Biochimie

Article	Citations
The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2	211
The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response	103
Role of AMPK mediated pathways in autophagy and aging	101
May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?	98
Eicosapentaenoic and docosahexaenoic acid derived specialised pro-resolving mediators: Concentrations in humans and the effects of age, sex, disease and increased omega-3 fatty acid intake	93
Current perspectives for microbial lipases from extremophiles and metagenomics	77
Human health benefits of very-long-chain polyunsaturated fatty acids from microalgae	68
In silico molecular docking in DNA aptamer development	67
Vimentin: Regulation and pathogenesis	60
Reactive oxygen and nitrogen species and innate immune response	56
Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein	55
Jejunum: The understudied meeting place of dietary lipids and the microbiota	48
Stroke treatment: Is exosome therapy superior to stem cell therapy?	44
Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines	39
Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?	38
Biochemical properties, nutritional values, health benefits and sustainability of palm oil	38
Role of Nrf2 and mitochondria in cancer stem cells; in carcinogenesis, tumor progression, and chemoresistance	37
Inhibition of interleukin-2-inducible T-cell kinase causes reduction in imiquimod-induced psoriasiform inflammation through reduction of Th17 cells and enhancement of Treg cells in mice	36
Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways	36
Mesenchymal stem cells: Biological characteristics and application in disease therapy	35
Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection	35
Role of pyroptosis in cancer cells and clinical applications	34
Role of tryptophan metabolism in cancers and therapeutic implications	34
BAP31: Physiological functions and roles in disease	34
Therapeutic applications of mitochondrial transplantation	33

Functional effects of protein variants	33
The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms	31
Diabetes mellitus and melatonin: Where are we?	30
Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells	29
DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand	29
Advances in characterization of SIRT3 deacetylation targets in mitochondrial function	28
A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation	28
Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action	28
Biotechnology tools and applications for development of oilseed crops with healthy vegetable oils	27
Bis(monoacylglycero)phosphate, a new lipid signature of endosome-derived extracellular vesicles	27
LncRNA ZFAS1 inhibits triple-negative breast cancer by targeting STAT3	27
Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors	27
Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible?	26
Membrane heist: Coronavirus host membrane remodeling during replication	26
PCR enhancers: Types, mechanisms, and applications in long-range PCR	26
Osteoporosis: A role for lipids	26
Adipokines from white adipose tissue in regulation of whole body energy homeostasis	26
The chemical composition and lipid profile of the chub mackerel (Scomber colias) show a strong seasonal dependence: Contribution to a nutritional evaluation	25
High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification	25
Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters	24
Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases	24
Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence	24
Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy	23
Bis(monoacylglycero)phosphate, an important actor in the host endocytic machinery hijacked by SARS-CoV-2 and related viruses	23
The impact of endocrine disrupting compounds and carcinogens in wastewater: Implications for breast cancer	23
Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression	23
The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway	22
KDM6B (JMJD3) and its dual role in cancer	22
Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer	22
Na/K-ATPase: Their role in cell adhesion and migration in cancer	22
Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases	21
A novel anionic cathelicidin lacking direct antimicrobial activity but with potent anti-inflammatory and wound healing activities from the salamander Tylototriton kweichowensis	21
Bacillus thuringiensis: From biopesticides to anticancer agents	21
Plant lectin: A promising future anti-tumor drug	21
Nuclear transformation of Chlamydomonas reinhardtii: A review	19
Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation	19
Dbr1 functions in mRNA processing, intron turnover and human diseases	19
Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity	19
The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications	19
Beyond amyloid proteins: Thioflavin T in nucleic acid recognition	19
Adipokines in obesity and metabolic-related-diseases	19
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?	19
HIV-1 Tat: An update on transcriptional and non-transcriptional functions	18
Plasmodium’s journey through the Anopheles mosquito: A comprehensive review	18
Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential	18
EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus	17
Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs	17
Involvement of aquaglyceroporins in energy metabolism in health and disease	17
Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9	17
Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis	17

Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs	17
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies	17
Prolidase – A protein with many faces	17
Proteomics analysis of Cyclobalanopsis gilva provides new insights of low seed germination	17
Single and consecutive application of near-infrared and green irradiation modulates adipose derived stem cell proliferation and affect differentiation factors	16
Stability and context of intercalated motifs (i-motifs) for biological applications	16
Extracellular vesicles of MSCs and cardiomyoblasts are vehicles for lipid mediators	16
Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment	16
Contribution of Apaf-1 to the pathogenesis of cancer and neurodegenerative diseases	16
ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation	16
Biomembrane lipids: When physics and chemistry join to shape biological activity	16
Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA	15
Tanshinone IIA exerts autophagic cell death through down-regulation of β-catenin in renal cell carcinoma cells	15
Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors	15
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy	15
Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status	15
trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats	15
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme	15
G-quadruplex motifs are functionally conserved in cis-regulatory regions of pathogenic bacteria: An in-silico evaluation	15
Cellular and molecular modification of egg envelope hardening in fertilization	15
Novel G-quadruplex prone sequences emerge in the complete assembly of the human X chromosome	15
Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase	15
Role of mitochondrial calcium in hypochlorite induced oxidative damage of cells	15
Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein	14
Adipose-derived stem/stromal cell secretome modulates breast cancer cell proliferation and differentiation state towards aggressiveness	14
The diversity of lipocalin receptors	14
α-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy	14
The role of G-Quadruplex DNA in Paraspeckle formation in cancer	14
Lipidomic analysis of human corneal epithelial cells exposed to ocular irritants highlights the role of phospholipid and sphingolipid metabolisms in detergent toxicity mechanisms	14
The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells	14
Intestinal interplay of quorum sensing molecules and human receptors	14
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2	14
Regulation of mitochondrial function by forkhead transcription factors	14
Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications	14
EPHA2 antisense RNA modulates EPHA2 mRNA levels in basal-like/triple-negative breast cancer cells	14
Non-B DNA structures as a booster of genome instability	13
High salt diet contributes to hypertension by weakening the medullary tricarboxylic acid cycle and antioxidant system in Dahl salt-sensitive rats	13
Histone code reader SPIN1 is a promising target of cancer therapy	13
Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis	13
Exosomal lipids from membrane organization to biomarkers: Focus on an endolysosomal-specific lipid	13
Stabilization of a DNA aptamer by ligand binding	12
Production, characteristics and applications of microbial heparinases	12
Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency	12
Inhibition of LPAR6 overcomes sorafenib resistance by switching glycolysis into oxidative phosphorylation in hepatocellular carcinoma	12
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase	12
Biochemical aspects of hemoglobin-xenobiotic interactions and their implications in drug discovery	12
The role of melatonin in bone regeneration: A review of involved signaling pathways	12
Coronaviruses, cholesterol and statins: Involvement and application for Covid-19	12
Serotonergic drugs modulate the phase behavior of complex lipid bilayers	12
Oleochemistry potential from Brazil northeastern exotic plants	12
Human sperm functioning is related to the aquaporin-mediated water and hydrogen peroxide transport regulation	12
The structural and molecular biology of type IV galactosemia	12
Musculoskeletal regeneration: A zebrafish perspective	11
Structure and activation mechanism of the human liver-type glutaminase GLS2	11
Novel activity of human BChE: Lipid hydrolysis	11
Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells	11
Zinc binding loop mutations of hSOD1 promote amyloid fibrils under physiological conditions: Implications for initiation of amyotrophic lateral sclerosis	11
Aquaporins with lactate/lactic acid permeability at physiological pH conditions	11
A two-quartet G-quadruplex topology of human KIT2 is conformationally selected by a perylene derivative	11
Evaluating the role of nitric oxide in myogenesis in vitro	11
Skatole: A thin red line between its benefits and toxicity	11
Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B	11
The stimulation of succinate-fueled respiration of rat liver mitochondria in state 4 by α,ω-hexadecanedioic acid without induction of proton conductivity of the inner membrane. Intrinsic uncoupling of	11
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2	11
A regenerative approach to the pharmacological management of hard-to-heal wounds	11
Mitochondrial peptide Mtln contributes to oxidative metabolism in mice	11
Relaxin in hepatic fibrosis: What is known and where to head?	11
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy [Biochimie 200 (2022) 44–59]	11
Mig6 not only inhibits EGFR and HER2 but also targets HER3 and HER4 in a differential specificity: Implications for targeted esophageal cancer therapy	11
Free advanced glycation end product distribution in blood components and the effect of genetic polymorphisms	11
Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation	11
Functional roles of human Up-frameshift suppressor 3 (UPF3) proteins: From nonsense-mediated mRNA decay to neurodevelopmental disorders	10
Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX	10
TRPP2 ion channels: The roles in various subcellular locations	10
Fatty acid binding protein 7 mediates linoleic acid-induced cell death in triple negative breast cancer cells by modulating 13-HODE	10
Intraspecific venom variation of Mexican West Coast Rattlesnakes (Crotalus basiliscus) and its implications for antivenom production	10
Structural and thermodynamic analyses of human TMED1 (p24γ1) Golgi dynamics	10
Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups	10
Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease	10
Guidelines for G-quadruplexes: I. In vitro characterization	10

Biochemical, pharmacological and structural characterization of BmooMP-I, a new P–I metalloproteinase from Bothrops moojeni venom	10
Skin aquaporins as druggable targets: Promoting health by addressing the disease	10
Glucose deprivation using 2-deoxyglucose and acarbose induce metabolic oxidative stress and apoptosis in female mice bearing breast cancer	10
Molecular and cellular mechanisms of melatonin in breast cancer	10
Pigment epithelium-derived factor and its role in microvascular-related diseases	10
Transcriptional regulation of alcohol induced liver fibrosis in a translational porcine hepatocellular carcinoma model	10
The enzymes in COVID-19: A review	10
Structural considerations on lipoxygenase function, inhibition and crosstalk with nitric oxide pathways	10
Metal effect on intein splicing: A review	10
Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity	10
Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids	10
Phylogenetics and biochemistry elucidate the evolutionary link between l-malate and l-lactate dehydrogenases and disclose an intermediate group of sequences with mix functional properties	9
Mutations in the coordination spheres of T1 Cu affect Cu2+-activation of the laccase from Thermus thermophilus	9
Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions	9
Humanizing plant-derived snakins and their encrypted antimicrobial peptides	9
Aquaporins implicated in the cell proliferation and the signaling pathways of cell stemness	9
Phospholipase A2, a nonnegligible enzyme superfamily in gastrointestinal diseases	9
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain	9
Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation	9
Thiolatocobalamins repair the activity of pathogenic variants of the human cobalamin processing enzyme CblC	9
Shift in phospholipid and fatty acid contents accompanies brain myelination	9
Heart and kidney H2S production is reduced in hypertensive and older rats	9
Elucidating carbohydrate metabolism in Euglena gracilis: Reverse genetics-based evaluation of genes coding for enzymes linked to paramylon accumulation	9
AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes	9
Imbalance between alpha-1-antitrypsin and interleukin 6 is associated with in-hospital mortality and thrombosis during COVID-19	9
CRISPR/Cas gene-editing technology and its advances in dentistry	9
Exosomes derived from mesenchymal stem cells: A promising cell-free therapeutic tool for cutaneous wound healing	9
Binding of SARS-CoV-2 protein ORF9b to mitochondrial translocase TOM70 prevents its interaction with chaperone HSP90	9
Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application	9
DHEA-pretreatment attenuates oxidative stress in kidney-cortex and liver of diabetic rabbits and delays development of the disease	8
X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma	8
3-aminobenzamide protects against colitis associated diabetes mellitus in male BALB/c mice: Role of PARP-1, NLRP3, SIRT-1, AMPK	8
Recent progress in leptin signaling from a structural perspective and its implications for diseases	8
Grapevine aquaporins: Diversity, cellular functions, and ecophysiological perspectives	8
Neuroprotective effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline mediated via regulation of antioxidant system and inhibition of inflammation and apoptosis in a rat model of cerebral ischemia/	8
Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes	8
In-solution structural studies involving a phospholipase A2-like myotoxin and a natural inhibitor: Plasticity of oligomeric assembly affects mechanisms of inhibition	8
What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?	8
What happens when the mitochondrial H+-translocating F1FO-ATP(hydrol)ase becomes a molecular target of calcium? The pore opens	8
Biological evaluation and spectral characterization of a novel tetracenomycin X congener	8
Travel light: Essential packing for membrane proteins with an active lifestyle	8
Cancer stem cell-derived exosome-induced metastatic cancer: An orchestra within the tumor microenvironment	8
Lactic acid fermentation: A maladaptive mechanism and an evolutionary throwback boosting cancer drug resistance	8
NMS-873 functions as a dual inhibitor of mitochondrial oxidative phosphorylation	8
Lactose-binding lectin from Vatairea macrocarpa seeds induces in vivo angiogenesis via VEGF and TNF-ɑ expression and modulates in vitro doxorubicin-induced genotoxicity	8
Cytotoxic effects of aptamer-doxorubicin conjugates in an ovarian cancer cell line	8
Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle	8
Anticancer activity of D-LAK-120A, an antimicrobial peptide, in non-small cell lung cancer (NSCLC)	8
Crystal structure of Dictyoglomus thermophilum β-d-xylosidase DtXyl unravels the structural determinants for efficient notoginsenoside R1 hydrolysis	8
Fractionating stem cells secretome for Parkinson's disease modeling: Is it the whole better than the sum of its parts?	8
Functions of long non-coding RNA ROR in patient-derived glioblastoma cells	8
Daidzein-directed methionine γ-lyase in enzyme prodrug therapy against breast cancer	8
Site-directed mutations reflecting functional and structural properties of Ec-NhaA	7
Mechanistic physicochemical insights into glycation and drug binding by serum albumin: Implications in diabetic conditions	7
The digestion of diacylglycerol isomers by gastric and pancreatic lipases and its impact on the metabolic pathways for TAG re-synthesis in enterocytes	7
The biochemical association between R157H mutation in human αB-crystallin and development of cardiomyopathy: Structural and functional analyses of the mutant protein	7
Delta or Omega? Δ12 (ω6) fatty acid desaturases count 3C after the pre-existing double bond	7
Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib	7
Glutathione is required for growth and cadmium tolerance in the amphibian chytrid fungus, Batrachochytrium dendrobatidis	7
Gene cluster from plant to microbes: Their role in genome architecture, organism's development, specialized metabolism and drug discovery	7
Following tyrothricin peptide production by Brevibacillus parabrevis with electrospray mass spectrometry	7
The NRSF/REST transcription factor in hallmarks of cancer: From molecular mechanisms to clinical relevance	7
Analysis of the mechanisms of action of isopentenyl caffeate against Leishmania	7
CRISPR/Cas9-mediated knock-out of AGXT1 in HepG2 cells as a new in vitro model of Primary Hyperoxaluria Type 1	7
The hide-and-seek game of the oncogenic Epstein-Barr virus-encoded EBNA1 protein with the immune system: An RNA G-quadruplex tale	7
p53 knock-down and hypoxia affects glutathione peroxidase 4 antioxidant response in hepatopancreas of the white shrimp Litopenaeus vannamei	7
CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion	7
Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions	7
Cassava (Manihot esculenta) defensins: Prospection, structural analysis and tissue-specific expression under biotic/abiotic stresses	7
The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice	7
Multimodal plasma metabolomics and lipidomics in elucidating metabolic perturbations in tuberculosis patients with concurrent type 2 diabetes	7
Recent advances in the use of legume lectins for the diagnosis and treatment of breast cancer	7
The potential of antifungal peptide Sesquin as natural food preservative	7
Molecular basis of melatonin protective effects in metastasis: A novel target of melatonin	7
Impact of protein dynamics on secondary structure prediction	7
SNAIL Transctiption factor in prostate cancer cells promotes neurite outgrowth	7
Crystal structure of SFPQ-NONO heterodimer	7
Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism	7
LEAP2 is a more conserved ligand than ghrelin for fish GHSRs	7
Unveiling the biodiversity of lipid species in Corynebacteria- characterization of the uncommon lipid families in C. glutamicum and pathogen C. striatum by mass spectrometry	7
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines	7