotoxicity	12
Editorial Board	12
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	11
Can virophages be used for management of viral infections?	11
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism	11
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	11
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	10
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	10
Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain	10
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	9
Editorial Board	9
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	9
Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?	9
Exploring the link between sacral neuromodulation and body balance mechanism	9

Acupressure at LI4 and LU10 as a modulator of cortical microstates and autonomic tone: a hypothetical mechanism	9
Activation of resident immune cells induces enteric neuronal death	9
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	9
SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells	8
Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters	8
Are fungi responsible for the pathogenesis of oral lichen planus?	8
Local hematoma may be a cause of peripheral fusion after spinal surgery	8
BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients	7
Speechreading as a secondary diagnostic tool in bipolar disorder	7
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	7
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	7
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	7
Primary aldosteronism: A consequence of sugar and western Diet?	7
Editorial Board	6
Investigating myelin oligodendrocyte glycoprotein antibodies in hereditary citrullinemia	6
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data	6
Cigarette smoke as a superspreading vector of SARS-CoV-2, measles virus, and influenza virus: A hypothesis on virus-laden aerosol formation and transport	6
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	6
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	6
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	6
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	6
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	6
Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility	6
Regular intake of vasodip (lercanidipine) relieves migraine attacks	6
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	6
The hypothesis – A dual-front attack on TB: Vitamin D–fluoroquinolone conjugates as next generation therapeutic strategy against drug-resistant Mycobacterium tuberculosis	6
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	6
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	5
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	5
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	5
Editorial Board	5
Transient Receptor Potential Vanilloid 1 (TRPV1) as a plausible novel therapeutic target for treating neurological complications in ZikaVirus	5
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	5
Tubular visual field defect relies on hyperbolic geometry spatial representations	5
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	5
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	5
A novel hypothesis on the pathogenesis of knee osteoarthritis: the muscle weakness-joint instability-uneven bone settlement cascade	5
Can human metapneumovirus infection be prevented by exercise?	5
Pathological Demand Avoidance is a result of mental process opacity	5
Editorial Board	5
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	5
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	5
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	5
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
Is iron dysregulation in the mirror motor cortex associated with misophonia?	4
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	4
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	4
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	4

Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	4
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4
Exercise may enhance the anti-metastatic effects of cyclooxygenase 1 inhibitors	4
Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach	4
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	4
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID	4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease	4
Autophagy: A self-guard against SARS-CoV-2	4
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	4
Bayesian interpretation of the hygiene hypothesis	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
Editorial Board	4
Vitamin D may prevent COVID-19 induced pregnancy complication	4
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	4
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
Whole-body vibration combined with exercise may be more effective in lowering blood pressure and arterial stiffness than exercise alone in older adults with hypertension	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Editorial Board	3
l-Methionine may modulate the assembly of SARS-CoV-2 by interfering with the mechanism of RNA polymerase	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
A diametrically opposed view of the role of glucocorticoids in central serous chorioretinopathy	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Editorial Board	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	3
Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review	3
Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?	3
Estimate of benefit attributable to wearing masks in Chicago during the early days of the pandemic	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	3
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	3
Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
Intrathecal administration of clozapine to reduce side effects: A hypothesis	3
CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism	3
Editorial Board	3
Hypothesis of subcortical visual pathway impairment in schizophrenia	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
COUP-TFII as a potential therapeutic target for metabolic dysfunction-associated steatotic liver disease	3
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	3
Disease is essentially a biodiversity: A hypothesis	3
Editorial Board	3
Handgrip exercise: An innovative non-pharmacological strategy for chronic hypertension in pregnancy	3
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Editorial Board	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
The digestive Enzyme-Based nasal dysbiosis in Empty nose Syndrome: A theory	2
Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia	2
Comment on: Could the administration of SGLT2i agents serve as a viable prophylactic approach against CNI-induced toxicities?	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
Editorial Board	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	2
Is vestibular migraine really a separate form of migraine?	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2

Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy	2
Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
Neuroimmune hijacking: a hypothetical mechanism by which brain tumors reprogram immune cells to promote tumor progression	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
Could neutrophil extracellular traps drive the development of autism?	2
Gut barrier dysfunction and type 2 immunity: Implications for compulsive behavior	2
The organ transplant recipient, a chimera subject, who develops a neoplastic lesion may be the suitable model to reconstruct the hierarchical organization of tumors	2
Could dysbiosis of urban air microbiota be an overlooked contributor to pediatric asthma and neurodevelopmental disorders?	2
Adenosine deaminase and cytokines associated with infectious diseases as risk factors for inflammatory arthritis and methotrexate as a potential prophylactic agent	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Time and the body: A new approach to disease	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
The postulated role of brain pulsations and arachnoid membranes in cerebrospinal fluid circulation, ventriculomegaly and related CSF disorders	2
The development and evolution of inner speech: Hippocampal contribution	2
Unilateral multifidus hypoplasia as a potential cause of adolescent idiopathic scoliosis: A hypothesis	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Comment on “Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice”	2
Bridging the gap: Compressing non-unions for proper cellular signaling	2
“Idiopathic” adhesive capsulitis is caused by reactivation of latent neurotrophic virus involving peripheral nerves around the shoulder capsule: A hypothesis	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
The potential role of fixation eye movements in the development of myopia	2
Möbius strip and cancer	2
Do ‘nature’ mediate stem cells empowerment in women?	2
Red blood cells as intelligent antioxidant carriers to rescue sperm in in vitro fertilization (IVF): A hypothesis	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Regular short exposures to cold environment as an adjunct therapy for patients with sleep apnea syndrome (SAS)	2
Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
Editorial Board	2
The mint versus Covid hypothesis	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A hypothesis	2