Pain

Article	Citations
Neuronal–immune axis alters pain and sensory afferent damage during dental pulp injury	457
Impact of spinal cord stimulation on sick leave and disability pension in patients with chronic neuropathic pain: a real-world evidence study in Sweden	282
Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty	123
Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis	121
Was it “conditioned” or “suggested” pain? Reply to S. Kang et al.	113
Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice	102
Reply to Venda Nova et al.	94
Autoantibodies in patients with fibromyalgia syndrome	91
Maddalena Opioid Switching Score in patients with cancer pain	90
Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty	81
Association between prescribed opioid dose and risk of motor vehicle crashes	73
Visually evoked pain and its extinction using virtual reality in a patient with complex regional pain syndrome type II	68
Reply to Gholamrezaei and Ashton-James	63
Improving the art and science of communication in people living with chronic pain	56
Beyond social support: in search of psychosocial predictors of chronic postsurgical pain	53
Reply to Riddle	52
Delphi study to explore a new diagnosis for “ineffective” long-term opioid therapy for chronic pain	50
Reconsidering Fordyce's classic article, “Pain and suffering: what is the unit?” to help make our model of chronic pain truly biopsychosocial	50
Cortical function and sensorimotor plasticity are prognostic factors associated with future low back pain after an acute episode: the Understanding persistent Pain Where it ResiDes prospective cohort	49
Encoding of inflammatory hyperalgesia in mouse spinal cord	49
Reply to Currie et al.	46
Comparative differences in musculoskeletal pain consultation and analgesic prescription for people with dementia: a UK-wide matched cohort study	44
External validation and updating of prognostic prediction models for nonrecovery among older adults seeking primary care for back pain	42
Brain-predicted age difference estimated using DeepBrainNet is significantly associated with pain and function—a multi-institutional and multiscanner study	42
Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study	42

Practical nonpharmacologic pain interventions for hospitalized cancer patients	41
Placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease and healthy participants	41
UnCRMPing Nav1.7 to treat trigeminal neuropathic pain	41
Commentary on: A systematic review of self and observer assessment of pain and related functioning in youth with brain-based developmental disabilities	40
In search of conditioned pain: an experimental analysis	39
Neurobiology and long-term impact of bladder-filling pain in humans: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network study	39
The prevalence of persistent post-traumatic headache in adult civilian traumatic brain injury: a systematic review and meta-analysis on the past 14 years	38
Validation of the pediatric version of the Graded Chronic Pain Scale Revised in school-aged children and adolescents	38
The role of evolving concepts and new technologies and approaches in advancing pain research, management, and education since the establishment of the International Association for the Study of Pain	37
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations	37
Fifty years of pain research and clinical advances: highlights and key trends	37
Future perspectives: the next fifty years of the International Association for the Study of Pain	36
Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice	35
Proinflammatory cytokines and their receptors as druggable targets to alleviate pathological pain	35
Cognitive decline over time in patients with chronic pain and headache: how can different outcomes be explained?	35
Diagnosis of neuropathic pain in polyneuropathy: should screening questionnaires be thrown out?	34
Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus–mediated peripheral analgesia	34
Chronic pain conditions and use of analgesics among nursing home patients with dementia	34
A rose by another name? Characteristics that distinguish headache secondary to temporomandibular disorder from headache that is comorbid with temporomandibular disorder	34
Autoantibodies from patients with complex regional pain syndrome induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro	34
Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas	34
Reply to dos Santos Ferreira and Velly	33
Effects of opioid rotation to buprenorphine/naloxone on pain, pain thresholds, pain tolerance, and quality of life in patients with chronic pain and opioid use disorder	32
A synthesis of meta-analyses of mindfulness-based interventions in pain	32
Opioid deprescribing in patients with chronic noncancer pain: a systematic review of international guidelines	31
Reply to Yang and Lu	31
The dynamics of pain avoidance: the exploration–exploitation dilemma	30
Altered pain sensitivity in 5×familial Alzheimer disease mice is associated with dendritic spine loss in anterior cingulate cortex pyramidal neurons	30
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice	30
Barriers and enablers to exercise adherence in people with nonspecific chronic low back pain: a systematic review of qualitative evidence	29
On the adverse effects of gabapentinoids	29
The relationship between traumatic exposure and pain perception in children: the moderating role of posttraumatic symptoms	29
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	29
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	28
Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations	28
Rethinking clinically significant pain: a marker of recovery rather than a warning of injury	28
Tools for assessing labour pain: a comprehensive review of research literature	26
Long-term opioid therapy dose patterns in United States patients	26
Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell–derived sensory neurons	25
Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test	25
Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration	25
Adolescent pain: appraisal of the construct and trajectory prediction-by-symptom between age 12 and 17 years in a Canadian twin birth cohort	25
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	24
Randomized controlled trials of pain treatment: essential research tools, a framework for clinical care	24
Individual differences in conditioned pain modulation are associated with functional connectivity within the descending antinociceptive pathway	24
Stratified health care for low back pain using the STarT Back approach: holy grail or doomed to fail?	24
Under the insula: a commentary on “electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain”	24
Allostasis theory in opioid tolerance	24
Sex differences in chromatin structure within the dorsal root ganglion	24
Strengthening the pain care ecosystem to support equitable, person-centered, high-value musculoskeletal pain care	24

Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	24
Vaporized cannabis extract–induced antinociception in male vs female rats with persistent inflammatory pain	24
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	24
Reply to Huang and Chen	24
Promoting multidisciplinary pain management in low- and middle-income countries—challenges and achievements	24
High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model	23
Gray matter volume of limbic brain structures during the development of chronic back pain: a longitudinal cohort study	23
Noninvasive targeted modulation of pain circuits with focused ultrasonic waves: Erratum	23
Advanced neuroimaging of the trigeminal nerve and the whole brain in trigeminal neuralgia: a systematic review	22
The relationship between sustained hamstring pain and reorganisation of somatosensory representations: a randomised, controlled study	22
Microbiome contributions to pain: a review of the preclinical literature	22
Pain catastrophizing and pain anxiety mediate changes in physical function in a mind–body intervention for adults with traumatic orthopedic injuries	22
Neuroanatomical evidence and a mouse calcitonin gene–related peptide model in line with human functional magnetic resonance imaging data support the involvement of peptidergic Edinger–Westphal nucleus	22
Species-specific differences and the role of Nav1.9 in pain pathophysiology	22
What has brain diffusion magnetic resonance imaging taught us about chronic primary pain: a narrative review	22
The unmet mental health needs of U.S. adults living with chronic pain	22
Effect of prolonged experimental neck pain on exercise-induced hypoalgesia	21
Sex effects in the interaction of acute stress and pain perception	21
Pain is common after sexual assault and posttraumatic arousal/reactivity symptoms mediate the development of new or worsening persistent pain	21
Reply to Quintner	21
Targeted muscle reinnervation prevents and reverses rat pain behaviors after nerve transection	21
The social nature of human pain	21
Development and evaluation of the patient-reported outcomes measurement information system (PROMIS) pediatric pain quality item bank and short form	21
Peoples' beliefs about their chronic hip pain and its care: a systematic review of qualitative studies. “I'm just getting old and breaking down”	21
Membrane potential instabilities in sensory neurons: mechanisms and pathophysiological relevance	21
Refining lidocaine studies for inflammatory arthritis	20
Persistent opioid use after hospital admission due to trauma: a population-based cohort study	20
Reply to Torta and Meyers	20
NaViGating arthritis pain	20
Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography	19
Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala	19
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice	19
Bruxism, temporomandibular disorders, and headache: a narrative review of correlations and causalities	19
Signatures of chronic pain in multiple sclerosis: a machine learning approach to investigate trigeminal neuralgia	19
Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice	19
Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging	19
Microglia senescence is related to neuropathic pain–associated comorbidities in the spared nerve injury model	19
Mortality after concurrent treatment with gabapentin and opioids in older adults with spine diagnoses	19
Pain after cancer: navigating the complexities and embracing psychological insights	19
Partnering with patients in clinical trials of pain treatments: a narrative review	19
Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation	19
Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice	18
Exploring sex differences in alpha brain activity as a potential neuromarker associated with neuropathic pain	18
Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics	18
Disruption of working memory and contralateral delay activity by nociceptive stimuli is modulated by task demands	18
Looking beyond the obvious: the importance of outcomes and outcomes measures in trigeminal neuralgia	18
Whiplash injuries associated with experienced pain and disability can be visualized with [11C]-D-deprenyl positron emission tomography and computed tomography	17
Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn	17
Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities	17
Information is power: a qualitative study exploring the lived experiences of patients with degenerative cervical radiculopathy	17
Reply to Blatt	17
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	17
Transcranial direct current stimulation of 3 cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial	17
Education can reassure people with rotator cuff–related shoulder pain: a 3-arm, randomised, online experiment	17
A prospective long-term follow-up of dorsal root ganglion stimulation for the management of chronic intractable pain	17
Associations between patient-reported functional disability and measures of physical ability in juvenile fibromyalgia	17
The prevalence of chronic pain in young adults: a systematic review and meta-analysis	17
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain	16
Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene–related peptide and amylin-induced pain in mice	16
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	16
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor–dependent itch	16
What is known and what is still unknown within chronic musculoskeletal pain? A systematic evidence and gap map	16
Long-term opioid therapy unsettles us both coming and going	16
Extended reality used in the treatment of phantom limb pain: a multicenter, double-blind, randomized controlled trial	16
Intersectional identity approach to chronic pain disparities using latent class analysis	16
TRPM3-mediated dynamic mitochondrial activity in nerve growth factor–induced latent sensitization of chronic low back pain	16
Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations	16
Nerve pathology and neuropathic pain after whiplash injury: a systematic review and meta-analysis	16
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	16
Neuropathic pain and neurocognitive functioning in children treated for acute lymphoblastic leukemia	16
A proteome signature for acute incisional pain in dorsal root ganglia of mice	15
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	15
Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell	15
Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice	15
Activation of GABAergic neurons in the dorsal raphe nucleus alleviates hyperalgesia induced by ovarian hormone withdrawal	15
Longitudinal study of early adaptation to the coronavirus disease pandemic among youth with chronic pain and their parents: effects of direct exposures and economic stress	15
Sex differences in facial expressions of pain: results from a combined sample	15
Relationship between gait complexity and pain attention in chronic low back pain	15
Do endogenous opioids mediate or fine-tune human pain relief?	15
Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial	15

In memoriam: Joel D. Greenspan 1952 to 2021	15
Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury	14
Chronic pain in patients with inflammatory bowel disease	14
Patient outcomes after opioid dose reduction among patients with chronic opioid therapy	14
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	14
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	14
Differential expression of a brain aging biomarker across discrete chronic pain disorders	14
Time-varying phase synchronization of resting-state functional magnetic resonance imaging reveals a shift toward self-referential processes during sustained pain	14
Towards harmonizing the concepts and definitions of pain in the World Health Organization's Family of International Classifications	14
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	14
The sociocultural context of pediatric pain: an examination of the portrayal of pain in children's popular media	14
Intensive interdisciplinary pain treatment for children and adolescents with chronic noncancer pain: a preregistered systematic review and individual patient data meta-analysis	14
Astrocytes in the rostral ventromedial medulla mediate the analgesic effect of electroacupuncture in a rodent model of chemotherapy-induced peripheral neuropathic pain	14
Treatment effect modifiers for individuals with acute low back pain: secondary analysis of the TARGET trial	14
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	14
Behavioral characterization of G-protein-coupled receptor 160 knockout mice	14
Updated recommendations on measures for clinical trials in pediatric chronic pain: a multiphase approach from the Core Outcomes in Pediatric Persistent Pain (Core-OPPP) Workgroup	14
Eveningness intensifies the association between musculoskeletal pain and health-related quality of life: a Northern Finland Birth Cohort Study 1966	14
Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care	14
Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis	14
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	14
Nociplastic pain: helping to explain disconnect between pain and pathology	14
Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain	14
Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain	14
Habituation to pain: self-report, electroencephalography, and functional magnetic resonance imaging in healthy individuals. A scoping review and future recommendations	13
Activation of TGR5 in the injured nerve site according to a prevention protocol mitigates partial sciatic nerve ligation–induced neuropathic pain by alleviating neuroinflammation	13
Tyrosine kinase type A–specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis	13
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain	13
Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons	13
On the importance of baseline pain intensity and measurement methods	13
Reply to Zhao et al.	13
Immigration background as a risk factor of chronic pain and high-impact chronic pain in children and adolescents living in Spain: differences as a function of age	13
Independent effects of transcranial direct current stimulation and social influence on pain	13
Regression to the mean, heteroscedasticity, and prognostic imbalance in randomized controlled trials: a call for graphical methods	13
Pain management in older adults: facts to consider	13
A global look at RNA splicing in human dorsal root ganglion: ex uno plures	13
Impact of rescue medication in placebo-controlled trials of pharmacotherapy for neuropathic pain and low back pain	13
At my own pace, space, and place: a systematic review of qualitative studies of enablers and barriers to telehealth interventions for people with chronic pain	13
Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer	12
Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of li	12
Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system	12
Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9	12
Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study	12
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	12
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	12
Characteristics of retracted publications related to pain research: a systematic review	12
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse	12
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	12
Biomarkers of stress as mind–body intervention outcomes for chronic pain: an evaluation of constructs and accepted measurement	12
Effect of intraoperative methadone vs other opioids on postoperative outcomes: a meta-analysis of randomized controlled studies	12
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	12
Psychiatric disorders, personality traits, and childhood traumatic events predicting incidence and persistence of chronic pain: results from the CoLaus|PsyCoLaus study	12
Peripheral or central origin of chronic pain? Mu!	12
Discrimination as one of the social plights facing people with pain	12
Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain	12
Neurofilament light chain as a biomarker of axonal damage in sensory neurons and paclitaxel-induced peripheral neuropathy in patients with ovarian cancer	12
Spatial illusion of pain: the influence of nociception on body ownership	11
Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms	11
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system	11
Increased risk of persistent neuropathic pain after traumatic nerve injury and surgery for carriers of a human leukocyte antigen haplotype	11
Reply to Li et al.	11
Reply to Mickle and Sibille	11
Injection of kaolin/carrageenan in the rat knee joint induces progressive experimental knee osteoarthritis	11
Heart rate variability is not suitable as a surrogate marker for pain intensity in patients with chronic pain	11
Preparing the brain for pain: new insights and potential biomarkers	11
Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography	11
Reply to Russo et al.	11
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	11
Preventing a prescription opioid epidemic in Switzerland	11
Race-specific associations: inflammatory mediators and chronic low back pain	11
The value of the International Association for the Study of Pain to career development: perspectives of trainee and early career members	11
Message from the president of the International Association for the Study of Pain	11
Reply to Beaulieu	11
Central sensitization: clinical utility of a physiological concept for the International Statistical Classification of Diseases and Related Health Problems and for nociplastic pain	11
Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study	11
Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis	11
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	11
Taxonomy and pain clinic patients	11
Open-label placebo hypoalgesia: what works for whom under which circumstances	11
Communication and activation in pain to enhance relationships and treat pain with equity (COOPERATE): a randomized clinical trial	11
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	11
Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain	11
Selective androgen receptor modulator microparticle formulation reverses muscle hyperalgesia in a mouse model of widespread muscle pain	11
Reply to Kajiwara et al.	10
Race differences in pain and pain-related risk factors among former professional American-style football players	10
Responsiveness of quantitative sensory testing-derived sensory phenotype to disease-modifying intervention in patients with entrapment neuropathy: a longitudinal study	10
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	10
An alternative perspective on the causes of pain in osteoarthritis of the knee and its persistence after total knee replacement surgery	10
The Mas-related G protein–coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy	10
Predicting placebo analgesia in patients with chronic pain using natural language processing: a preliminary validation study	10
Chronic pain experience through COVID-19: a comparison of reports prior and during the early stages of the pandemic	10
When experience is not enough: learning-based cognitive pain modulation with or without instructions	10
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	10
Sex differences in medical cannabis-related adverse effects? Do not forget the context!	10
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	10