Clinical and Experimental Pharmacology and Physiology

Article	Citations
Discovery of Novel HCV NS5B polymerase inhibitor, 2‐(3,4‐dimethyl‐5,5‐dioxidobenzo[e]pyrazolo[4,3‐c][1,2]thiazin‐2(4H)‐yl)‐N‐(2‐fluorobenzyl)acetamide via molecular docking	53
The renal excretory responses to acute renal interstitial angiotensin (1–7) infusion in anaesthetised spontaneously hypertensive rats	29
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Brazilin inhibits bladder cancer by promoting cell necroptosis	26
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Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge	25
CircADSS contributes to hepatocellular carcinoma development by regulating miR‐431‐5p/TOP2A	24
Effect of escitalopram on an acetic acid‐induced ulcerative colitis model	24
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells	23
Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR‐194‐5p and elevating HK2 expression	23
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Efficacy and safety profile of sitagliptin, vildagliptin, and metformin in newly diagnosed type 2 diabetic subjects	20
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Characteristics, treatments, and prognosis of a critical illness polyneuromyopathy patient with positive anti‐GM1 after severe traumatic brain injury: A case report	19
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Nicorandil a magic bullet or a double edged sword in critically ill COVID‐19 patients?	18
Evaluation of right atrium structure and function in a rat model of monocrotaline‐induced pulmonary hypertension: Exploring the possible antiarrhythmic properties of amiodarone	18
New missense mutation p.Trp387Ser affecting the functionally important TrpXXTrp motif in the TSR1 repeat of ADAMTS13 metalloproteinase: Case report	17
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability	17
Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐1	17
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Hemin mitigates contrast‐induced nephropathy by inhibiting ferroptosis viaHO‐1/Nrf2/GPX4pathway	15

Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	15
Development of a new pharmacokinetic model for target‐concentration controlled infusion of vancomycin in critically ill patients	14
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Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	14
The impact of metformin on hypothalamic–pituitary–thyroid axis activity in postmenopausal women with untreated non‐autoimmune subclinical hypothyroidism	14
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A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway	13
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Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure	13
Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients	13
Propofol attenuates prostate cancer progression by upregulating TRHDE‐AS1 expression, and METTL14 could mediate its m6A modification	12
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms	12
Phillygenin attenuates cell apoptosis and microglia activation in cerebral ischaemia–reperfusion rats through activation of peroxisome proliferator‐activated receptor γ	12
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebra	12
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Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	11
Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis	11
Blockage of PD‐L1 by FERMT3‐mediated Wnt/β‐catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells	11
Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress	11
Effect of SH2B1 on glucose metabolism during pressure overload‐induced cardiac hypertrophy and cardiac dysfunction	10
An update of genetics, co‐morbidities and management of hyperuricaemia	10
Thromboxane A2 receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats	10
LncRNA Miat knockdown alleviates endothelial cell injury through regulation of miR‐214‐3p/Caspase‐1 signalling during atherogenesis	10
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR‐1827	10
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Fibroblast growth factor 10 ameliorates renal ischaemia–reperfusion injury by attenuating mitochondrial damage	10
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p	10
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	10
Curcumol reduces lower limb arteriosclerosis in rats by inhibiting human arterial smooth muscle cell activity	10
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and int	10
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation	9
Comparison of disease‐modifying anti‐rheumatic drugs and hyperbaric oxygen therapy in the experimental model of rheumatoid arthritis in rats	9
Odoratin balances ROS/NO through EZH2/PPARγ signalling to improve myocardial fibrosis	9
The RNA N6‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	9
Quercetin‐4′‐O‐β‐D‐glucopyranoside inhibits podocyte injury by SIRT5‐mediated desuccinylation of NEK7	9
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma	9
Mechanisms of cancer stem cell senescence: Current understanding and future perspectives	9
Comprehensive analysis of EphA2 in pan‐cancer: A prognostic biomarker associated with cancer immunity	9
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3‐mediated ZO‐1 expression	9
GLP‐1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy	8
Empagliflozin attenuates liver fibrosis in high‐fat diet/streptozotocin‐induced mice by modulating gut microbiota	8
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	8
Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients	8
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies	8
Jianpi‐Tiaoqi decoction inhibits tumour proliferation and lung metastasis in tumour‐bearing mice with triple‐negative breast cancer	8
Circ_0017274 acts on miR‐637/CDX2 axis to facilitate cisplatin resistance in gastric cancer	8
High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2‐Mediated Ferroptosis	8
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway	8
Correction to geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor	7
Withdrawn: ‘Tripartite motif 8 (TRIM8) plays a protective role in a cell model of Parkinson's disease via modulation of NF‐ κB activation through targeting of IκBa ubiquitination’, Yingqiao Pan	7

Pharmacogenomics and adverse effects of anti‐infective drugs in children	7
A novel synthetised sulphonylhydrazone coumarin (E)‐4‐methyl‐N′‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐ yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol‐induced myoca	7
IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells	7
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Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway	7
Diclofenac Enhances the Response of BRAF Inhibitor to Melanoma Through ROS/p38/p53 Signaling	7
Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers	7
Histamine via histamine H1 receptor enhances the muscarinic receptor‐induced calcium response to acetylcholine in an enterochromaffin cell model	7
The L‐arginine‐NO‐cGMP pathway mediates the locomotor activity alterations during the expression of sensitization to mephedrone in mice	6
Circ_0026579 knockdown ameliorates lipopolysaccharide‐induced human lung fibroblast cell injury by regulating CXCR1 via miR‐370‐3p	6
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Growth hormone‐releasing hormone beyond cancer	6
Connexin 43 participates in atrial electrical remodelling through colocalization with calcium channels in atrial myocytes	6
Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction	6
Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation	6
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification	6
Withdrawn: ‘Downregulation of circPPFIA1 elevates radiosensitivity via miR‐1299–mediated TXNRD1 inhibition in oesophageal squamous cell carcinoma’, Weihui Yu, Ke Ning,	6
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers	6
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Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome	6
β‐Carotene regulates glucose transport and insulin resistance in gestational diabetes mellitus by increasing the expression of SHBG	6
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D‐pinitol attenuates isoproterenol‐induced myocardial infarction by alleviating cardiac inflammation, oxidative stress and ultrastructural changes in Swiss albino mice	6
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Protective effects of FK 506 against haemorrhagic shock‐induced microvascular hyperpermeability	6
SIRT1 targeted by miR‐211‐5p regulated proliferation and apoptosis of Dex‐treated growth plate chondrocytes via mediating SOX2	6
Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin‐induced allergic enteritis in mice	6
Mito‐targeted antioxidant prevents cardiovascular remodelling in spontaneously hypertensive rat by modulation of energy metabolism	6
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Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial	6
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HDAC6 inhibitor promotes reactive oxygen species‐meditated clearance of Staphylococcus aureus in macrophage	5
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Physical exercise attenuates obesity development in Western‐diet fed obese rats independently of vitamin D supplementation	5
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3‐aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6‐hydroxydopamine models of Parkinson's disease	5
Metformin ameliorates endometrial thickness in a rat model of thin endometrium	5
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Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009–2010	5
Inosine monophosphate dehydrogenase activity and mycophenolate pharmacokinetics in children with nephrotic syndrome treated with mycophenolate mofetil	5
The expected advantage of administering prophylactic antibiotics using target‐ concentration controlled infusion: Development of a new pharmacokinetic model of cefazolin	5
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A non‐antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti‐fatigue protein orosomucoid in mice	4
Epigallocatechin gallate for Parkinson's disease	4
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The role and therapeutic applications of exosomes in multiple sclerosis disease	4
Weight‐based oxytocin infusion for preventing uterine atony during caesarean delivery in non‐labouring patients: A dose–response study	4
Myrtenol complexed with β‐cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine‐induced animal model of Parkinsonism	4
Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo	4
LPS preconditioning of MSC‐CM improves protection against hypoxia/reoxygenation‐induced damage in H9c2 cells partly via HMGB1/Bach1 signalling	4
Pre‐pandemic autonomic function as a predictor of the COVID clinical course in young adults	4
The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of ran	4
Attenuation of renal fibrosis in mice due to lack of bombesin receptor‐activated protein homologue	4
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression	4
CircSAMD11 facilitates progression of cervical cancer via regulating miR‐503/SOX4 axis through Wnt/β‐catenin pathway	4
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression	4
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation	4
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Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats	4
SS‐31 protect retinal pigment epithelial cells from H2O2‐induced cell injury by reducing apoptosis	4
Nicotine‐conditioned place preference, reversal learning and social interaction in MK‐801‐induced schizophrenia model: Effects of post‐weaning enriched environment	4
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	4
Activation of peripheral group III metabotropic glutamate receptors suppressed formalin‐induced nociception	4
Intranasal (2R, 6R)‐hydroxynorketamine for acute pain: Behavioural and neurophysiological safety analysis in mice	4
Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	4
Oxycodone attenuates lipopolysaccharide‐induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2/HO‐1 signalling pathway	4
Overexpression of HSP27 accelerates stress‐induced gastric ulcer healing via the CXCL12/CXCR4 axis	4
Analysis of very important pharmacogene variants in the Tibetan population from China	4
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage	4
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Monocarboxylate transporter 4 protects against myocardial ischemia/reperfusion injury by inducing oxidative phosphorylation/glycolysis interconversion and inhibiting oxidative stress	4
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation	4
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	4
Low molecular weightNGFmimeticGK‐2 normalizes the parameters of glucose and lipid metabolism and exhibits a hepatoprotective effect on a prediabetes model in obese Wistar rats	4
Down‐regulation of CYTL1 attenuates bleomycin‐induced pulmonary fibrosis in mice by inhibiting M2 macrophage polarization via the TGF‐β/CCN2 axis	4

Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease

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