OOIR: Observatory of International Research

Papers

(The median citation count of Basic Research in Cardiology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?	152
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level	87
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cere	79
Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities	76
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action	72
Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy	72
Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS	70
Cellular and mitochondrial mechanisms of atrial fibrillation	62
CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly	61
PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia	55
Vascular autophagy in health and disease	54
Perspective: cardiovascular disease and the Covid-19 pandemic	52
Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration	48
Cytokines as therapeutic targets for cardio- and cerebrovascular diseases	48
Mouse models of atherosclerosis and their suitability for the study of myocardial infarction	47
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways	44
Coronary blood flow in heart failure: cause, consequence and bystander	44
Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury	43
Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response	41
Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series	41
Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis	39
Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages	39
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy	38
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering	37
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function	37

NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux	37
Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy	35
Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling	35
Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia	35
Remote ischemic preconditioning reduces myocardial ischemia–reperfusion injury through unacylated ghrelin-induced activation of the JAK/STAT pathway	35
Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors	34
Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis	34
Targeting myocardial ischaemic injury in the absence of reperfusion	32
miR-106a–363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury	32
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke	32
Metoprolol blunts the time-dependent progression of infarct size	31
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants	31
Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles	29
A future for remote ischaemic conditioning in high-risk patients	29
Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology	29
Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy	28
Functional investigation of the coronary artery disease gene SVEP1	27
Adenosine and adenosine receptor-mediated action in coronary microcirculation	27
Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart	27
SAIL: a new conserved anti-fibrotic lncRNA in the heart	27
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension	26
LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway	26
Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI)	25
Matrix metalloproteinase-7 in platelet-activated macrophages accounts for cardiac remodeling in uremic mice	25
Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure	25
HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype	24
Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study	24
Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning	24
Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases	24
Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury	24
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects	23
The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy	23
Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects	23
Macrophage-mediated regulation of catecholamines in sympathetic neural remodeling after myocardial infarction	23
AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism	23
Reverse re-modelling chronic heart failure by reinstating heart rate variability	23
Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration	21
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes	21
Cardioprotection by selective SGLT-2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?	21
Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop	21
SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation	20
Intracellular O-linked glycosylation directly regulates cardiomyocyte L-type Ca2+ channel activity and excitation–contraction coupling	20
Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis	19
The importance of clinically relevant background therapy in cardioprotective studies	19
Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs	19
Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes	19
Longitudinal metabolic profiling of cardiomyocytes derived from human-induced pluripotent stem cells	18
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs	18
Cardioprotection by early metoprolol- attenuation of ischemic vs. reperfusion injury?	18
Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms	18

Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis	17
Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia	17
The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner	17
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1	17
Translation of experimental cardioprotective capability of P2Y12 inhibitors into clinical outcome in patients with ST-elevation myocardial infarction	16
Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis	16
Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging	16
Autocrine effects of PCSK9 on cardiomyocytes	16
Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome	16
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant	16
Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model	16
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue func	15
Osteopontin promotes infarct repair	15
A practical guide for investigating cardiac physiology using living myocardial slices	15
Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans	15
CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes	15
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells	15