OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Pharmacology and Physiology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Paracetamol – An old drug with new mechanisms of action	72
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis	49
A role for retinoids in the treatment of COVID‐19?	49
LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR‐200c‐3p to upregulate ANLN	38
A novel concept for treatment and vaccination against Covid‐19 with an inhaled chitosan‐coated DNA vaccine encoding a secreted spike protein portion	26
Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway	25
Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics	24
MiR‐325‐3p inhibits renal inflammation and fibrosis by targeting CCL19 in diabetic nephropathy	22
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases	21
Modulation of bleomycin‐induced oxidative stress and pulmonary fibrosis by N‐acetylcysteine in rats via AMPK/SIRT1/NF‐κβ	21
Ginsenoside 20(S)‐Rg3 upregulates HIF‐1α‐targeting miR‐519a‐5p to inhibit the Warburg effect in ovarian cancer cells	21
A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review	20
Atractylenolide III reduces NLRP3 inflammasome activation and Th1/Th2 imbalances in both in vitro and in vivo models of asthma	20
Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis	19
Diagnostic and prognostic value of thymidylate synthase expression in breast cancer	18
Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation	18
Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe	18
Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression	17
Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review	17
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms	17
The JAK2 inhibitor AG490 regulates the Treg/Th17 balance and alleviates DSS‐induced intestinal damage in IBD rats	16
MiR‐342 attenuates lipopolysaccharide‐induced acute lung injury via inhibiting MAPK1 expression	16
Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance	16
Alpha‐lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes	16
Keratin 18 induces proliferation, migration, and invasion in gastric cancer via the MAPK signalling pathway	16

Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge	16
ELABELA improves endothelial cell function via the ELA–APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells	16
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling	15
Assessment of heavy metals by ICP‐OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes	15
Renal lipotoxicity: Insights from experimental models	15
Mechanisms of cancer stem cell senescence: Current understanding and future perspectives	15
Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis	14
Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re‐establishing autophagic flux via promoting leptin signalling in a 6‐hydroxydopamine rat model of Parkinson's disease	14
Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis	14
Low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner	14
Quercetin promotes locomotor function recovery and axonal regeneration through induction of autophagy after spinal cord injury	14
Genetic and phenotypic frequency distribution of CYP2C9, CYP2C19 and CYP2D6 in over 3200 Han Chinese	14
Enhanced oxidative stress mediates pathological autophagy and necroptosis in cardiac myocytes in pressure overload induced heart failure in rats	14
Dexmedetomidine in the prevention of postoperative delirium in elderly patients following non‐cardiac surgery: A systematic review and meta‐analysis	14
Spirulina supplementation and oxidative stress and pro‐inflammatory biomarkers: A systematic review and meta‐analysis of controlled clinical trials	13
Antihypertensive effect of carvacrol is improved after incorporation in β‐cyclodextrin as a drug delivery system	13
Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats	13
Tenacissoside H promotes neurological recovery of cerebral ischaemia/reperfusion injury in mice by modulating inflammation and oxidative stress via TrkB pathway	13
The composite alliance of FTO locus with obesity‐related genetic variants	13
Administering crocin ameliorates anxiety‐like behaviours and reduces the inflammatory response in amyloid‐beta induced neurotoxicity in rat	13
Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor	12
The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin	12
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	12
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model	12
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice	12
Expressions of m6A RNA methylation regulators and their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma	12
Long non‐coding RNA DDX11‐AS1 promotes non‐small cell lung cancer development via regulating PI3K/AKT signalling	12
Melatonin and its derivative disrupt cancer stem‐like phenotypes of lung cancer cells via AKT downregulation	12
The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma	12
Taurine prevents high‐fat diet‐induced‐hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element‐binding proteins and activation of AMPK	11
Cross‐sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure	11
A comprehensive review on medicinal plants possessing antioxidant potential	11
Transcription of CLDND1 in human brain endothelial cells is regulated by the myeloid zinc finger 1	11
Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells	11
Long non‐coding RNA H19 promotes myoblast fibrogenesis via regulating the miR‐20a‐5p‐Tgfbr2 axis	11
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	11
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats	11
Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo	11
Cell and extracellular matrix interaction models in benign mesothelial and malignant pleural mesothelioma cells in 2D and 3D in‐vitro	11
Oncogenic pseudogene DUXAP10 knockdown suppresses proliferation and invasion and induces apoptosis of papillary thyroid carcinoma cells by inhibition of Akt/mTOR pathway	11
Donepezil down‐regulates propionylation, 2‐hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion‐induced vascular dementia ra	11
Curcumin‐coated gold nanoparticles attenuate doxorubicin‐induced cardiotoxicity via regulating apoptosis in a mouse model	10
Effect of orexin‐A on mitochondrial biogenesis, mitophagy and structure in HEK293‐APPSWE cell model of Alzheimer's disease	10
Association between periodontitis and hyperlipidaemia: A systematic review and meta‐analysis	10
An update of genetics, co‐morbidities and management of hyperuricaemia	10
Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload	10
The pivotal relation between glucagon‐like peptides, NFκB and inflammatory bowel disease	10
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF‐β1/Smads and NFκB pathways	10
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation	10
MiR‐599 regulates LPS‐mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells	10

Biochemical investigation of rs1801282 variations in PPAR‐γ gene and its correlation with risk factors of diabetes mellitus in coronary artery disease	10
Liraglutide improves obesity‐induced renal injury by alleviating uncoupling of the glomerular VEGF–NO axis in obese mice	10
Dysfunction of perivascular adipose tissue in mesenteric artery is restored by aerobic exercise in high‐fat diet induced obesity	10
The anti‐tumourigenic effect of ellagic acid in SKOV‐3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK	10
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and int	10
Nebivolol protects against cyclophosphamide‐induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis	9
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue	9
Toll‐like receptor‐2 mediates systemic inflammation in gentamicin‐induced rat nephrotoxicity	9
Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers	9
Cerebral palsy: Aetiology, pathophysiology and therapeutic interventions	9
A novel metformin derivative showed improvement of lipid metabolism in obese rats with type 2 diabetes	9
Hypothesis: The potential therapeutic role of nicorandil in COVID‐19	9
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	9
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers	9
Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma	9
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR‐1827	9
The association between serum albumin/prealbumin level and disease severity in non‐CF bronchiectasis	9
Solamargine induces autophagy‐mediated apoptosis and enhances bortezomib activity in multiple myeloma	9
Salvianolic acid A blocks vasculogenic mimicry formation in human non‐small cell lung cancer via PI3K/Akt/mTOR signalling	9
The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell pr	9
Characterization of B cell‐mediated PD‐1/PD‐L1 interaction in pancreatic cancer patients	9
Cardioprotective potential of vanillic acid	9
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	9
Role of the SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection	9
Therapeutic potential of curcumin in ARDS and COVID‐19	8
Sodium butyrate ameliorates non‐alcoholic fatty liver disease by upregulating miR‐150 to suppress CXCR4 expression	8
Salidroside protects against diabetes mellitus‐induced kidney injury and renal fibrosis by attenuating TGF‐β1 and Wnt1/3a/β‐catenin signalling	8
Hesperidin inhibits L‐NAME‐induced vascular and renal alterations in rats by suppressing the renin–angiotensin system, transforming growth factor‐β1, and oxidative stress	8
Sildenafil attenuates nonsteroidal anti‐inflammatory‐induced gastric ulceration in mice via antioxidant and antigenotoxic mechanisms	8
Altered renal medullary blood flow: A key factor or a parallel event in control of sodium excretion and blood pressure?	8
The effect of the protective face mask on cardiorespiratory response during aerobic exercise	8
Renal water conservation and the volume kinetics of fluid‐induced diuresis: A retrospective analysis of two cohorts of elderly men	8
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome	8
Hemin mitigates contrast‐induced nephropathy by inhibiting ferroptosis via HO‐1/Nrf2/GPX4 pathway	8
Dipeptidyl peptidase 4 inhibitors attenuate cardiac ischaemia–reperfusion injury in rats with diabetes mellitus type 2	8
Signalling pathway of U46619‐induced vascular smooth muscle contraction in mouse coronary artery	8
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression	8
Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury	8
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies	8
Omega‐3 polyunsaturated fatty acids in the treatment of non‐alcoholic fatty liver disease: An umbrella systematic review and meta‐analysis	7
Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	7
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression	7
The RNA N⁶‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	7
Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells	7
Potential of crocodile blood as a medication and dietary supplement: A systemic review	7
LPS preconditioning of MSC‐CM improves protection against hypoxia/reoxygenation‐induced damage in H9c2 cells partly via HMGB1/Bach1 signalling	7
Epigallocatechin gallate for Parkinson's disease	7
Effects of polyphenols onncRNAsin cancer—An update	7
Policosanol attenuates Pi‐induced calcification via AMPK‐mediated INSIGs expression in rat VSMCs	7
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	7
Rotenone restrains the proliferation, motility and epithelial–mesenchymal transition of colon cancer cells and the tumourigenesis in nude mice via PI3K/AKT pathway	7
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	6
Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation	6
The use of Ca‐transient to evaluate Ca²⁺ utilization by myofilaments in living cardiac muscle	6
DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression	6
Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint	6
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	6
A glimpse at growth hormone–releasing hormone cosmos	6
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	6
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	6
The sphingosine‐1‐phosphate receptor modulator, FTY720, prevents the incidence of diabetes in Spontaneously Diabetic Torii rats	6
Reversible bronchial dilatation in adults	6
Renal functional recovery among inpatients: A plausible marker of reduced renal functional reserve	6
Cold‐inflammaging: When a state of homeostatic‐imbalance associated with aging precedes the low‐grade pro‐inflammatory‐state (inflammaging): Meaning, evolution, inflammaging phenotypes	6
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden	6
Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	6
Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study	6
Synthesis, characterization, biological activity and electrochemistry studies of iron(III) complex with curcumin‐oxime ligand	6
Rosuvastatin and low‐dose carvedilol combination protects against isoprenaline‐induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO‐1 signalling	6
Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial	6
Effect of papaverine on developmental hyperserotonemia induced autism spectrum disorder related behavioural phenotypes by altering markers of neuronal function, inflammation, and oxidative stress in r	6
1,25‐dihydroxyvitamin D3 prevents deleterious effects of erythromycin on mitochondrial function in rat heart isolated mitochondria	6
Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women	6
SS‐31 protect retinal pigment epithelial cells from H₂O₂‐induced cell injury by reducing apoptosis	6
Circ_0017274 acts on miR‐637/CDX2 axis to facilitate cisplatin resistance in gastric cancer	6