OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Pharmacology and Physiology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	35
Fibroblast growth factor 10 ameliorates renal ischaemia–reperfusion injury by attenuating mitochondrial damage	32
Issue Information	32
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway	31
The RNA N⁶‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	30
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Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells	28
LncRNA Miat knockdown alleviates endothelial cell injury through regulation of miR‐214‐3p/Caspase‐1 signalling during atherogenesis	28
Issue Information	28
The impact of metformin on hypothalamic–pituitary–thyroid axis activity in postmenopausal women with untreated non‐autoimmune subclinical hypothyroidism	28
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	26
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability	22
Withdrawn: ‘Tripartite motif 8 (TRIM8) plays a protective role in a cell model of Parkinson's disease via modulation of NF‐ κB activation through targeting of IκBa ubiquitination’, Yingqiao Pan	22
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3‐mediated ZO‐1 expression	22
Reliability of Matrix‐Assisted Laser Desorption‐Ionisation Time‐of‐Flight Mass Spectrometry as a Method for Drug‐Resistant Tuberculosis Gene Identification	21
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	20
Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial	20
SIRT1 targeted by miR‐211‐5p regulated proliferation and apoptosis of Dex‐treated growth plate chondrocytes via mediating SOX2	18
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The expected advantage of administering prophylactic antibiotics using target‐ concentration controlled infusion: Development of a new pharmacokinetic model of cefazolin	17
ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma	17
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Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin‐resistant sodium currents	17
Connexin 43 participates in atrial electrical remodelling through colocalization with calcium channels in atrial myocytes	17
Weight‐based oxytocin infusion for preventing uterine atony during caesarean delivery in non‐labouring patients: A dose–response study	16

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2	16
Myrtenol complexed with β‐cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine‐induced animal model of Parkinsonism	16
Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice	15
Association between anti‐fibrillin‐2 protein induced retinal degeneration via intravitreous delivery and activated TGF‐β signalling in mice	15
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Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder	15
Correction to “low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner”	15
Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction	14
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Substance P ameliorates TNF‐α‐mediated impairment of human aortic vascular cells in vitro	13
Cardioprotective effects of the proline‐rich oligopeptide Bj‐PRO‐7a in spontaneously hypertensive rats	13
Issue Information	13
EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway	12
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	12
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Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia	12
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue	12
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects	11
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study	11
Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	11
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A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle	11
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Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission	10
Bufalin reduces myocardial infarction‐induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL‐1β signalling pathway	10
Differential effects of inhibitors of PTZ‐induced kindling on glutamate transporters and enzyme expression	10
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling	10
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TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF‐ κB/NLRP3<	9
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Artesunate alleviates psoriasis‐like dermatitis by reducing interleukin‐23 expression in tumor necrosis factor‐alpha‐induced HaCaT cells	9
Angiotensin receptor‐neprilysin inhibitor attenuates cardiac hypertrophy and improves diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction	9
Reinvestigation of the tonic natriuretic action of intrarenal dopamine: comparison of two variants of salt‐dependent hypertension and spontaneously hypertensive rats	9
Thioredoxin‐1 regulates the autophagy induced by oxidative stress through LC3‐II in human lens epithelial cells	9
GSK3β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycaemic subarachnoid haemorrhage rats	8
RETRACTION: Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis	8
A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract	8
Rapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model	8
Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation	8
Erythropoietin hyporesponsiveness in non‐alcoholic fatty liver disease	8
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression	8
Sevoflurane‐induced P300 promotes neuron apoptosis via Sp1/CDK9 pathway	8
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Potential of crocodile blood as a medication and dietary supplement: A systemic review	8
Retraction statement: Zhang K, Wang L, Chen H, Shi Y, Liu Y, Liu J, Hong X, Liu J‐P. Pulmonary alveolar stem cells undergo senescence, apoptosis and differentiation by p53‐dependent and ‐independent m	8
Sex Steroid Control of Serotonergic System: Clinical Implications for Psychiatric Disorders and Addiction Treatment	8
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF	8
Investigation of the effect of ghrelin on bone fracture healing in rats	8
Possible involvement of apoptosis in the antipsychotics side effects: A mini‐review	8
Electroacupuncture Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway	7

The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases	7
Tau and stathmin proteins in breast cancer: A potential therapeutic target	7
Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway	7
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	7
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Therapeutic potential of curcumin in ARDS and COVID‐19	7
Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF‐β1/PI3K/Akt1‐p/mTOR axis in rats	7
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	7
Agomelatine alleviates steroid‐induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats	7
BCR::ABL1‐positive chronic myeloid leukaemia with CALR mutation	7
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	6
Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF‐κB signalling pathway	6
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4⁺ T Cells	6
Issue Information	6
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma	6
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The renal excretory responses to acute renal interstitial angiotensin (1–7) infusion in anaesthetised spontaneously hypertensive rats	6
Comprehensive analysis of EphA2 in pan‐cancer: A prognostic biomarker associated with cancer immunity	6
Issue Information	6
In vitro effects and mathematical modelling of CTCE‐9908 (a chemokine receptor 4 antagonist) on melanoma cell survival	6
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve	6
Inhibition of mTOR by temsirolimus overcomes radio‐resistance in nasopharyngeal carcinoma	6
Thromboxane A₂ receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats	6
Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients	6
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p	6
GLP‐1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy	6
A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway	6
Global, Regional, and National Temporal Trend and Patterns of Change in the Burden of Asthma From 1990 to 2021: An Analysis of the Global Burden of Disease Study 2021	6
ICOS⁺ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis	6
Issue Information	6
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation	6
Propofol attenuates prostate cancer progression by upregulating TRHDE‐AS1 expression, and METTL14 could mediate its m6A modification	6
Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway	5
Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress	5
Growth hormone‐releasing hormone beyond cancer	5
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	5
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Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	5
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Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	5
Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis	5
Issue Information	5
Endothelin System Blockade Extenuates Sepsis‐Induced Acute Heart and Kidney Injuries via Modulating ET‐1/Klotho/p38‐MAPK	5
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Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation	5
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage	5
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Pretreatment with nicotinamide mononucleotide increases the effect of ischaemic postconditioning on cardioprotection and mitochondrial function following ex vivo myocardial reperfusion injury in aged	4
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	4
Electrical modelling of tissue experiments confirms precise locations of resistance and compliance in systemic arterial tree—they are mutually exclusive	4
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	4
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden	4
Palovarotene inhibits the NF‐κB signalling pathway to prevent heterotopic ossification	4
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice	4
Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension	4
Rab35 regulates insulin secretion via phogrin in pancreatic β cells	4
Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review	4
GAB1 alleviates septic lung injury by inhibiting the TLR4/ NF‐κB pathway	4
Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway	4
Disk diffusion‐based method aids in the detection of vanM‐positive Enterococcus faecium with low vancomycin minimum inhibitory concentrations	4
Impact of JAK/STAT inhibitors on human monocyte‐derived‐macrophages stimulated by cigarette smoke extract and lipopolysaccharide	4
Application of 3D computed tomography in emphysematous parenchyma patients scheduled for bronchoscopic lung volume reduction	4
RETRACTED: Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats	4
SMYD2 epigenetically activates MEX3A and suppresses CDX2 in colorectal cancer cells to augment cancer growth	4
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Age dependent effects of Retigabine on absence seizure in WAG/Rij rats; an experimental study	4
Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo	4
Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009–2010	4
Nimodipine reduces delayed cerebral vasospasm after intracranial tumour surgery: A Retrospective Study	4
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid‐β Aggregation in Cardiovascular Disease	4
Cancer‐associated fibroblast‐derived circFARP1 modulates non–small cell lung cancer invasion and metastasis through the circFARP1/miR‐338‐3p/SOX4 axis	4
Research trends in ferroptosis since the origin of the concept: A bibliometric analysis	4
Issue Information	4