Molecular Biology Reports

Article	Citations
Codon usage bias	202
Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals	154
Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review	143
Microalgae: therapeutic potentials and applications	130
Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease	124
Silent hypoxia in COVID-19: pathomechanism and possible management strategy	106
A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds	84
Pharmacological and therapeutic applications of Sinapic acid—an updated review	77
Potential therapeutic and pharmacological effects of Wogonin: an updated review	72
Interplay between PI3K/AKT pathway and heart disorders	69
DNA barcoding, an effective tool for species identification: a review	68
Analyzing the regulatory role of heat shock transcription factors in plant heat stress tolerance: a brief appraisal	65
Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds	62
Exogenous phytohormones in the regulation of growth and development of cereals under abiotic stresses	52
Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets	51
Tissue culture-induced DNA methylation in crop plants: a review	51
Niclosamide for Covid-19: bridging the gap	49
Role and relevance of fish cell lines in advanced in vitro research	49
Expatiating the molecular approaches of HMGB1 in diabetes mellitus: Highlighting signalling pathways via RAGE and TLRs	49
ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine	48
An update on vascular calcification and potential therapeutics	47
Molecular mechanisms of physical exercise on depression in the elderly: a systematic review	43
Particle bombardment technology and its applications in plants	42
Psychedelics as an emerging novel intervention in the treatment of substance use disorder: a review	42
Understanding angiogenesis and the role of angiogenic growth factors in the vascularisation of engineered tissues	41

LncRNA as a multifunctional regulator in cancer multi-drug resistance	40
Immune cell metabolism and metabolic reprogramming	40
Genetically modified crop regulations: scope and opportunity using the CRISPR-Cas9 genome editing approach	38
Breast cancer in the era of precision medicine	38
SARS-CoV-2 cell entry beyond the ACE2 receptor	38
The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: a systematic review of human intervention trials	37
Endosomes, lysosomes, and the role of endosomal and lysosomal biogenesis in cancer development	37
Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells	36
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish	36
The deadly cross-talk between Hippo pathway and epithelial–mesenchymal transition (EMT) in cancer	36
The cell cycle, cancer development and therapy	36
Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting	36
Immunotherapy: an alternative promising therapeutic approach against cancers	35
Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis	35
Genome-editing in millets: current knowledge and future perspectives	35
The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells	34
Phosphorus homeostasis: acquisition, sensing, and long-distance signaling in plants	34
Cancer treatment therapies: traditional to modern approaches to combat cancers	33
Antibiotic resistance, biofilm production ability and genetic diversity of carbapenem-resistant Pseudomonas aeruginosa strains isolated from nosocomial infections in southwestern Iran	32
Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy	32
Enteromorpha compressa extract induces anticancer activity through apoptosis and autophagy in oral cancer	32
Gut microbiota-derived metabolites and their importance in neurological disorders	32
CRISPR/Cas9-mediated mutagenesis of WRKY3 and WRKY4 function decreases salt and Me-JA stress tolerance in Arabidopsis thaliana	32
Treg cells in atherosclerosis	31
M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways	31
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder	31
The significance of the SDF-1/CXCR4 signaling pathway in the normal development	31
Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance	31
Differential regulation of the durum wheat Pathogenesis-related protein (PR1) by Calmodulin TdCaM1.3 protein	31
Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms	31
The role of miRNA in plant–virus interaction: a review	30
Nitazoxanide and COVID-19: A review	30
Development and validation of heat-responsive candidate gene and miRNA gene based SSR markers to analysis genetic diversity in wheat for heat tolerance breeding	30
Recent advances in the application of probiotic yeasts, particularly Saccharomyces, as an adjuvant therapy in the management of cancer with focus on colorectal cancer	29
Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway	29
Fatty acid desaturases (FADs) modulate multiple lipid metabolism pathways to improve plant resistance	29
Evaluation of oxidative stress, inflammation, apoptosis, oxidative DNA damage and metalloproteinases in the lungs of rats treated with cadmium and carvacrol	28
GRAS transcription factors emerging regulator in plants growth, development, and multiple stresses	28
Unfolding Nrf2 in diabetes mellitus	28
Osteoblast role in the pathogenesis of rheumatoid arthritis	28
Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions	28
Biomarkers of liver diseases	27
Advances in the regulation of plant salt-stress tolerance by miRNA	27
The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine	27
NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer	27
Integrating speed breeding with artificial intelligence for developing climate-smart crops	27
Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway	27
Genome sequence analysis provides insights on genomic variation and late blight resistance genes in potato somatic hybrid (parents and progeny)	27
Molecular characterization and genetic diversity studies of Indian soybean (Glycine max (L.) Merr.) cultivars using SSR markers	27
Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12	26

RNA sequencing and its applications in cancer and rare diseases	26
Improving Zinc and Iron Biofortification in Wheat through Genomics Approaches	26
Signals in systemic acquired resistance of plants against microbial pathogens	26
Trehalose: a promising osmo-protectant against salinity stress—physiological and molecular mechanisms and future prospective	26
Impact of heat stress responsive factors on growth and physiology of cotton (Gossypium hirsutum L.)	26
Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response	26
Urinary exosomal microRNA-96-5p and microRNA-183-5p expression as potential biomarkers of bladder cancer	26
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis	25
Pathological mechanism of joint destruction in haemophilic arthropathy	25
Acute lymphoid leukemia etiopathogenesis	25
SARS-COV-2 infection and lung tumor microenvironment	25
Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages	25
TGF-β promote epithelial-mesenchymal transition via NF‐κB/NOX4/ROS signal pathway in lung cancer cells	25
Anticancer activity of monoterpenes: a systematic review	25
N-glycosylation, a leading role in viral infection and immunity development	25
The role of hypoxia on prostate cancer progression and metastasis	24
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions	24
Argonaute proteins: structures and their endonuclease activity	24
The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines	24
CRISPR-Cas9 based stress tolerance: New hope for abiotic stress tolerance in chickpea (Cicer arietinum)	24
Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions	24
GDM-complicated pregnancies: focus on adipokines	24
Development of EST-SSR markers for genetic diversity analysis in coconut (Cocos nucifera L.)	24
Natural polyphenols: a promising bioactive compounds for skin care and cosmetics	24
Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics	24
Aging and its treatment with vitamin C: a comprehensive mechanistic review	24
Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors	23
Deciphering the genetic diversity and population structure of Turkish bread wheat germplasm using iPBS-retrotransposons markers	23
Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway	23
Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer	23
Mechanism of tumour microenvironment in the progression and development of oral cancer	23
miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells	23
MicroRNA-424-5p enhances chemosensitivity of breast cancer cells to Taxol and regulates cell cycle, apoptosis, and proliferation	23
Cross-talk between non-coding RNAs and PI3K/AKT/mTOR pathway in colorectal cancer	22
Carcinogenic effects of heavy metals by inducing dysregulation of microRNAs: A review	22
Blocking TNF signaling may save lives in COVID-19 infection	22
Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury	22
Insights into the antitumor mechanism of ginsenosides Rg3	22
Mass propagation through direct and indirect organogenesis in three species of genus Zephyranthes and ploidy assessment of regenerants through flow cytometry	22
Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq	22
Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson’s disease: an overview and update on new developments	22
siRNA-mediated silencing of CD44 delivered by Jet Pei enhanced Doxorubicin chemo sensitivity and altered miRNA expression in human breast cancer cell line (MDA-MB468)	21
Lipoic acid. Kinetics and pluripotent biological properties and derivatives	21
Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis	21
Evaluation of genetic diversity by morphological, biochemical and molecular markers in sour cherry genotypes	21
Therapeutic potential of Nrf-2 pathway in the treatment of diabetic neuropathy and nephropathy	21
Methanolic extract of Artemisia absinthium prompts apoptosis, enhancing expression of Bax/Bcl-2 ratio, cell cycle arrest, caspase-3 activation and mitochondrial membrane potential destruction in human	21
Unsaturated fatty acids as a co-therapeutic agents in cancer treatment	21
Genetic relationships and diversity analysis in Turkish laurel (Laurus nobilis L.) germplasm using ISSR and SCoT markers	21
Potential in vitro therapeutic effects of targeting SP/NK1R system in cervical cancer	21
Heat shock proteins with an emphasis on HSP 60	21
Neuroprotection with Bacopa monnieri–A review of experimental evidence	21
Apolipoprotein C-III and cardiovascular diseases: when genetics meet molecular pathologies	21
Long non-coding RNAs: an overview on miRNA sponging and its co-regulation in lung cancer	20
Circulating levels of asprosin and its association with insulin resistance and renal function in patients with type 2 diabetes mellitus and diabetic nephropathy	20
Kaempferol suppresses androgen-dependent and androgen-independent prostate cancer by regulating Ki67 expression	20
16S rRNA gene profiling of rhizospheric microbial community of Eichhornia crassipes	20
Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish	20
Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective	20
Bioprocesses optimization and anticancer activity of camptothecin from Aspergillus flavus, an endophyte of in vitro cultured Astragalus fruticosus	20
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis	20
Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches	20
Corticosteroids for COVID-19: worth it or not?	20
An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer	20
Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases	20
Modulation of autophagy as the target of mesenchymal stem cells-derived conditioned medium in rat model of myocardial ischemia/reperfusion injury	19
CRISPR-Cas technology based genome editing for modification of salinity stress tolerance responses in rice (Oryza sativa L.)	19
Research progress of whole-cell-SELEX selection and the application of cell-targeting aptamer	19
Resistance to endocrine therapy in HR + and/or HER2 + breast cancer: the most promising predictive biomarkers	19
Therapeutic potential of neurotrophic factors in Alzheimer’s Disease	19
COVID-19-associated-mucormycosis: possible role of free iron uptake and immunosuppression	19
Long non-coding RNA-based glycolysis-targeted cancer therapy: feasibility, progression and limitations	19
Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease	19
The role of ferroptosis in neurodegenerative diseases	19
Role of metformin in inflammation	19
Genome-wide identification and expression analysis of metal tolerance protein (MTP) gene family in soybean (Glycine max) under heavy metal stress	19
Renal proximal tubular epithelial cells: review of isolation, characterization, and culturing techniques	19
Prevalence of resistance genes to biocides in antibiotic-resistant Pseudomonas aeruginosa clinical isolates	19
Utilization of genetic diversity and marker-trait to improve drought tolerance in rice (Oryza sativa L.)	19
Aberrant expression of miRNAs in epilepsy	19

35S promoter-driven transgenes are variably expressed in different organs of Arabidopsis thaliana and in response to abiotic stress	19
Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells	19
Pro-inflammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced inflammation demonstrated in an in-vivo zebrafish larval model	18
Latent tuberculosis: interaction of virulence factors in Mycobacterium tuberculosis	18
New diagnostic molecular markers and biomarkers in odontogenic tumors	18
Osteoporosis and cardiovascular disease: a review	18
Necroptosis and RhoA/ROCK pathways: molecular targets of Nesfatin-1 in cardioprotection against myocardial ischemia/reperfusion injury in a rat model	18
Fabrication and evaluation of aptamer-conjugated paclitaxel-loaded magnetic nanoparticles for targeted therapy on breast cancer cells	18
FOXM1 mediates GDF-15 dependent stemness and intrinsic drug resistance in breast cancer	18
CRISPR/Cas9 is a powerful tool for precise genome editing of legume crops: a review	18
Neutralizing antibody: a savior in the Covid-19 disease	18
Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary results	18
Role of Sp1 in atherosclerosis	18
Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis	18
Occurrence of Cotton leaf curl Multan virus and associated betasatellites with leaf curl disease of Bhut-Jolokia chillies (Capsicum chinense Jacq.) in India	18
Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats	18
Selection and evaluation of reference genes for qRT-PCR of Scutellaria baicalensis Georgi under different experimental conditions	18
Nanosized paclitaxel-loaded niosomes: formulation, in vitro cytotoxicity, and apoptosis gene expression in breast cancer cell lines	18
Potentiation of Folate-Functionalized PLGA-PEG nanoparticles loaded with metformin for the treatment of breast Cancer: possible clinical application	18
MYB transcription factors and their role in Medicinal plants	18
Role of ZBTB7A zinc finger in tumorigenesis and metastasis	18
A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases	18
Presentation of a new mutation in FMF and evaluating the frequency of distribution of the MEFV gene mutation in our region with clinical findings	18
Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice	18
Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus	18
Resolving the equation between mucormycosis and COVID-19 disease	17
CRISPR/Cas9 system: a reliable and facile genome editing tool in modern biology	17
Zebrafish an experimental model of Huntington’s disease: molecular aspects, therapeutic targets and current challenges	17
Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro	17
Trends in extracellular matrix biology	17
Origanum vulgare essential oil: antibacterial activities and synergistic effect with polymyxin B against multidrug-resistant Acinetobacter baumannii	17
Prospects of advanced metagenomics and meta-omics in the investigation of phytomicrobiome to forecast beneficial and pathogenic response	17
A review on EBV encoded and EBV-induced host microRNAs expression profile in different lymphoma types	17
Expression of a Pennisetum glaucum gene DREB2A confers enhanced heat, drought and salinity tolerance in transgenic Arabidopsis	17
Early growth response 1 (EGR1) activation in initial stages of host–pathogen interactions	17
Synaptic plasticity and depression: the role of miRNAs dysregulation	17
Recent advances of the biological and biomedical applications of CRISPR/Cas systems	17
Neurospheres: a potential in vitro model for the study of central nervous system disorders	17
Analysis of genetic diversity among common bean germplasm by start codon targeted (SCoT) markers	17
Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma	17
Novel insights into the pathological mechanisms of metabolic related dyslipidemia	17
mTOR-Rictor-EGFR axis in oncogenesis and diagnosis of glioblastoma multiforme	17
An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model	17
Bisphenol S leads to cytotoxicity-induced antioxidant responses and oxidative stress in isolated rainbow trout (Oncorhyncus mykiss) hepatocytes	16
Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms	16
Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms	16
Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway	16
BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion	16
Assessment of genetic stability on in vitro and ex vitro plants of Ficus carica var. black jack using ISSR and DAMD markers	16
Identifying fish eggs and larvae: from classic methodologies to DNA metabarcoding	16
Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride	16
Metabolite fingerprinting, in vitro antimicrobial and antioxidant activities and in-silico docking in Alloteropsis cimicina and its endophytic fungus Penicillium pinophilum	16
Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs	16
Christia vespertilionis extract induced antiproliferation and apoptosis in breast cancer (MCF7) cells	16
HSPA6 and its role in cancers and other diseases	16
Identification and functional prediction of long non-coding RNAs of rice (Oryza sativa L.) at reproductive stage under salinity stress	16
A systematic review about biological control of phytopathogenic Phytophthora cinnamomi	16
Differentially expressed miR-20, miR-21, miR-100, miR-125a and miR-146a as a potential biomarker for prostate cancer	16
The potential role of miR-124-3p in tumorigenesis and other related diseases	16
Quercetin potentiates the chemosensitivity of MCF-7 breast cancer cells to 5-fluorouracil	16
Prognostic significance of CHAC1 expression in breast cancer	16
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal	16
Repairing plasma membrane damage in regulated necrotic cell death	16
Mesenchymal glioblastoma-induced mature de-novo vessel formation of vascular endothelial cells in a microfluidic device	16
Molecular mechanisms involved in the prevention and reversal of ketamine-induced schizophrenia-like behavior by rutin: the role of glutamic acid decarboxylase isoform-67, cholinergic, Nox-2-oxidative	16
The role of TRPV channels in osteoporosis	16
The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases	16
The role of GLUT2 in glucose metabolism in multiple organs and tissues	16
Synthetic β-hydroxy ketone derivative inhibits cholinesterases, rescues oxidative stress and ameliorates cognitive deficits in 5XFAD mice model of AD	16
Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer	16
Association of differentially expressed R-gene candidates with leaf spot resistance in peanut (Arachis hypogaea L.)	15
PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway	15
Curcumin sensitizes carboplatin treatment in triple negative breast cancer through reactive oxygen species induced DNA repair pathway	15
Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities	15
Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach	15
DNA repair pathways and their roles in drug resistance for lung adenocarcinoma	15
Pathogenesis of the inflammatory bowel disease in context of SARS-COV-2 infection	15
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling	15
WRKY transcription factors: a promising way to deal with arsenic stress in rice	15
The role of miRNA-377 as a tumor suppressor in lung cancer by negative regulation of genes belonging to ErbB signaling pathway	15
Identification of a consensus DNA-binding site for the TCP domain transcription factor TCP2 and its important roles in the growth and development of Arabidopsis	15
Genome survey sequencing and genetic diversity of cultivated Akebia trifoliata assessed via phenotypes and SSR markers	15
MiR-196: emerging of a new potential therapeutic target and biomarker in colorectal cancer	15
Thymol has anticancer effects in U-87 human malignant glioblastoma cells	15
Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer	15
The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae	15
Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats	15
A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes	15
High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts	15
GWAS to spot candidate genes associated with grain quality traits in diverse rice accessions of North East India	15
The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer	15
How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?	15
Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway	15
Comparative transcriptome analyses reveal genes related to pigmentation in the petals of a flower color variation cultivar of Rhododendron obtusum	15
Characterization of the gut microbiota in patients with primary sclerosing cholangitis compared to inflammatory bowel disease and healthy controls	15