OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Letters is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Extrinsic factors associated with the response to immunotherapy in glioblastoma	328
Editorial Board	300
Ethnic Diversity and Metabolic Variations in Ovarian Cancer Cells: Implications for Personalized Medicine Strategies	253
Versatility of Exosomes for Cancer Therapy	249
Editorial Board	193
ASPH dysregulates cell death and induces chemoresistance in hepatocellular carcinoma	156
Selpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model	148
An emerging aspect of cancer neuroscience: A literature review on chemotherapy-induced peripheral neuropathy	148
Nervous system in colorectal cancer	143
IBI379, a novel B cell maturation antigen/CD3 bispecific T-cell engager, displays high antitumor efficacy in preclinical models of multiple myeloma	134
Bypassing the Tollway; a novel path to TLR4 independent stemness regulation	123
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation	123
Intratumoral injection of mRNA encoding survivin in combination with STAT3 inhibitor stattic enhances antitumor effects	121
CXCL13 promotes intestinal tumorigenesis through the activation of epithelial AKT signaling	117
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2	116
Hypoxia effects on glioblastoma progression through YAP/TAZ pathway regulation	112
KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA	109
Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor	107
ERBB3 targeting: A promising approach to overcoming cancer therapeutic resistance	99
Sphingosine-1 phosphate receptor 1 (S1PR1) expression maintains stemness of acute myeloid leukemia stem cells	96
Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer	95
PROTACs: Novel tools for improving immunotherapy in cancer	94
Osteopontin promotes tumor microenvironment remodeling and therapy resistance	92
Editorial Board	92
Evaluation and preservation of fertility in patients with hematologic malignancies	90

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells	89
Intracellular AGR2 transduces PGE2 stimuli to promote epithelial–mesenchymal transition and metastasis of colorectal cancer	87
Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer	87
CD155 in tumor progression and targeted therapy	86
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling	85
Combination treatment with 17β-estradiol and anti-PD-L1 suppresses MC38 tumor growth by reducing PD-L1 expression and enhancing M1 macrophage population in MC38 colon tumor model	85
Dual mTORC1/2 inhibitor AZD2014 diminishes myeloid-derived suppressor cells accumulation in ovarian cancer and delays tumor growth	84
MDSCs in bone metastasis: Mechanisms and therapeutic potential	83
Targeting p53 for immune modulation: Exploring its functions in tumor immunity and inflammation	82
Cancer-associated fibroblasts in non-small cell lung cancer: Recent advances and future perspectives	80
Metronomic chemotherapy regimens and targeted therapies in non-Hodgkin lymphoma: The best of two worlds	79
Interleukin-17 activates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma	78
The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes	77
CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia	76
Accelerating the clinical translation of CD70-targeted chimeric antigen receptor-based cell therapies in oncology: A comprehensive clinical investigation panorama analysis based on the Trialtrove data	75
METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth	73
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma	73
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy	72
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy	72
Tuning cellular metabolism for cancer virotherapy	72
Clinical development of immuno-oncology therapeutics	71
Targeting LINC01607 sensitizes hepatocellular carcinoma to Lenvatinib via suppressing mitophagy	70
Neoantigen discovery and applications in glioblastoma: An immunotherapy perspective	69
Fatty acids in cancer chemoresistance	67
Ubiquitin-specific peptidase 22 in cancer	66
Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells	64
FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity	64
Understanding the significance of biological clock and its impact on cancer incidence	63
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics	63
Exosomal circ_0030167 derived from BM-MSCs inhibits the invasion, migration, proliferation and stemness of pancreatic cancer cells by sponging miR-338-5p and targeting the Wif1/Wnt8/β-catenin axis	63
The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives	63
TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer	63
Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?	62
A natural compound melatonin enhances the effects of Nimotuzumab via inhibiting EGFR in glioblastoma	62
Tumor-targeted exosomes for delivery of anticancer drugs	62
M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1	62