Pain

Article	Citations
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	231
Translational control by general control nonderepressible 2 kinase regulates methylglyoxal-induced pain in mice	145
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	107
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	90
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	82
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	81
On the adverse effects of gabapentinoids	77
The future of pain research: neuromodulation and surgery	75
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	74
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	72
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	70
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	68
Diagnostic accuracy of quantitative sensory testing for detecting small fiber impairment in polyneuropathy and diagnosing small fiber neuropathy	68
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	64
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	64
Improving the art and science of communication in people living with chronic pain	60
Reply to dos Santos Ferreira and Velly	55
Reply to Quintner	49
Association between prescribed opioid dose and risk of motor vehicle crashes	49
Future perspectives: the next fifty years of the International Association for the Study of Pain	46
White matter microstructural associations with pain experiences in a large community sample of youth	46
Reply to Currie et al.	46
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	45
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	43
Autoantibodies in patients with fibromyalgia syndrome	42

Episodic pain in Fabry disease is mediated by a heat shock protein-transient receptor potential cation channel A1 axis	42
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	41
The social nature of human pain	39
Subjective salience ratings are a reliable proxy for physiological measures of arousal	39
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	38
Selective targeting of voltage-gated sodium channels to achieve analgesia: current status and future directions	38
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	38
Sex differences in facial expressions of pain: results from a combined sample	37
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	36
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	36
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	35
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	35
Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides	34
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	34
The contribution of baseline circulating endocannabinoids to individual differences in human pain sensitivity: a quantitative sensory testing study	34
Can we improve patient outcomes through using evidence-based opioid deprescribing guidelines to reduce opioid use?	34
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	34
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system: erratum	33
Dyspareunia: a novel clinical approach for diagnosis based on pain mechanisms	33
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	33
Prevalence and correlates of “undiagnosed pain”—Evidence from the US national Medical Expenditure Panel Survey	33
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus	32
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization	32
Gaining a new footing on molecular mechanisms of neuropathic pain in patients	32
Leveraging technologies to upskill primary care providers in person-centred pain care	31
Astrocytogenic bidirectional plasticity at spinal nociceptive synapses regulates acute nociceptive processing	31
Forward and reverse engineering the pain system: from computational neuroscience to neuro-engineering	31
Reply to Andrassy and Mukhdomi	31
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review	30
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use	30
Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging	30
Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents	29
Editorial Board	29
Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review	28
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain	28
Thermal grill–induced pain: further evidence for its pathophysiological and clinical relevance	28
Social disparities in pain	28
Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses	27
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	27
Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: results from the randomized controlled phase 2a PUCCINI study	27
Incidence of chronic pelvic pain after childbirth and its causal association with C-section	26
The impact of chronic pain on brain gene expression	26
[11C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis	26
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch	26
Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents	26
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	26
How the next 50 years of positron emission tomography can transform our understanding of chronic pain	25
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	25
Social integration of adolescents with chronic pain: a social network analysis	25
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019	25

The biopsychosocial model of pain 40 years on: time for a reappraisal?	25
Open data sharing: what could possibly go wrong?	24
Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming	24
Reply to Chang, Gau, and Jhang	24
Effect modifiers of virtual reality in pain management: a systematic review and meta-regression analysis	24
Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway	24
Microneurographic portrait of 19 patients with small fiber neuropathy: a pilot study	23
Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis: Erratum	23
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion	23
Pain's puzzle pieces: MAGI-1, NaV1.8, degradation, analgesia	23
The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al.	23
Reply to Hoegh et al.	22
Inequities in time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members	22
Pain relief after topical capsaicin: does it result from nociceptor degeneration or regeneration?	22
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance: Erratum	22
Interpretation bias and the transition from acute to chronic pain	22
A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours	22
Beyond the ambiguity of interpretation bias for pain-related information	22
Table of Contents	21
Moving beyond pain intensity as the primary outcome measure: the INTEGRATE pain framework and beyond	21
Dose–response relationship and effect modifier of stabilisation exercises in nonspecific low back pain: a project-wide individual patient data re-analysis on 1483 intervention participants	21
The use of quantitative sensory testing for personalized pain medicine in the age of AI	21
Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module	21
Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank	20
Adding a nonpainful end to reduce pain recollection of Pap smear screening: a randomized controlled trial	20
Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments	20
Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome	20
Effects of commonly used analgesics on sleep architecture: a topical review	20
Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study	20
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates	20
Small nerve fibre pathology in non-neuropathic chronic pain conditions: a systematic review and meta-analysis	20
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience	20
Converging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain	19
Assessing spontaneous sensory neuron activity using in vivo calcium imaging	19
Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain	19
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology	19
Abdominoplasty as an acute postoperative pain model: insights from 8 years of clinical trials	19
The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis	19
Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.	19
Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception	19
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort	19
Cannabis use disorder in patients with chronic pain: overestimation and underestimation in a cross-sectional observational study in 3 German pain management centres	19
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features	19
Informing about side effects: putting patients (preferences) first	18
Unraveling the puzzle of pain in pancreatic diseases	18
Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia: Erratum	18
Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex	18
Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or “something else”: Erratum	18
Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study	18
Reply to Manhapra	18
CD304+ adipose tissue–derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes	18
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain	18
“Belief-based” medicine is not evidence-based medicine	18
Is there really no association between postoperative opioid use and long-term surgical outcomes in patients diagnosed with liver cancer?	18
Upregulation of LncRNA71132 in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	17
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception	17
Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury	17
Leveraging value-based health principles to improve translation and impact of digital psychological interventions for people with chronic pain	17
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain	17
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review	17
Interoception and pain: body–mind integration, rupture, and repair	17
In memoriam: Stephen B. McMahon, PhD, FMedSci December 21, 1954 to October 9, 2021	17
Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing	17
CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2	17
Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia	17
Advances in the analysis of intensive longitudinal pain data: a commentary on Leroux et al.	17
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling	16
Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial	16
Educational disparities in joint pain within and across US states: do macro sociopolitical contexts matter?	16
Chronic pain in the 11th Revision of the International Classification of Diseases: users' questions answered	16
Deep learning–guided postoperative pain assessment in children	16
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain	16
Three dimensions of pain in osteoarthritis: development and validation of the Osteoarthritis Symptom Inventory Scale	16
Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis	16
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine	16
Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone	16
Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders	16
Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans	16
Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials	16
The Canadian version of the National Institutes of Health minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study	16

The associations of opioid and benzodiazepine prescriptions with injuries among US military service members	16
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury	16
Give and take: an evolutionary framework for social transactions in pain	16
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm	16
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropat	16
Standardizing research methods for opioid dose comparison: the NIH HEAL morphine milligram equivalent calculator	15
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome	15
Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic:	15
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings	15
TRPV1 is the burner	15
Reply to Zhang and Pan	15
Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions	15
Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation	15
Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?	15
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain	15
Sympathetic modulation of tumor necrosis factor alpha-induced nociception in the presence of oral squamous cell carcinoma	15
Introduction to the biennial review of pain	14
Body image, sex, gender, and pain: towards an improved understanding of pain mechanisms	14
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain	14
The thermal grill elicits central sensitization	14
Reply to Moulton et al.	14
Reply to Manhapra	14
Reply to Ali	14
Functioning in chronic pain: a call for a global definition	14
Reliability and validity of the Pediatric PainSCAN: a screening tool for pediatric neuropathic pain and complex regional pain syndrome	14
Unlocking the secrets of daily diary data: can we improve our understanding of the reinforcing effects of pain medication?	14
Enhancing healthcare professionals' biopsychosocial perspective to chronic pain: assessing the impact of implementing an interdisciplinary training program	14
Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain in male mice	14
Predictors of response to full agonist opioids in enriched enrollment randomized withdrawal clinical trials: a participant-level data meta-analysis	14
Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis	14
Nociplastic pain—grading the unknown	14
Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes	14
A novel potential strategy for the treatment of inflammatory and neuropathic pain	14
Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain	14
The “External Validity Crisis”: now is the time to address the attack on diversity, equity, and inclusion in pain science	14
Educational initiatives and achievements of the International Association for the Study of Pain	13
Lumbar tactile acuity associated with S1-thalamic functional connectivity and S1 microstructure in patients with low back pain and pain-free controls	13
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies	13
The local molecular signature of human peripheral neuropathic pain	13
Advancing understanding of opioid mortality risks beyond initial findings in noncancer pain patients	13
Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury	13
Reply to Esposto and Cioeta (2023): Clarification regarding classical conditioning and conditioned pain	13
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial	13
Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities	13
Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines	13
Gonadal hormone–dependent nociceptor sensitization maintains nociplastic pain state in female mice	13
A randomized-controlled pilot trial of telemedicine-delivered cognitive-behavioral therapy tailored for interstitial cystitis/bladder pain syndrome	13
Mast cell chymases: essential for preventing the transition from acute to chronic pain	13
The invisible cost of pain management by the current International Classification of Diseases coding system: a study in a tertiary care inpatient setting	13
Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain	13
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury–induced physiological and behavioral maladaptations	13
A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care	13
Patient engagement in pain research: no gain without the people in pain	13
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study	13
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy	13
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity	12
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study	12
Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching	12
Is blue light a red herring in a rodent model of “computer vision syndrome”?	12
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy	12
Reply to Blomqvist and Evrard	12
Intrathecal administration of the Nav1.7 inhibitor PF-05089771 produces rapid and side-effect-free analgesia in mice	12
Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion	12
Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial	12
Do “central sensitization” questionnaires reflect measures of nociceptive sensitization or psychological constructs? A systematic review and meta-analyses	12
Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network	12
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision	12
Editorial Board	12
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter p	12
CaV3.2 calcium channels contribute to trigeminal neuralgia	12
Haves and have-nots: socioeconomic position improves accuracy of machine learning algorithms for predicting high-impact chronic pain	12
Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspeci	12
Selection of corticosteroids for epidural steroid injections	12
Immunotherapy, a new approach for the treatment of human pain	12
Deciphering relationships between stress biomarkers and fibromyalgia syndrome with implications relevant to other chronic pain conditions	12
Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia	12
Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location	12
A catheter-associated urinary tract infection mouse model to study bladder dysfunction and pain	12
A revisit of soreness and acidosis-related pain	11
Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms	11
Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation	11
Can a suggested physical activity paradox explain pain in workers?	11
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations	11
The role of corticolimbic perineuronal nets in mice with chronic neuropathic pain	11
Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms	11
Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study	11
What is known and what is still unknown within chronic musculoskeletal pain? A systematic evidence and gap map	11
Deep learning modelling of structural brain MRI in chronic head and neck pain after mild traumatic brain injury	11
Beyond Ammann's pain classification: multidimensional pain phenotyping and cluster analysis in chronic pancreatitis	11
Effect of prolonged experimental neck pain on exercise-induced hypoalgesia	11
Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice	11
Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell	11
Pain catastrophizing and pain anxiety mediate changes in physical function in a mind–body intervention for adults with traumatic orthopedic injuries	11
Delphi study to explore a new diagnosis for “ineffective” long-term opioid therapy for chronic pain	11
Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care	11