OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Pharmacology and Physiology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis	52
Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation	27
A comprehensive review on medicinal plants possessing antioxidant potential	27
Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway	27
Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics	26
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases	25
Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe	25
Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis	23
Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression	23
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling	23
A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review	21
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms	21
Renal lipotoxicity: Insights from experimental models	21
Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance	21
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	20
Cardioprotective potential of vanillic acid	19
Low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner	17
Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge	17
Enhanced oxidative stress mediates pathological autophagy and necroptosis in cardiac myocytes in pressure overload induced heart failure in rats	17
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model	17
Mechanisms of cancer stem cell senescence: Current understanding and future perspectives	17
Quercetin promotes locomotor function recovery and axonal regeneration through induction of autophagy after spinal cord injury	16
Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats	16
Administering crocin ameliorates anxiety‐like behaviours and reduces the inflammatory response in amyloid‐beta induced neurotoxicity in rat	16
Spirulina supplementation and oxidative stress and pro‐inflammatory biomarkers: A systematic review and meta‐analysis of controlled clinical trials	16

The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma	15
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	15
Long non‐coding RNA H19 promotes myoblast fibrogenesis via regulating the miR‐20a‐5p‐Tgfbr2 axis	14
Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells	14
Hemin mitigates contrast‐induced nephropathy by inhibiting ferroptosis viaHO‐1/Nrf2/GPX4pathway	14
The composite alliance of FTO locus with obesity‐related genetic variants	14
Sodium butyrate ameliorates non‐alcoholic fatty liver disease by upregulating miR‐150 to suppress CXCR4 expression	14
Solamargine induces autophagy‐mediated apoptosis and enhances bortezomib activity in multiple myeloma	14
Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re‐establishing autophagic flux via promoting leptin signalling in a 6‐hydroxydopamine rat model of Parkinson's disease	14
Curcumin‐coated gold nanoparticles attenuate doxorubicin‐induced cardiotoxicity via regulating apoptosis in a mouse model	13
Tenacissoside H promotes neurological recovery of cerebral ischaemia/reperfusion injury in mice by modulating inflammation and oxidative stress via TrkB pathway	13
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice	13
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF‐β1/Smads and NFκB pathways	13
Melatonin and its derivative disrupt cancer stem‐like phenotypes of lung cancer cells via AKT downregulation	13
Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers	13
Cell and extracellular matrix interaction models in benign mesothelial and malignant pleural mesothelioma cells in 2D and 3D in‐vitro	12
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue	12
Cross‐sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure	12
Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma	12
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and int	12
Nebivolol protects against cyclophosphamide‐induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis	12
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats	12
An update of genetics, co‐morbidities and management of hyperuricaemia	12
Dipeptidyl peptidase 4 inhibitors attenuate cardiac ischaemia–reperfusion injury in rats with diabetes mellitus type 2	11
Effect of orexin‐A on mitochondrial biogenesis, mitophagy and structure in HEK293‐APPSWE cell model of Alzheimer's disease	11
Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo	11
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	11
Salvianolic acid A blocks vasculogenic mimicry formation in human non‐small cell lung cancer via PI3K/Akt/mTOR signalling	11
Therapeutic potential of curcumin in ARDS and COVID‐19	11
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome	11
Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload	10
Rosmarinic acid protects against lipopolysaccharide‐induced cardiac dysfunction via activating Sirt1/PGC‐1α pathway to alleviate mitochondrial impairment	10
Signalling pathway of U46619‐induced vascular smooth muscle contraction in mouse coronary artery	10
Hesperidin inhibits L‐NAME‐induced vascular and renal alterations in rats by suppressing the renin–angiotensin system, transforming growth factor‐β1, and oxidative stress	10
The effect of the protective face mask on cardiorespiratory response during aerobic exercise	10
Renal water conservation and the volume kinetics of fluid‐induced diuresis: A retrospective analysis of two cohorts of elderly men	10
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	10
The RNA N⁶‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	10
Effects of polyphenols onncRNAsin cancer—An update	10
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden	10
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation	10
Omega‐3 polyunsaturated fatty acids in the treatment of non‐alcoholic fatty liver disease: An umbrella systematic review and meta‐analysis	9
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers	9
Role of the SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection	9
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR‐1827	9
Rosuvastatin and low‐dose carvedilol combination protects against isoprenaline‐induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO‐1 signalling	9
The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell pr	9
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	9
Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the ulcerative colitis mice through inhibiting the TXNIP‐mediated activation of NLRP3 inflammasome	8
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	8

Epigallocatechin gallate for Parkinson's disease	8
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	8
Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation	8
LPS preconditioning of MSC‐CM improves protection against hypoxia/reoxygenation‐induced damage in H9c2 cells partly via HMGB1/Bach1 signalling	8
Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	8
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression	8
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies	8
Klotho inhibits H₂O₂‐induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression	8
SS‐31 protect retinal pigment epithelial cells from H₂O₂‐induced cell injury by reducing apoptosis	8
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression	8
Circ_0017274 acts on miR‐637/CDX2 axis to facilitate cisplatin resistance in gastric cancer	8
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	7
Policosanol attenuates Pi‐induced calcification via AMPK‐mediated INSIGs expression in rat VSMCs	7
The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA‐binding protein PCBP2	7
Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells	7
Reversible bronchial dilatation in adults	7
Palovarotene inhibits the NF‐κB signalling pathway to prevent heterotopic ossification	7
Resolvin D1 prevents cadmium chloride‐induced memory loss and hippocampal damage in rats by activation/upregulation of PTEN‐induced suppression of PI3K/Akt/mTOR signaling pathway	7
Potential of crocodile blood as a medication and dietary supplement: A systemic review	7
Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	7
DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression	7
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	7
Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP‐mediated inflammatory response inhibition	7
Effect of papaverine on developmental hyperserotonemia induced autism spectrum disorder related behavioural phenotypes by altering markers of neuronal function, inflammation, and oxidative stress in r	7
Inhibition of sphingosine 1‐phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast‐like synoviocyte MH7A cells through Gαi/Gαs rebalancing	6
Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model	6
Metabolomics reveal dynamic changes in eicosanoid profile in patients with ST‐elevation myocardial infarction after percutaneous coronary intervention	6
Salvianolic acid B, a new type I IRE1 kinase inhibitor, abrogates AngII‐induced angiogenesis by interacting with IRE1 in its active conformation	6
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression	6
Associations between peripheral perfusion disorders, mean arterial pressure and dose of norepinephrine administrated in the early phase of septic shock	6
ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma	6
Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients	6
Effects of obesity and diabesity on heart rhythm in the Zucker rat	6
Perivascular adipose tissue and microvascular endothelial dysfunction in obese mice: Beneficial effects of aerobic exercise in adiponectin receptor (AdipoR1) and peNOS_Ser1177	6
Methyltransferase‐like 3 promotes the progression of lung cancer via activating PI3K/AKT/mTOR pathway	6
Renal functional recovery among inpatients: A plausible marker of reduced renal functional reserve	6
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study	6
Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF‐β/Smad pathway	6
Cucurbitacin IIb improved active chromatin‐induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells	6
Blockage of PD‐L1 by FERMT3‐mediated Wnt/β‐catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells	6
Inhibition of mTOR by temsirolimus overcomes radio‐resistance in nasopharyngeal carcinoma	6
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations	6
Tau and stathmin proteins in breast cancer: A potential therapeutic target	6
Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint	6
Dapagliflozin modulates the faecal microbiota after myocardial infarction in non‐diabetic mice	6
Expression of anti and pro‐inflammatory genes in human endothelial cells activated by 25‐hydroxycholesterol: A comparison of rivaroxaban and dabigatran	6
Efficacy and safety of eptinezumab as preventive treatment for episodic/chronic migraine: A systematic review and meta‐analysis	6
Myrtenol complexed with β‐cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine‐induced animal model of Parkinsonism	6
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	6
Atorvastatin reverses high cholesterol‐induced cardiac remodelling and regulates mitochondrial quality‐control in a cholesterol‐independent manner: An experimental study	5
Diosmetin‐7‐O‐β‐D‐glucopyranoside suppresses endothelial–mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis	5
Comparative effectiveness of Lopinavir/Ritonavir‐based regimens in COVID‐19	5
Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing	5
CircSAMD11 facilitates progression of cervical cancer via regulating miR‐503/SOX4 axis through Wnt/β‐catenin pathway	5
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p	5
Effect of escitalopram on an acetic acid‐induced ulcerative colitis model	5
Therapeutic potential of targeted‐gold nanospheres on collagen‐induced arthritis in rats	5
A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle	5
EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway	5
GAB1 alleviates septic lung injury by inhibiting the TLR4/ NF‐κB pathway	5
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway	5
Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway	5
Cold‐inflammaging: When a state of homeostatic‐imbalance associated with aging precedes the low‐grade pro‐inflammatory‐state (inflammaging): Meaning, evolution, inflammaging phenotypes	5
Impact of JAK/STAT inhibitors on human monocyte‐derived‐macrophages stimulated by cigarette smoke extract and lipopolysaccharide	5
Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women	5
The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of ran	5
Association of natriuretic peptide and adverse outcomes in patients with atrial fibrillation: A meta‐analysis	5
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	5