Medical Hypotheses

Article	Citations
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	37
A quantum mechanical explanation for auditory-visual hallucinations	16
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	16
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	14
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	14
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	12
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	12
Editorial Board	12
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	11
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	11
Can virophages be used for management of viral infections?	11
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	11
Protective effect of methylene blue in iron-induced neurotoxicity	11
Post-menopause cardiovascular risk – lack of hormones or bleeding? – Increased blood viscosity due to cessation in menstrual bleeding	10
Integration of parenteral nutrition with galactose may improve neurodevelopmental outcomes for preterm newborns	10
The mechanical protector paradox: a hypothesis linking transition zone enlargement, urethral angle, and carcinogenesis via intraprostatic reflux	10
Acupressure at LI4 and LU10 as a modulator of cortical microstates and autonomic tone: a hypothetical mechanism	10
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	10
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	10
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	8
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	8
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	8
Controlled intracranial pressure elevation via cerebrospinal fluid infusion: a novel hemostatic hypothesis for hematoma expansion in traumatic brain contusion	7
Exploring the link between sacral neuromodulation and body balance mechanism	7

Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	7
Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?	7
Editorial Board	7
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	6
Editorial Board	6
Parkinson’s disease as a superposition of wake and sleep states: a hypothesis of vicious cycle neurodegeneration	6
Activation of resident immune cells induces enteric neuronal death	6
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	6
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	6
Acute diffuse brain swelling during surgery — Hypothalamic injury or the “dual-switch” hypothesis	6
Local hematoma may be a cause of peripheral fusion after spinal surgery	6
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	5
Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters	5
The hypothesis – A dual-front attack on TB: Vitamin D–fluoroquinolone conjugates as next generation therapeutic strategy against drug-resistant Mycobacterium tuberculosis	5
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	5
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	5
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	5
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	5
Iron chelators reduce prostaglandins and leukotrienes by inhibiting cyclooxygenase and lipoxygenase: A hypothesis to attenuate PPARγ transcriptional activity in prostate cancer	5
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	5
Cigarette smoke as a superspreading vector of SARS-CoV-2, measles virus, and influenza virus: A hypothesis on virus-laden aerosol formation and transport	5
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	5
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	5
Regular intake of vasodip (lercanidipine) relieves migraine attacks	5
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	5
Molecular hydrogen and heat-stressed exercise: a mechanistic hypothesis and framework for future investigation	5
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data	5
Nasal breathing and brain Function: A hypothesis of nasal cavity as a localized interface for gas exchange	5
A novel hypothesis on the pathogenesis of knee osteoarthritis: the muscle weakness-joint instability and stress overload – uneven bone settlement cascade	5
Editorial Board	5
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
Species-specific biofilm traits and virulence gene expression in recurrent vulvovaginal candidiasis: a translational hypothesis	4
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID	4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Editorial Board	4
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	4
Can human metapneumovirus infection be prevented by exercise?	4
Sickle Cell Crisis – Home Oxygen in the Golden Half Hour, can prevent or stop a crisis, prevent complications and change the trajectory of disease	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	4
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	4
Autophagy: A self-guard against SARS-CoV-2	4
Is iron dysregulation in the mirror motor cortex associated with misophonia?	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
Tubular visual field defect relies on hyperbolic geometry spatial representations	4
Pathological Demand Avoidance is a result of mental process opacity	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4

Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	4
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
Editorial Board	4
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	4
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	4
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	4
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
A substrate-competition hypothesis for type 2 diabetes driven by nutrient excess rather than a primary insulin-signaling defect	3
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	3
Bayesian interpretation of the hygiene hypothesis	3
Late intraocular lens dislocation arises from two independent biomechanical pathways: Structural failure and interface fatigue	3
COUP-TFII as a potential therapeutic target for metabolic dysfunction-associated steatotic liver disease	3
Intrathecal administration of clozapine to reduce side effects: A hypothesis	3
Stress-conditioned small extracellular vesicles from young cells to restore resilience in aging	3
Targeting conserved dynamic regions of SARS-CoV-2 spike protein identified by normal mode analysis for broad-spectrum antiviral therapy	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
A diametrically opposed view of the role of glucocorticoids in central serous chorioretinopathy	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Exercise may enhance the anti-metastatic effects of cyclooxygenase 1 inhibitors	3
Effects of biological clock on acute pancreatitis: Roles and mechanisms	3
Editorial Board	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Delayed acclimatization and persistent hyperdynamic circulation amplify capillary stress in severe high-altitude illness	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
Editorial Board	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Editorial Board	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
HIV-induced neuroinflammation may influence an increase in sexual behavior: A testable hypothesis	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
Hybrid GAN–P-TransUNet framework for alveolar bone regeneration in dental implant planning: A hypothesis	3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	3
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	3
Handgrip exercise: An innovative non-pharmacological strategy for chronic hypertension in pregnancy	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	3
Osteoclasts may play key roles in initiating vascular calcification during atherosclerosis	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach	3
Editorial Board	3
Disease is essentially a biodiversity: A hypothesis	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	3
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
Möbius strip and cancer	2
The Stage 1 Plus hypothesis in status epilepticus: predicting resistance before it happens	2
Brainstem dysfunction as a potential etiology of ME/CFS and long COVID: A mechanical basis	2
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Editorial Board	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Editorial Board	2
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
The potential role of fixation eye movements in the development of myopia	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
Time and the body: A new approach to disease	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2

Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Moderate-intensity exercise as a preventive strategy against dopaminergic dysfunction in Long COVID: A mechanistic hypothesis	2
Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	2
The mint versus Covid hypothesis	2
The development and evolution of inner speech: Hippocampal contribution	2
Creatine insufficiency as an energetic amplifier of brainstem dysfunction in ME/CFS and long COVID	2
Unilateral multifidus hypoplasia as a potential cause of adolescent idiopathic scoliosis: A hypothesis	2
Enhancing the effects of mindfulness in migraine patients through transcranial magnetic stimulation: A plausible hypothesis	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
Do ‘nature’ mediate stem cells empowerment in women?	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Could neutrophil extracellular traps drive the development of autism?	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
Premaxilla and incisive papilla as a nasopalatine sensory gateway: A developmental hypothesis linking trigeminal V2 afference to brainstem state calibration, oral posture, breathing mode, and childhoo	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
Comment on: Could the administration of SGLT2i agents serve as a viable prophylactic approach against CNI-induced toxicities?	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Heat shock protein 90, death-associated protein kinase 1 and other cold-induced proteins: Who’s to blame for cold-induced inflammasome activation in familial cold autoinflammatory syndromes?	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
The postulated role of brain pulsations and arachnoid membranes in cerebrospinal fluid circulation, ventriculomegaly and related CSF disorders	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
Asymmetric mechanical stress on both sides of the spine – Based on human functional chiral asymmetry – May constitute the underlying Pathomechanism of adolescent idiopathic scoliosis (AIS)	2
Red blood cells as intelligent antioxidant carriers to rescue sperm in in vitro fertilization (IVF): A hypothesis	2
A novel strategy combining high-intensity interval training and exogenous ketone supplementation for obesity treatment	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
Could dysbiosis of urban air microbiota be an overlooked contributor to pediatric asthma and neurodevelopmental disorders?	2
3D Doppler territorial vascular mapping as a prognostic tool in uterine EMV/AVM	2
Is vestibular migraine really a separate form of migraine?	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Complement overactivation: A potential mechanistic bridge between immunothrombosis and thromboinflammation in venous thromboembolism	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
“Idiopathic” adhesive capsulitis is caused by reactivation of latent neurotrophic virus involving peripheral nerves around the shoulder capsule: A hypothesis	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Editorial Board	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Editorial Board	2
Mitochondrial silencing as an apoptosis-evasive metabolic state preceding senescence fixation: A hypothesis	2
Altered iron homeostasis in neonatal hypoxic-ischemic encephalopathy	1
Response to: Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	1
Reducing fibrosis progression of biliary atresia by continuous administration of aducanumab at low dose: A potential treatment	1
Myocardial cell-derived exosomal miR-155-5p promotes depressive disorders in CVD via microglial SIRT1 pathway	1
Anastomoses between cranial nerves, the dorsal roots of the first four cervical vertebrae, and the sympathetic trunk are key to understanding the types of primary headache and their integrative treatm	1
The aging spiral hypothesis: mitochondrial decline, CO2 regulation, and the metabolic collapse of aging	1
A hypotheses to explain acute adjustment disorder after phakic intraocular lens implantation in a highly myopic patient: Potential causes and suggested remedies	1
Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?	1
Editorial Board	1
Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder	1
Temporal-scaffolding: a model linking internal clocks, oscillatory dynamics, and phenomenology in mood and psychotic disorders	1
The cheeky ape hypothesis: Is rosacea the evolutionary price of human buccal fat?	1
Can we reduce cancer progression via disrupting autophagy-cholesterol uptake nexus?	1
The role of hemispheric sensory shifts: Impacts on stretch reflex and motor plasticity post-stroke	1
MALAT1: A novel hypothesis on the pathology of vascular injury in patients with β-thalassemia	1
Infrapatellar fat pad resection: A potential approach for slowing knee osteoarthritis progression	1
Long COVID may be treatable with noradrenergic transmission reducing drugs	1
The role of spinal cord pulsatility in the pathogenesis of Post-traumatic syringomyelia: A novel hypothesis	1
Traffic-derived metal bioaccumulation in bone tissue as a driver of osteoporosis	1
Exploring the influence of physical activity on the efficacy of chondroprotective agents for osteoarthritis: The role of diffusion conditions	1
Downregulation of interleukin-13 as a possible proxy for ergolytic effects of hydrogen gas	1
Is Epstein Barr virus latency protective against type 1 diabetes?	1
Can atrial lead system ameliorate the diagnosis of atrial arrhythmias?	1
Shedding light on an enigmatic occlusal condition: hypothesis on the etiology of occlusal dysesthesia	1
No one left behind: Inclusion of individuals experiencing homelessness in TBI stem cell therapy	1
Active Inference as a theoretical framework for external locus of control in chronic pain: the role of aberrant interoceptive integration	1
Editorial Board	1
Evolution of male-to-female oral sex as a detection tool of bacterial vaginosis and subsequent infertility	1
Venous intracerebral hemorrhage hypotheses: Hydrostatic pressure-induced bleeding mechanism and comparative analysis with arterial hemorrhage	1
A hypothesis on the suitability of the aquatic crustacean, Daphnia pulex as an animal model for investigating Parkinson’s disease mechanisms	1
Automated phage therapy in smart hospitals: a hypothesis for an AI, metagenomics, and IoT pipeline to treat resistant infections	1
Excess iron in food could indirectly affect lipid metabolism by affecting intestinal lithocholic acid levels: A scientific hypothesis	1
Revolution of artificial intelligence in antimicrobial, anti-biofilm, and anti-inflammatory techniques: Smart photo-sonodynamic appliance in the internet of dental things (IoDT)	1
Platelets could be key regulators of epithelial/endothelial-to- mesenchymal transition in atherosclerosis and wound healing	1
Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients	1
Possible immune mechanisms initiated by 7-ketocholesterol that contribute to synovial oxidative stress and inflammation	1
Use of Nile tilapia fish skin in oral submucous fibrosis therapeutics	1
Tissue thinning in the inguinal region following human bipedalism	1
Why do some tali collapse in avascular necrosis while others don’t? A biomechanical hypothesis based on a three-pillar load model	1
Deep cervical lymphovenous bypass for Parkinson’s disease: A hypothesis	1