Biochimie

Article	Citations
The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2	162
Renin-angiotensin system at the heart of COVID-19 pandemic	99
The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response	96
May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?	92
Eicosapentaenoic and docosahexaenoic acid derived specialised pro-resolving mediators: Concentrations in humans and the effects of age, sex, disease and increased omega-3 fatty acid intake	84
Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall	76
Antibody stability: A key to performance - Analysis, influences and improvement	74
Synthetic antimicrobial peptides: From choice of the best sequences to action mechanisms	71
Current perspectives for microbial lipases from extremophiles and metagenomics	69
Role of AMPK mediated pathways in autophagy and aging	67
SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention	58
Human health benefits of very-long-chain polyunsaturated fatty acids from microalgae	54
Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein	52
In silico molecular docking in DNA aptamer development	51
The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders	51
Vimentin: Regulation and pathogenesis	50
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing	49
Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway	47
Reactive oxygen and nitrogen species and innate immune response	45
Stroke treatment: Is exosome therapy superior to stem cell therapy?	42
Jejunum: The understudied meeting place of dietary lipids and the microbiota	41
Bacteria and bacterial anticancer agents as a promising alternative for cancer therapeutics	37
Protein promiscuity in drug discovery, drug-repurposing and antibiotic resistance	35
Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines	35
Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?	34

Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection	33
Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways	32
Role of Nrf2 and mitochondria in cancer stem cells; in carcinogenesis, tumor progression, and chemoresistance	32
Inhibition of interleukin-2-inducible T-cell kinase causes reduction in imiquimod-induced psoriasiform inflammation through reduction of Th17 cells and enhancement of Treg cells in mice	31
Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases	31
Mesenchymal stem cells: Biological characteristics and application in disease therapy	31
Role of pyroptosis in cancer cells and clinical applications	30
Role of tryptophan metabolism in cancers and therapeutic implications	30
The complex interplay between DNA methylation and miRNAs in gene expression regulation	29
Functional effects of protein variants	29
Biomedical applications of microbial phenylalanine ammonia lyase: Current status and future prospects	28
Biochemical properties, nutritional values, health benefits and sustainability of palm oil	28
Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells	26
Epigenetically silenced LINC02381 functions as a tumor suppressor by regulating PI3K-Akt signaling pathway	26
Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies	26
Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells	25
Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors	25
Advances in characterization of SIRT3 deacetylation targets in mitochondrial function	25
BAP31: Physiological functions and roles in disease	25
Biotechnology tools and applications for development of oilseed crops with healthy vegetable oils	25
Crowded environment affects the activity and inhibition of the NS3/4A protease	25
High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification	24
Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism	24
A glance into the evolution of template-free protein structure prediction methodologies	24
Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria	24
Membrane heist: Coronavirus host membrane remodeling during replication	24
LncRNA ZFAS1 inhibits triple-negative breast cancer by targeting STAT3	23
One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects?	23
Bis(monoacylglycero)phosphate, a new lipid signature of endosome-derived extracellular vesicles	23
Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action	23
Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?	23
Therapeutic applications of mitochondrial transplantation	22
Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression	22
A panel of circulating long non-coding RNAs as liquid biopsy biomarkers for breast and cervical cancers	22
A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation	22
The chemical composition and lipid profile of the chub mackerel (Scomber colias) show a strong seasonal dependence: Contribution to a nutritional evaluation	22
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles	22
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation	22
DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand	21
GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research	21
Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence	21
Diabetes mellitus and melatonin: Where are we?	21
Bis(monoacylglycero)phosphate, an important actor in the host endocytic machinery hijacked by SARS-CoV-2 and related viruses	21
The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway	21
Regulatory T cells in patients with early untreated rheumatoid arthritis: Phenotypic changes in the course of methotrexate treatment	21
Identification and characterization of dihydropyrimidinase inhibited by plumbagin isolated from Nepenthes miranda extract	20
Adipokines from white adipose tissue in regulation of whole body energy homeostasis	20
Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy	19
Na/K-ATPase: Their role in cell adhesion and migration in cancer	19
Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer	19

Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases	19
The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to the G-quadruplex of the BAG-1 5′UTR	19
Conformational selection in the flaviviral NS2B-NS3 protease	19
Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible?	19
PCR enhancers: Types, mechanisms, and applications in long-range PCR	19
Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity	19
Alternagin-C (ALT-C), a disintegrin-like protein, attenuates alpha2beta1 integrin and VEGF receptor 2 signaling resulting in angiogenesis inhibition	18
Osteoporosis: A role for lipids	18
Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression	18
The therapeutic potential of targeting CD73 and CD73-derived adenosine in melanoma	18
Zika virus subversion of chaperone GRP78/BiP expression in A549 cells during UPR activation	18
Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases	17
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex	17
Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation	17
Bacillus thuringiensis: From biopesticides to anticancer agents	17
Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer	17
Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters	17
KDM6B (JMJD3) and its dual role in cancer	17
Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs	16
Unique functional properties of slow skeletal muscle tropomyosin	16
The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms	16
Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential	16
The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications	16
Tetracycline derivatives resist the assembly behavior of human islet amyloid polypeptide	16
Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial	16
De novo methyltransferases: Potential players in diseases and new directions for targeted therapy	16
Dbr1 functions in mRNA processing, intron turnover and human diseases	16
The impact of endocrine disrupting compounds and carcinogens in wastewater: Implications for breast cancer	15
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies	15
Nuclear transformation of Chlamydomonas reinhardtii: A review	15
Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9	15
Plant lectin: A promising future anti-tumor drug	15
Rational design and structure insights for thermostability improvement of Penicillium verruculosum Cel7A cellobiohydrolase	15
An aptamer-based, fluorescent and radionuclide dual-modality probe	15
Acute exposure to bis(2-ethylhexyl)phthalate disrupts calcium homeostasis, energy metabolism and induces oxidative stress in the testis of Danio rerio	15
Novel G-quadruplex prone sequences emerge in the complete assembly of the human X chromosome	14
Plasmodium’s journey through the Anopheles mosquito: A comprehensive review	14
Beyond amyloid proteins: Thioflavin T in nucleic acid recognition	14
Cartilage acidic protein 1 promotes increased cell viability, cell proliferation and energy metabolism in primary human dermal fibroblasts	14
A novel anionic cathelicidin lacking direct antimicrobial activity but with potent anti-inflammatory and wound healing activities from the salamander Tylototriton kweichowensis	14
Proteomics analysis of Cyclobalanopsis gilva provides new insights of low seed germination	14
Ion mobility mass spectrometry of human melanoma gangliosides	14
Lipidomic analysis of human corneal epithelial cells exposed to ocular irritants highlights the role of phospholipid and sphingolipid metabolisms in detergent toxicity mechanisms	14
Prolidase – A protein with many faces	14
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme	14
Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype	14
Exoproduction and characterization of a detergent-stable alkaline keratinase from Arthrobacter sp. KFS-1	14
Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein	14
EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus	14
EDA2R mediates podocyte injury in high glucose milieu	14
Extracellular vesicles of MSCs and cardiomyoblasts are vehicles for lipid mediators	14
Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors	14
Involvement of aquaglyceroporins in energy metabolism in health and disease	14
Biomembrane lipids: When physics and chemistry join to shape biological activity	13
Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis	13
Cytochrome 450 metabolites of arachidonic acid (20-HETE, 11,12-EET and 14,15-EET) promote pheochromocytoma cell growth and tumor associated angiogenesis	13
Deiminated proteins and extracellular vesicles as novel biomarkers in pinnipeds: Grey seal (Halichoerus gryptus) and harbour seal (Phoca vitulina)	13
Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment	13
ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation	13
Stability and context of intercalated motifs (i-motifs) for biological applications	13
Intestinal interplay of quorum sensing molecules and human receptors	13
Cellular and molecular modification of egg envelope hardening in fertilization	13
Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase	13
G-quadruplex motifs are functionally conserved in cis-regulatory regions of pathogenic bacteria: An in-silico evaluation	13
Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis	12
Adipose-derived stem/stromal cell secretome modulates breast cancer cell proliferation and differentiation state towards aggressiveness	12
α-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy	12
Tough synthetic spider-silk fibers obtained by titanium dioxide incorporation and formaldehyde cross-linking in a simple wet-spinning process	12
Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy	12
The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells	12
Development and validation of a rapid, specific and sensitive LC-MS/MS bioanalytical method for eicosanoid quantification - assessment of arachidonic acid metabolic pathway activity in hypertensive ra	12
Single and consecutive application of near-infrared and green irradiation modulates adipose derived stem cell proliferation and affect differentiation factors	12
Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs	12
Serotonergic drugs modulate the phase behavior of complex lipid bilayers	11
A two-quartet G-quadruplex topology of human KIT2 is conformationally selected by a perylene derivative	11
Protein–protein interactions of ER–resident selenoproteins with their physiological partners	11
Adipokines in obesity and metabolic-related-diseases	11
The role of G-Quadruplex DNA in Paraspeckle formation in cancer	11
Evaluating the role of nitric oxide in myogenesis in vitro	11
Exosomal lipids from membrane organization to biomarkers: Focus on an endolysosomal-specific lipid	11

Coronaviruses, cholesterol and statins: Involvement and application for Covid-19	11
High salt diet contributes to hypertension by weakening the medullary tricarboxylic acid cycle and antioxidant system in Dahl salt-sensitive rats	11
Mig6 not only inhibits EGFR and HER2 but also targets HER3 and HER4 in a differential specificity: Implications for targeted esophageal cancer therapy	11
The diversity of lipocalin receptors	11
EPHA2 antisense RNA modulates EPHA2 mRNA levels in basal-like/triple-negative breast cancer cells	11
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?	10
Lipid excess affects chaperone-mediated autophagy in hypothalamus	10
Stabilization of a DNA aptamer by ligand binding	10
Production, characteristics and applications of microbial heparinases	10
Biochemical, pharmacological and structural characterization of BmooMP-I, a new P–I metalloproteinase from Bothrops moojeni venom	10
Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency	10
HIV-1 Tat: An update on transcriptional and non-transcriptional functions	10
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy	10
Contribution of Apaf-1 to the pathogenesis of cancer and neurodegenerative diseases	10
The structural and molecular biology of type IV galactosemia	10
trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats	10
Functional roles of human Up-frameshift suppressor 3 (UPF3) proteins: From nonsense-mediated mRNA decay to neurodevelopmental disorders	10
Histone code reader SPIN1 is a promising target of cancer therapy	10
Oleochemistry potential from Brazil northeastern exotic plants	10
Crystal structures and RNA-binding properties of Lsm proteins from archaea Sulfolobus acidocaldarius and Methanococcus vannielii: Similarity and difference of the U-binding mode	10
Metal effect on intein splicing: A review	10
StpA represses CRISPR-Cas immunity in H-NS deficient Escherichia coli	10
Human L-Dopa decarboxylase interaction with annexin V and expression during apoptosis	10
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2	10
Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status	10
Structure and activation mechanism of the human liver-type glutaminase GLS2	10
Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA	10
In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver	10
Dietary choline is related to increased risk of acute myocardial infarction in patients with stable angina pectoris	10
Functional role of annexins in zebrafish caudal fin regeneration – A gene knockdown approach in regenerating tissue	10
Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications	10
Aquaporins with lactate/lactic acid permeability at physiological pH conditions	9
Tanshinone IIA exerts autophagic cell death through down-regulation of β-catenin in renal cell carcinoma cells	9
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase	9
In vitro and computational studies of natural products related to perezone as anti-neoplastic agents	9
Upregulation of enzymatic antioxidants in CD4+ T cells of autistic children	9
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy [Biochimie 200 (2022) 44–59]	9
Interaction of 5-substituted pyrimidine nucleoside analogues and M.Tuberculosis: A view through an electron microscope	9
Structural and thermodynamic analyses of human TMED1 (p24γ1) Golgi dynamics	9
ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism	9
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2	9
A regenerative approach to the pharmacological management of hard-to-heal wounds	9
Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease	9
Musculoskeletal regeneration: A zebrafish perspective	9
Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex	9
Human sperm functioning is related to the aquaporin-mediated water and hydrogen peroxide transport regulation	9
Is the gut microbiota dysbiotic in patients with classical homocystinuria?	9
Toxinological characterization of venom from Leptodeira annulata (Banded cat-eyed snake; Dipsadidae, Imantodini)	9
Cyclical amyloid beta-astrocyte activity induces oxidative stress in Alzheimer’s disease	9
Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions	9
Mitochondrial peptide Mtln contributes to oxidative metabolism in mice	9
Murine cellular model of mucopolysaccharidosis, type IIIB (MPS IIIB) – A preliminary study with particular emphasis on the non-oxidative l-cysteine metabolism	9
Elucidating carbohydrate metabolism in Euglena gracilis: Reverse genetics-based evaluation of genes coding for enzymes linked to paramylon accumulation	9
Regulation of mitochondrial function by forkhead transcription factors	9
Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B	9
Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity	9
The stimulation of succinate-fueled respiration of rat liver mitochondria in state 4 by α,ω-hexadecanedioic acid without induction of proton conductivity of the inner membrane. Intrinsic uncoupling of	9
Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids	9
Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection	8
Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups	8
Diacylglycerol kinase η regulates C2C12 myoblast proliferation through the mTOR signaling pathway	8
X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma	8
Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX	8
Relaxin in hepatic fibrosis: What is known and where to head?	8
Crystal structure of Dictyoglomus thermophilum β-d-xylosidase DtXyl unravels the structural determinants for efficient notoginsenoside R1 hydrolysis	8
Inhibition of LPAR6 overcomes sorafenib resistance by switching glycolysis into oxidative phosphorylation in hepatocellular carcinoma	8
Zinc binding loop mutations of hSOD1 promote amyloid fibrils under physiological conditions: Implications for initiation of amyotrophic lateral sclerosis	8
Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes	8
Humanizing plant-derived snakins and their encrypted antimicrobial peptides	8
What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?	8
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain	8
Aquaporins implicated in the cell proliferation and the signaling pathways of cell stemness	8
TRPP2 ion channels: The roles in various subcellular locations	8
Mutations in the coordination spheres of T1 Cu affect Cu2+-activation of the laccase from Thermus thermophilus	8
Free advanced glycation end product distribution in blood components and the effect of genetic polymorphisms	8
Role of mitochondrial calcium in hypochlorite induced oxidative damage of cells	8
Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle	8
Biochemical aspects of hemoglobin-xenobiotic interactions and their implications in drug discovery	8
Phosphorylation of the acyl-CoA binding pocket of the FadR transcription regulator in Sulfolobus acidocaldarius	8
Probing the DNA-binding center of the MutL protein from the Escherichia coli mismatch repair system via crosslinking and Förster resonance energy transfer	8
Structural considerations on lipoxygenase function, inhibition and crosstalk with nitric oxide pathways	8