OOIR: Observatory of International Research

Papers

(The TQCC of Neuropathology and Applied Neurobiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Intracerebral endotheliitis and microbleeds are neuropathological features of COVID‐19	95
Dysfunction of the blood–brain barrier in Alzheimer's disease: Evidence from human studies	75
Classification of diseases with accumulation of Tau protein	47
Deep learning‐based model for diagnosing Alzheimer's disease and tauopathies	44
Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease	43
Cell senescence in neuropathology: A focus on neurodegeneration and tumours	42
Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis	36
Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo	32
Impaired brain insulin signalling in Parkinson's disease	30
A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC)	29
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer’s patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability	27
Utrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies	26
A systems‐level analysis highlights microglial activation as a modifying factor in common epilepsies	26
Machine learning‐based decision tree classifier for the diagnosis of progressive supranuclear palsy and corticobasal degeneration	23
Robust methylation‐based classification of brain tumours using nanopore sequencing	22
Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review	21
NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature	21
TRAPPC11‐related muscular dystrophy with hypoglycosylation of alpha‐dystroglycan in skeletal muscle and brain	20
The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia	20
Neurodegenerative movement disorders: An epigenetics perspective and promise for the future	20
Expression pattern of perilipins in human brain during aging and in Alzheimer's disease	19
Balloon cells promote immune system activation in focal cortical dysplasia type 2b	19
MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis	19
Non‐coding regulatory elements: Potential roles in disease and the case of epilepsy	18
Neutrophil extracellular traps (NETs) infiltrate haematoma and surrounding brain tissue after intracerebral haemorrhage: A post‐mortem study	18

Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies	18
Olfactory bulb SARS‐CoV‐2 infection is not paralleled by the presence of virus in other central nervous system areas	18
The autophagy‐enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease	17
Arteriolar neuropathology in cerebral microvascular disease	17
DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: A prospective population‐based study	17
Molecular pathophysiology of human MICU1 deficiency	17
Intranuclear inclusions in skin biopsies are not limited to neuronal intranuclear inclusion disease but can also be seen in oculopharyngodistal myopathy	17
HnRNP K mislocalisation in neurons of the dentate nucleus is a novel neuropathological feature of neurodegenerative disease and ageing	16
RAPGEF2 mediates oligomeric Aβ‐induced synaptic loss and cognitive dysfunction in the 3xTg‐AD mouse model of Alzheimer’s disease	16
Concurrent tau pathologies in frontotemporal lobar degeneration with TDP‐43 pathology	16
Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals	16
CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia‐mediated phagocytosis	16
BRAIN UK: Accessing NHS tissue archives for neuroscience research	15
Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency	15
Faster disease progression in Parkinson’s disease with type 2 diabetes is not associated with increased α‐synuclein, tau, amyloid‐β or vascular pathology	15
Tumour‐associated CD204⁺ microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin‐6‐enriched inflammatory profile in glioblastoma	15
A rare case of paediatric astroblastoma with concomitant MN1‐GTSE1 and EWSR1‐PATZ1 gene fusions altering management	14
G protein‐coupled receptor kinases are associated with Alzheimer's disease pathology	14
Neuron types in the primate striatum: Stereological analysis of projection neurons and interneurons in control and parkinsonian monkeys	14
Potent T cell‐mediated anti‐inflammatory role of the selective CB2 agonist lenabasum in multiple sclerosis	14
Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice	14
The blood–CSF–brain route of neurological disease: The indirect pathway into the brain	13
Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment	13
The prognostic significance of clinicopathological features in meningiomas: Microscopic brain invasion can predict patient outcome in otherwise benign meningiomas	13
Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data	12
Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin–proteasome and autophagy–lysosomal system	12
Characterisation of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high‐pressure freezing/freeze‐substitution	12
Old age genetically confirmed frontotemporal lobar degeneration with TDP‐43 has limbic predominant TDP‐43 deposition	12
Emerging roles for the YAP/TAZ transcriptional regulators in brain tumour pathology and targeting options	12
L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism	12
Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types	12
The severity of behavioural symptoms in FTD is linked to the loss of GABRQ‐expressing VENs and pyramidal neurons	11
MOBP and HIP1 in multiple system atrophy: New α‐synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis	11
Seizure activity and brain damage in a model of focal non‐convulsive status epilepticus	11
Capillary pathology with prominent basement membrane reduplication is the hallmark histopathological feature of scleromyositis	11
Pathogenic variants of Valosin‐containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells	11
Heterozygous APOE Christchurch in familial Alzheimer’s disease without mutations in other Mendelian genes	11
AKT1^E17K‐mutated meningioma cell lines respond to treatment with the AKT inhibitor AZD5363	11
Telomeric alterations in the default mode network during the progression of Alzheimer’s disease: Selective vulnerability of the precuneus	11
Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta‐analysis based on a Cochrane systematic review	11
Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration	11
Automated immunofluorescence analysis for sensitive and precise dystrophin quantification in muscle biopsies	10
Alpha adaptins show isoform‐specific association with neurofibrillary tangles in Alzheimer's disease	10
ALK‐rearranged histiocytosis: Report of two cases with involvement of the central nervous system	10
Pathological substrate of memory impairment in multiple system atrophy	10
The contribution of brain banks to knowledge discovery in amyotrophic lateral sclerosis: A systematic review	10
Splicing factor proline and glutamine rich intron retention, reduced expression and aggregate formation are pathological features of amyotrophic lateral sclerosis	10
Cortical morphometric vulnerability to generalised epilepsy reflects chromosome‐ and cell type‐specific transcriptomic signatures	10
The desmin mutation R349P increases contractility and fragility of stem cell‐generated muscle micro‐tissues	9
Prodromal sensory neuropathy in Pink1^−/−SNCA^A53T double mutant Parkinson mice	9

Cauda equina paragangliomas express HOXB13	9
Genetic knockdown of Klk8 has sex‐specific multi‐targeted therapeutic effects on Alzheimer’s pathology in mice	9
Post‐treatment hypermutation in a recurrent diffuse glioma with H3.3 p.G34 Mutation	9
Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation	9
Neuropathology of genetically defined malformations of cortical development—A systematic literature review	9
Cutaneous sensory and autonomic denervation in progressive supranuclear palsy	9
Respiratory chain dysfunction in perifascicular muscle fibres in patients with dermatomyositis is associated with mitochondrial DNA depletion	9
Delineating selective vulnerability of inhibitory interneurons in Alpers' syndrome	9
Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications	8
Treatment with the copper compound CuATSM has no significant effect on motor neuronal pathology in patients with ALS	8
CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy	8
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis	8
Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma	8
Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue	8
Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease	8
Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis	8
Expression, prognostic significance and therapeutic implications of PD‐L1 in gliomas	8
Low‐grade epilepsy‐associated neuroepithelial tumours with a prominent oligodendroglioma‐like component: The diagnostic challenges	8
Rosette‐forming glioneuronal tumours are midline, FGFR1‐mutated tumours	8
Brain TDP‐43 pathology in corticobasal degeneration: Topographical correlation with neuronal loss	8
Gonadotroph tumours with a low SF‐1 labelling index are more likely to recur and are associated with enrichment of the PI3K‐AKT pathway	8
Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics	8
Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model	8