Biochimie

Article	Citations
Small molecule chaperones facilitate the folding of RNA G-quadruplexes	110
Central nervous system pathways targeted by amylin in the regulation of food intake	77
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2	67
Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters	56
Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation	42
Cellular and molecular modification of egg envelope hardening in fertilization	36
The copper P-type ATPase CtpA is involved in the response of Mycobacterium tuberculosis to redox stress	35
A U2 snRNP-specific protein, U2A′, is involved in stress response and drug resistance in Cryptococcus deneoformans	35
An update on inflammation in uveal melanoma	34
Structural insights into the evolution of late steps of translation initiation in the three domains of life	34
Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation	34
Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1	34
Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids	33
Loops constructing the substrate-binding site controlled the catalytic efficiency of Thermus thermophilus SG0.5JP17-16 laccase	33
Identification of a survival associated gene trio in chemical induced breast cancer	31
The molecular crosstalk of the hippo cascade in breast cancer: A potential central susceptibility	30
Aquaporins with lactate/lactic acid permeability at physiological pH conditions	29
Epithelium-specific ETS transcription factor-1 regulates NANOG expression and inhibits NANOG-induced proliferation of human embryonic carcinoma cells	29
Functions of long non-coding RNA ROR in patient-derived glioblastoma cells	28
Daidzein-directed methionine γ-lyase in enzyme prodrug therapy against breast cancer	28
Zacharias Dische and the discovery of feedback inhibition: A landmark paper published in the forerunner of Biochimie	28
Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease	27
Editorial	27
Serum fatty acid profiling in patients with SDHx mutations: New advances on cellular metabolism in SDH deficiency	27
Methodologies and tools to shed light on erythrophagocytosis	26

The current state of amyloidosis therapeutics and the potential role of fluorine in their treatment	24
Cell cycle and mitosis progression during ZIKA virus infection: The viral non-structural protein NS5 as a master regulator of the APC/cyclosome?	22
Characterization of SLA RNA promoter from dengue virus and its interaction with the viral non-structural NS5 protein	22
Inside front cover-EDB	22
Unraveling the impact of the p.R107L mutation on the structure and function of human αB-Crystallin: Implications for cataract formation	22
The ‘Not-So-Famous Five’ in tumorigenesis: tRNAs, tRNA fragments, and tRNA epitranscriptome in concert with AARSs and AIMPs	22
Inside front cover-EDB	21
Evaluation of microRNA variant maturation prior to genome edition	21
A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin	19
A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression	19
Lipids play music at the cellular membrane: From membranes dynamics to signaling via lipid mediators, vesicles and lipid droplets	19
Human DNA ligases I and IIIα as determinants of accuracy and efficiency of base excision DNA repair	19
DNA damage-induced senescence is associated with metabolomic reprogramming in breast cancer cells	19
Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions	19
Reviewer Acknowledgement	18
Body, ambient and felt temperature: An attempt to resolve a human and mice dilemma	18
Proteomics of the haemolymph of the terrestrial crustacean Porcellio scaber reveals components of its innate immunity under baseline conditions	18
Mycobacterium tuberculosis and its secreted tyrosine phosphatases	18
Potential elevation of exopeptidase activity of Glu-specific endopeptidase I/GluV8 mediated by hydrophobic P1′-position amino acid residue	18
Disruption of mitochondrial bioenergetics, calcium retention capacity and cell viability caused by D-2-hydroxyglutaric acid in the heart	17
Phytoestrogens decorated nanocapsules for therapeutic methionine γ-lyase targeted delivery	17
Zwitterionic fluorinated detergents: From design to membrane protein applications	17
Emerging therapeutic roles of small heat shock protein-derived mini-chaperones and their delivery strategies	17
Deciphering the Akt1-HuD interaction in HuD-mediated neuronal differentiation	17
Inside front cover-EDB	17
Inside front cover-EDB	16
The non-Newtonian behavior of detergents during concentration is increased by macromolecules, in trans, and results in their over-concentration	16
Reviewer Acknowledgement	16
Shift in phospholipid and fatty acid contents accompanies brain myelination	16
Dual-targeted anti-CMV/anti-HIV-1 heterodimers	15
Inside front cover-EDB	15
Cryptic inhibitory regions nearby activation domains	15
Human microbial dysbiosis as driver of gynecological malignancies	15
Inside front cover-EDB	15
Identification of new Omega-3 very long chain poly-unsaturated fatty acids in meibomian gland secretions	15
Inside front cover-EDB	15
Inside front cover-EDB	15
Molecular and cellular outcomes of quercetin actions on healthy and tumor osteoblasts	15
The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line	15
The key role of aquaporins in animals and plants	14
Thermoneutral housing does not rescue olanzapine-induced trabecular bone loss in C57BL/6J female mice	14
Multimodal plasma metabolomics and lipidomics in elucidating metabolic perturbations in tuberculosis patients with concurrent type 2 diabetes	14
Circadian rhythmicity of the thioredoxin system in cultured murine peritoneal macrophages	14
Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition	14
Isolation and characterization of a lectin-like chitinase from the hepatopancreas of freshwater prawn, Macrobrachium rosenbergii	14
TolC-AcrA complex formation monitored by time dependent single-channel electrophysiology	14
Editorial: Regeneration in Health and Disease	14
Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis	14
Blood derived extracellular vesicles as regenerative medicine therapeutics	14
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines	13

Leishmania donovani mevalonate kinase regulates host actin for inducing phagocytosis	13
Involvement of aquaglyceroporins in energy metabolism in health and disease	13
Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status	13
A mass spectrometric approach to study the interaction of amyloid β peptides with human α-2-macroglobulin	13
DNA binding site kinetics of a large antiviral polyamide	13
The structural and molecular biology of type IV galactosemia	12
New transaminase from Odontosyllis undecimdonta the first potential enzyme of the luciferin biosynthesis pathway	12
Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes	12
Melatonin as an adjuvant treatment modality with doxorubicin	12
NMS-873 functions as a dual inhibitor of mitochondrial oxidative phosphorylation	12
Optimized high-yield expression of envelope glycoprotein domain III from dengue virus serotypes 1 to 4	12
Achatina fulica haemocyanin-derived peptides as novel antimicrobial agents	12
Ex vivo tolerization and M2 polarization of macrophages dampens both pro- and anti-inflammatory cytokine production in response to diabetic wound fluid stimulation	12
Molecular and cellular mechanisms of melatonin in breast cancer	12
Unveiling the mechanism of hesperidin-induced LdTopI-mediated cell death pathway in protozoan parasite Leishmania donovani	12
Syndecan-1 and -4 influence Wnt signaling and cell migration in human breast cancers	12
Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups	12
Advances in fluorescence microscopy can reveal important new aspects of tissue regeneration	11
Potential of TSPO radioligands: Bridging brain tumor diagnostics to the peripheries	11
The pro-inflammatory responses of innate immune cells to Leishmania RNA virus 2-infected L. major support the survival and proliferation of the parasites	11
In vitro and in silico characterization of a novel glutamate carboxypeptidase from Cohnella sp. A01	11
Evaluating the cytotoxicity mechanism of the cell-penetrating peptide TP10 on Jurkat cells	11
Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription	11
Naked mole-rat hyaluronan	11
N-terminal processing by dipeptidyl peptidase 9: Cut and Go!	11
Antimicrobial nano-assemblies of tryptocidine C, a tryptophan-rich cyclic decapeptide, from ethanolic solutions	11
Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer	11
Impact of missense mutations in the ALDH7A1 gene on enzyme structure and catalytic function	11
Functional analysis of Lsm protein under multiple stress conditions in the extreme haloarchaeon Haloferax mediterranei	11
Enhanced structure/function of mTSPO translocator in lipid:surfactant mixed micelles	11
Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover	11
Elucidating the pivotal role of TSPO in porphyrin-related cellular processes, in Bacillus cereus	11
Inside front cover-EDB	11
Biomembrane lipids: When physics and chemistry join to shape biological activity	11
Establishment of fibroblast and myofibroblast phenotypes for use in in vitro co-culture models	10
A meal rich in palm oil or butter modifies the sphingolipid profile of postprandial triglyceride-rich lipoproteins from type 2 diabetic women	10
Revealing O-acetylhomoserine sulfhydrylase involved in direct sulfhydrylation pathway in Clostridium tetani	10
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy	10
Does housing temperature influence glucose regulation and muscle-fat crosstalk in mice?	10
Reactive oxygen and nitrogen species and innate immune response	10
Intraovarian condensed platelet cytokines for infertility and menopause—Mirage or miracle?	10
History of how viruses can fight cancer: From the miraculous healings to the approval of oncolytic viruses	10
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?	10
Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies	10
The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications	10
The mitochondrial translocator protein (TSPO) in Alzheimer's disease: Therapeutic and immunomodulatory functions	10
Viral nanoparticles: Current advances in design and development	10
DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand	10
Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment	10
Role of mitochondrial calcium in hypochlorite induced oxidative damage of cells	10
Characterization of the Arabidopsis thaliana chromatin remodeler DEK3 for its interaction with histones and DNA	9
Established and emerging players in phospholipid scrambling: A structural perspective	9
Assessment of membrane labelling mechanisms with exogenous fatty acids and detergents in bacteria	9
Molecular etiology of defective nuclear and mitochondrial ribosome biogenesis: Clinical phenotypes and therapy	9
Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila	9
CD38/NAD+ glycohydrolase and associated antigens in chronic lymphocytic leukaemia: From interconnected signalling pathways to therapeutic strategies	9
Lipid droplets degradation mechanisms from microalgae to mammals, a comparative overview	9
Loxosceles amazonica Brown Spider venom: Insights into enzymatic activities, immunorecognition, and novel phospholipase D isoforms	9
Unveiling overlooked pathways: The uric acid catabolism genes in the human genome	9
Deciphering the substrate specificity of housekeeping sortase A and pilus-specific sortase C of probiotic bacterium Lactococcus lactis	9
The role of the gut microbial metabolism of sterols and bile acids in human health	9
Diabetes mellitus and melatonin: Where are we?	9
Inside front cover-EDB	9
Glycolysis as key regulatory step in FSH-induced rat Sertoli cell proliferation: Role of the mTORC1 pathway	9
Beneficial and deleterious effects of sitagliptin on a methionine/choline-deficient diet-induced steatohepatitis in rats	9
A-family anti-inflammatory cyclopentenone prostaglandins: A novel class of non-statin inhibitors of HMG-CoA reductase	8
Advanced profiling and structural analysis of anencephaly gangliosides by ion mobility tandem mass spectrometry	8
Intestinal interplay of quorum sensing molecules and human receptors	8
Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model	8
Structural and thermodynamic analyses of human TMED1 (p24γ1) Golgi dynamics	8
The antibacterial activity and mechanisms of Trp-containing peptides against multidrug-resistant Pseudomonas aeruginosa persisters	8
Translocator protein (TSPO), still an enigmatic transmembrane protein: From structures to functions	8
Neuroprotectin D1, a lipid anti-inflammatory mediator, in patients with intracerebral hemorrhage	8
Kinetic and pharmacokinetic characteristics of therapeutic methinoninе γ-lyase encapsulated in polyion complex vesicles	8
Housing temperature plays a critical role in determining gut microbiome composition in research mice: Implications for experimental reproducibility	8
Retraction notice to “MiR-650 regulates the proliferation, migration and invasion of human oral cancer by targeting Growth factor independent 1 (Gfi1)” [Biochimie 156 (2018) 69–78]	8
Neutrophils and purinergic signaling: partners in the crime against Leishmania parasites?	8
The modulation of low molecular weight sulfur compounds levels in visceral adipose tissue of TLR2-deficient mice on a high-fat diet	8
Cold stress during room temperature housing alters skeletal response to simulated microgravity (hindlimb unloading) in growing female C57BL6 mice	8
Antioxidant cytochrome c-like activity of para-Mn(III)TMPyP	8

CRISPR genotyping methods: Tracing the evolution from spoligotyping to machine learning	8
Glucose deprivation using 2-deoxyglucose and acarbose induce metabolic oxidative stress and apoptosis in female mice bearing breast cancer	8
Macrolactin a is an inhibitor of protein biosynthesis in bacteria	8
Retraction notice to “Effects of geniposide on hepatocytes undergoing epithelial-mesenchymal transition in hepatic fibrosis by targeting TGFβ/Smad and ERK-MAPK signaling pathways” [Biochimie 113 (2015	8
Retraction notice to “Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via PKC/ERK/c-Fos pathways in RAW264.7 macrophages” [Biochimie 119C (2015) 192–203]	8
α-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy	8
Microbial β-glucosidases: Recent advances and applications	8
Functional and structural characterization of an endo-β-1,3-glucanase from Euglena gracilis	8
Epithelial mesenchymal transition induced nuclear localization of the extracellular matrix protein Fibronectin	8
Crystal structure of Methionyl-tRNA Synthetase from Rickettsia typhi in complex with its cognate amino acid	7
Exosomes derived from mesenchymal stem cells: A promising cell-free therapeutic tool for cutaneous wound healing	7
Molecular explorations of the Leishmania donovani 6-phosphogluconolactonase enzyme, a key player in the pentose phosphate pathway	7
Enhanced activity of split trehalase biosensors by interspecies domain combineering	7
G-quadruplex motifs are functionally conserved in cis-regulatory regions of pathogenic bacteria: An in-silico evaluation	7
Influence of the aquatic environment and 1α,25(OH)2 vitamin D3 on calcium influx in the intestine of adult zebrafish	7
Characterization of novel gliotoxin biosynthesis-related genes from deep-sea-derived fungus Geosmithia pallida FS140	7
Stability and context of intercalated motifs (i-motifs) for biological applications	7
Effects of biophysical membrane properties on recognition of phosphatidylserine, or phosphatidylinositol 4-phosphate by lipid biosensors LactC2, or P4M	7
Role of AMPK mediated pathways in autophagy and aging	7
Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity	7
The Barnase-Barstar-based pre-targeting strategy for enhanced antitumor therapy in vivo	7
HIV-1 Tat: An update on transcriptional and non-transcriptional functions	7
INTERPIN: A repository for intrinsic transcription termination hairpins in bacteria	7
Comparison of the calcium signaling alterations in GABA-ergic medium spiny neurons produced from iPSCs of different origins	7
The glycoprotein gp63– a potential pan drug target for developing new antileishmanial agents	7
The complex repertoire of Tityus spp. venoms: Advances on their composition and pharmacological potential of their toxins	7
Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications	7
The cysteine protease legumain decreases glucose metabolism and enhances fatty acid uptake in human myotubes	7
Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation	7
The stimulation of succinate-fueled respiration of rat liver mitochondria in state 4 by α,ω-hexadecanedioic acid without induction of proton conductivity of the inner membrane. Intrinsic uncoupling of	7
Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver	7
Inhibitory effects of sesquiterpene lactones on the aggregation and cytotoxicity of prion neuropeptide	7
Cloning and characterization of glycogen branching and debranching enzymes from the parasitic protist Trichomonas vaginalis	6
Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease	6
Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD+/NADH redox method	6
Coronaviruses, cholesterol and statins: Involvement and application for Covid-19	6
Biochemical characterization of a unique DNA polymerase A from the extreme radioresistant organism Deinococcus radiodurans	6
Generation of the novel anti-FXYD5 monoclonal antibody and its application to the diagnosis of pancreatic and lung cancer	6
The rise of RNA: From fundamental research to therapeutic applications	6
Basic protein- and peptide-induced stabilization of long-loop DNA G-guadruplexes	6
Bring the heat: Thermal stress, metabolic plasticity, and considerations for biomedical research	6
Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange	6
Therapeutical growth in oligodendroglial fate induction via transdifferentiation of stem cells for neuroregenerative therapy	6
Glycine disrupts myelin, glutamatergic neurotransmission, and redox homeostasis in a neonatal model for non ketotic hyperglycinemia	6
G·U base pairing motifs in long non-coding RNAs	6
The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice	6
Structural and mechanistic insights into the substrate specificity and hydrolysis of GH31 α-N-acetylgalactosaminidase	6
Circadian clock gene disruption in white blood cells of patients with celiac disease	6
Inside front cover-EDB	6
Quadruplexes and aging: G4-binding proteins regulate the presence of miRNA in small extracellular vesicles (sEVs)	6
Inside front cover-EDB	6
Counteracting diabetes-induced adipose tissue derived-stromal cell senescence	6
Inside front cover-EDB	6
Mycobacterium tuberculosis H37Rv enolase (Rv1023)- expression, characterization and effect of host dependent modifications on protein functionality	6
The stability and function of human cochaperone Hsp40/DNAJA1 are affected by zinc removal and partially restored by copper	6
Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction	6
Human transcriptional gene regulatory network compiled from 14 data resources	6
Syndecan-4 regulates the HER2-positive breast cancer cell proliferation cells via CK19/AKT signalling	6
Analysis of the interaction of a non-canonical twin half-site of Cyclic AMP-Response Element (CRE) with CRE-binding protein	6
Sequencing of the Lumbricus terrestris genome reveals degeneracy in its erythrocruorin genes	6
First functional and proteomic analysis of Bothrops asper snake venom from Gorgona Island - Colombia, and its comparative characterization with two Colombian Southwest ecoregions	6
CogiTx1: A novel subtilisin A inhibitor isolated from the sea anemone Condylactis gigantea belonging to the defensin 4 protein family	6
Is the small heat shock protein HSPB7 (cvHsp) a genuine actin-binding protein?	5
Pyridoxal kinase gene deletion leads to impaired growth, deranged redox metabolism and cell cycle arrest in Leishmania donovani	5
Dimer stilbene, a resveratrol analogue exhibits synergy with antibiotics that target protein synthesis in eradicating Staphylococcus aureus infection	5
MotSASi: Functional short linear motifs (SLiMs) prediction based on genomic single nucleotide variants and structural data	5
Effects of natural polymorphisms in SARS-CoV-2 RNA-dependent RNA polymerase on its activity and sensitivity to inhibitors in vitro	5
Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors	5
Current perspectives for microbial lipases from extremophiles and metagenomics	5
The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells	5
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis	5
Mutations in the coordination spheres of T1 Cu affect Cu2+-activation of the laccase from Thermus thermophilus	5
Neuroprotective effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline mediated via regulation of antioxidant system and inhibition of inflammation and apoptosis in a rat model of cerebral ischemia/	5
Thiolatocobalamins repair the activity of pathogenic variants of the human cobalamin processing enzyme CblC	5
Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity	5
Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase	5
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein	5
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae)	5
LEAP2 is a more conserved ligand than ghrelin for fish GHSRs	5
Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines	5
Gene cluster from plant to microbes: Their role in genome architecture, organism's development, specialized metabolism and drug discovery	5
Adipokines in obesity and metabolic-related-diseases	5
Molecular insights into the mechanism of substrate binding and catalysis of bifunctional FAD synthetase from Staphylococcus aureus	5
Dioclea violacea lectin inhibits tumorigenesis and tumor angiogenesis in vivo	5
Exploring the selenium-over-sulfur substrate specificity and kinetics of a bacterial selenocysteine lyase	5
Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential	5
DNA methyltransferase isoforms regulate endothelial cell exosome proteome composition	5
Coordination between human DNA polymerase β and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair	5
Zinc binding loop mutations of hSOD1 promote amyloid fibrils under physiological conditions: Implications for initiation of amyotrophic lateral sclerosis	5
Modular architecture and functional annotation of human RNA-binding proteins containing RNA recognition motif	5
TRIM28 regulates transcriptional activity of methyl-DNA binding protein Kaiso by SUMOylation	5
Purification and characterization of a hemocyanin with lectin-like activity isolated from the hemolymph of speckled shrimp, Metapenaeus monoceros	5
Rapid detection and imaging of methylglyoxal in plant tissues by the near-infrared fluorescent probe SWJT-2	5
Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model	5
Modeling G4s in chromatin context confirms partial nucleosome exclusion and reveals nucleosome-disrupting effects of the least selective G4 ligands	5